Medication-related Osteonecrosis of the Jaws (MRONJ), a literature review about professional knowledge and guidance given to patients to reduce risk
DOI:
https://doi.org/10.33448/rsd-v11i12.33818Keywords:
Prevention; Dental Care; Health Education; Awareness; Bisphosphonate-Associated Osteonecrosis of the Jaw ; Osteonecrosis.Abstract
Medication-related osteonecrosis of the jaws (MRONJ), is a complication that can occur in the maxillofacial region due to the use of antiresorptive and antiangiogenic medications, which negatively affects the patient's quality of life. Adequate knowledge on the part of health professionals involved in the care of this patient, especially physicians and dentists, regarding this complication is essential for the identification of patients “at risk” and, consequently, for the control of predisposing factors and for adequate guidance and management of this complication. patient. The objective of this study was to understand the influence of professionals' knowledge about the ONMM and the guidance given to patients to reduce its risk. Methodology: This is a narrative review of the literature with an exploratory character and qualitative descriptive analysis., carried out in the VHL and Pubmed databases and using descriptors indexed in DeCs. Results: Several studies pointed out the insufficient knowledge of health professionals. Most of the studies used questionnaires and were aimed at medical professionals, dentists, pharmacists and nurses. Conclusion: The knowledge of professionals is essential to pass information and guidance to the patient and directly influences the incidence of ONMM. Adopting preventive measures, therefore, is essential for the management of Osteonecrosis.
References
Aghaloo, T. L., Felsenfeld, A. L., & Tetradis, S. (2010). Osteonecrosis of the jaw in a patient on Denosumab. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 68(5), 959–963. https://doi.org/10.1016/j.joms.2009.10.010
Al Abdullateef, A., & Alhareky, M. S. (2020). Awareness among patient at risk of developing Medication Related Osteonecrosis of the Jaw (MRONJ) - A primary prevention strategy. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 28(6), 771–778. https://doi.org/10.1016/j.jsps.2020.05.004
Al-Samman, A. A., & Al-Ani, R. S. (2019). Across-sectional survey on medication-related osteonecrosis of the jaws' knowledge and awareness in a sample of dental society. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 47(6), 926–931. https://doi.org/10.1016/j.jcms.2019.02.006
Brandão, T.B., Migliorati, C.A., Santos Silva, A.R., Filho Vechiato, A.J., Querido de Oliveira, M.A. (2021). Diagnóstico e tratamento odontológico para pacientes oncológicos. 1.ed. Rio de Janeiro, RJ: GEN/ Grupo Editoral Nacional A.A. Publicado pelo selo Editora Guanabara Koogan Ltda.
Cordeiro, A. M., Oliveira, G. M. D., Rentería, J. M. & Guimarães, C. A. (2007). Revisão sistemática: uma revisão narrativa. Revista do colégio brasileiro de cirurgiões, 34 (6), s. 428–431. https://doi:10.1590/s0100-69912007000600012
de Cassia Tornier, S., Macedo, F. J., Sassi, L. M., & Schussel, J. L. (2021). Quality of life in cancer patients with or without medication-related osteonecrosis of the jaw. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(11), 6713–6719. https://doi.org/10.1007/s00520-021-06275-w
de Lima, P. B., Brasil, V. L., de Castro, J. F., de Moraes Ramos-Perez, F. M., Alves, F. A., dos Anjos Pontual, M. L., & da Cruz Perez, D. E. (2015). Knowledge and attitudes of Brazilian dental students and dentists regarding bisphosphonate-related osteonecrosis of the jaw. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 23(12), 3421–3426. https://doi.org/10.1007/s00520-015-2689-6
Eduardo, F, de P., Bezinelli, L.M., Corrêa, L. (2019). Odontologia na Oncologia. 1.ed. Rio de Janeiro,RJ: Atheneu.
Franchi, S., Brucoli, M., Boffano, P., Dosio, C., & Benech, A. (2020). Medical students' knowledge of medication related osteonecrosis of the jaw. Journal of stomatology, oral and maxillofacial surgery, 121(4), 344–346. https://doi.org/10.1016/j.jormas.2019.10.005
García-Martínez, L., Martín-Payo, R., Pelaz-García, A., Sierra-Vega, M., & Junquera-Gutiérrez, L. M. (2017). Intervention to improve awareness of the risk factors for osteonecrosis of the jaw in patients under treatment with bisphosponates. Randomised clinical trial. Intervención para la mejora del conocimiento de los factores de riesgo para el desarrollo de osteonecrosis maxilar en pacientes a tratamiento con bisfosfonatos. Ensayo clínico aleatorizado. Enfermeria clinica, 27(6), 352–360. https://doi.org/10.1016/j.enfcli.2017.04.001
Green, B. N., Johnson, C. D., & Adams, A. (2006). Writing narrative literature reviews for peer-reviewed journals: secrets of the trade. Journal of chiropractic medicine, 5(3), 101–117. https://doi.org/10.1016/S0899-3467(07)60142-6
Han A. L. (2021). The awareness and practice of dentists regarding medication-related osteonecrosis of the jaw and its prevention: a cross-sectional survey. BMC oral health, 21(1), 155. https://doi.org/10.1186/s12903-021-01475-6
Hillner, B. E., Ingle, J. N., Chlebowski, R. T., Gralow, J., Yee, G. C., Janjan, N. A., Cauley, J. A., Blumenstein, B. A., Albain, K. S., Lipton, A., Brown, S., & American Society of Clinical Oncology (2003). American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 21(21), 4042–4057. https://doi.org/10.1200/JCO.2003.08.017
Kim, J. W., Jeong, S. R., Kim, S. J., & Kim, Y. (2016). Perceptions of medical doctors on bisphosphonate-related osteonecrosis of the jaw. BMC oral health, 16(1), 92. https://doi.org/10.1186/s12903-016-0290-0
Marx R. E. (2003). Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 61(9), 1115–1117. https://doi.org/10.1016/s0278-2391(03)00720-1
Miranda-Silva, W., Montezuma, M. A., Benites, B. M., Bruno, J. S., Fonseca, F. P., & Fregnani, E. R. (2020). Current knowledge regarding medication-related osteonecrosis of the jaw among different health professionals. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 28(11), 5397–5404. https://doi.org/10.1007/s00520-020-05374-4
Nicolatou-Galitis, O., Schiødt, M., Mendes, R. A., Ripamonti, C., Hope, S., Drudge-Coates, L., Niepel, D., & Van den Wyngaert, T. (2019). Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment. Oral surgery, oral medicine, oral pathology and oral radiology, 127(2), 117–135. https://doi.org/10.1016/j.oooo.2018.09.008
Otto, S., Aljohani, S., Fliefel, R., Ecke, S., Ristow, O., Burian, E., Troeltzsch, M., Pautke, C., & Ehrenfeld, M. (2021). Infection as an Important Factor in Medication-Related Osteonecrosis of the Jaw (MRONJ). Medicina (Kaunas, Lithuania), 57(5), 463. https://doi.org/10.3390/medicina57050463
Ozkan, E., Bereket, M. C., & Ozkan, N. (2021). Knowledge and attitude regarding bisphosphonates and related osteonecrosis among Turkish dentist: A cross sectional study. Nigerian journal of clinical practice, 24(10), 1485–1491. https://doi.org/10.4103/njcp.njcp_684_20
Patil, V., Acharya, S., Vineetha, R., & Nikhil, K. (2020). Awareness About Medication-Related Osteonecrosis of the Jaw Among Dental Professionals: A Multicentre Study. Oral health & preventive dentistry, 18(1), 505–509. https://doi.org/10.3290/j.ohpd.a43361
Poxleitner, P., Engelhardt, M., Schmelzeisen, R., & Voss, P. (2017). The Prevention of Medication-related Osteonecrosis of the Jaw. Deutsches Arzteblatt international, 114(5), 63–69. https://doi.org/10.3238/arztebl.2017.0063
Rosella, D., Papi, P., Pompa, G., Capogreco, M., De Angelis, F., & Di Carlo, S. (2017). Dental students' knowledge of medication-related osteonecrosis of the jaw. European journal of dentistry, 11(4), 461–468. https://doi.org/10.4103/ejd.ejd_27_17
Ruggiero, S. L., & Woo, S. B. (2008). Biophosphonate-related osteonecrosis of the jaws. Dental clinics of North America, 52(1), 111–ix. https://doi.org/10.1016/j.cden.2007.09.002
Ruggiero, S. L., Dodson, T. B., Fantasia, J., Goodday, R., Aghaloo, T., Mehrotra, B., O'Ryan, F., & American Association of Oral and Maxillofacial Surgeons (2014). American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(10), 1938–1956. https://doi.org/10.1016/j.joms.2014.04.031
Ruggiero, S. L., Dodson, T. B., Aghaloo, T., Carlson, E. R., Ward, B. B., & Kademani, D. (2022). American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 80(5), 920–943. https://doi.org/10.1016/j.joms.2022.02.008
Schiodt, M., Reibel, J., Oturai, P., & Kofod, T. (2014). Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system. Oral surgery, oral medicine, oral pathology and oral radiology, 117(2), 204–213. https://doi.org/10.1016/j.oooo.2013.10.010
Senturk, M. F., Cimen, E., Tuzuner Oncul, A. M., & Cambazoglu, M. (2016). Oncologists awareness about bisphosphonate related osteonecrosis of the jaws. JPMA. The Journal of the Pakistan Medical Association, 66(7), 880–883.
Sturrock, A., Preshaw, P. M., Hayes, C., & Wilkes, S. (2017). Attitudes and perceptions of GPs and community pharmacists towards their role in the prevention of bisphosphonate-related osteonecrosis of the jaw: a qualitative study in the North East of England. BMJ open, 7(9), e016047. https://doi.org/10.1136/bmjopen-2017-016047
Tanna, N., Steel, C., Stagnell, S., & Bailey, E. (2017). Awareness of medication related osteonecrosis of the jaws (MRONJ) amongst general dental practitioners. British dental journal, 222(2), 121–125. https://doi.org/10.1038/sj.bdj.2017.79
Vinitzky-Brener, I., Ibáñez-Mancera, N.G., Álvarez, J.A.P., Serra-Rico, L.J, Carrasco, R.C.A., Fernández, P.R., Briseño, D.M. (2021). Conocimiento y conciencia de los médicos sobre la osteonecrosis relacionada con bifosfonatos. Rev ADM. 2021; 78 (1): 28-32. https://dx.doi.org/10.35366/98384
Wan, J. T., Sheeley, D. M., Somerman, M. J., & Lee, J. S. (2020). Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors. Bone research, 8, 14. https://doi.org/10.1038/s41413-020-0088-1
Yarom, N., Shapiro, C. L., Peterson, D. E., Van Poznak, C. H., Bohlke, K., Ruggiero, S. L., Migliorati, C. A., Khan, A., Morrison, A., Anderson, H., Murphy, B. A., Alston-Johnson, D., Mendes, R. A., Beadle, B. M., Jensen, S. B., & Saunders, D. P. (2019). Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 37(25), 2270–2290. https://doi.org/10.1200/JCO.19.01186
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