Global analysis to acute pancreatitis: a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i11.33920

Keywords:

Humans; Acute pancreatitis; Therapeutics; Incidence.

Abstract

Acute pancreatitis (AP) is one of the most common emergencies causes of hospitalization for gastrointestinal diseases. Many studies in different countries have been performed to identify the etiology, pathomechanisms and therapeutic strategies for AP treatment. This systematic review perform a global analysis of knowledge production about AP. The SCOPUS database using for our systematic review. The study considers the period between 2016 and 2020 and considered scientific journals with respect to the subject of publications, quantity of studies published, citations and leading countries in this area of research. A total of 75 publications were eligible among 16,563 records in the database. The subjects most discussed in the articles is the search for new drugs and therapies for the treatment of AP is a central concern of the researchers involved in the study of AP (26.6%). The etiology of AP corresponded to n = 11 articles (14.6%), highlighting the recent focus on the causes of AP such as hypertriglyceridemia (HTG). The results show that AP is becoming a globalized subject. Altogether, institutions from 36 countries contributed to the knowledge of pancreatitis over the period considered. The USA has the most publications (20) and occupies the vanguard position on the subject. China is the second largest center in AP knowledge production (17). The recent evidence in the form of systematic reviews represent a viable tool to understand the patterns in knowledge production about AP and to identify gaps in the networks about the subject.

References

Adeleye, B. N., Gershon, O., Ogundipe, A., Owolabi, O., Ogunrinola I., & Adediran, O. (2020). Comparative investigation of the growth-poverty-inequality trilemma in Sub-Saharan Africa and Latin American and Caribbean Countries. Heliyon, 6 (12): e05631.

Agarwal, S., George, J., Padhan, R. K., Vadiraja, P. K., Behera, S., Hasan, A., Dhingra R., & Garg, P. K. (2016). Reduction in mortality in severe acute pancreatitis: A time trend analysis over 16 years. Pancreatology, 16 (2): 194-199.

Bálint, E. R., Fűr, G., Kiss, L., Németh, D. I., Soós, A., Hegyi, P., Szakács, Z., Tinusz, B., Varjú, P., Vincze, Á., Erőss, B., Czimmer, J., Szepes, Z., Varga, G., & Rakonczay, Z. (2020). Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis. Scientific Reports, 10 (1): 17936.

Barbeiro, D. F., Koike, M. K., Coelho, A. M. M., da Silva, F. P., & Machado, M. C. (2016). Intestinal barrier dysfunction and increased COX-2 gene expression in the gut of elderly rats with acute pancreatitis. Pancreatology, 16 (1): 52-56.

Bellin, M. D., Kerdsirichairat, T., Beilman, G. J., Dunn, T. B., Chinnakotla, S., Pruett, T. L., Radosevich, D. R., Schwarzenberg, S. J., Sutherland, D. E. R., Arain, M. A., & Freeman, M. L. (2016). Clinical Gastroenterology and Hepatology, 14 (9): 1317-1323.

Bierma, M. J., Coffey, M. J., Nightingale, S., van Rheenen, P. F., & Ooi, C. Y. (2016). Predicting severe acute pancreatitis in children based on serum lipase and calcium: A multicentre retrospective cohort study. Pancreatology, 16 (4): 529-534.

Bradley, E. L. (1993). A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis. Arch Surg, 128 (5): 586-590.

Chatila, A. T., Bilal M., & Guturu, P. (2019). Evaluation and management of acute pancreatitis. World journal of clinical cases, 7 (9): 1006-1020.

da Cunha, J. E. (1994). Acute pancreatitis: a clinically based classification. Arq Gastroenterol, 31 (2): 52-56.

Davies, J., & Mullan, Z. (2016). Research capacity in Africa—will the sun rise again? The Lancet Global Health, 4 (5): e287.

Di Bitetti, M. S., & Ferreras, J. A. (2017). Publish (in English) or perish: The effect on citation rate of using languages other than English in scientific publications. Ambio, 46 (1): 121-127.

Fei, Y., Gao, K., & Li, W.-q. (2019). Prediction and evaluation of the severity of acute respiratory distress syndrome following severe acute pancreatitis using an artificial neural network algorithm model. HPB, 21 (7): 891-897.

Garg, P. K., & Mahapatra, S. J. (2021). Optimum Fluid Therapy in Acute Pancreatitis Needs an Alchemist. Gastroenterology, 160 (3): 655-659.

Garg, P. K., & Singh, V. P. (2019). Organ Failure Due to Systemic Injury in Acute Pancreatitis. Gastroenterology, 156 (7): 2008-2023.

Grech, V., & Rizk, D. E. E. (2018). Increasing importance of research metrics: Journal Impact Factor and h-index. International Urogynecology Journal, 29 (5): 619-620.

Hu, F., Lou, N., Jiao, J., Guo, F., Xiang, H., & Shang, D. (2020). Macrophages in pancreatitis: Mechanisms and therapeutic potential. Biomedicine & Pharmacotherapy, 131: 110693.

Index, N. (2020). Ten countries with high-performing hubs of natural-sciences research. Nature Index 2020 Annual Tables. Nature. 580, S44. doi:10.1038/d41586-020-01229-4.

Jo, S. I., Chang, J. H., Kim, T. H., Kim, C. W., Kim, J. K., & Han, S. W. (2019). Subsets associated with developing acute pancreatitis in patients with severe hypertriglyceridemia and the severity of pancreatitis. Pancreatology, 19 (6): 795-800.

Kim, S. J., Kang, H., Kim, E. J., Kim, Y. S., & Cho, J. H. (2020). Clinical features and outcomes of hypertriglyceridemia-induced acute pancreatitis: Propensity score matching analysis from a prospective acute pancreatitis registry. Pancreatology, 20 (4): 617-621.

Kirkegård, J., Cronin-Fenton, D., Heide-Jørgensen, U., & Mortensen, F. V. (2018). Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-Cohort Study in Denmark. Gastroenterology, 154 (6): 1729-1736.

Kirkegård, J., Mortensen, F. V., Heide-Jørgensen, U., & Cronin-Fenton, D. (2020). Predictors of underlying pancreatic cancer in patients with acute pancreatitis: a Danish nationwide cohort study. HPB, 22 (4): 553-562.

Koutroumpakis, E., Slivka, A., Furlan, A., Dasyam, A. K., Dudekula, A., Greer, J. B., Whitcomb, D. C., Yadav, D., & Papachristou, G. I. (2017). Management and outcomes of acute pancreatitis patients over the last decade: A US tertiary-center experience. Pancreatology, 17 (1): 32-40.

Lipinski, M., Rydzewska-Rosolowska, A., Rydzewski, A., Cicha, M., & Rydzewska, G. (2017). Soluble urokinase-type plasminogen activator receptor (suPAR) in patients with acute pancreatitis (AP) - Progress in prediction of AP severity. Pancreatology, 17 (1): 24-29.

Ma, R., Yuan, F., Wang, S., Liu, Y., Fan, T., & Wang, F. (2018). Calycosin alleviates cerulein-induced acute pancreatitis by inhibiting the inflammatory response and oxidative stress via the p38 MAPK and NF-κB signal pathways in mice. Biomedicine & Pharmacotherapy, 105: 599-605. doi: 10.1016/j.biopha.2018.05.080.

Masamune, A., Kikuta, K., Hamada, S., Tsuji, I., Takeyama, Y., Shimosegawa, T., Okazaki, K., Matsumoto, R., Kume, K., Miura, S., Takikawa, T., Hongo, S., Tanaka, Y., Sakai, T., Ueno, M., Unno, J., Toki, M., Nishimura, M., Kitamura, K., Kobashigawa, K., Ashida, K., Takahashi, K., Watanabe, T., Sato, Y., Satoh, Yoshida, A. N., Tanaka, K., Kondo, H., Suzuki, N., Sato, H., Mitoro, A., Minami, K., Iwasaki, E., Okuwaki, K., Mukai, T., Kudo, Y., Azuma, S., Takeda, Y., Setsuda, M., Tsuchida, K., Irisawa, A., Motoya, D., Shirahata, N., Iwata, K., Oza, N., Kawaguchi, Y., Hoshino, A., Hirano, A., Sakakihara, I., Watanabe, N., Funayama, H., Nakamura, Y., Yamamoto, T., Uchida, H. H., Iizawa, Y., Imamura, M., Inui, M., Yamamoto, K., Sato, S., Ishii, S., Yakushijin, S., Yamamoto, T., Masaka, K., Yoshida, T., Arizumi, T., Goto, M., Takenaka, M., Miyakawa, H. M., Otsuka, Y., Nishi, M., Suwa, K., Sakagami, J., Satoh, M., Koga, H., Takagi, T., Nagahama, M., Hatayama, K., Kaneko, N., Mori, M., Nakai, Y., Iwashita, Y., Iwatsuka, K., Hayashi, K., Terai, S., Kaneto, H., Nishikawa, T., Uchi, M., Honjo, M., Takagi, T., Mizukami, K., Tamura, T., Gushima, T., Sato, A., Shimizu, K., Aruga, Y., Nonogaki, K., Kaino, M., Iwashita, T., Tsuruoka, M., Miura, M., Hasegawa, H., Takai, T., Yokota, H., Fujisawa, T., Uetsuki, K., Kobayashi, T., yamaji, N., Itoi, T., Muraki, T., Watanabe, T., Inatomi, O., Ushijima, T., Takehara, Y., Kawamura, H., Fukasawa, M., Hagiwara, H., Tamura, H., Moriya, T., Kuwatani, M., Kawaji, Y., Kamisawa, T., Abue, M., Fukunishi, M., Onoyama, H., Mochizuki, S., Sumimoto, K., Koyabu, M., Nishio, A., Sakao, M., Imamura, Y., Ohta, H., Nishimura, N., Shiihara, M., Anan, H., Motoya, M., Chiba, M., Deguchi, T., Kofunato, Y., Sawada, N., Katada, K., Matsumoto, S., Higashide, S., Okano, H., Ishida, M., Yamazaki, M., Tamura, N., Muraoka, T., Uza, N., Kodama, Y., Muro, S., Fujimori, N., Ikeda, T., Shimokawahara, N., Otsu, N., Yano, Y., Sugawara, S., Takaura, K., Ogura, Y., Furuuchi, T., Shibasaki M., & Kishimoto, M. (2020). Clinical practice of acute pancreatitis in Japan: An analysis of nationwide epidemiological survey in 2016. Pancreatology, 20 (4): 629-636.

Matta, B., Gougol, A., Gao, X., Reddy, N., Talukdar, R., Kochhar, R., Goenka, M. K., Gulla, A., Gonzalez, J. A., Singh, V. K., Ferreira, M., Stevens, T., Barbu, S. T., Nawaz, H., Gutierrez, S. C., Zarnescu, N. O., Capurso, G., Easler, J., Triantafyllou, K., Pelaez-Luna, M., Thakkar, S., Ocampo, C., de-Madaria, E., Cote, G. A., Wu, B. U., Paragomi, P., Pothoulakis, I., Tang, G. & Papachristou, G. I. (2020). Worldwide Variations in Demographics, Management, and Outcomes of Acute Pancreatitis. Clinical Gastroenterology and Hepatology, 18 (7): 1567-1575.e2.

Miao, B., Qi, W. J., Zhang, S. W., Wang, H., Wang, C., Hu, L., Huang, G. W., Li, S. R., & Wang, H. (2019). miR-148a suppresses autophagy by down-regulation of IL-6/STAT3 signaling in cerulein-induced acute pancreatitis. Pancreatology, 19 (4): 557-565.

Mosko, J. D., Leiman, D. A., Ketwaroo, G. A., & Gupta, N. (2020). Development of Quality Measures for Acute Pancreatitis: A Model for Hospital-Based Measures in Gastroenterology. Clin Gastroenterol Hepatol, 18 (2): 272-275.e2.

Mosztbacher, D., Hanák, L., Farkas, N., Szentesi, A., Mikó, A., Bajor, J., Sarlós, P., Czimmer, J., Vincze, Á., Hegyi, P. J., Erőss, B., Takács, T., Czakó, L., Németh, B. C., Izbéki, F., Halász, A., Gajdán, L., Hamvas, J., Papp, M., Földi, I., Fehér, K. E., Varga, M., Csefkó, K., Török, I., Farkas, H. P., Mickevicius, A., Maldonado, E. R., Sallinen, V., Novák, J., Ince, A. T., Galeev, S., Bod, B., Sümegi, J., Pencik, P., Dubravcsik, Z., Illés, D., Gódi, S., Kui, B., Márta, K., Pécsi, D., Varjú, P., Szakács, Z., Darvasi, E., Párniczky, A., & Hegyi, P. (2020). Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases. Pancreatology, 20 (4): 608-616.

Munigala, S., & Yadav, D. (2016). Case-fatality from acute pancreatitis is decreasing but its population mortality shows little change. Pancreatology, 16 (4): 542-550.

Padma, T. V. (2016). India. Nature. 536 (7617): S26-S27. doi: 10.1038/536S26a.

Pasari, L. P., Khurana, A., Anchi, P., Aslam Saifi, M., Annaldas S., & Godugu C. (2019). Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction. Biomed Pharmacother, 112: 108629. doi: 10.1016/j.biopha.2019.108629.

Petrov, M. S., & Yadav, D. (2019). Global epidemiology and holistic prevention of pancreatitis. Nature reviews Gastroenterology & hepatology, 16 (3): 175-184. doi: 10.1038/s41575-018-0087-5.

Roberts, S. E., Morrison-Rees, S., John, A., Williams, J. G., Brown, T. H., & Samuel, D. G. (2017). The incidence and aetiology of acute pancreatitis across Europe. Pancreatology, 17 (2): 155-165.

Ruiz-Rebollo, M. L., Muñoz-Moreno, M. F., Mayo-Iscar, A., Udaondo-Cascante, M. A., & Nistal, R. B. (2019). Statin intake can decrease acute pancreatitis severit. Pancreatology, 19 (6): 807-812.

SCImago (2021). SJR - SCImago Journal & Country Rank. SJR - SCImago Journal & Country Rank: https://www.scimagojr.com/countryrank.php.

Sendler, M., van den Brandt, C., Glaubitz, J., Wilden, A., Golchert, J., Weiss, F. U., Homuth, G., De Freitas Chama, L. L., Mishra, N., Mahajan, U. M., Bossaller, L., Völker, U., Bröker, B. M., Mayerle J., & Lerch, M. M. (2020). NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis. Gastroenterology, 158 (1): 253-269.e214.

Sternby, H., Hartman, H., Johansen, D., Thorlacius, H., & Regnér, S. (2017). IL-6 and CRP are superior in early differentiation between mild and non-mild acute pancreatitis. Pancreatology, 17 (4): 550-554.

Stigliano, S., Sternby, H., de Madaria, E., Capurso, G., & Petrov, M. S. (2017). Early management of acute pancreatitis: A review of the best evidence. Digestive and Liver Disease, 49 (6): 585-594.

Stirling, A. D., Moran, N. R., Kelly, M. E., Ridgway, P. F., & Conlon, K. C. (2017). The predictive value of C-reactive protein (CRP) in acute pancreatitis – is interval change in CRP an additional indicator of severity? HPB, 19 (10): 874-880.

Sun, H., Tian, J., & Li, J. (2020). MiR-92b-3p ameliorates inflammation and autophagy by targeting TRAF3 and suppressing MKK3-p38 pathway in caerulein-induced AR42J cells. International Immunopharmacology, 88: 106691.

Szabo, F. K., Hornung, L., Oparaji, J. A., Alhosh, R., Husain, S. Z., Liu, Q. Y., Palermo, J., Lin, T. K., Nathan, J. D., Podberesky, D. J., Lowe, M., Fei, L., & Abu-El-Haija, M. (2016). A prognostic tool to predict severe acute pancreatitis in pediatrics. Pancreatology, 16 (3): 358-364.

Tang, M. Y., Chen, T. W., Bollen, T. L., Wang, Y. X., Xue, H. D., Jin, Z. Y., Huang, X. H., Xiao, B., Li, X. H., Ji, Y. F., & Zhang, X. M. (2018). MR imaging of hemorrhage associated with acute pancreatitis. Pancreatology, 18 (4): 363-369.

Tarasiuk, A., & Fichna, J. (2019). Effectiveness and therapeutic value of phytochemicals in acute pancreatitis: A review. Pancreatology, 19 (4): 481-487.

Toldi, G., Bekő, G., Kádár, G., Mácsai, E., Kovács, L., Vásárhelyi, B., & Balog, A. (2013). Soluble urokinase plasminogen activator receptor (suPAR) in the assessment of inflammatory activity of rheumatoid arthritis patients in remission. Clin Chem Lab Med, 51 (2): 327-332.

Tollefson, J. (2018). China declared world’s largest producer of scientific articles. Nature. 553: 390. doi: 10.1038/d41586-018-00927-4.

van den Berg, F. F., de Bruijn, A. C., van Santvoort, H. C., Issa, Y., & Boermeester, M. A. (2020). Early laboratory biomarkers for severity in acute pancreatitis; A systematic review and meta-analysis. Pancreatology, 20 (7): 1302-1311.

Vasconcelos, S. M., Sorenson, M. M., & Leta, J. (2007). Scientist-friendly policies for non-native English-speaking authors: timely and welcome. Braz J Med Biol Res, 40 (6): 743-747.

Vege, S. S., Horibe, M., Chari, S. T., Clemens, M. A., Loftus, C. G. & Enders, F. T. (2020). A single center randomized double blind controlled trial of pentoxifylline in acute pancreatitis: Challenges and opportunities. Pancreatology, 20 (8): 1592-1597.

Woolston, C., & Joana, O., (2019). When English is not your mother tongue. Nature, 570(7760):265-267. doi: 10.1038/d41586-019-01797-0.

Xiao, H., Huang, J.H., Zhang, X. W., Ahmed, R., Xie, Q. L., Li, B., Zhu, Y. M., Cai, X., Peng, Q. H., Qin, Y. H., Huang, H. Y., & Wang, W. (2017). Identification of potential diagnostic biomarkers of acute pancreatitis by serum metabolomic profiles. Pancreatology, 17 (4): 543-549.

Xie, Y., Zhang, C., & Lai, Q. (2014). China’s rise as a major contributor to science and technology. Proceedings of the National Academy of Sciences, 111 (26): 9437.

Yang, J., Zhou, Y., & Shi, J. (2020). Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK. Life Sciences, 251: 117645. doi: 10.1016/j.lfs.2020.117645.

Yu, J. H., & Kim, H. (2014). Oxidative stress and inflammatory signaling in cerulein pancreatitis. World J Gastroenterol, 20 (46): 17324-17329.

Zhang, L., Zhang, J., Shea, K., Xu, L., Tobin, G., Knapton, A., Sharron, S., & Rouse, R. (2014). Autophagy in pancreatic acinar cells in caerulein-treated mice: immunolocalization of related proteins and their potential as markers of pancreatitis. Toxicol Pathol, 42 (2): 435-457.

Zhang, R., Deng, L., Jin, T., Zhu, P., Shi, N., Jiang, K., Li, L., Yang, X., Guo, J., Yang, X., Liu, T., Mukherjee, R., Singh, V. K., Windsor, J. A., Sutton, R., Huang, W., & Xia, Q. (2019). Hypertriglyceridaemia-associated acute pancreatitis: diagnosis and impact on severity. HPB, 21 (9): 1240-1249.

Zheng, J., Wu, J., Chen, J., Liu, J., Lu, Y., Huang, C., Hu, G., Wang, X., & Zeng, Y. (2016). Therapeutic effects of quercetin on early inflammation in hypertriglyceridemia-related acute pancreatitis and its mechanism. Pancreatology, 16 (2): 200-210. doi: 10.1016/j.pan.2016.01.005

Zheng, Z., Ding, Y.X., Qu, Y.X., Cao, F., & Li, F. (2021). A narrative review of the mechanism of acute pancreatitis and recent advances in its clinical management. American journal of translational research, 13 (3): 833-852.

Zhu, H., Huang, L., Zhu, S., Li, X., Li, Z., Yu, C., & Yu, X. (2016). Regulation of autophagy by systemic admission of microRNA-141 to target HMGB1 in l-arginine-induced acute pancreatitis in vivo. Pancreatology, 16 (3): 337-346.

Zimmermann, H. W., Koch, A., Seidler, S., Trautwein, C., & Tacke, F. (2012). Circulating soluble urokinase plasminogen activator is elevated in patients with chronic liver disease, discriminates stage and aetiology of cirrhosis and predicts prognosis. Liver Int, 32 (3): 500-509.

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29/08/2022

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FALCÃO, K. V. G. .; AZEVEDO, R. D. S. de .; LIMA, L. R. A. de .; BEZERRA, R. de S. . Global analysis to acute pancreatitis: a systematic review. Research, Society and Development, [S. l.], v. 11, n. 11, p. e470111133920, 2022. DOI: 10.33448/rsd-v11i11.33920. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/33920. Acesso em: 19 apr. 2024.

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Vol. 11 No. 11

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Agrarian and Biological Sciences

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