Applicability of ozone therapy in the treatment of oral lesions: An integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i11.33991

Keywords:

Ozone therapy; Oral lichen planus; Stomatitis; Oral candidiasis.

Abstract

Objective: To evaluate the applicability and adverse effects of ozone therapy in Stomatology, through the analysis of some oral lesions. Method: This is a review with a qualitative approach with controlled primary studies, PICO question strategy and guiding question: is ozone therapy effective and safe in the treatment of oral lesions? The search for articles was performed on the virtual portals VHL, PubMed, Scielo, and the Cochrane Library. Results: 65 scientific productions were found, 32 were excluded, 32 were repeatedly indexed and 21 did not meet the inclusion criteria: complete articles published between 2000 and 2020, primary experimental and observational controlled studies with individuals with lichen planus, oral candidiasis and recurrent aphthous stomatitis or prosthetics who used ozone therapy for treatment. And the exclusion criteria: repeated indexed articles, studies of the gray literature, as they are productions not controlled by scientific or commercial editors, animal and in vitro tests, and case reports or series. In the end 11 articles were selected. Conclusions: Ozone in gaseous, aqueous or oily form promotes healing of the analyzed oral lesions without significant adverse effects.

References

Akpan, A., & Morgan, R. (2002). Oral candidiasis. Postgraduate medical journal, 78(922), 455–459. https://doi.org/10.1136/PMJ.78.922.455

Al-Omiri, M. K., Alhijawi, M., Alzarea, B. K., Hassan, R. S. A., & Lynch, E. (2016). Ozone treatment of recurrent aphthous stomatitis: a double blinded study. Scientific Reports 2016 6:1, 6(1), 1–7. https://doi.org/10.1038/srep27772

Anzolin, A., Da Silveira-Kaross, N., & Bertol, C. (2020). Ozonated oil in wound healing: what has already been proven? Medical gas research, 10(1), 54–59. https://doi.org/10.4103/2045-9912.279985

Ayeshathabusum, D., Sudhakara Reddy, R., & Rajesh, N. (2015). “Ozone” – the new nemesis of canker sore. Journal of Clinical and Diagnostic Research, 9(3), ZC01–ZC04. https://doi.org/10.7860/JCDR/2015/11911.5617

Bocci, V. (2005). Ozone: A new medical drug. Ozone: A New Medical Drug, 1–295. https://doi.org/10.1007/1-4020-3140-8

Carreira Piloto, V., & Almagro Urrutia, Z. E. (2000). Efectividad del oleozón en el tratamiento de la estomatitis subprótesis. Rev. cuba. estomatol, 140–145. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072000000300002

Chiang, C. P., Yu-Fong Chang, J., Wang, Y. P., Wu, Y. H., Lu, S. Y., & Sun, A. (2018). Oral lichen planus – Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management. Journal of the Formosan Medical Association, 117(9), 756–765. https://doi.org/10.1016/J.JFMA.2018.01.021

de Andrade, R. R., de Oliveira‐Neto, O. B., Barbosa, L. T., Santos, I. O., de Sousa‐Rodrigues, C. F., & Barbosa, F. T. (2019). Efetividade da ozonioterapia comparada a outras terapias para dor lombar: revisão sistemática com metanálise de ensaios clínicos randomizados. Brazilian Journal of Anesthesiology, 69(5), 493–501. https://doi.org/10.1016/J.BJAN.2019.06.007

Díaz-Couso, Y. (2020). Efectividad de la ozonoterapia en el tratamiento de enfermedades bucales en pacientes de un área de salud. Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 45(5), 4. http://revzoilomarinello.sld.cu/index.php/zmv/article/view/2165

Giannetti, L., Murri Dello Diago, A., & Lo Muzio, L. (2018). Recurrent aphtous stomatitis. In Minerva Stomatologica (Vol. 67, Número 3). https://doi.org/10.23736/S0026-4970.18.04137-7

Gupta, A. K., & Brintnell, W. (2012). Ozone gas effectively kills laboratory strains of Trichophyton rubrum and Trichophyton mentagrophytes using an in vitro test system. https://doi.org/10.3109/09546634.2012.714456, 25(3), 251–255. https://doi.org/10.3109/09546634.2012.714456

He, H., Xia, X., Yang, H., Peng, Q., & Zheng, J. (2020). A pilot study: A possible implication of Candida as an etiologically endogenous pathogen for oral lichen planus. BMC Oral Health, 20(1), 1–8. https://doi.org/10.1186/S12903-020-1042-8/FIGURES/6

Hellstein, J. W., & Marek, C. L. (2019). Candidiasis: Red and White Manifestations in the Oral Cavity. Head and Neck Pathology, 13(1), 25. https://doi.org/10.1007/S12105-019-01004-6

I Kovach 1, L Kravchenko 2, Yu Khotimska 1, R Nazaryan 1, V. G. (2022). INFLUÊNCIA DA TERAPIA DE OZÔNIO NO TECIDO ORAL NA MODELAGEM DE ESTOMATITE AFTOSA RECORRENTE CRÔNICA - PUBMED. https://pubmed.ncbi.nlm.nih.gov/28480862/

Jiménez López, Y., Mavis, D., Cantillo, M., Yanet, L., Laborí, P., De La, M., Muguercia, C., & Celia, C. (2018). Efectividad del Oleozón® tópico en la estomatitis subprótesis. Revista Información Científica, 97(2), 261–269. http://www.revinfcientifica.sld.cu/index.php/ric/article/view/1856/3591

Karino, M. E., & Felli, V. E. A. (2012). Enfermagem baseada em evidências: avanços e inovações em revisões sistemáticas. Ciência, Cuidado e Saúde, 11(5). https://doi.org/10.4025/CIENCCUIDSAUDE.V11I5.17048

Kazancioglu, H. O., & Erisen, M. (2015). Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus. Annals of dermatology, 27(5), 485–491. https://doi.org/10.5021/AD.2015.27.5.485

Khatri, I., Moger, G., & Anil Kumar, N. (2015). Evaluation of effect of topical ozone therapy on salivary Candidal carriage in oral candidiasis. Indian Journal of Dental Research, 26(2), 158–162. https://doi.org/10.4103/0970-9290.159146

Krunić, J., Stojanović, N., Đukić, L., Roganović, J., Popović, B., Simić, I., & Stojić, D. (2018). Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal. Clinical Oral Investigations 2018 23:2, 23(2), 785–792. https://doi.org/10.1007/S00784-018-2495-X

Lewis, M. A. O., & Williams, D. W. (2017). Diagnosis and management of oral candidosis. British Dental Journal 2017 223:9, 223(9), 675–681. https://doi.org/10.1038/sj.bdj.2017.886

Ley Sifontes, L. I., Yordana Silva Martínez, D. I., Odalys Martín Reyes III, D., Elvia Paz Latorre III, D. I., & Clara Landrián Díaz, D. I. (2008). Eficacia del aceite de girasol ozonizado en el tratamiento de la estomatitis subprótesis grado I y II. Revista Archivo Médico de Camagüey, 12(3), 0–0. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552008000300005&lng=es&nrm=iso&tlng=es

Mauro, R. Di, Cantarella, G., Bernardini, R., Rosa, M. Di, Barbagallo, I., Distefano, A., Longhitano, L., Vicario, N., Nicolosi, D., Lazzarino, G., Tibullo, D., Gulino, M. E., Spampinato, M., Avola, R., & Volti, G. L. (2019). The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases. International Journal of Molecular Sciences, 20(3). https://doi.org/10.3390/IJMS20030634

Monzillo, V., Lallitto, F., Russo, A., Poggio, C., Scribante, A., Arciola, C. R., Bertuccio, F. R., & Colombo, M. (2020). Ozonized Gel Against Four Candida Species: A Pilot Study and Clinical Perspectives. Materials (Basel, Switzerland), 13(7). https://doi.org/10.3390/MA13071731

Mostafa, B., & Zakaria, M. (2018). Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus. Open access Macedonian journal of medical sciences, 6(5), 879–884. https://doi.org/10.3889/OAMJMS.2018.219

Neves, I. M. dos S. M. (2015). Abordagem do paciente com estomatite protética. https://bdigital.ufp.pt/handle/10284/5261

Neville, B. W., Damm, D. D., Allen, C. M., & Bouquot, J. E. (2016). Patologia Oral e Maxilofacial. In Patologia Oral e Maxilofacial (4° ed). Elsevier.

Sánchez-Bernal, J., Conejero, C., & Conejero, R. (2020). Recurrent Aphthous Stomatitis. Actas dermo-sifiliograficas, 111(6), 471–480. https://doi.org/10.1016/J.AD.2019.09.004

Sen, S., & Sen, S. (2020). Ozone therapy a new vista in dentistry: integrated review. Medical Gas Research, 10(4), 189. https://doi.org/10.4103/2045-9912.304226

Shavit, E., Klieb, H., & Shear, N. H. (2020). Oral lichen planus: a novel staging and algorithmic approach and all that is essential to know. F1000Research 2020 9:206, 9, 206. https://doi.org/10.12688/f1000research.18713.1

Shichiri-Negoro, Y., Tsutsumi-Arai, C., Arai, Y., Satomura, K., Arakawa, S., & Wakabayashi, N. (2021). Ozone ultrafine bubble water inhibits the early formation of Candida albicans biofilms. PloS one, 16(12). https://doi.org/10.1371/JOURNAL.PONE.0261180

Sosa, Y. M., Velázquez, Y. L. T., Zamora, R. M. V., & Tamayo, M. R. (2017). Ozonoterapia en la estomatitis subprótesis, 2016. MULTIMED, 21(3), 241–260. http://www.revmultimed.sld.cu/index.php/mtm/article/view/540/870

Sridharan, K., & Sivaramakrishnan, G. (2021). Interventions for oral lichen planus: A systematic review and network meta-analysis of randomized clinical trials. Australian dental journal, 66(3), 295–303. https://doi.org/10.1111/ADJ.12835

Suh, Y., Patel, S., Kaitlyn, R., Gandhi, J., Joshi, G., Smith, N., & Khan, S. (2019). Clinical utility of ozone therapy in dental and oral medicine. Medical Gas Research, 9(3), 163. https://doi.org/10.4103/2045-9912.266997

Tartari, A. P. S., Moreira, F. F., Pereira, M. C. D. S., Carraro, E., Cidral-Filho, F. J., Salgado, A. I., & Kerppers, I. I. (2020). Anti-inflammatory Effect of Ozone Therapy in an Experimental Model of Rheumatoid Arthritis. Inflammation, 43(3), 985–993. https://doi.org/10.1007/S10753-020-01184-2

Tavares De Souza, M., Dias Da Silva, M., & De Carvalho, R. (2010). Revisão integrativa: o que é e como fazer Integrative review: what is it? How to do it? 8(1), 102–108.

Telles, D. R., Karki, N., & Marshall, M. W. (2017). Oral Fungal Infections: Diagnosis and Management. Dental clinics of North America, 61(2), 319–349. https://doi.org/10.1016/J.CDEN.2016.12.004

Veneri, F., Bardellini, E., Amadori, F., Conti, G., & Majorana, A. (2020). Efficacy of ozonized water for the treatment of erosive oral lichen planus: a randomized controlled study. Medicina oral, patologia oral y cirugia bucal, 25(5), e675–e682. https://doi.org/10.4317/MEDORAL.23693

Published

04/09/2022

How to Cite

FERREIRA, N. M. .; SEIXAS, Z. de A.; OLIVEIRA JÚNIOR, L. P. R. de . Applicability of ozone therapy in the treatment of oral lesions: An integrative review. Research, Society and Development, [S. l.], v. 11, n. 11, p. e589111133991, 2022. DOI: 10.33448/rsd-v11i11.33991. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/33991. Acesso em: 6 oct. 2022.

Issue

Section

Health Sciences