Cannabinoids as a possible alternative in the treatment of psoriasis

Authors

DOI:

https://doi.org/10.33448/rsd-v11i11.34651

Keywords:

Cannabidiol; Psoriasis; Treatment.

Abstract

With strong genetic predisposition, relationship with the environment and autoimmune pathogenic traits, psoriasis is a chronic, non-infectious disease that affects people regardless of age or gender. Treatment aims to control the differentiation and proliferation of keratinocytes. With this in mind, the objective of this narrative review is to analyze the existing literature involving the effects of Cannabis sativa in the treatment of the disease, focusing on its effectiveness. An active search in Google Scholar, Pubmed and LILACS databases showed that cannabinoids have therapeutic potential in psoriasis, mainly in relation to the proliferation of keratinocytes and the modulation of inflammation, but most of the available studies are in vitro. More clinical studies in humans are needed for better elucidation, so that cannabinoids can be recommended as a safe and effective treatment in psoriasis.

References

Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants (Basel, Switzerland), 9(1), 21. https://doi.org/10.3390/antiox9010021

Azulay, R. D. (2017). Dermatologia, (7ª edição.) Grupo GEN. https://integrada.minhabiblioteca.com.br/books/9788527732475

Baswan, S. M., Klosner, A. E., Glynn, K., Rajgopal, A., Malik, K., Yim, S., & Stern, N. (2020). Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders. Clinical, cosmetic and investigational dermatology, 13, 927–942. https://doi.org/10.2147/CCID.S286411

Brasileiro, G. F. (2016). Bogliolo - Patologia (9th edição). Grupo GEN. https://integrada.minhabiblioteca.com.br/books/9788527736992

Friedman, A. J., Momeni, K., & Kogan, M. (2020). Topical Cannabinoids for the Management of Psoriasis Vulgaris: Report of a Case and Review of the Literature. Journal of drugs in dermatology : JDD, 19(8), 795. https://doi.org/10.36849/JDD.2020.5229

Gęgotek, A., Atalay, S., Wroński, A., Markowska, A., & Skrzydlewska, E. (2021). Cannabidiol Decreases Metalloproteinase Activity and Normalizes Angiogenesis Factor Expression in UVB-Irradiated Keratinocytes from Psoriatic Patients. Oxidative medicine and cellular longevity, 2021, 7624389. https://doi.org/10.1155/2021/7624389

Grant, M. J., & Booth, A. (2009). A typology of reviews: an analysis of 14 review types and associated methodologies. Health information and libraries journal, 26(2), 91–108. https://doi.org/10.1111/j.1471-1842.2009.00848.x

Jarocka-Karpowicz, I., Biernacki, M., Wroński, A., Gęgotek, A., & Skrzydlewska, E. (2020). Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris. Biomolecules, 10(3), 367. https://doi.org/10.3390/biom10030367

Jastrząb, A., Gęgotek, A., & Skrzydlewska, E. (2019). Cannabidiol Regulates the Expression of Keratinocyte Proteins Involved in the Inflammation Process through Transcriptional Regulation. Cells, 8(8), 827. https://doi.org/10.3390/cells8080827

Kumar, V., Abbas, A., & Aster, J. (2016). Robbins & Cotran Patologia - Bases Patológicas das Doenças (9th edição). Grupo GEN. https://integrada.minhabiblioteca.com.br/books/9788595150966

Kupczyk, P., Reich, A., & Szepietowski, J. C. (2009). Cannabinoid system in the skin - a possible target for future therapies in dermatology. Experimental dermatology, 18(8), 669–679. https://doi.org/10.1111/j.1600-0625.2009.00923.x

Łuczaj, W., Dobrzyńska, I., Wroński, A., Domingues, M. R., Domingues, P., & Skrzydlewska, E. (2020). Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients. International journal of molecular sciences, 21(18), 6592. https://doi.org/10.3390/ijms21186592

Martinelli, G., Magnavacca, A., Fumagalli, M., DellʼAgli, M., Piazza, S., & Sangiovanni, E. (2022). Cannabis sativa and Skin Health: Dissecting the Role of Phytocannabinoids. Planta medica, 88(7), 492–506. https://doi.org/10.1055/a-1420-5780

Martins, A. M., Gomes, A. L., Vilas Boas, I., Marto, J., & Ribeiro, H. M. (2022). Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review. Pharmaceuticals (Basel, Switzerland), 15(2), 210. https://doi.org/10.3390/ph15020210

Michalek, I. M., Loring, B., & John, S. M. (2017). A systematic review of worldwide epidemiology of psoriasis. Journal of the European Academy of Dermatology and Venereology : JEADV, 31(2), 205–212. https://doi.org/10.1111/jdv.13854

Norooznezhad, A. H., & Norooznezhad, F. (2017). Cannabinoids: Possible agents for treatment of psoriasis via suppression of angiogenesis and inflammation. Medical hypotheses, 99, 15–18. https://doi.org/10.1016/j.mehy.2016.12.003

Ogawa, E., Sato, Y., Minagawa, A., & Okuyama, R. (2018). Pathogenesis of psoriasis and development of treatment. The Journal of dermatology, 45(3), 264–272. https://doi.org/10.1111/1346-8138.14139

Puaratanaarunkon, T., Sittisaksomjai, S., Sivapornpan, N., Pongcharoen, P., Chakkavittumrong, P., Ingkaninan, K., Temkitthawon, P., Promgool, T., Waranuch, N., & Asawanonda, P. (2022). Topical cannabidiol-based treatment for psoriasis: A dual-centre randomized placebo-controlled study. Journal of the European Academy of Dermatology and Venereology : JEADV, 36(9), e718–e720. https://doi.org/10.1111/jdv.18215

Ramot, Y., Sugawara, K., Zákány, N., Tóth, B. I., Bíró, T., & Paus, R. (2013). A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ. PeerJ, 1, e40. https://doi.org/10.7717/peerj.40

Rendon, A., & Schäkel, K. (2019). Psoriasis Pathogenesis and Treatment. International journal of molecular sciences, 20(6), 1475. https://doi.org/10.3390/ijms20061475

Scheau, C., Badarau, I. A., Mihai, L. G., Scheau, A. E., Costache, D. O., Constantin, C., Calina, D., Caruntu, C., Costache, R. S., & Caruntu, A. (2020). Cannabinoids in the Pathophysiology of Skin Inflammation. Molecules (Basel, Switzerland), 25(3), 652. https://doi.org/10.3390/molecules25030652

Shao, K., Stewart, C., & Grant-Kels, J. M. (2021). Cannabis and the skin. Clinics in dermatology, 39(5), 784–795. https://doi.org/10.1016/j.clindermatol.2021.05.006

Sheriff, T., Lin, M. J., Dubin, D., & Khorasani, H. (2020). The potential role of cannabinoids in dermatology. The Journal of dermatological treatment, 31(8), 839–845. https://doi.org/10.1080/09546634.2019.1675854

Tammaro, A., Magri, F., Chello, C., Giordano, D., Parisella, F. R., De Marco, G., & Persechino, S. (2019). A successful topical treatment for cutaneous inflammatory diseases:an additional or alternative therapy to topical steroids. European annals of allergy and clinical immunology, 51(3), 129–130. https://doi.org/10.23822/EurAnnACI.1764-1489.79

Wilkinson, J. D., & Williamson, E. M. (2007). Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. Journal of dermatological science, 45(2), 87–92. https://doi.org/10.1016/j.jdermsci.2006.10.009

Wójcik, P., Garley, M., Wroński, A., Jabłońska, E., & Skrzydlewska, E. (2020). Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients. International journal of molecular sciences, 21(18), 6795. https://doi.org/10.3390/ijms21186795

Wójcik, P., Gęgotek, A., Žarković, N., & Skrzydlewska, E. (2021). Disease-Dependent Antiapoptotic Effects of Cannabidiol for Keratinocytes Observed upon UV Irradiation. International journal of molecular sciences, 22(18), 9956. https://doi.org/10.3390/ijms22189956

Published

18/09/2022

How to Cite

COIMBRA, B. Z. .; BERTOZZI, J. G. .; BORGES, E. D. .; PITLIUK, R.; FUCCI, T. P. P. da C. S. .; ABREU , M. A. M. M. de . Cannabinoids as a possible alternative in the treatment of psoriasis . Research, Society and Development, [S. l.], v. 11, n. 11, p. e450111134651, 2022. DOI: 10.33448/rsd-v11i11.34651. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/34651. Acesso em: 20 apr. 2024.

Issue

Section

Review Article