Relationship of the high incidence of Kaposi's sarcoma in HIV-seropositive patients
DOI:
https://doi.org/10.33448/rsd-v11i12.35011Keywords:
Human immunodeficiency virus (HIV); Acquired immunodeficiency syndrome (AIDS); Human immunodeficiency vírus; Kaposi sarcoma.Abstract
HIV is the human immunodeficiency virus that causes AIDS, acquired immunodeficiency syndrome, and after its evolution and high rate of cases in the world, Kaposi's Sarcoma was present concomitantly with these patients, which is a disease that affects the lymphatic vessels, and that can reach from the oral cavity to other and various organs. Therefore, the present work is an integrative, descriptive-explanatory review of a basic nature on the relationship between the high incidence of Kaposi's sarcoma in HIV-seropositive patients. Thus, the work aims to describe the mechanisms of HIV in terms of its defense cells and TCD4+ variation, the role of HHV-8 in the disease and also the action of antiretroviral therapy in this context. Furthermore, to analyze the interaction of the aforementioned mechanisms for the conclusion of the etiology and, in addition, the analysis of the treatment and prognosis of the disease.
References
Ablanedo-Terrazas, Y., Alvarado-de la Barrera, C., Ormsby, C. E., Ruiz-Cruz, M., & Reyes-Terán, G. (2015). Intralesional bevacizumab in patients with human immunodeficiency virus-associated Kaposi's sarcoma in the upper airway. The Laryngoscope, 125(4), E132–E137. https://doi.org/10.1002/lary.24988
Cáceres, C., Vargas, P. A., Sánchez-Romero, C., Bunn, B. K., Heerden, W., & Fonseca, F. P. (2019). Distribution of Dendritic Cells in AIDS-Associated Oral Kaposi's Sarcoma. Brazilian dental journal, 30(6), 617–625. https://doi.org/10.1590/0103-6440201902599
Carvalho, L. P. B., Lucena, L. P., Honorato, M. C. T. M., Andrade, G. S. S., & Freitas, R. A. (2016). Mucocutaneous Kaposi’s sarcoma in an HIV-positive patient: diagnosis and treatment. Jornal Brasileiro de Patologia e Medicina Laboratorial, 52(3), e194-e197. http://dx.doi.org/10.5935/1676-2444.20160033.
Chagaluka, G., Stanley, C., Banda, K., Depani, S., Nijram'madzi, J., Katangwe, T., Israels, T., Bailey, S., Mukaka, M., & Molyneux, E. (2014). Kaposi's sarcoma in children: an open randomised trial of vincristine, oral etoposide and a combination of vincristine and bleomycin. European journal of cancer (Oxford, England : 1990), 50(8), 1472–1481. https://doi.org/10.1016/j.ejca.2014.02.019
de Almeida, V. L., Lima, I., Ziegelmann, P. K., Paranhos, L. R., & de Matos, F. R. (2017). Impact of highly active antiretroviral therapy on the prevalence of oral lesions in HIV-positive patients: a systematic review and meta-analysis. International journal of oral and maxillofacial surgery, 46(11), 1497–1504. https://doi.org/10.1016/j.ijom.2017.06.008
Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.
Fang, Q., Liu, Z., Zhang, Z., Zeng, Y., & Zhang, T. (2017). Prevalence of Kaposi's sarcoma-associated herpesvirus among intravenous drug users: a systematic review and meta-analysis. Virologica Sinica, 32(5), 415–422. https://doi.org/10.1007/s12250-017-4051-2
Gruffaz, M., Zhang, T., Marshall, V., Gonçalves, P., Ramaswami, R., Labo, N., Whitby, D., Uldrick, T. S., Yarchoan, R., Huang, Y., & Gao, S. J. (2020). Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA. PLoS pathogens, 16(1), e1008114. https://doi.org/10.1371/journal.ppat.1008114
Hosseinipour, M. C., Kang, M., Krown, S. E., Bukuru, A., Umbleja, T., Martin, J. N., Orem, J., Godfrey, C., Hoagland, B., Mwelase, N., Langat, D., Nyirenda, M., MacRae, J., Borok, M., Samaneka, W., Moses, A., Mngqbisa, R., Busakhala, N., Martínez-Maza, O., Ambinder, R., & A5264/AMC-067 REACT-KS Team (2018). As-Needed Vs Immediate Etoposide Chemotherapy in Combination With Antiretroviral Therapy for Mild-to-Moderate AIDS-Associated Kaposi Sarcoma in Resource-Limited Settings: A5264/AMC-067 Randomized Clinical Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(2), 251–260. https://doi.org/10.1093/cid/ciy044
Krown, S. E., Moser, C. B., MacPhail, P., Matining, R. M., Godfrey, C., Caruso, S. R., Hosseinipour, M. C., Samaneka, W., Nyirenda, M., Busakhala, N. W., Okuku, F. M., Kosgei, J., Hoagland, B., Mwelase, N., Oliver, V. O., Burger, H., Mngqibisa, R., Nokta, M., Campbell, T. B., Borok, M. Z., & A5263/AMC066 protocol team (2020). Treatment of advanced AIDS-associated Kaposi sarcoma in resource-limited settings: a three-arm, open-label, randomised, non-inferiority trial. Lancet (London, England), 395(10231), 1195–1207. https://doi.org/10.1016/S0140-6736(19)33222-2
Lima, C. T., Araújo, P., Teixeira, H. M., Santos, J., & Silveira, V. (2017). Clinical and laboratory characteristics, staging, and outcomes of individuals with AIDS-associated Kaposi's sarcoma at an university hospital. Anais brasileiros de dermatologia, 92(2), 172–176. https://doi.org/10.1590/abd1806-4841.20175377
Machado, P. R., Farias, K. J., Pereira, M. G., Freitas, P. P., & Fonseca, B. A. (2015). Human herpesvirus 8 (HHV-8) detected by nested polymerase chain reaction (PCR) in HIV patients with or without Kaposi's sarcoma. An analytic cross-sectional study. Sao Paulo medical journal = Revista paulista de medicina, 134(3), 187–192. https://doi.org/10.1590/1516-3180.2014.8973010
Moraes, M. (2012). Solitary Kaposi’s sarcoma in retromolar region of an HIV positive patient: case report. J Bras Patol Med Lab, 48(1) e45-e49.
Paksoy, N. (2019). Simultaneous occurrence of Kaposi sarcoma and tuberculosis; Kaposi sarcoma and lymphoma in the same lymph node: a report on two HIV-positive patients from Zimbabwe. Revista da Sociedade Brasileira de Medicina Tropical, 52, e20180188. https://doi.org/10.1590/0037-8682-0188-2018
Pereira, A. G. L. (2013). Sobrevida de pacientes com Síndrome da Imunodeficiência Adquirida em hospital geral no Rio de Janeiro, a partir de dados da vigilância epidemiológica. Cad. Saúde Colet, 21(2), e160-e167.
Pereira, P. F., Cuzzi, T., & Galhardo, M. C. (2013). Immunohistochemical detection of the latent nuclear antigen-1 of the human herpesvirus type 8 to differentiate cutaneous epidemic Kaposi sarcoma and its histological simulators. Anais brasileiros de dermatologia, 88(2), 243–246. https://doi.org/10.1590/S0365-05962013000200010
Pires, C., Monteiro, J., Rego, R. M., & Lodi, V. (2020). Kaposi's sarcoma in a HIV-positive patient: an exuberant and widespread case report in the Amazon. Revista do Instituto de Medicina Tropical de Sao Paulo, 62, e2. https://doi.org/10.1590/S1678-9946202062002
Rossetto, J. D., Molles, S., & Gracitelli, C. (2019). Extensive bulbar conjunctival Kaposi's sarcoma as initial symptom of human immunodeficiency virus. Arquivos brasileiros de oftalmologia, 82(5), 429–431. https://doi.org/10.5935/0004-2749.20190083
Santos, M., Vilasboas, V., Mendes, L., Talhari, C., & Talhari, S. (2013). Lymphangiectatic Kaposi's sarcoma in a patient with AIDS. Anais brasileiros de dermatologia, 88(2), 276–278. https://doi.org/10.1590/S0365-05962013000200019
Schuch, L. F., Kovalski, L., Leite, A. A., Carrard, V. C., Martins, M., Vargas, P. A., & Martins, M. D. (2022). Oral lymphangioma-like Kaposi sarcoma: a Brazilian case report in a scenario of a still high number of HIV infections. Oral and maxillofacial surgery, 26(1), 171–176. https://doi.org/10.1007/s10006-021-00974-8
Sousa, R. H., Souza, L. L., Guedes, P. T., Prado-Ribeiro, A. C., Rodrigues-Oliveira, L., Brandão, T. B., Alves, B. W., Lopes, M. A., Santos-Silva, A. R., Monteiro, J. C., Gonçalves, T. T., & Almeida, O. P. (2021). Oral Kaposi sarcoma development is associated with HIV viral load, CD4+ count and CD4+/CD8+ ratio. Medicina oral, patologia oral y cirugia bucal, 26(6), e748–e753. https://doi.org/10.4317/medoral.24708
Tancredi, M. V., Pinto, V. M., Silva, M., Pimentel, S. R., Silva, T., Ito, S., Golub, J. E., & Toscano, A. (2017). Prevalence of Kaposi's sarcoma in patients with AIDS and associated factors, São Paulo-SP, Brazil, 2003-2010. Prevalência de sarcoma de Kaposi em pacientes com aids e fatores associados, São Paulo-SP, 2003-2010. Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil, 26(2), 379–387. https://doi.org/10.5123/S1679-49742017000200015
Tiussi, R. M., Caus, A. L., Diniz, L. M., & Lucas, E. A. (2012). Kaposi's sarcoma: clinical and pathological aspects in patients seen at the Hospital Universitário Cassiano Antônio Moraes - Vitória - Espírito Santo - Brazil. Anais brasileiros de dermatologia, 87(2), 220–227. https://doi.org/10.1590/s0365-05962012000200005
Wagner, A. K., Tozo, J. P., Abreu, M. A. M. M., & Wedy, G. F. (2018). Sarcoma de Kaposi em paciente portador de HIV: relato de caso. Medicina (Ribeirao Preto. Online, 51(2), 157-161. http://dx.doi.org/10.11606/issn.2176-7262.v51i2p157-161
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Larissa Rocha Borges Silva; Leonardo Bíscaro Pereira; Ivânia Aparecida Pimenta Santos Silva; Stella Diniz Caixeta ; Daniella Cristina Borges; Helvécio Marangon Júnior ; Marcos Bilharinho Mendonca; Rodrigo Soares de Andrade
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.