Burning moutg syndrome and hormonal changes: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i13.35110

Keywords:

Burning mouth syndrome; Hormones; Menopause.

Abstract

Burning Mouth syndrome (BAS) is a disorder characterized by a burning sensation, associated with dryness, loss or alteration in taste and psychosocial distress, in which the oral mucosa is clinically normal and no causal factor is found. The burning sensation is bilateral and the tongue is the most commonly affected site. There seems to be a higher prevalence in females, especially over the age of 50. The etiology is multifactorial, and one of the factors associated with the development of SAB is the change in hormonal parameters typical of the menopausal period. However, the clear scientific understanding of this interrelationship still remains unclear. The objective of this integrative review was to evaluate current studies that report an association between Mouth Blistering Syndrome and hormonal changes. Through the analysis of related articles in the PubMed, Web of Science, and Embase databases from 2016 to 2021. The descriptors "burning mouth syndrome" and "hormone" were used together and no language restrictions were imposed. A total of 61 articles were found, but 14 papers were included in this research. According to the literature searched, the influence of hormonal changes on SAB seems plausible. The selected articles provided evidence of this interrelationship. However, further studies are still needed to assure this interrelationship, as well as the mechanism by which it occurs.

Author Biographies

Edjane Nóbrega de Paiva , Universidade de Pernambuco

Especialista em Disfunção Temporomandibular e Dor Orofacial 

Milena Patrícia Nóbrega de Paiva, Universidade Federal da Paraíba

Mestre em Ciências Odontológicas

Maurício Kosminsky , Universidade de Pernambuco

Professor da Faculdade de Odontologia de Pernambuco 

Fábio Andrey da Costa Araújo, Universidade de Pernambuco

Professor da Faculdade de Odontologia de Pernambuco 

Fernanda Souto Maior de Araújo dos Santos , Universidade de Pernambuco

Professora da Faculdade de Odontologia de Pernambuco 

References

Azzi, L., Veronesi, G., Tagliabue, A., Croveri, F., Maurino, V., Reguzzoni, M., ... & Spadari, F. (2019). Is there an association between drugs and burning mouth syndrome? A case–control study. Oral Diseases, 25(6), 1634-1644.

Bergdahl, M., & Bergdahl, J. (1999). Burning mouth syndrome: prevalence and associated factors. Journal of Oral Pathology & Medicine, 28(8), 350-354.

Bruckmann, C. (2016). Menopause und Mundgesundheit. Gynäkologische Endokrinologie, 14(3), 223-225.

Burger, H. G., Dudley, E. C., Robertson, D. M., & Dennerstein, L. (2002). Hormonal changes in the menopause transition. Recent progress in hormone research, 57, 257-276.

Cherubini, K., Maidana, J. D., Weigert, K. L., & Figueiredo, M. A. (2005). Síndrome da ardência bucal: revisão de cem casos. Revista Odonto Ciência, 20(48), 109-113.

Chiang, C. P., Chang, J. Y. F., Wang, Y. P., Wu, Y. H., Wu, Y. C., & Sun, A. (2019). Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis. Journal of the Formosan Medical Association, 118(6), 973-978.

das Neves de Araújo Lima, E., Barbosa, N. G., Dos Santos, A. C. S., AraújoMouraLemos, T. M., de Souza, C. M., Trevilatto, P. C., ... & de Medeiros, A. M. C. (2016). Comparative analysis of psychological, hormonal, and genetic factors between burning mouth syndrome and secondary oral burning. Pain Medicine, 17(9), 1602-1611.

Gao, J., Chen, L., Zhou, J., & Peng, J. (2009). A case–control study on etiological factors involved in patients with burning mouth syndrome. Journal of oral pathology & medicine, 38(1), 24-28.

Lima, E. D. N. D. A. (2014). Análise de fatores clínico-demográficos, psicológicos, hormonais e genéticos na síndrome da ardência bucal e ardor bucal secundário.

Ilankizhai, R. J., & Kumar, S. S. (2016). Burning Mouth Syndrome-A Review. Journal of Pharmaceutical Sciences and Research, 8(6), 450.

Kang, J. H., Kim, Y. Y., Chang, J. Y., & Kho, H. S. (2017). Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome. Archives of Oral Biology, 78, 58-64.

Koike, K., Shinozaki, T., Hara, K., Noma, N., Okada-Ogawa, A., Asano, M., ... & Imamura, Y. (2014). Immune and endocrine function in patients with burning mouth syndrome. The Clinical Journal of Pain, 30(2), 168-173.

Kim, H. I., Kim, Y. Y., Chang, J. Y., Ko, J. Y., & Kho, H. S. (2012). Salivary cortisol, 17β‐estradiol, progesterone, dehydroepiandrosterone, and α‐amylase in patients with burning mouth syndrome. Oral Diseases, 18(6), 613-620.

Lamey, P. J., & Lamb, A. B. (1994). Lip component of burning mouth syndrome. Oral surgery, oral medicine, oral pathology, 78(5), 590-593.

Lamey, P. J., & Lamb, A. B. (1988). Prospective study of a etiological factors in burning mouth syndrome. Br Med J (Clin Res Ed), 296(6631), 1243-1246.

Lee, Y. H., & Chon, S. (2020). Burning mouth syndrome in postmenopausal women with self-reported sleep problems. Cranio®, 38(4), 221-232.

Lončar-Brzak, B., Vidranski, V., Andabak-Rogulj, A., Vidović-Juras, D., Todorić-Laidlaw, I., Gabrić, D., &Škrinjar, I. (2020). Salivary Hormones and Quality of Life in Female Postmenopausal Burning Mouth Patients—A Pilot Case-Control Study. Dentistry Journal, 8(4), 111.

LeeY-H,AuhQ-S,ChunY-H,KangS-K, Hong J-P. (2019) Comparison ofsleepproblems and clinical features between men and postmenopausal women with burning mouth syndrome. SleepMedicine.;64:S220.

McMillan, R., Forssell, H., Buchanan, J. A., Glenny, A. M., Weldon, J. C., & Zakrzewska, J. M. (2016). Interventions for treating burning mouth syndrome. Cochrane Database of Systematic Reviews, (11).

Meurman, J. H., Tarkkila, L., & Tiitinen, A. (2009). The menopause and oral health. Maturitas, 63(1), 56-62..

Molina, P. E. (2021). Fisiologia Endócrina-5. McGraw Hill Brasil.

Morr Verenzuela, C. S., Davis, M. D., Bruce, A. J., & Torgerson, R. R. (2017). Burning mouth syndrome: results of screening tests for vitamin and mineral deficiencies, thyroid hormone, and glucose levels—experience at Mayo Clinic over a decade. International journal of dermatology, 56(9), 952-956.

Nelson, H. D., Haney, E. M., Humphrey, L., Miller, J., Nedrow, A., Nicolaidis, C., ... & Nygren, P. (2005). Management of menopause-related symptoms. Agency for Healthcare Research and Quality Publication.

Nosratzehi, T., Salimi, S., & Parvaee, A. (2017). Comparison of salivary cortisol and α‐amylase levels and psychological profiles in patients with burning mouth syndrome. Special Care in Dentistry, 37(3), 120-125.

Pereira, S. R., Tello Velasquez, J., Duggan, S., Ivanisevic, B., McKenna, J. P., McCreary, C., & Downer, E. J. (2022). Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: Focus on the actions of cannabinoids. European Journal of Neuroscience, 55(4), 1032-1050.

Friedlander, A. H. (2002). The physiology, medical management and oral implications of menopause. The Journal of the American Dental Association, 133(1), 73-81.

Silva, M. M., & Furuse, T. A. (2007). Síndrome da ardência bucal: relato de caso clínico. Revista Brasileira de Pesquisa em Saúde/Brazilian Journal of Health Research, 9(3).

Shinohara, C., Ito, K., Takamatsu, K., Ogawa, M., Kajii, Y., Nohno, K., ... & Inoue, M. (2021). Factors associated with xerostomia in perimenopausal women. Journal of Obstetrics and Gynaecology Research, 47(10), 3661-3668.

Talattof, Z., Dabbaghmanesh, M. H., Parvizi, Y., Esnaashari, N., & Azad, A. (2019). The association between burning mouth syndrome and level of thyroid hormones in Hashimotos thyroiditis in public hospitals in Shiraz, 2016. Journal of Dentistry, 20(1), 42.

Valimaa, H., Savolainen, S., Soukka, T., Silvoniemi, P., Makela, S., Kujari, H., ... & Laine, M. (2004). Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands. Journal of Endocrinology, 180(1), 55-62

Varoni, E. M., Faro, A. F. L., Lodi, G., Carrassi, A., Iriti, M., & Sardella, A. (2018). Melatonin treatment in patients with burning mouth syndrome: A triple-blind, placebo-controlled, crossover randomized clinical trial.

Yoshida, N., Sugimoto, K., Suzuki, S., & Kudo, H. (2018). Change in oral health status associated with menopause in Japanese dental hygienists. International Journal of Dental Hygiene, 16(1), 157-164.

Zakrzewska, J. M. (1995). The burning mouth syndrome remains an enigma. Pain, 62(3), 253-257.

Lamey, P. J. (1996). Burning mouth syndrome. Dermatologic clinics, 14(2), 339-354.

Published

27/09/2022

How to Cite

PAIVA , E. N. de; PAIVA, M. P. N. de; LINS, L. B. C.; CASTRO , I. C. de .; WANDERLEY , Álvaro de S.; BÉRGAMO , M. S. de M. .; KOSMINSKY , M. .; ARAÚJO, F. A. da C.; SANTOS , F. S. M. de A. dos . Burning moutg syndrome and hormonal changes: an integrative review . Research, Society and Development, [S. l.], v. 11, n. 13, p. e51111335110, 2022. DOI: 10.33448/rsd-v11i13.35110. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/35110. Acesso em: 19 apr. 2024.

Issue

Section

Health Sciences