Adverse reactions after COVID-19 vaccination: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i13.35278

Keywords:

Vaccines; COVID-19; Injection site reaction; Hypersensitivity.

Abstract

Objective: To identify in the literature the main adverse reactions of vaccines against COVID-19. Methodology: Integrative review, conducted using the Virtual Health Library (VHL), Scopus (Elsevier) and Embase search strategies. Through the following research question: “What adverse reactions have been evidenced in the literature in patients vaccinated by COVID-19?”. RAYYAN software was used to import the data. Results: 1,816 studies were identified, of which 57 included the review. The results were summarized in the form of a table and there were several reactions classified into local, systemic and severe reactions, there was a higher incidence of adverse reactions in females and the manifestations were immediate to late. Conclusion: It was evidenced that the majority of post-vaccination adverse reactions by COVID-19 were local, immediate and self-limiting. Nurses should promote actions to prevent and identify post-vaccination adverse reactions.

References

Abdulgayoom, M., Albuni, M. K, Abdelmahmoud, E., Murshed, K., & Eldeeb, Y. (2021). Minimal change nephrotic syndrome four days after the administration of Pfizer-BioNTech COVID-19 vaccine—a new side effect or coincidence. Clinical Case Reports, 9 (10),05003. https://doi.org/10.1002/ccr3.5003

Abu-halaweh, S., Algassieh, R., Suleiman, A., Al-Sabbagh, M. Q., Abu-Halaweh, M., Al Khader, D., & Bsisu, I. (2021). Qualitative Assessment of Early Adverse Effects of Pfizer–BioNTech and Sinopharm COVID-19 Vaccines by Telephone Interviews.Vacinas, 9 (9), 950. https://doi.org/10.3390/vaccines9090950

Adam, M., Gameraddin, M., Alelyani, M., Alsharani, M. Y., Gareeballah, A., Ahmad, I., & Musa, A. (2021). Evaluation of post-vaccination symptoms of two common COVID-19 vaccines used in abha, aseer region, kingdom of Saudi Arabia. Patient Preference and Adherence, 15, 963-1970. https://doi.org/10.2147PPA.330689

Ahsan, W., Syed, N. K., Alsraeya, A. A., Alhazmia, H. A., Najmi, A., Al Bratty, M., & Albarraq, A. A. (2021). Post-vaccination survey for monitoring the side effects associated with COVID-19 vaccines among healthcare professionals of Jazan province.Saudi Medical Journal, 42(12),1341-1352. https://doi.org/10.15537/smj.2021.42.12.20210576

Ahmad, S. A., Salih, B. K., Hama Hussein, K. F., Mikael, T. M., Kakamad, F. H., & Salih, A. M. (2021). Aseptic meningoencephalitis after COVID-19 vaccination: A case report. Annals of Medicine and Surgery, 71,103028. https://doi.org/10.1016/j.amsu.2021.103028

Al Bahrani, S., Albarrak, A., Alghamdi, O. A., Alghamdi, M. A., Hakami, F. H., Al Abaadi, A. K., & Al-Tawfiq, J. A. (2021). Safety and Reactogenicity of the ChAdOx1 (AZD1222) COVID-19 Vaccine in Saudi Arabia. Infectious Diseases of Poverty, 110, 359-362.https://doi.org/10.1016/j.ijid.2021.07.052

Alghamdi, A. N., Alotaib, M. I., Algatahni, A. S., Al aboud, D., & Abdel-Moneim, A. S. (2021). BNT162b2 and ChAdOx1 SARS-CoV-2 Post-vaccination Side-Effects Among Saudi Vaccinees. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.760047

Almohaya, A. M., Alsubie, H., Alqarni, B., Alzayad, B., Algharal, A., Alshahrani, K., & Barry, M. (2021). Acute unsolicited adverse events following BNT162b2 vaccine in Saudi Arabia, a real-world data. Vaccine, 40(3), 477-482. https://doi.org/10.1016/j.vaccine.2021.12.001

Akmufty, H. B., Mohammed, S. A., Abdullah, A. M., & Merza, M. A. (2021). Potential adverse effects of COVID19 vaccines among Iraqi population; a comparison between the three available vaccines in Iraq; a retrospective cross-sectional study. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 15(5). https://doi.org/10.1016/j.dsx.2021.102207

Al-Rasbi, S., Al-Mqbali, J. S., Al-Farsi, R., Al Shukailial, M. A., Al-Riyami, M. H.; Al-Falahi, Z., & Abdullah, M. Al Alawi. (2022). Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of Pfizer-BioNTech BNT162b2 mRNA COVID-19 Vaccine: A Case Report- Jornal of Medical Case Report, 23 (1),23. https://doi.org/10.12659/AJCR.934399

Ameratunga, R., Woon, S. T., Sheppard, M. N., Garland, J., Ondruschka, B., Wong, C. X., & Rexson, D. T. (2021). First Identified Case of Fatal Fulminant Necrotizing Eosinophilic Myocarditis Following the Initial Dose of the Pfizer-BioNTech mRNA COVID-19 Vaccine (BNT162b2, Comirnaty): an Extremely Rare Idiosyncratic Hypersensitivity Reaction. Journal Clinical Immunology, 42, 441-447. https://doi.org/1007/s10875-021-01187-0

Andrzejczak, S., Czudy, Z., & Donderska, M. (2022). Side effects after COVID-19 vaccinations among residents of Poland. European Review for Medical and Pharmacological Sciences, 25(12),4418-4421. https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-1296353

Aronson, J. K., & Ferner, R. E. (2018).Clarification of terminology in drug safety. Drug Saf, 28(10), 70-851. https://doi.org/10.2165/00002018-200528100-00003

Azimi, M., Dehzad, W. M., Atiq, M. A., Bahain, B., & Asady, A. (2021). Adverse effects of the COVID-19 vaccine reported by lecturers and staff of kabul university of medical sciences Kabul, Afghanistan. Infection and Drug Resistance, 14, 4077- 4083. https://doi.org/10.2147/IDR.S332354

Baffa, M. E., Maglie, R., Giovannozzi, N., Montefusco, F., Senatore, S., Massi, D., & Antiga, E. (2021). Sweet syndrome following sars-cov2 vaccination.Vaccines, 9(11), 1212. https://doi.org/10.3390/vaccines9111212

Batista, E. C. C., Ferreira, A. P., Alexandre, B. G. P., Lima, M. R. S., Oliveira, V. C., & Guimarães, E. A. A. (2022). A influência das condutas de enfermagem na vigilância de eventos adversos pós- vacinação. Revista Brasileira de Enfermagem, 75(3), 20210132. https://doi.org/10.1590/0034-7167-2021-0132

Beatty, A. L., Peyser, N. D., Butcher, X. E., Cocohoba, J. M., Lin, F., Olgin, J. E., Pletcher, M. J., & Marcus, G. M. (2021). Analysis of COVID-19 Vaccine Type and Adverse Effects Following Vaccination. JAMA Network Open, 4(12), 2140364. https://doi.org/10.1001/jamanetworkopen.2021.40364

Benjamanukul, S., Traiyan, S.,Yorsaeng, R., Vichaiwattana, P., Sudhinaraset, N., Wanlapakorn, N., & Poovorawan, Y.(2022). Safety and immunogenicity of inactivated COVID-19 vaccine in health care workers. Journal of Medical Virology, 94(4), 1442-1449. https://doi.org/10.1002/jmv.27458

Burlando, M., Herzum, A., Micalizzi, C., Cozzani, E., & Parodi, A. (2022). Cutaneous reactions to COVID-19 vaccine at the dermatology primary careimmun. Immunity, Inflammation and Disease,10(2), 265-271. https://doi.org/10.1002/iid3.568

Brasil. (2013).Ministério da Saúde. Secretaria de vigilância em saúde. Departamento de vigilância das doenças transmissíveis. Programa Nacional de Imunização. Brasília (df).

Brasil. (2020). Ministério da Saúde. Manual de vigilância epidemiológica de eventos adversos pós-vacinação. Departamento de Imunizações e Doenças Transmissíveis.https://www.gov.br/anvisa/pt-br/assuntos/fiscalizacao-e-monitoramento/farmacovigilancia/arquivos/manual_vigilancia_epidemiologica_eventos_vacinacao_4ed.pdf.

Brasil. (2021). Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Anvisa faz recomendações sobre doses de reforço de vacinas contra Covid-19. Anvisa faz recomendações sobre doses de reforço de vacinas contra Covid-19 — Português (Brasil) (www.gov.br).

Brasil.(2021b). Ministério da Saúde. Nota Técnica Secovid/Gab Nº 65/2021c. Antecipação do intervalo para dose de reforço de vacinas contra a COVID-19 em pessoas com mais de 18 anos e imunossuprimidos. Sei/Ms-0024429242.

Brasil. (2021c). Ministério da Saúde. Instituto Nacional de Câncer. Fases de desenvolvimento de um novo medicamento. https://www.inca.gov.br/pesquisa/ensaios-clinicos/fases-desenvolvimento-um-novo-medicamento

Brasil. (2022). Ministério da Saúde. Vacinômetro COVID-19.2022b. Vacinometro COVID-19 (saude.gov.br).

Brasil.(2022b). Ministério da saúde. Nota técnica secovid/gab nº 24/2022d. Recomendação da segunda dose de reforço de vacinas contra a COVID-19 em pessoas com 60 anos ou mais. Sei/ms-0024429242.

Catalá, A., Santos, C. M., Casas, C. G., Riesco, M. R., Nebreda, D. R., Truyols, A., ...Guilabert, A.(2021).Cutaneous reactions after sars-cov-2 vaccination: a cross-sectional spanish nationwide study of 405 cases.British Journal of Dermatology, 186(1), 142-152. https://doi.org/10.1111/bjd.20639

Cai, C., Peng, Y., Shen, E., Huang, Q., Chen Y., Liu, P., & Hong, S. (2021). A comprehensive analysis of the efficacy and safety of COVID-19 vaccines. Molecular Therapy, 29(9), 2794-2805. https://doi.org/10.1016/j.ymthe.2021.08.001

Chapin-Bardales, J., Gee, J., & Myers, T. (2021). Reactogenicity following receipt of mrna-based covid-19 vaccines. Journal of the American Medical Association, 325(21), 2201-2202. https://doi.org/10.1001/jama.2021.5374

Chen, M., Yuan, Y., Zhou, Y., Deng, Z., Zhao, J., Feng, F., Huachun, Z., & Caijun, S. (2021). Safety of SARS-CoV-2 vaccines: a systematic review and meta-analysis of randomized controlled trials. Infectious Disease Poverty, 10(1), 94. https://doi.org/10.1186/s40249-021-00878-5

Cieslewicz, A., Dudek, M., Krela-Kazmierczak, I., Jableka, A., Lesiak, M., & Korzeniowska, K. (2021). Pancreatic injury after covid-19 vaccine—a case report. Vaccines, 9(6), 576. https://doi.org/10.3390/vaccines9060576

Constantino, M., Sellitto, C., Conti, V., Corbi, G., Marongiu, F., Genovese, G., & De Caro, F. (2022). Adverse Events Associated with BNT162b2 and AZD1222 Vaccines in the Real World: Surveillance Report in a Single Italian Vaccine Center. Journal of Clinical Medicine,11(5). https://doi.org/10.3390/jcm11051408

Cuschieri, S., Borg, M., Agius, S., Souness, J., Brincat, A., & Grench, V. (2021). Adverse reactions to Pfizer-BioNTech vaccination of healthcare workers at Malta's state hospital. International Journal of Clinical Practice, 75(10), 14605.https://doi.org/10.1111/ijcp.14605

Daou, C. A. Z, Natout, M. A., & El Hadi, N. (2021). Biphasic anaphylaxis after exposure to the first dose of Pfizer‐BioNTech COVID‐19 mRNA vaccine. Journal of Medical Virology, 93(10), 6027–6029. https://doi.org/10.1002/jmv.27109

Domingues, C. M. A., & Teixeira, A. M. S. (2013). Coberturas Vacinais e doenças imunopreveníveis no Brasil no período de 1982-2012: avanços e desafios no programa nacional de Imunizações. Epidemiology Service Saúde, 22(1), 9-27. http://dx.doi.org/10.5123/S1679-49742013000100002

Dziedzic, A., Riad, A., Attia, S., Klugar, M., & Tanasiewicz, M. (2021). Self-reported adverse events of COVID-19 vaccines in polish healthcare workers and medical students. Cross-sectional study and pooled analysis of CoVaST project results in central europe. Journal of Clinical Medicine,10(22),5338. https://doi.org/10.3390/jcm10225338

Elgendy, M. O., EL-Gendy, A. O., Mahmoud, S., Mohammed, T. Y., Abdelrahim, M. E. A., & Sayed, A. M. (2022). Side Effects and Efficacy of COVID-19 Vaccines among the Egyptian Population. Vaccines, 10(1), 109. https://doi.org/10.3390/vaccines10010109

Ferreira, V. L. R. (2018). Avaliação de coberturas vacinais de crianças em uma cidade de médio porte (Brasil) utilizando registro informatizado de imunização. Caderno de Saúde Pública, 34(9),00184317. https://doi.org/10.1590/0102-311X00184317

Fischinger, S., Boudreau, C. M., Butler, A. L., Steeck, H., & Alter, G. (2019). Sex differences in vaccine-induced humoral immunity. Seminary Immunopathology, 41(2), 239-249. https://doi.org/10.1007/s00281-018-0726-5

Fowler, N., Martinez, N. R. M., Pallares, B. V., & Maldonado, R. S. (2021). Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine. American Journal of Ophthalmology, 23, 101136. https://doi.org/10.1016/j.ajoc.2021.101136

Frustaci, A., Verardo, R., Galea, N., Lavalle, C., Bagnato, G., Scialla, R., & Chimenti, C. (2022). Hypersensitivity Myocarditis after COVID-19 mRNA Vaccination. Journal of Clinical Medicine, 11(6), 1660. https://doi.org/10.3390/jcm11061660

Galvão, C. M.(2006). Níveis de evidência. Acta Paulista de Enfermagem, 19(2), 5. https://doi.org/10.1590/S0103-21002006000200001

Galvão, T. F., Pansani, T. S. A., & Harrad, D. (2015). Principais itens para relatar Revisões sistemáticas e meta-análises: A recomendação PRISMA. Epidemiologia e Serviços da Saúde, 24(2) 335-342. http://scielo.iec.gov.br/scielo.php?script=sci_arttext&pid=S1679-49742015000200017

Graham, B. S.(2020). Rapid COVID-19 vaccine development. Science, 368(6494), 945-946. https://doi.org/10.1126/science.abb8923

Grieco, T., Maddalena, P., Sernicola, A., Muharremi, R., Basili, S., Alvaro, D., Cangemi, R., Rossi, A., & Pellacani, G. (2021). Cutaneous adverse reactions after COVID-19 vaccines in a cohort of 2740 Italian subjects: An observational study. Dermatologic therapy, 34(6),15153. https://doi.org/10.1111/dth.15153

Haas, J. W., Bender, F. L., Ballou, S., Kelley, J. M., Wilhelm, M., Miller, F. G., Rief, W., & Kaptchuk, T. J. (2022). Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials: A Systematic Review and Meta-analysis. JAMA Netw Open, 5(1), 2143955. https://doi.org/10.1001/jamanetworkopen.2021.43955. Erratum in: JAMA Netw Open. 2022 Feb 1;5(2):e221277.

Hai, J., Shawa, H., Kim-Lim, P., Wang, J. Z., Vy, M., Fung, M. A., Sood, A., & Tartar, D. M. (2021). Systemic drug-related intertriginous and flexural exanthema induced by the Pfizer-BioNTech COVID-19 vaccine: A report of 2 cases. JAAD Case Reports, 18, 57-60. https://doi.org/10.1016/j.jdcr.2021.10.016

Im, J. H., Kim, E., Lee, E., Seo, Y., Lee, Y., Jang, Y., & Baek, J. H. (2021). Adverse events with the pfizer-BioNTech COVID-19 vaccine among Korean healthcare workers. Journal Yonsei Medicine, 62(12), 1162-1168. https://doi.org/10.3349/ymj.2021.62.12.1162

Javed, D., Alharbi, Y. H., Javed, A., & Gbal, J.(2021). Symptoms and Side Effects of the ChAdOx1 nCoV-19 vaccine (AZD1222) among healthcare workers: A Single Center Experience Pak. Journal Medicine Health Sciense, 15(12), 3202-3204. https://doi.org/10.53350/pjmhs2115123202

Jeon, M., Kim, J., Oh, C. E., & Lee, J. Y. (2021). Adverse Events Following Immunization Associated with Coronavirus Disease 2019 Vaccination Reported in the Mobile Vaccine Adverse Events Reporting System. Journal of Korean Medical Science, 36(17), 1-8. https://doi.org/10.3346/jkms.2021.36.e114

Kim, B., Park, Y., Kim, E. K., & Lee, S. H.(2021). Supraclavicular lymphadenopathy after COVID-19 vaccination in Korea: serial follow-up using ultrasonography. Clinical Imaging, 79, 201-203. https://doi.org/10.1016/j.clinimag.2021.05.031

Kitagawa, H., Kaiki, Y., Sugiyama, A., Nagashima, S., Kurisu, A., Nomura, T., & Ohge, H. (2022). Adverse reactions to the BNT162b2 and mRNA-1273 mRNA COVID-19 vaccines in Japan. Journal Infectology Chemother, 28(4), 576-581. https://doi.org/10.1016/j.jiac2021.12.034

Klugar, M., Riad, A., Mekhemar, M., Conrad, J., Buchbender, M., Howaldt, H. P., & Attia, S. (2021). Side effects of mrna-based and viral vector-based covid-19 vaccines among german healthcare workers. Biology, 10(8), 752. https://doi.org/10.3390/biology10080752

Lim, S. M., Chan, H. C., Santosa, A., Quek, S. C., Liu, E. H. C., & Somani, J. (2021). Safety and side effect profile of pfizer-biontech covid-19 vaccination among healthcare workers: A tertiary hospital experience in Singapore. Annals – Academy of Medicine Singapore, 50(9), 703-711. https://doi.org/10.47102/annals-acadmedsg.2021160

Liu, Q., Qin, C., Liu, M., & Liu, J. (2021). Effectiveness and safety of SARS-CoV-2 vaccine in real-world studies: a systematic review and meta-analysis. Infectious Disease Poverty, 10(1), 132. https://doi.org/ 10.1186/s40249-021-00915-3

Manilgama, S. R., Hettiarachchi, N. M., Jayasinghe, I. K., Silva, S. T., Jayalath, T., Wanigaratne, T., & Thilini, D. K. M.(2022).Adverse events following COVISHIELD (ChAdOx1nCoV-19) vaccination among health care workers in Sri Lanka; a multi-centre cross sectional survey. The Preprint Server for Health Sciences. https://www.medrxiv.org/content/10.1101/2022.01.26.22269788v1

Mcmahon, D. E., Amerson, E., Rosenbach, M., Lipoff, J. B., Moustafa, D., Tyagi, A., & Freeman, E. E.(2021).Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. Journal of the American Academy of Dermatology, 85(1), 46-55. https://doi.org/10.1016/j.jaad.2021.03.092

Mendes, K. D. S., Silveira, R. C. C. P., & Galvão, C. M.(2009).Revisão integrativa: método de pesquisa para incorporação de evidências na saúde e na enfermagem. Texto Contexto Enfermagem, 17(4), 758. https://doi.org/10.1590/S0104-07072008000400018

Mira, F. S., Carvalho, J. C., Almeida, P. A., Pimenta, A. C., Coutinho, I. A., Figueiredo, C., & Alves R. A. (2021). A case of acute interstitial nephritis after two doses of the BNT162b2 SARS-CoV-2 vaccine. International Journal of Nephrology and Renovascular Disease, 14, 421-426.https://doi.org/10.2147/IJNRD.S345898

Mizuta, A. H., Succi, G. M., Montalli, V. A. M., & Succi, R. C. M.(2019). Percepções acerca da importância das vacinas e da recusa vacinal numa escola de medicina. Revista Paulista de Pediatria, 37(1), 34-40. https://doi.org/10.1590/1984-0462/;2019;37;1;00008

Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G.(2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLOS Medicine, 6(7), 339. https://doi.org/10.1136/bmj.b2535

Niebel, D., Novak, N., Wilhelmi, J., Ziob, J., Wilsmann-Theis, D., Bieber, T., Wenzel, J., & Braegelmann, C. (2021). Cutaneous Adverse Reactions to COVID-19 Vaccines: Insights from an Immuno-Dermatological Perspective. Vaccines, 9(9), 944. https://doi.org/10.3390/vaccines9090944

Omeish, H., Najadat, A., Al-Azzam, S., Tarabin, N., Abu Hameed, A., Al-Gallab, N., & Aldeyab, M. A.(2021). Reported COVID-19 vaccines side effects among Jordanian population: a cross sectional study. Human Vaccines & Immunotherapeutics, 18(1), 1981086. https://doi.org/10.1080/21645515.2021.1981086

Organização Mundial da Saúde.(2022). Organização Pan-Americana De Saúde.Com 14 países que ainda não vacinaram 40% de sua população, Américas continuam sendo região mais desigual do mundo na luta contra COVID-19. https://www.paho.org/pt/noticias/2-2-2022-com-14-paises-que-ainda-nao-vacinaram-40-sua-populacao-americas-continuam-sendo .

Ouzanni, M., Hammady, H., Fedorowicz, Z., & Elmagarmide, A. (2016). Rayyan – a web and mobile app for systematic reviews. Systematic Reviews, 5(210). https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-016-0384-4

Park, J. Y., Lee, J. Y., & Yi, S. Y.(2022). Axillary Lymphadenopathy on Ultrasound after COVID-19 Vaccination and Its Influencing Factors: A Single-Center Study. Journal of Clinical Medicine,11(1), 238. https://doi.org/10.3390/jcm11010238

Patel, Y. R., Louis, D. W., Atalay, M., Agarwal, S., & Shan, N. R.(2021). Cardiovascular magnetic resonance findings in young adult patients with acute myocarditis following mRNA COVID-19 vaccination: a case series. Journal of Cardiovascular Magnetic Resonance, 23(1), 101. https://doi.org/10.1186/s12968-021-00795-4

Pokharel, K., Dawadi, B. R., & Karki, A.(2021).Side effects after second dose of covishield vaccine among healthcare workers: A descriptive cross-sectional study. Journal of Nepal Medical Association, 59(238), 577-579. https://doi.org/10.31729/jnma.6556

Porfirio, T. C., & Moreira, R. L.(2019). Assistência de enfermagem nos eventos adversos pós-vacinação da BCG na infância. Brazilian Journal of Health Review, 2(2), 1455-1470. http://www.brjd.com.br/index.php/BJHR/article/view/1370/1256

Pormohammad, A., Zarei, M., Ghorbani, S., Mohammadi, M., Razizadeh, M. H., Turner, D. L., & Raymond, J. T. (2021). Efficacy and safety of COVID-19 vaccines: a systematic review and meta-analysis of randomized clinical trials. Vacinas, 9(5), 467. https://doi.org/10.3390/vaccines9050467

Pourani, M. R., Dradas, M. S., Salari, M., Diab, R., Namazi, N., & Abdollahimajda, F.(2021).Cutaneous adverse events related to COVID-19 vaccines: A cross-sectional questionnaire-based study of 867 patients. Dermatologic Therapy, 35(2), 15223. https://doi.org/10.1111/dth.15223

Pur, D. R., Bursztyn, L. L. C. B., & Iordanous, Y.(2022). Branch retinal vein occlusion in a healthy young man following mRNA COVID-19 vaccination. American Journal of Ophthalmology Case Reports, 26, 101445 https://doi.org/10.1016/j.ajoc.2022.101445

Riad, A., Hocková, B., Kantorová, L., Slávik, R., Spurná, L., Stebel, A., & Klugar, M.(2021).Side effects of mrna-based covid-19 vaccine: Nationwide phase iv study among healthcare workers in slovakia. Pharmaceuticals, 14(9), 873. https://doi.org/10.3390/ph14090873

Riad, A., Pokorná, A., Attia, S., Klugarová, J., Koscík, M., & Klugar, M.(2021b).Prevalence of covid-19 vaccine side effects among healthcare workers in the Czech Republic. Journal of Clinical Medicine,10(7), 1428. https://doi.org/10.3390/jcm10071428

Riad, A., Pokorná, A., Klugarová, J., Antolova, N., Kantorova, L., Koscík, M., & Klugar, M.(2021c).Side effects of mrna-based covid-19 vaccines among young adults (18–30 years old): An independent post-marketing study. Pharmaceuticals, 14(10),1049. https://doi.org/10.3390/ph14101049

Rosenblum, H. G, Hadler, S. C, Moulia, D., Shimabukuro, T. T., Su, J. R., Tepper. N. K., & Oliver, S. E. (2021). Use of COVID-19 Vaccines After Reports of Adverse Events Among Adult Recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 Vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices. Morbidity and Mortallity Weekly Report, 70(32), 1094-1099. https://doi.org/10.15585/mmwr.mm7032e4

Saita, M., Yan, Y., Ito, K., Sasano, H., Seyama, K., & Naito, T. (2021). Reactogenicity following two doses of the BNT162b2 mRNA COVID-19 vaccine: Real-world evidence from healthcare workers in Japan. Journal of Infection and Chemotherapy, 28(1), 116-119. https://doi.org/10.1016/j.jiac.2021.09.009

Serwaa, D., Boakye, F. O., Nkansah, C., Ahiatrogah, S., lamptey, E., Abdulai, R., & Danquah, M.(2021). Non-life-threatening adverse reactions from COVID-19 vaccine; a cross-sectional study with self-reported symptoms among Ghanaian healthcare workers. Human Vaccines Immunotherapeutics,7(11), 3881-3886. https://doi.org/10.1080/21645515.2021.1963600

Sharif, N., Alazharani, K. J., Ahmed, S. N., & Dey, S. K.(2021). Efficacy, Immunogenicity and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis. Frontiers in Immunology,12, 714170. https://doi.org/10.3389/fimmu.2021.714170

Singh, H., & Sharma, S. (2021). Adverse events with COVID-19 vaccination among the health care professionals of Himachal Pradesh-A Rapid SurveyIndian. Journal of Community Health, 33(3), 531-533. https://doi.org/10.47203/IJCH.2021.V33I03.023

Solomon, Y., Eshete, T., Mekasha, B., & Assefa, W.(2021). COVID-19 vaccine: Side effects after the first dose of the oxford astrazeneca vaccine among health professionals in low-income country: Ethiopia. Journal of Multidisciplinary Healthcare, 14, 2577-2585. https://doi.org/10.2147/JMDH.S331140

Sultana, A., Shahriar, S., Tahsin, M. R., Mim, S. R., Fatema, K. R., Saha, A., & Amran, M. S. A.(2021). retrospective cross-sectional study assessing self-reported adverse events following immunization (AEFI) of the COVID-19 vaccine in Bangladesh. Vaccines, 9(10), 1090. https://doi.org/10.3390/vaccines9101090.

Sprute, R., Schumacher, S., Pauls, M., Pauls, W., & Cornely, O. A. (2021). Delayed Cutaneous Hypersensitivity Reaction to Vaxzevria (ChAdOx1-S) Vaccine against SARS-CoV-2. Drugs in R&D, 21(4),371-374. https://doi.org/10.1007/s40268-021-00358-z

Sun, Q., Fathy, R., Mcmahon, D. E., & Freeman, E. E.(2021).COVID-19 Vaccines and the Skin: The Landscape of Cutaneous Vaccine Reactions Worldwide. Dermatologic clinics, 39(4), 653-673. https://doi.org/10.1016/j.det.2021.05.016

Tanriover, M. D., Doganay, H. L., Akova, M., Guner, H. R., Azap, A., Akhan, S., & Aksu, K.(2021). CoronaVac Study Group; Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey. The Lancet, 398(10296), 213-222. https://doi.org/10.1016/S0140-6736(21)01429-X

Telí, S. E. S. I., Ramanand, J., Bhangale, C. S., Mahajan, H. M., & Mandhare, R.(2021). Analysis of all the adverse events following immunization by covishield™ vaccine among healthcare workers at government medical college, Jalgaon. National Journal of Physiology, Pharmacy and Pharmacology, 12(1), 65-68. https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho -1627655.

Ternoplskil, C. A., Baratieri, T., & Lentsck, M. (2015). Eventos adversos pós-vacinação: Educação permanente para a equipe de enfermagem. Revista de Saúde Pública do Paraná,16(4), 109-119. https://doi.org/10.22421/1517-7130.2015v16n4p109

Tihy, M., Menzinger, S., André, R., Laffitte, E., Toutous-Trellu, L., & Kaya, G. (2021). Clinicopathological features of cutaneous reactions after mRNA-based COVID-19 vaccines. Journal of the European Academy of Dermatology and Venereology: JEADV,35(12), 2456-2461. https://doi.org/10.1111/jdv.17633

United States.(2021). Department of Health & Human Services. Centers for Disease Control and Prevention. How COVID-19 spreads. https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/how-covid-spreads.html

United States.(2021b). Department of Health & Human Services. Centers for Disease Control and Prevention. Possible Side Effects After Getting a COVID-19 Vaccine https://www.cdc.gov/coronavirus/2019-ncov/vaccines/expect/after.html#:~:text=So%20far%2C%20reactions%20reported%20after,effects%20were%20mild%20to%20moderate.

Vigezzi, G. P., Lume, A., Minerva, M., Nizzero, P., Biancardi, A., Gianfredi, V., & Moro, M.(2021). Safety surveillance after BNT162b2 mRNA COVID-19 vaccination: Results from a cross-sectional survey among staff of a large italian teaching hospital. Acta Biomedica Brasiliensia, 92(S6), 2021450. https://doi.org/110.23750/abm.v92iS6.12217

Witberg, G., Barda, N., Hoss, S., Richter, I., Wiessman, M., Aviv, Y., & Kornowski, R. (2021). Myocarditis after Covid-19 Vaccination in a Large Health Care Organization. The New England Journal of Medicine, 385(23), 2132–2139. https://doi.org/10.1056/NEJMoa2110737

World Health Organization. (2022).Coronavírus (COVID-19). Dashboard. https://covid19.who.int/.

Zhang, L., Zhou, P., Yang, X. L., Wang, X. G., & Hu, B. (2020).An outbreak of pneumonia associated with a novel coronavirus of likely bat origin. Natureza, 579, 270-273. https://doi.org/110.1038/s41586-020-2012-7

Zhang, M. X., Zhang, T. T., Shi, G. F., Cheng, F. M., Zheng, Y. M.,Tung, T. H., & Chen, H. X.(2021).Safety of an inactivated SARS-CoV-2 vaccine among healthcare workers in China. Expert Review of Vaccines, 20(7), 891-898. https://doi.org/110.1080/14760584.2021

Yamamoto, K. (2022). Adverse efects of COVID-19 vaccines and measures to prevent them. Virology Journal,19(100), 1-3. https://doi.org/10.1186/s12985-022-01831-0

Published

04/10/2022

How to Cite

CORREA, I.; PEREIRA , M. A.; LUZ, K. C. S. I.; TEIXEIRA, M. M.; SANTOS, F. G. T. Adverse reactions after COVID-19 vaccination: an integrative review. Research, Society and Development, [S. l.], v. 11, n. 13, p. e188111335278, 2022. DOI: 10.33448/rsd-v11i13.35278. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/35278. Acesso em: 16 apr. 2024.

Issue

Section

Health Sciences