Main complications in pregnant women with antiphospholipid antibody syndrome: integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i13.35382

Keywords:

Miscarriage; Pregnancy complications; Pregnancy complications, hematologic; Thrombosis.

Abstract

Antiphospholipid Antibody Syndrome (APS), an autoimmune disease characterized by the occurrence of thrombotic events in any vascular bed and gestational events. This study aims to identify the main obstetric complications in pregnant women with APS, based on the analysis of scientific productions. This is an integrative literature review, with a qualitative approach, using the DeCS: pregnancy, abortion, thrombosis. The Medical Literature Analysis and Retrievel System Online (MEDLINE) and Latin American and Caribbean Literature on Health Sciences (LILACS) databases were used through the Virtual Health Library (BVS), in October 2021, for through the Descriptors in Health Sciences (DeCS): “pregnancy”, “abortion” and “thrombosis”, using the Boolean term AND in the searches. 249 articles were found, and through the inclusion and exclusion criteria, 4 articles were selected for analysis. The results showed that FAS is treated as an immunodeficiency and among the main complications in pregnancy are: fetal death, recurrent miscarriages in the first months due to placental insufficiency, deep vein thrombosis (DVT) in the lower limbs, and pulmonary thromboembolism (PTE). It can result in maternal death. For this, it is extremely important that any signs of bleeding and miscarriage that occur, the pregnant woman should seek specialized medical assistance to manage the problem. Primary care has the role of instructing these women to carry out laboratory tests, as well as offering prenatal care and quality obstetric follow-up.

Author Biographies

Thiozano Afonso de Carvalho, Universidade Federal de Campina Grande

He is currently a student at the Federal University of Campina Grande in the Bachelor of Nursing course at the UFCG/CFP Teacher Training Center. Graduated in Nursing Technician from the Technical School of Health of Cajazeiras - ETSC/UFCG/CFP. Former member of the Violence and Health Research Group - GPVS/CNPq. Member of the research group Multidisciplinary Laboratory of Scientific Design and Writing - LaMDEC/HUJB. Member of CORESAE (Council of Nursing Room Representatives - UFCG/CFP). He works as an extension officer at the Pro-Rectory of Research and Extension at UFCG/CFP. I have affinities for the lines of research: Urgency and Emergency, nursing in women's health, mental health and collective health.

Raquel Vieira Rodrigues, Universidade Federal de Campina Grande

Nursing student at the Federal University of Campina Grande - Teacher Training Center/Cajazeiras campus

Thalita Regina Morais dos Santos, Universidade Federal de Campina Grande

Nursing student at the Federal University of Campina Grande - UFCG/CFP. He served as a member of CORESAE - Council of Nursing Room Representatives (2019-2021) and as an extension officer for the Dean of Research and Extension of UFCG/CFP (2019-2021). Current coordinator of teaching, research and extension of the Academic Nursing Center (CAEC-Dália) of UFCG/CFP.

Magna Jaíne Alves de Brito, Universidade Federal de Campina Grande

Nursing student at the Federal University of Campina Grande -UFCG/CFP; Nursing technician graduated from the Academic Unit of the Technical School of Health of Cajazeiras - ETSC (2016-2018), linked to the Federal University of Campina Grande - UFCG/CFP; Member of the Multidisciplinary Health Research Group at the Federal University of Campina Grande - UFCG; Former Member of the Academic Nursing Center of Cajazeiras Dália - CAEC Dália.

Verônica Mendes de Carvalho, Universidade Federal de Campina Grande

Graduate student of the Bachelor's Degree in Nursing at the Federal University of Campina Grande (UFCG), member of the Laboratory of Information and Communication Technologies in Health (LATICS) in the Biochemistry research line

Suzana Marques Martins, Centro Universitário Santa Maria

Graduating in Physiotherapy at the Santa Maria University Center, Cajazeiras-PB, Occupational Safety Technician, formed by the Miriam Benevides Gadelha Professional Training Center- SENAI-PB. Currently, she monitors the Neurofunctional discipline of the Bachelor's Degree in Physiotherapy at FSM. Participant of the extension projects "Anda Risos" and "Awareness" 2020.1 to 2020.2. And from the research project "Nucleus of studies on mucopolysaccharidosis", in the period from 2020.1 to 2020.2.

Maria Berenice Gomes Nascimento, Universidade Federal de Campina Grande

Graduated in Nursing from the Federal University of Paraíba (1998). PhD in Health Science from the ABC School of Medicine (2022). Master in Collective Health from the Catholic University of Santos. She is currently Adjunct Professor I at the Federal University of Campina Grande (UFCG) T-40 regime in the Bachelor's Degree in Nursing, teaching the discipline Nursing in Urgency and Emergency, Intensive Care Nursing, Semiology and Semiology II and Supervised Curricular Internship II. Coordinator of the Nursing Course at UFCG. Member of the Research Group entitled: Laboratory of Information and Communication Technologies in Health (LATICS), in the Women's Health section. She has experience in the field of Nursing, with an emphasis on Collective Health Nursing, Occupational Nursing, Adult and Neonatal ICU and Emergency.

Symara Abrantes Albuquerque de Oliveira Cabral, Universidade Federal de Campina Grande

PhD in Health Sciences (FMSCSP-2020). Master in Agroindustrial Systems (UFCG-2016). Specialist in Educational Processes in Health with Emphasis on Constructivist Educational Technologies (IEP Sírio Libanês-2017). Specialist in Educational Processes in Health with Emphasis on Active Methodologies (IEP Sírio Libanês -2016). Specialist in Micropolitics of Management and Work in Health (UFF-2015). Specialist in Primary Care Management and Microregional Health Networks (UFPB-2014). Specialist in Food and Nutrition Policy Management (FIOCRUZ-2014). Specialist in Work Management and Health Education (UFRN-2014). Specialist in Family Health (FIP-2011). Graduated in Nursing (UFCG-2011). Degree in Portuguese Language Literature (IFPB-2019). Acting mainly on the following topics: Nursing, Women's Health Nursing, Teaching and Learning, Active Teaching and Learning Methodologies.

References

Andrade, J. R., Camargos, M. V., Reis, M. F. de R., Maciel, R. A. B., Melo, T. T., Batalha, S. H., Matos, V. M., Salgado, H. C., Rangel, J. M. de C., & Zimmermmann, J. B. (2019). A história obstétrica de gestantes com trombofilias hereditárias. Clin Biomed Res. 39(2). https://seer.ufrgs.br/index.php/hcpa/article/view/86858

Barros, V. I. P. V. L., Igai, A. M. K., Andres, M. P., Francisco, R. P. V., & Zugaib, M. (2014). Resultados gestacionais e trombofilias em mulheres com história de óbito fetal de repetição. Revista Brasileira de Ginecologia e Obstetrícia, 36 (02): 50-55.

Barros, V. I. P. V., Igai, A. M. K., Oliveira, A. L. M. L., Teruchkin, M. M., & Orsi, F. A. (2021). Síndrome Antifosfolípide obstétrica. Frebasgo Position Statement. 6: 1-6.

Febrasgo. (2017) Avaliação do Risco e Prevenção de Tromboembolismo no Pré-Natal. Febrasgo. Consultado a 10 de 03 de 2022. https://www.febrasgo.org.br/pt/noticias/item/117-avaliacao-do-risco-e-prevencao-de-tromboembolismo-no-pre-natal#:~:text=Conduta%3A,ter%20seu%20risco%20tromboemb%C3%B3lico%20reavaliado.

Ferreira, C. M., Figueiró-Filho, E. A., Oliveira, V. M., & Pereira, E. F. V. (2017). Tromboprofilaxia e desfechos materno-fetais de mulheres com marcadores séricos para trombofilias hereditárias e antecedentes de complicações obstétricas. Revista Brasileira de Saúde Materno Infantil. 17 (4), 693-698.

Figueiró-Filho, E. A., Oliveira, V. M., Coelho, L. R., & Breda, I. (2012). Marcadores séricos de trombofilias hereditárias e anticorpos antifosfolípides em gestantes com antecedentes de pré-eclâmpsia grave. Revista Brasileira de Ginecologia e Obstetrícia. 34 (1): 40-46.

França de, M. F., & Lins, S. R. O. (2020). Complicações obstétricas em mulheres trombofílicas com presença do anticorpo antifosfolípide. Braz. J. of Develop. 6(12): 94682-94694.

Gjorgjievski, N., & Dzekova-Vidimliski, P. (2020). Síndrome antifosfolípide primária em paciente em hemodiálise com trombose recorrente de fístulas arteriovenosas. Jornal Brasileiro de Nefrologia. 42(2): 259-263.

Klack, K., & Carvalho, J. F. de. (2008). A importância da intervenção nutricional na redução do peso corpóreo em pacientes com síndrome do anticorpo antifosfolípide. Revista Brasileira de Reumatologia. 48(3): 134-140.

Ministério da Saúde (BR). (2012) Gestação de Alto Risco: Manual Técnico. Normas e Manuais Técnicos, (5ª edição), Série A, Brasília - DF.

Penedo, C. R., & Santos, M. C. (2020). Lúpus Eritematoso Sistémico na Gravidez: implicações maternas, obstétricas e fetais. Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa.

Pereira, D. O., Ferreira, T. L. S., Araújo, D. V., Melo, K. D. F., & Andrade, F.B. (2018). Avaliação das consultas de pré-natal: adesão do pré-natal e complicações na saúde materno-infantil. Revista Ciência Plural. 3(3): 2-15.

Pinto, K. C. L. R., Ederli, S. F., Vicente, L. M., Batista, A. F., Bignardi, B., Santos, D. A. & Vicentini, E. C. (2020). Principais complicações gestacionais e obstétricas em adolescentes. Brazilian Journal of Health Review. 3(1): 873-882.

Rodriguez-Pintó, I., Espinosa, G., & Cervera, R. (2020). Medicina de precisão e a síndrome antifosfolípide: qual é o futuro?. Clinical Rheumatology. 39: 1015–1017.

Shi, T., Gu, Z., & Diao, Q. (2021). Meta-análise de aspirina combinada com heparina de baixo peso molecular para melhorar a taxa de nascimento vivo em pacientes com síndrome antifosfolipídica e sua correlação com níveis-dímero, Medicina. 100(25): 26264.

Silva, L. T., Meurer, N. C., Rodrigues, D. A. C., Rahal, Y. A., Souza, I. A., & Caran, L. L. (2021). Pregnancy and COVID-19 pandemic: Impacts on the maternal-fetal binomial. Research, Society and Development. 10(7): 23510716416. 10.33448/rsd-v10i7.16416.

Soares, M. P. L. (2017). Relação entre a Síndrome do Anticorpo Antifosfolipídeo e as complicações gestacionais. 2017. Monografia (Graduação) – Faculdade de Ciências da Educação e Saúde, Centro Universitário de Brasília, Brasília.

Sousa, L. M. M., Marques-Vieira, C. M. A., Severino, S. S. P., & Antunes, A. V. (2017). A metodologia de revisão integrativa da literatura em enfermagem. Revista Investigação em Enfermagem. 2: 17-26.

Tomaschewski-Barlem, J. G., Bordignon, S. S., Costa, C. F. S., Costa, C. O., & Barlem, E, L. D. (2016). Promovendo a autoestima na gestação: foco no acolhimento. Enfermagem em Foco. 7(2): 801.

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Published

07/10/2022

How to Cite

CARVALHO, T. A. de; RODRIGUES, R. V.; SANTOS, T. R. M. dos; BRITO, M. J. A. de; CARVALHO, V. M. de; MARTINS, S. M.; NASCIMENTO, M. B. G.; CABRAL, S. A. A. de O. Main complications in pregnant women with antiphospholipid antibody syndrome: integrative review . Research, Society and Development, [S. l.], v. 11, n. 13, p. e264111335382, 2022. DOI: 10.33448/rsd-v11i13.35382. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/35382. Acesso em: 24 apr. 2024.

Issue

Vol. 11 No. 13

Section

Health Sciences

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Copyright (c) 2022 Thiozano Afonso de Carvalho; Raquel Vieira Rodrigues; Thalita Regina Morais dos Santos; Magna Jaíne Alves de Brito; Verônica Mendes de Carvalho; Suzana Marques Martins; Maria Berenice Gomes Nascimento; Symara Abrantes Albuquerque de Oliveira Cabral

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