The impacts of radiotherapy on tooth structure and its consequences on dental treatment

Authors

DOI:

https://doi.org/10.33448/rsd-v11i13.35404

Keywords:

Radiotherapy; Tooth; Head and Neck Neoplasms; Dental care.

Abstract

Head and neck radiotherapy negatively affects the dental structure of permanent teeth, causing organic and morphological changes in enamel and dentin. The aim of this study was to evaluate what changes occur in these substrates and how these changes may affect rehabilitative dental treatment. An integrative literature review was carried out, where 20 articles were selected based on the eligibility criteria proposed in the PICO strategy, using the descriptors: radiotherapy, tooth, head and neck cancer, and dental treatment, crossing them with the boolean operator AND. The databases consulted were the National Library of Medicine (PubMed), Scientific Electronic Library Online (SciELO) and Medical Literature Analysis and Retrieval System online (MEDLINE). A prevalence of experimental studies dealing with the observed changes, a systematic review, and comparisons of materials and their performance under radiotherapy were verified. According to this study, organic and morphological changes are perceptible after 30Gy, so some materials showed better performance in the face of these limitations, and may offer better adhesion, sealing, and greater longevity in rehabilitative treatments.

References

Abdalla, R., Omar, A., & Eid, K. (2018). Detecting demineralization of enamel and cementum after gamma irradiation using radiographic densitometry. Radiation and environmental biophysics, 57(3), 293–299. https://doi.org/10.1007/s00411-018-0749-2

Aktemur Türker, S., Kaşıkçı, S., Uzunoğlu Özyürek, E., Olcay, K., & Elmas, Ö. (2021). The effect of radiotherapy delivery time and obturation materials on the fracture resistance of mandibular premolars. Clinical oral investigations, 25(3), 901–905. https://doi.org/10.1007/s00784-020-03378-2

Arid, J., Palma-Dibb, R. G., de Oliveira, H. F., Nelson-Filho, P., de Carvalho, F. K., da Silva, L., de Siqueira Mellara, T., da Silva, R., Faraoni, J. J., & de Queiroz, A. M. (2020). Radiotherapy impairs adhesive bonding in permanent teeth. Supportive care in câncer. Official journal of the Multinational Association of Supportive Care in Cancer, 28(1), 239–247. https://doi.org/10.1007/s00520-019-04782-5

Avelar, J., Nicolussi, A. C., Toneti, B. F., Sonobe, H. M., & Sawada, N. O. (2019). Fatigue in patients with head and neck cancer undergoing radiation therapy: a prospective study. Fadiga em pacientes com câncer de cabeça e pescoço em tratamento radioterápico: estudo prospectivo. Revista latino-americana de enfermagem, 27, e3168. https://doi.org/10.1590/1518-8345.2813-3168

Beech, N., Robinson, S., Porceddu, S., & Batstone, M. (2014). Dental management of patients irradiated for head and neck cancer. Australian dental journal, 59(1), 20–28. https://doi.org/10.1111/adj.12134

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492

Caccelli, E. M. N., & Rapoport, A. (2008). Complications of irradiation in mouth and oropharyngeal câncer. Revista Brasileira Cirurgia Cabeça Pescoço, 37(4), 198-201. http://www.sbccp.org.br/wp-content/uploads/2014/11/artigo_04.pdf

Campana, I. G., & Goiato, M. C. Head and neck tumors: epidemiology, risk factors, diagnosis and treatment. Revista Odontológica de Araçatuba, 34(1), 20-31, 2013. https://repositorio.unesp.br/handle/11449/133244

da Costa Santos, C. M., de Mattos Pimenta, C. A., & Nobre, M. R. (2007). The PICO strategy for the research question construction and evidence search. Revista latino-americana de enfermagem, 15(3), 508–511. https://doi.org/10.1590/S0104-11692007000300023

de Barros da Cunha, S. R., Fonseca, F. P., Ramos, P., Haddad, C., Fregnani, E. R., & Aranha, A. (2017). Effects of different radiation doses on the microhardness, superficial morphology, and mineral components of human enamel. Archives of oral biology, 80, 130–135. http://dx.doi.org/doi:10.1016/j.archoralbio.2017.04.007

Döbrossy L. (2005). Epidemiology of head and neck cancer: magnitude of the problem. Cancer metastasis reviews, 24(1), 9–17. https://doi.org/10.1007/s10555-005-5044-4

Duruk, G., Acar, B., & Temelli, Ö. (2020). Effect of different doses of radiation on morphogical, mechanical and chemical properties of primary and permanent teeth-an in vitro study. BMC oral health, 20(1), 242. https://doi.org/10.1186/s12903-020-01222-3

Fonseca, J. M., Troconis, C. C., Palmier, N. R., Gomes-Silva, W., Paglioni, M. D., Araújo, A. L., Arboleda, L. P., Filho, A. J., González-Arriagada, W. A., Goes, M. F., Lopes, M. A., Brandão, T. B., Vargas, P. A., Ribeiro, A. C., & Santos-Silva, A. R. (2020). The impact of head and neck radiotherapy on the dentine-enamel junction: a systematic review. Medicina oral, patologia oral y cirugia bucal, 25(1), e96–e105. http://dx.doi.org/ doi:10.4317/ medoral.23212

Freitas, D. A., et al.(2011). Oral sequelae of head and neck radiotherapy . Revista CEFAC, 13(6), 1103-1108. https://doi.org/10.1590/S1516-18462011005000071

Gonçalves, L. M., Palma-Dibb, R. G., Paula-Silva, F. W., Oliveira, H. F., Nelson-Filho, P., Silva, L. A., & Queiroz, A. M. (2014). Radiation therapy alters microhardness and microstructure of enamel and dentin of permanent human teeth. Journal of dentistry, 42(8), 986–992. https://doi.org/10.1016/j.jdent.2014.05.011

Jawad, H., Hodson, N. A., & Nixon, P. J. (2015). A review of dental treatment of head and neck cancer patients, before, during and after radiotherapy: part 1. British dental journal, 218(2), 65–68. https://doi.org/10.1038/sj.bdj.2015.28

Jham, B. C., & Freire, A. R.(2006). Complicações bucais da radioterapia em cabeça e pescoço. Revista Brasileira de Otorrinolaringologia, 72(5), 704-708. https://doi.org/10.1590/S0034-72992006000500019

Karino, M. E., & Felli, V. E. A. (2012). Enfermagem baseada em evidências: avanços e inovações em revisões sistemáticashttps://doi.org/10.4025/ciencuidsaude.v11i5.17048

Klarić Sever, E., Tarle, A., Vukelja, J., Soče, M., & Grego, T. (2021). Direct Induced Effects of Standard and Modified Radiotherapy Protocol on Surface Structure of Hard Dental Tissue. Acta stomatologica Croatica, 55(4), 334–345. https://doi.org/10.15644/asc55/4/1

Kudkuli, J., Abdulla, R., Rekha, P. D., Sharma, S. D., & Gurjar, O. (2019). Spectroscopic analyses reveal radiotherapy-induced variations in elemental composition and crystallite properties of human permanent teeth enamel. Journal of oral biosciences, 61(4), 207–214. https://doi.org/10.1016/j.job.2019.10.002

Kudkuli, J., Agrawal, A., Gurjar, O. P., Sharma, S. D., Rekha, P. D., Manzoor, M., Singh, B., Rao, B. S., & Abdulla, R. (2020). Demineralization of tooth enamel following radiation therapy; An in vitro microstructure and microhardness analysis. Journal of cancer research and therapeutics, 16(3), 612–618. https://doi.org/10.4103/jcrt.JCRT_8_19

Lopes, C., Soares, C. J., Lara, V. C., Arana-Chavez, V. E., Soares, P. B., & Novais, V. R. (2018). Effect of fluoride application during radiotherapy on enamel demineralization. Journal of applied oral science : revista FOB, 27, e20180044. http://dx.doi.org/10.1590/1678-7757-2018-0044

Lopes, F. C., Roperto, R., Akkus, A., de Queiroz, A. M., Francisco de Oliveira, H., & Sousa-Neto, M. D. (2020). Effect of carbodiimide and chlorhexidine on the bond strength longevity of resin cement to root dentine after radiation therapy. International endodontic journal, 53(4), 539–552. https://doi.org/10.1111/iej.13252

Lu, H., Zhao, Q., Guo, J., Zeng, B., Yu, X., Yu, D., & Zhao, W. (2019). Direct radiation-induced effects on dental hard tissue. Radiation oncology (London, England), 14(1),5.https://doi.org/10.1186/s13014-019-1208-1

Madrid, C. C., de Pauli Paglioni, M., Line, S. R., Vasconcelos, K. G., Brandão, T. B., Lopes, M. A., Santos-Silva, A. R., & De Goes, M. F. (2017). Structural Analysis of Enamel in Teeth from Head-and-Neck Cancer Patients Who Underwent Radiotherapy. Caries research, 51(2), 119–128. https://doi.org/10.1159/000452866

Muñoz, M. A., Garín-Correa, C., González-Arriagada, W., Quintela Davila, X., Häberle, P., Bedran-Russo, A., & Luque-Martínez, I. (2020). The adverse effects of radiotherapy on the structure of dental hard tissues and longevity of dental restoration. International journal of radiation biology, 96(7), 910–918. https://doi.org/10.1080/09553002.2020.1741718

Rodrigues, R. B., Soares, C. J., Junior, P., Lara, V. C., Arana-Chavez, V. E., & Novais, V. R. (2017). Influence of radiotherapy on the dentin properties and bond strength. Clinical oral investigations, 22(2), 875–883. https://doi.org/10.1007/s00784-017-2165-4

Siripamitdul, P., Sivavong, P., Osathanon, T., Pianmee, C., Sangsawatpong, W., Bunsong, C., & Nantanapiboon, D. (2022). The Effects of Radiotherapy on Microhardness and Mineral Composition of Tooth Structures. European journal of dentistry, https://doi.org/10.1055/s-0042-1746414

Thiagarajan, G., Vizcarra, B., Bodapudi, V., Reed, R., Seyedmahmoud, R., Wang, Y., Gorski, J. P., & Walker, M. P. (2017). Stress analysis of irradiated human tooth enamel using finite element methods. Computer methods in biomechanics and biomedical engineering, 20(14), 1533–1542. https://doi.org/10.1080/10255842.2017.1383401

Ugurlu M. (2020). Effect of the double application of universal adhesives on the dentine bond strength after radiotherapy. Australian dental journal, 65(3), 181–188. https://doi.org/10.1111/adj.12744

Velo, M., Farha, A., da Silva Santos, P. S., Shiota, A., Sansavino, S. Z., Souza, A. T., Honório, H. M., & Wang, L. (2018). Radiotherapy alters the composition, structural and mechanical properties of root dentin in vitro. Clinical oral investigations, 22(8), 2871–2878. https://doi.org/10.1007/s00784-018-2373-6

Yamin, P. A., Pereira, R. D., Lopes, F. C., Queiroz, A. M., Oliveira, H. F., Saquy, P. C., & Sousa-Neto, M. D. (2018). Longevity of bond strength of resin cements to root dentine after radiation therapy. International endodontic journal, 51(11), 1301–1312. https://doi.org/10.1111/iej.12945

Published

07/10/2022

How to Cite

FARIA, A. R.; CORRÊA, M. T. R. .; PEREIRA, M. K. S. .; MARTINS, V. da M. .; MONTES, T. C. The impacts of radiotherapy on tooth structure and its consequences on dental treatment. Research, Society and Development, [S. l.], v. 11, n. 13, p. e265111335404, 2022. DOI: 10.33448/rsd-v11i13.35404. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/35404. Acesso em: 16 nov. 2024.

Issue

Section

Health Sciences