The therapeutic properties of Mikania glomerata Spreng. (Asteraceae)

Authors

DOI:

https://doi.org/10.33448/rsd-v11i14.36185

Keywords:

Mikania glomerata; Guaco; Guaco properties.

Abstract

The Mikania glomerata Spreng is a specie found in Europe, Africa, North and South America and is commonly known as “guaco” and “guaco climber”. Many scientific studies confirm the bactericidal, anti-ophidic, antifungal, anti-inflammatory, antimalarial, and bronchodilator pharmacological activities. These studies aim to contribute to new research, report the phytotherapy aspects and describe the therapeutical properties of Mikania glomerata. This study is an integrative review with a descriptive approach. Were found during the study that the guaco therapeutical properties are diverse, such as: antiasthmatic, tonic, antipyretic, expectorant, appetite stimulant, anti-influenza, antirheumatic, soothing, healing, diuretic, emollient, fluidizing, bacterial growth inhibitor, antiallergic, antifungal, antioxidant, anthelmintic. Thereby, the analyzed texts show, besides the properties mentioned above, an expressive performance on duodenal and stomach ulcers, infectious diseases such as tonsillitis and oropharyngeal inflammation, influenzas, and upper airway infections (UAI), usually known as cold. Thus, is essential to highlight the value of the medicinal use of this compound, in a way to accentuate their benefits for the clinical improvement of various conditions that currently affect patients. However, given the data that were shown previously, as well as the limited number of studies, it is fundamental to carry out more research to define more safely the therapeutic properties of the M. glomerata, in addition to showing the long-term effects of the use of your phytotherapic and safe doses, such as side effects.

References

Bastos, C. L., da Mata, C. S., Maia, V. H., Borges, R. A. X., Franco, L. O., Ferreira, P. C. G., & Tamaio, N. (2011). Anatomical and molecular identification of “guaco” mikania glomerata and mikania laevigata (Asteraceae), two important medicinal species from Brazil. Journal of Medicinal Plant Research, 5(18), 4579–4583.

Bertol, G., Cobre, A. F., & Pontarolo, R. (2021). Differentiation of Mikania glomerata and Mikania laevigata Species Through Mid-infrared Spectroscopy and Chemometrics Guided by HPLC-DAD Analyses. Revista Brasileira de Farmacognosia, 31(4), 442–452. https://doi.org/10.1007/s43450-021-00170-5

Bertolucci, S. K. V., Pereira, A. B. D., Pinto, J. E. B. P., Ribeiro, J. A. D. A., De Oliveira, A. B., & Braga, F. C. (2009). Development and validation of an RP-HPLC method for quantification of cinnamic acid derivatives and kaurane-type diterpenes in Mikania laevigata and Mikania glomerata. Planta Medica, 75(3), 280–285. https://doi.org/10.1055/s-0028-1112195

Bolina, R. C., Garcia, E. D. F., & Duarte, M. G. R. (2009). Comparative study of the chemical composition of the species Mikania glomerata Sprengel and Mikania laevigata Schultz Bip. ex Baker. Revista Brasileira de Farmacognosia, 19(1 B), 294–298. https://doi.org/10.1590/S0102-695X2009000200019

Brasil. Ministério da Saúde. (2006). Portaria no 971/GM, de 3 de maio de 2006. Ministério Da Saúde. Retrieved from http://189.28.128.100/dab/docs/legislacao/portaria971_03_05_06.pdf

Brasil. Ministério da Saúde. (2012). 31 - PIC - Plantas Medicinais e Fitoterapia na Atenção Básica. In Cadernos de Atenção Básica (Vol. 31).

Costa, V. C. D. O., Borghi, A. A., Mayer, J. L. S., & Sawaya, A. C. H. F. (2018). Comparison of the Morphology, Anatomy, and Chemical Profile of Mikania glomerata and Mikania laevigata. Planta Medica, 84(3), 191–200. https://doi.org/10.1055/s-0043-119226

Coutinho, L. A., Gonçalves, C. P., & Marcucci, M. C. (2020). Composição química, atividade biológica e segurança de uso de plantas do gênero Mikania. Revista Fitos, 14(01), 118–144. https://doi.org/10.32712/2446-4775.2020.822

Czelusniak, K. E., Brocco, A., Pereira, D. F., & Freitas, G. B. L. (2012). Farmacobotânica, fitoquímica e farmacologia do Guaco: Revisão considerando Mikania glomerata Sprengel e Mikania laevigata Schulyz Bip. ex Baker. Revista Brasileira de Plantas Medicinais, 14(2), 400–409. https://doi.org/10.1590/S1516-05722012000200022

de Lazzari Almeida, C., Xavier, R. M., Borghi, A. A., dos Santos, V. F., & Sawaya, A. C. H. F. (2017). Effect of seasonality and growth conditions on the content of coumarin, chlorogenic acid and dicaffeoylquinic acids in Mikania laevigata Schultz and Mikania glomerata Sprengel (Asteraceae) by UHPLC–MS/MS. International Journal of Mass Spectrometry, 418, 162–172. https://doi.org/10.1016/j.ijms.2016.09.016

de Melo, L. V., & Sawaya, A. C. H. F. (2020). Stability of hydroalcoholic extracts of two species of guaco; mikania glomerata spreng. And mikania laevigata schultz. (asteraceae), by uhplc-ms. Brazilian Journal of Pharmaceutical Sciences, 56, 1–12. https://doi.org/10.1590/s2175-97902020000217194

Della Pasqua, C. S. P., Iwamoto, R. D., Antunes, E., Borghi, A. A., Sawaya, A. C. H. F., & Landucci, E. C. T. (2019). Pharmacological study of anti-inflammatory activity of aqueous extracts of Mikania glomerata (Spreng.) and Mikania laevigata (Sch. Bip. ex Baker). Journal of Ethnopharmacology, 231(November 2018), 50–56. https://doi.org/10.1016/j.jep.2018.11.012

Dos Santos, S. C., Krueger, C. L., Steil, A. A., Kreuger, M. R., Biavatti, M. W., & Wisniewski, A. (2006). LC characterisation of guaco medicinal extracts, Mikania laevigata and M. glomerata, and their effects on allergic pneumonitis. Planta Medica, 72(8), 679–684. https://doi.org/10.1055/s-2006-931577

E Silva, L. S., Da Silva, L. S., Brumano, L., Stringheta, P. C., De Oliveira Pinto, M. A., Dias, L. O. M., … Da Penha Henriques Do Amaral, M. (2012). Preparation of dry extract of Mikania glomerata sprengel (Guaco) and determination of its coumarin levels by spectrophotometry and HPLC-UV. Molecules, 17(9), 10344–10354. https://doi.org/10.3390/molecules170910344

Fraga, L. F., & Borges, L. L. (2020). Busca De Moléculas Com Atividade Broncodilatadora Na Espécie Mikania Glomerata Spreng Empregando Ferramentas in Silico. Revista Brasileira Militar de Ciências, 6(15). https://doi.org/10.36414/rbmc.v6i15.39

Fulanetti, F. B., Camargo, G. G. R., Ferro, M. C., & Randazzo-Moura, P. (2016). Toxic effects of the administration of Mikania glomerata sprengel during the gestational period of hypertensive rats. Open Veterinary Journal, 6(1), 23–29. https://doi.org/10.4314/ovj.v6i1.4

Gasparetto, João C., Campos, F. R., Budel, J. M., & Pontarolo, R. (2010). Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae: estudos agronômicos, genéticos, morfoanatômicos, químicos, farmacológicos, toxicológicos e uso nos programas de fitoterapia do Brasil. Revista Brasileira de Farmacognosia, 20(4), 627–640. https://doi.org/10.1590/s0102-695x2010000400025

Gasparetto, João Cleverson, Peccinini, R. G., De Francisco, T. M. G., Cerqueira, L. B., Campos, F. R., & Pontarolo, R. (2015). A kinetic study of the main guaco metabolites using syrup formulation and the identification of an alternative route of coumarin metabolism in humans. PLoS ONE, 10(3), 1–22. https://doi.org/10.1371/journal.pone.0118922

Menezes Filho A. C. P. de, Daniela Barbosa de Costa Souza, & Cinthia Alves Porfiro. (2022). Atividade broncodilatadora de Mikania glomerata Sprengel (guaco) em pacientes com asma. Revista Farmácia Generalista / Generalist Pharmacy Journal, 4(1), 1-23. https://publicacoes.unifal-mg.edu.br/revistas/index.php/revistafarmaciageneralista/article/view/1303

Moreira, M. R., Souza, A. B., Soares, S., Bianchi, T. C., De Souza Eugênio, D., Lemes, D. C., … Veneziani, R. C. S. (2016). Ent-Kaurenoic acid-rich extract from Mikania glomerata: In vitro activity against bacteria responsible for dental caries. Fitoterapia, 112, 211–216. https://doi.org/10.1016/j.fitote.2016.06.007

Moreti, D. L. C., Leandro, L. F., da Silva Moraes, T., Moreira, M. R., Sola Veneziani, R. C., Ambrosio, S. R., … Martins, C. H. G. (2017). Mikania glomerata Sprengel extract and its major compound ent-kaurenoic acid display activity against bacteria present in endodontic infections. Anaerobe, 47, 201–208. https://doi.org/10.1016/j.anaerobe.2017.06.008

Oliveira, A. L., Pozza, L. N. L., Santos, D. N., Kamimura, E. S., Vicente, E., & Cabral, F. A. (2013). Supercritical extraction of coumarin from guaco (Mikania laevigata and Mikania glomerata) for pharmaceutical applications. Journal of Supercritical Fluids, 83, 65–71. https://doi.org/10.1016/j.supflu.2013.07.019

Ormond, T. de S., Fernandes, D. D. de S., & Diniz, P. H. G. D. (2022). An eco-friendly analytical methodology based on digital images for quality control of commercial Mikania glomerata syrups. Microchemical Journal, 178(October 2021), 107338. https://doi.org/10.1016/j.microc.2022.107338

Pinto, D. S., de Sá, J. G. S., Costa, M. A. V., & Correia, T. V. (2021). Fitoterapia E Educação Popular Em Saúde: Manipulação E Uso Do Xarope De Guaco Nos Problemas Respiratórios. Ciências Da Saúde No Mundo Contemporâneo, 1–09. https://doi.org/10.51497/reflex.0000101

Polonio, J. C., Almeida, T. T., Garcia, A., Mariucci, G. E. G., Azevedo, J. L., Rhoden, S. A., & Pamphile, J. A. (2015). Biotechnological prospecting of foliar endophytic fungi of guaco (Mikania glomerata Spreng.) with antibacterial and antagonistic activity against phytopathogens. Genetics and Molecular Research, 14(3), 7297–7309. https://doi.org/10.4238/2015.July.3.5

Santana, L. C.L.R., Brito, M. R. M., Sousa, G. F., & Freitas, R. M. (2014). Estudo das propriedades físico-químicas e avaliação da toxicidade aguda do extrato etanólico das folhas de mikania glomerata sprengel. Revista Brasileira de Plantas Medicinais, 16(3), 670–678. https://doi.org/10.1590/1983-084X/12_130

Santana, Lorena C L R, Brito, M. R. M., Oliveira, G. L. S., Citó, A. M. G. L., Alves, C. Q., David, J. P., … de Freitas, R. M. (2014). Mikania glomerata : Phytochemical, Pharmacological, and Neurochemical Study. Evidence-Based Complementary and Alternative Medicine, 2014, 1–11. https://doi.org/10.1155/2014/710410

Saúde, A. (2009). MS elabora Relação de Plantas Medicinais de Interesse ao SUS 06/03/2009. MS Elabora Relação de Plantas Medicinais de Interesse Ao SUS, 3–5. Retrieved from http://bvsms.saude.gov.br/bvs/sus/pdf/marco/ms_relacao_plantas_medicinais_sus_0603.pdf

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Published

24/10/2022

How to Cite

SANTOS, E. P. dos .; MELO, R. de J. .; LIMA, O. V. A. .; TELES, D. C. S. .; ANDRADE, R. M. .; COSTA, A. M. B. .; MATOS, S. S. .; SILVA, L. A. S. .; SILVEIRA FILHO, A. J. .; ARAÚJO , G. R. S. de . The therapeutic properties of Mikania glomerata Spreng. (Asteraceae). Research, Society and Development, [S. l.], v. 11, n. 14, p. e209111436185, 2022. DOI: 10.33448/rsd-v11i14.36185. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36185. Acesso em: 9 dec. 2022.

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Health Sciences