Symptoms and Diagnosis of Celiac Disease: a bibliographic review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i14.36384

Keywords:

Glutens; Food intolerance; Autoimune disease.

Abstract

Celiac disease is an autoimmune disease caused by the ingestion of gluten, a protein found in some cereals such as wheat and barley. Genetic and dietary aspects determine the degree of inflammation, resulting in important nutritional repercussions. Despite being underdiagnosed, its prevalence has increased in recent years due to greater knowledge and detection of the disease. The methodological approach of the research is qualitative and descriptive, as analyzed and interpreted in the scientific literature. The main objective of this research is to provide a greater degree of understanding regarding the pathology of the disease, clarifying the possible impacts on the health of a celiac individual. Based on this, it is considered of paramount importance to provide scientifically sound information to the interested public about the triggers and consequences of celiac disease. This review provides a comprehensive overview of celiac disease, particularly the clinical picture and diagnosis. The broad symptomatology is triggered by the consumption of gluten, which initiates an inflammatory process in the body of the carrier with a genetic predisposition to develop celiac disease. Systemic manifestations result from an autoimmune process and make early diagnosis difficult, impairing treatment adherence and, consequently, worsening prognosis. The diagnosis is confirmed through clinical data and laboratory tests.

References

Arámburo-Gálvez, J. G., Beltrán-Cárdenas, C. E., André, T. G., Gomes, I. C., Macêdo-Callou, M. A., Braga-Rocha, É. M. & Vergara-Jiménez, M. J. (2020). Prevalence of Adverse Reactions to Glutenand People Going on a Gluten-Free Diet: a survey study conducted in brazil. Medicina, 56(4), 163. http://dx.doi.org/10.3390/medicina56040163.

Ashton, J. J., Smith, R., Smith, T., & Beattie, R M. (2020). Investigating coeliac disease in adults. Bmj, 2176. http://dx.doi.org/10.1136/bmj.m2176.

Batista, L.S., & Kumada, K. M. O. (2021). Análise metodológica sobre as diferentes configurações da pesquisa bibliográfica. Revista Brasileira de Iniciação Científica. 8(021029), 1-17.

Caio, G., Volta, U., Sapone, A., Leffler, D. A., Giorgio, R., Catassi, C., & Fasano, A. (2019). Celiac disease: a comprehensive current review. Bmc Medicine, 17(1), 1-20. http://dx.doi.org/10.1186/s12916-019-1380-z.

Cichewicz, A. B., Mearns, E. S., Taylor, A., Boulanger, T., Gerber, M., Leffler, D. A. & Lebwohl, B. (2019). Diagnosis and Treatment Patterns in Celiac Disease. Digestive Diseases And Sciences, 64(8), 2095-2106. http://dx.doi.org/10.1007/s10620-019-05528-3.

Dunne, M. R., Byrne, G., Chirdo, F. G., & Feighery, C. (2020). Coeliac Disease Pathogenesis: the uncertainties of a well-known immune mediated disorder. Frontiers In Immunology, 11,1-14. http://dx.doi.org/10.3389/fimmu.2020.01374.

Ensari, A., & Marsh, M. N. (2019). Diagnosing celiac disease: a critical overview. The Turkish Journal Of Gastroenterology, 30(5), 389-397. http://dx.doi.org/10.5152/tjg.2018.18635.

Hujoel, I. A., Reilly, N. R., & Rubio-Tapia, A. (2019). Celiac Disease. Gastroenterology Clinics Of North America, 48(1), 19-37. http://dx.doi.org/10.1016/j.gtc.2018.09.001.

Kaukinen, K. (2020). Updates on systemic consequences of coeliac disease. Nature Reviews Gastroenterology & Hepatology, 18(2), 87-88. http://dx.doi.org/10.1038/s41575-020-00387-0

Kowalski, K., Mulak, A., Jasińska, M., & Paradowski, L. (2017). Diagnostic challenges in celiac disease. Advances In Clinical And Experimental Medicine, 26(4), 729-737. http://dx.doi.org/10.17219/acem/62452.

Lebwohl, B., Sanders, D., & Green, P. H. R. (2018). Coeliac disease. The Lancet, 391(10115), 70-81. http://dx.doi.org/10.1016/s0140-6736(17)31796-8.

Leonard, M. M., Sapone, A., Catassi, C., Fasano, A. (2017). Celiac Disease and Nonceliac Gluten Sensitivity. Jama, 318(7), 647. http://dx.doi.org/10.1001/jama.2017.9730.

Ludvigsson, J. F., & Murray, J. A. (2019). Epidemiology of Celiac Disease. Gastroenterology Clinics Of North America, 48(1), 1-18. http://dx.doi.org/10.1016/j.gtc.2018.09.004.

Muniz, J. G., Sdepanian, V. L., & Fagundes Neto, U. (2016). Prevalence of genetic susceptibility for celiac disease in blood donors in São Paulo, Brazil. Arquivos de Gastroenterologia, 53(4), 267-272. http://dx.doi.org/10.1590/s0004-28032016000400011.

Malamut, G., Cording, S., & Cerf-Bensussan, N. (2019). Recent advances in celiac disease and refractory celiac disease. F1000Research, 8(969). http://dx.doi.org/10.12688/f1000research.18701.1.

Penny, H. A., Raju, S., & Sanders, D. (2020). Progress in the serology-based diagnosis and management of adult celiac disease. Expert Review Of Gastroenterology & Hepatology, 14(3), 147-154. http://dx.doi.org/10.1080/17474124.2020.1725472.

Pratesi, C., Häuser, W., Uenishi, R., Selleski, N., Nakano, E., Gandolfi, L. & Zandonadi, R. (2018). Quality of Life of Celiac Patients in Brazil: questionnaire translation, cultural adaptation and validation. Nutrients, 10(9), 1167. http://dx.doi.org/10.3390/nu10091167.

Rubin, J. E., & Crowe, S. E. (2020). Celiac Disease. Annals Of Internal Medicine, 172(1), 1. http://dx.doi.org/10.7326/aitc202001070.

Sansotta, N., Amirikian, K., Guandalini, S., & Jericho, H. (2018). Celiac Disease Symptom Resolution: effectiveness of the gluten-free diet. Journal Of Pediatric Gastroenterology & Nutrition, 66(1), 48-52. http://dx.doi.org/10.1097/mpg.0000000000001634.

Singh, P., Arora, A., Strand, T. A., Leffler, D. A., Catassi, C., Green, P. H. & Makharia, G. K. (2018). Global Prevalence of Celiac Disease: systematic review and meta-analysis. Clinical Gastroenterology And Hepatology, 16(6), 823-836. http://dx.doi.org/10.1016/j.cgh.2017.06.037.

Sousa, J.R., & Santos, S. C. M. (2020). Análise do conteúdo em pesquisa qualitativa. Revista Pesquisa e Debate em Educação. 10(2), 1396-1416. http://dx.doi.org/10.34019/2237-9444.2020.v10.31559.

Villanueva, M., Oyarzôn, A., Leyton, B., González, M., Navarro, E., Canales, P. & Araya, M. (2020). Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades. Nutrients, 12(1), 156. http://dx.doi.org/10.3390/nu12010156.

Zafeiropoulou, K., Nichols, B., Mackinder, M., Biskou, O., Rizou, E., Karanikolou, A. & Duncan, H. (2020). Alterations in Intestinal Microbiota of Children With Celiac Disease at the Time of Diagnosis and on a Gluten-free Diet. Gastroenterology, 159(6), 2039-2051. http://dx.doi.org/10.1053/j.gastro.2020.08.007.

Published

29/10/2022

How to Cite

CAMPOS, L. M. .; FERRI , A. L. C. .; PEREIRA JUNIOR , E. M. A. .; CHUEIRE , A. F. W. . Symptoms and Diagnosis of Celiac Disease: a bibliographic review . Research, Society and Development, [S. l.], v. 11, n. 14, p. e333111436384, 2022. DOI: 10.33448/rsd-v11i14.36384. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36384. Acesso em: 26 nov. 2022.

Issue

Section

Health Sciences