Epidemiological profile of neonatal jaundice in the State of Pernambuco

Authors

DOI:

https://doi.org/10.33448/rsd-v11i15.36794

Keywords:

Jaundice neonatal; Indicators of Morbidity and Mortality; Epidemiology; Information Systems; Vital statistics.

Abstract

Objectives: To analyze neonatal morbidity and mortality due to jaundice in Pernambuco from 2008 to 2017. Methods: This is a descriptive and ecological epidemiological study which studied the population composed of newborns whose mothers reside in Pernambuco, under 28 days old, born between 2008 and 2017. Through data collected of DATASUS, temporal analysis of the indicators of Neonatal Mortality due to Jaundice (TMNI) and Proportion of Hospital Admissions (PIH) were performed Results: Between 2008 and 2017, the TMNI rate in Pernambuco was 4.92 deaths per 100,000 live births and its early component was more important than the late one. Over time, the TMNI rate declined, replicating the Brazilian standard. As for the hospital admissions, jaundice corresponds to 23% of all hospital admissions in patients aged 0 to 27 days in relation to conditions originating in the perinatal period. Unlike TMNI, the PIH rate for neonatal jaundice showed a significant increase over the study period, showing a strong and inverse correlation between the two indicators. Conclusions: By giving visibility to neonatal morbidity and mortality rates due to jaundice, it is possible to identify opportunities for timely intervention reorientation of care practices, efficient strategies in reducing unfavorable outcomes.

References

Almeida M. F. B. & Draque C.M (2012). Icterícia no recém-nascido com idade gestacional > 35 semanas. Sociedade Brasileira de Pediatria.

Battersby C., Michaelides S., Upton M. & Rennie J. M. (2017). Term admissions to neonatal units in England: a role for transitional care? A retrospective cohort study. BMJ open. 7(5).

Bhutani V. K. et al. (2013). Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels. Pediatric research. 74 (1): 86-100.

Blencowe H., Calvert C., Lawn J. E., Cousens S. & Campbell O. M. R. (2016). Measuring maternal, fetal and neonatal mortality: challenges and solutions. Best Practice & Research Clinical Obstetrics & Gynaecology. 36: 14-29.

Brasil. (2011). Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Ações Programáticas e Estratégicas. Atenção à saúde do recém-nascido: guia para os profissionais de saúde / Ministério da Saúde, Secretaria de Atenção à Saúde, Departamento de Ações Programáticas e Estratégicas. Brasília: Ministério da Saúde.

Brasil. (2014). Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Ações Programáticas e Estratégicas. Atenção à saúde do recém-nascido: guia para os profissionais de saúde. Brasília: Ministério da Saúde. v. 2.

Cheng L. et al. (2020). Silica microbeads capture fetal nucleated red blood cells for noninvasive prenatal testing of fetal ABO genotype. Electrophoresis. 41(10-11): 966-972.

Christensen R. D. et al. (2014). Causes of hemolysis in neonates with extreme hyperbilirubinemia. Journal of Perinatology. 34(8): 616-619.

Christensen R. D., Baer V. L., MacQueen B.C., O’Brien E.A. & Ilstrup S. J. (2018). ABO hemolytic disease of the fetus and newborn: thirteen years of data after implementing a universal bilirubin screening and management program. Journal of Perinatology. 38 (5): 517-525.

Das S. & Van Landeghem F. K. (2019). Clinicopathological spectrum of bilirubin encephalopathy/kernicterus. Diagnostics. 9(1).

Du L., Ma X., Shen X., Bao Y., Chen L. & Bhutani V.K. (2021). Neonatal hyperbilirubinemia management: clinical assessment of bilirubin production. Seminars In Perinatology. 45 (1): 1-7.

Ebbesen F., Vandborg P.K. & Donneborg M.L. (2020). The effectiveness of phototherapy using blue-green light for neonatal hyperbilirubinemia – Danish clinical trials. Seminars In Perinatology. 45 (1): 1-6.

Farouk Z. L., Usman F., Musa B. M., Ezeaka V. C. & Okolo A. (2020) Societal Awareness on Neonatal Hyperbilirubinemia: A Systematic Review and Meta-Analysis. Seminars in Perinatology.

França E. B. & Vasconcelos A. M. N. (2017). Principais causas da mortalidade na infância no Brasil, entre 1990 e 2015: estimativas do estudo de Carga Global de Doença. Revista Brasileira de Epidemiologia. 20 (1): 46-60.

França E. & Lansky S. (2016). Mortalidade infantil neonatal no Brasil: situação, tendências e perspectivas. Anais. 1-29.

Global Burden of Disease (GBD). (2016). Causes of Death Collaborators. Global, regional and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden od Diasease Study Lancet. 2017; 390.

Iskander I. & Gamaleldin R. (2020). Acute Bilirubin Encephalopathy: Some Lessons Learned. Seminars in Perinatology. 45 (1): 1-6.

Lansky S. et al. (2014). Pesquisa Nascer no Brasil: perfil da mortalidade neonatal e avaliação da assistência à gestante e ao recém-nascido. Cadernos de Saúde Pública. 30: 192-207.

Mir S., Geest B. A. M. V. D. & Been J. V. (2019). Management of neonatal jaundice in low- and lower-middle-income countries. Bmj Pediatrics Open. 3 (1): 12-13.

Mitra S. & Rennie J. (2017). Neonatal jaundice: aetiology, diagnosis and treatment. British Journal Of Hospital Medicine. 78 (12): 699-704.

Olusanya B. O., Kaplan M. & Hansen T. W. R. (2018). Neonatal hyperbilirubinaemia: a global perspective. The Lancet Child & Adolescent Health. 2 (8): 610-620.

Olusanya B. O., Teeple S. & Kassebaum N. J. (2018). The Contribution of Neonatal Jaundice to Global Child Mortality: findings from the gbd 2016 study. Pediatrics. 141 (2): 1-6.

Rede Interagencial de Informações para a saúde (Ripsa). (2008). Indicadores básicos para a saúde no Brasil: conceitos e aplicações. 2 ed. Brasília: Organização Pan-Americana da Saúde.

Ree I. M. C., Smits-Wintjens V. E. H. J. et al. (2017) Neonatal management and outcome in alloimmune hemolytic disease. Expert Review Of Hematology. 10 (7): 607-616.

Shapiro A. et al. (2021). A low-cost bilirubin measurement tool for neonatal jaundice monitoring at the point-of-care: a comparison of bilidx with a standard laboratory bilirubinometer and transcutaneous bilirubinometer. The Lancet Global Health; 9.

Ullah S., Rahman K. & Hedayati M. (2016). Hyperbilirubinemia in neonates: types, causes, clinical examinations, preventive measures and treatments: a narrative review article. Iranian journal of public health.; 45 (5).

UNICEF, WHO, World Bank Group, United Nations. (2019) Levels and trends in child malnutrition: Report 2019 - Estimates developed by the UN Inter-agency Group for Child Mortality Estimation.

Variane G. F. & Sant'Anna G. M. (2020). Rhesus Disease in Brazil: A Multi-Professional National Survey. Seminars in Perinatology.

Vieira S. (2011). Introdução à bioestatística. Elsevier.

Viktorinova A. (2018). Iron-mediated oxidative cell death is a potential contributor to neuronal dysfunction induced by neonatal hemolytic hyperbilirubinemia. Archives Of Biochemistry And Biophysics. 654: 185-193.

Published

10/11/2022

How to Cite

FREITAS, S. M. S. de; PONTES, T. M. de A.; GOMES, A. G. N.; PIMENTEL, F. C.; BRANDÃO, D. C. B.; PORTELA, N. M. Epidemiological profile of neonatal jaundice in the State of Pernambuco. Research, Society and Development, [S. l.], v. 11, n. 15, p. e67111536794, 2022. DOI: 10.33448/rsd-v11i15.36794. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36794. Acesso em: 19 apr. 2024.

Issue

Section

Health Sciences