Current aspects on the selection of patients who are candidates for lung transplantation
Keywords:Lung transplantation; Selection; Contraindications.
Currently, the main indications for lung transplantation worldwide are chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, cystic fibrosis, alpha-1-antitrypsin (alpha-1) deficiency, idiopathic pulmonary arterial hypertension, bronchiectasis, retransplantation, sarcoidosis and severe lung injury caused by COVID-19, and these candidates must demonstrate knowledge regarding the procedure, good adherence to the medical treatment performed, adequate psychosocial structure and family support. Furthermore, the proper assessment of contraindications contributes to a lower occurrence of unfavorable clinical outcomes unrelated to the graft, benefiting patients with a greater chance of success and, thus, improving overall survival with treatment. Among the absolute contraindications, lung cancer, cardiac dysfunction unrelated to lung disease, significant organic dysfunction of any other noble organ, hepatitis B and C virus infections, active pulmonary tuberculosis and severe rib cage deformity stand out. Furthermore, among the relative contraindications, there is age over 65 years, severe clinical instability, HIV infection, obesity, severe osteoporosis and decompensated systemic diseases.
Afonso, J. E., et al. (2015). Lung transplantation. Albert Einstein's Journal of Medicine, 13 (2).
Barr, M. L., et al. (2015). Living donor lobar lung transplantation: current status and future directions. Transplant Proc., 37(9), 3983-3986.
Bennett, D., et al. (2020). Lung transplantation in patients with familial pulmonary fibrosis. Brazilian Journal of Pulmonology, 46 (6).
Camargo, J. J, et al. (2014). Lung transplantation: current indications. Brazilian Journal of Pulmonology, 23 (1), 36-44.
Camargo, P. C. L. B., et al. (2015). Lung transplantation: a general approach on its main aspects. Brazilian Journal of Pulmonology, 41 (6).
Ferreira, L. L., et al. (2018). Functional clinical profile of lung disease patients undergoing pre-lung transplantation physiotherapeutic evaluation. Conscientiae Saúde, 17 (1), 72-77.
Higemura N., et al. (2022). Lung transplantation in patients with previous cardiothoracic surgical procedures. Am J Transplant, 12 (8), 1249-1255.
Empire, F. (2016). Criteria for indication and selection of candidates for lung transplantation. Brazilian Journal of Pulmonology, 15 (3), 175-183.
Jatene, F. B., et al. (2018). Lung transplantation challenges. Brazilian Journal of Pulmonology, 34 (5).
Jatene, F. B., et al. (2019). Lung transplantation. Journal of Medicine of USP, 88 (3).
Orens, J. B., et al. (2013). A review of lung transplant donor acceptability criteria. J Heart Lung Transplant., 22(11), 1183-1200.
Orens, J. B., et al. (2016). International guidelines for the selection of lung transplant candidates: 2006 update - a consensus report from the Lung Scientific Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant, 25 (1), 745-55.
Pavec, J. L., et al. (2018). Lung transplantation: current indications, prognosis and specific considerations. Journal of Thoracic Disease, 5 (9).
Pierre, A. F., et al. (2012). Marginal donor lungs: A reassessment. J Thorac Cardiovasc Surg., 123 (3), 421-427.
Reynaud-Gaubert, M., et al. (2018). Lung transplantation for lymphangioleiomyomatosis: the French experience. Transplant, 86 (3), 15-20.
Shweish, O., et al. (2019). Indications for lung transplant referral and listing. Journal of Thoracic Disease, 7(8).
Svartman, F. B., et al. (2017). Lung transplantation in cystic fibrosis. Clin Biomed Res., 31 (2).
Weil, D. (2018). Lung transplantation: indications and contraindications : Journal of Thotacic Disease, 4 (8).
Weill, D., et al. (2015). A consensus document for the selection of lung transplant candidates: 2014 – an update from the Lung Transplant Board of the International Heart and Lung Transplant Society. J Heart Lung Transplant, 34 (8), 1-15.
Yusen, R. D., et al. (2016). The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Lung and Heart–Lung Transplant Report—2016; Focus Theme: Primary Diagnostic Indications for Transplant. The Journal of Heart and Lung Transplantation, 35 (10), 1170-1184.
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Copyright (c) 2022 Bárbara Queiroz de Figueiredo; Álvaro Nunes Machado Júnior; Ana Clara Alves Andrade; Brenda Ribeiro Julio; Franciana Machado Nunes; Hiago Henrique de Souza Ferreira; Lara Lima Pereira da Cunha; Maria Anthônia Gundim Lemos; Yohanna Costa Araujo
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