Efficacy of the non-instrumentation endodontic treatment with CTZ paste in primary molars: Protocol of a multicenter randomized clinical trial with two years of follow-up

Authors

DOI:

https://doi.org/10.33448/rsd-v11i16.37140

Keywords:

Endodontic Treatment; Primary Teeth; Non-instrumentation technique; CTZ paste; Pulpectomy.

Abstract

Objective: There is a lack of high-quality evidence on the efficacy of the non-instrumentation endodontic treatment (NIET) in primary molars, compared to the conventional endodontic treatment technique. This protocol describes a multicenter randomized clinical trial that aims to evaluate the efficacy of a NIET technique for primary molars using a paste containing antibiotics (chloramphenicol and tetracycline – CTZ group) compared to a control group of conventional technique and root filling with zinc oxide eugenol (ZOE). Methodology: Children aged 3 to 9 years (N=218) will be randomly allocated to one of the groups: CTZ or ZOE. In CTZ, after the location of root canals entrance, irrigation will be performed using 1% sodium hypochlorite and CTZ paste will be placed over the root canal entrances, with no instrumentation of the root canals. In ZOE group, manual instrumentation of root canals with endodontic K-files will be performed, and then, the root canals will be filled with ZOE paste. At the same appointment, teeth will be restored with a double-seal of glass ionomer and a bulk fill resin composite. Children will be followed-up for 6, 12, 18 and 24 months. The primary endpoint will be the success of endodontic treatments evaluated by clinical and radiographic criteria after 24 months. Conclusions: NIET with CTZ paste could be an option to manage primary teeth, once the technique could have non-inferior efficacy to the conventional technique that involves root canal instrumentation. The approach could have good acceptance from children and parents considering the reduced clinical time.

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Published

01/12/2022

How to Cite

SANTOS, P. S.; OLIVEIRA, N. M. de; RAMOS, T.; DORNELLAS, A. P. .; ROCHA, A. de O.; VITALI, F. C.; MOCCELINI, B. S.; RIGO, D. C. A. .; MARQUES, R. P. de S.; PONTES, L. R. A.; MATOS, J. de M. .; LOUVAIN, M. C.; SOVIERO, V. L. V. M.; FIDALGO, T. K. da S.; BOLAN, M.; SANTANA, C. M.; CARDOSO, M.; MENDES, F. M. Efficacy of the non-instrumentation endodontic treatment with CTZ paste in primary molars: Protocol of a multicenter randomized clinical trial with two years of follow-up. Research, Society and Development, [S. l.], v. 11, n. 16, p. e111111637140, 2022. DOI: 10.33448/rsd-v11i16.37140. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37140. Acesso em: 8 nov. 2024.

Issue

Section

Health Sciences