Vitamin A in Cystic Fibrosis: Effects of its supplemented and non-supplemented use

Authors

DOI:

https://doi.org/10.33448/rsd-v9i7.3732

Keywords:

Cystic Fibrosis; Therapeutics; Antioxidant; Nutritional supplementation.

Abstract

Objective: This study aimed to investigate in the literature the effects of vitamin A supplementation or not in patients with cystic fibrosis (CF). Methodology: This is an integrative review carried out by searching for original articles, published in English, Portuguese and Spanish, indexed in the Scielo and Pubmed databases. Results: Of the 8 studies included in the review, 25% (n=2) identified an association between elevated serum retinol levels and improvement of the fibrocystic condition, and 50% (n=4) found positive effects on lung function and clinical conditions, from vitamin A supplementation. In contrast, 25% (n=2) did not observe any correlation between vitamin A use, although they identified an improvement in their status resulting from the intervention. Conclusion: Most studies have shown that the supplemented or not use of vitamin A proved to be potentially beneficial for the clinical and nutritional profile, as well as for the survival of patients with cystic fibrosis. However, there is a need for more research, especially in humans, that address the theme.

References

Almeida, A.C., Wamosy, R.M.G., Ludwig Neto, N., Mucha, F.C., Schivinski, C.I.S. (2019). Pediatric Glittre ADL-test in cystic fibrosis: Physiological parameters and respiratory mechanics. Physiother Theory Pract, 20, 1-8.

Bertolaso, C., Groleau, V., Schall, J., Maqbool, A., Mascarenhas, M., Latham, N., Dougherty, K., Stallings, V. (2014). Fat-Soluble Vitamins In Cystic Fibrosis And Pancreatic Insufficiency: Efficacy Of A Nutritional Intervention. J Pediatr Gastroenterol Nutr, 58 (4), 443-448.

Brasil. (2016). Registro Brasileiro de Fibrose Cística. Relatório Anual pelo Grupo Brasileiro de Estudos de Fibrose Cística (REBRAFC).

Brasil. (2019). Ministério da Saúde. Fibrose cística.

Brei, C., Simon, A., Krawinkel M., Naehrlich, L. (2013). Individualized Vitamin A Supplementation For Cystic Fibrosis Patients. Clin Nutr, 32 (5), 805-810.

Chaves, C., & Cunha, A. (2012). Nutritional assessment and recommendations for children and adolescents with cystic fibrosis. Rev. Paul. Pediatr., 30 (1).

De Vries, J.J.V., Chang, A.B., Bonifant, C.M., Shevill, E., Marchant, J.M. (2018). Vitamin A and Beta (β)-carotene Supplementation For Cystic Fibrosis. Cochrane Database of Systematic Reviews (8), CD006751.

Galli, R., Battistoni, A., Gambaric, R., Pompellad, A., Bragonzi, A., Pilolli, F., Iuliano, L., Piroddia, M., Dechecchig, M., Cabrinig, G. (2012). Estresse oxidativo e terapia antioxidante na fibrose cística. Biochimica et Biophysica Acta, 18 (22), 690 – 713.

Guilbault, C., Wojewódka, G., Saeed, Z., Hajduch, H., Matouk, E., De Sanctis, JB., Radzioch, D. (2009). Cystic Fibrosis Fatty Acid Imbalance Is Linked to Ceramide Deficiency and Corrected by Fenretinide. Am J Respir Cell Mol Biol, 41 (1), 100-106.

King, C.S., Brown, A.W., Aryal, S., Ahmad, K., Donaldson, S. (2019). Critical Care of the Adult Patient With Cystic Fibrosis. Chest, 155 (1), 202-214.

Li, L., & Somerset, S. (2014). The Clinical Significance Of The Gut Microbiota In Cystic Fibrosis And The Potential For Dietary Therapies. Clin Nutr., 33 (4), 571-80.

Li, L., Kraus, L., Somers, S. (2017). Associations Between Micronutrient Ingestion And Intestinal Microbiota In A Cystic Fibrosis Adult Group. Clin Nutr., 36 (4), 1097-1104.

Mocelin, H., Fischer, G.B., Castro, S.M., Grandi, T., Chapper, M., Rispoli, T., Sanseverino, P.B. (2017). Triagem neonatal para fibrose cística no SUS no Rio Grande do Sul. Bol Cient Pediatr, 06 (1), 3-8.

Morton A., Wolfe S. (2015). Vitamin Supplements: A Role in Cystic Fibrosis Patients? Diet and exercice in cystic fibrosis. 17, 133-144.

Musch, M.W., Wang, Y., Claud, E.C., Chang, E.B. (2013). Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota. Dig Dis Sci., 58 (3), 668-77.

Nichols, D.P., & Chmiel, J.F. (2015). Inflammation and its genesis in cystic fibrosis. Pediatr Pulmonol, 50, 539-556.

Oehlers, S.H., Flores, M.V., Hall, C.J., Crosier, K.E., Crosier, P.S. (2012). Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis. Disease Models & Mechanisms, 5, 457-467.

Okayasu, I., Fujiwara, M., Yoshida, T., Zepka, L., Rosso, V., Jacob-Lopes, E. (2018). The Role of Vitamin A-Storing Cells (Stellate Cells) in Inflammation and Tumorigenesis. IntechOpen. 1-16.

Perrem, L., & Ratjen, F. (2019). Anti-inflammatories and mucociliary clearance therapies in the age of CFTR modulators. Pediatr Pulmonol., 54 (3), S46-S55.

Rana, M., Wong-See, D., Katz, T., Gaskin, K., Whitehead, B., Jaffe, A., Coakley, J., Lochhead, A. (2014). Fat-soluble vitamin deficiency in children and adolescents with cystic fibrosis. Journal of Clinical Pathology, 67, 605-608.

Registro Do Paciente Da Fibrose Cística. (2012). Relatório Anual de Dados de 2011. Bethesda, MD: Fundação de fibrose cística.

Rivas-Crespo, M., Jiménez, F., González, D., Quirós, A., Maria, D., Sojo, A., González, H., Martín, D., Juan, J., Otero, G., Jesús, M., Almarza, L., Bousoño-García, C. (2013). High Serum Retinol And Pulmonary Function In Young Patients With Cystic Fibrosis. Journal of Gastroenterology and Nutrition Pediátrico, 56 (6), 657–662.

Sagel, S., Khan, U., Jain, R., Graff, G., Daines, C., Dunitz, J., Borowitz, D., Orenstein, D., Abdulhamid, I., Noe, J., Clancy, J., Slovis, B., Rock, M., Mccoy, K., Strausbaugh, S., Livingston, F., Papas, K., Shaffer, M. (2018). Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis. A Randomized, Controlled, Multicenter Clinical Trial. Am J Respir Crit Care Med, 198 (5), 639-647.

Sagel, S., Sontag, M., Anthony, M., Emmett, P., Papas, K. (2011). Effect Of An Antioxidant-Rich Multivitamin Supplement In Cystic Fibrosis. J Fibras de Cisto, 10 (1), 31-36.

Sapiejka, E., Krzyżanowska, P., Walkowiak, D., Wenska-chyży, E., Szczepanik, M., Cofta, S., Pogorzelski, A., Skorupa, W., Walkowiak, J. (2017). Vitamin A Status And Its Determinants In Patients With Cystic Fibrosis. Acta Sci. Pol. Technol. Aliment, 16 (3), 345-354.

Silva, AG.S., Dantas, L.S.A., Nogueira, T.R., Freitas, B.J.S.A. (2020). Comportamento do selênio e atividade da glutationa peroxidase dependente de selênio na fibrose cística. Research, Society and Development, 9 (4), 1-15.

Turck, D., Braegger, C.P, Colombo, C., Declercq, D., Morton, A., Pancheva, R., Robberecht, E., Stern, M., Strandvik, B., Wolfe, S., Schneider, S.M., Wilschanski, M. (2016). ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis. Clin. Nutr. xxx, 1-21.

Ursi, E., & Galvão, C. (2006). Prevenção de lesões de pele no perioperatório: revisão integrativa da literatura. Revista LatinoAmericana de Enfermagem, 14 (1), 124-131.

Woestenenk, J., Broos, N., Stellato, R., Arets, H., Van Der Ent, C., Houwen, R. (2016). Vitamin A Intake And Serum Retinol Levels In Children And Adolescents With Cystic Fibrosis. Clin Nutr,35 (3), 654-659.

Published

27/04/2020

How to Cite

MACHADO, M. G. da C.; PEREIRA, P. B.; SILVA, M. C. L. da; NOGUEIRA, T. R. Vitamin A in Cystic Fibrosis: Effects of its supplemented and non-supplemented use. Research, Society and Development, [S. l.], v. 9, n. 7, p. e30973732, 2020. DOI: 10.33448/rsd-v9i7.3732. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/3732. Acesso em: 5 nov. 2024.

Issue

Section

Review Article