Photodynamic Therapy in the treatment of oral lesions in patients with COVID-19 in the ICU: Two case reports

Authors

DOI:

https://doi.org/10.33448/rsd-v11i16.37436

Keywords:

Oral Manifestations; COVID-19; Intensive Care Units; Laser Therapy.

Abstract

Patients admitted to intensive care units (ICUs) who suffers from COVID-19 in a serious and/or critical condition are susceptible to several manifestations that can be fatal or generate long-term sequelae. Oral complications were observed and the hypotheses about their etiology suggest that they are due to infection by the SARS-CoV-2 it self or secondary manifestations of the patient's systemic condition, being necessary more research at a multidisciplinary level for further discoveries related to etiopathogenesis of these manifestations. The purpose of this study was to evaluate and describe oral lesions presented by two patients admitted to the Intensive Care Unit with COVID-19 at a University Hospital treated with photodynamic therapy (aPDT). Patients were evaluated by a dentist who performed treatment of the lesions using the aPDT technique and associated therapies for control and remission of alterations. In view of the report, it was possible to conclude that Photodynamic Therapy is effective in the treatment of alterations in the mouth when correctly indicated, evidencing the importance of the dentist in a hospital environment inserted in a multiprofessional team to perform the diagnosis and treatment of oral alterations.

References

Batista, A. A. F., Ramos, K. P. P., Amaral, M. A. S., Prado, L. F. A., Araújo, A. A. S., Martins-Filho, P. R., & Nunes, P. S. (2022). Oral lesions in patients with COVID-19 hospitalized in na intensive care unit: a case-series study. Brazilian Oral Research, 36, 108.

Bermúdez, M. B., Montero, K. M. C., Sanabria, E. A. P., Jiménez, A. R., & Vega, C. P. P. (2021). Manifestaciones em la cavidad bucal y em la cara asociadas a la COVID-19. Universitas Medica, 62(3).

Brandão, T. B., Gueiros, L. A., Melo, T. S., Prado-Ribeiro, A. C., Nesrallah, A., Prado, G., Santos-Silva, A. R., & Migliorati, C. A. (2021). Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ?. Oral surgery, oral medicine, oral pathology and oral radiology, 131(2), 45-51.

Cardoso, T. F., Dias, M. J. L. E, Chini, M. C., Pereira, B. L. B., & Orrico, S. R. P. (2020). COVID-19 e a Cavidade Bucal: Interações, Manifestações Clínicas e Prevenção. ULAKES Journal of Medicine, 1, 98-105.

Costa, R. L., Lamas, C. C., Simvoulidis, L. F. N., Espanha, C. A., Moreira, L. P. M., Bonancim, R. A. B. & Oliveira, L. P. (2022). Secondary infections in a cohort of patients with COVID-19 admitted to na intensive care unit: impact of gram-negative bacterial resistance. Revista do Instituto de Medicina Tropical de São Paulo, 64.

Cruz Tapia, R. O., Peraza Labrador, A. J., Guimaraes, D. M., & Matos Valdez, L. H. (2020). Oral mucosal lesions in patients with SARS-CoV-2 infection. Report of four cases. Are they a true sign of COVID-19 disease?. Special care in dentistry: oficial publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, 40(6), 555-560.

Favia, G., Tempesta, A., Barile, G., Brienza, N., Capodiferro, S., Vestito, M. C., & Limongelli, L. (2021). Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification. Journal of clinical medicine, 10(4), 757.

Fernandes, T. P., Abreu, C. M. de., Rocha, J. O., Bianchetti, L. de O., Sales, L. de A., Alves, M. Q., & Corrêa, M. I. (2021). Infecções secundárias em pacientes internados por COVID-19: consequências e particularidades associadas. Revista Eletrônica Acervo Científico, 34, 8687.

Garcez, A. S., Delgado, M., Sperandio, M., Dantas E Silva, F. T., de Assis, J., & Suzuki, S. S. (2021). Photodynamic Therapy and Photobiomodulation on Oral Lesion in Patient with Coronavirus Disease 2019:A Case Report. Photobiomodulation, photomedicine, and laser surgery, 39(6), 386-389.

Hocková, B., Riad, A., Valky, J., Šulajová, Z., Stebel, A., Slávik, R., & Klugar, M. (2021). Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases. Journal of clinical medicine, 10(4), 581.

Iranmanesh, B., Khalili, M., Amiri, R., Zartab, H., & Aflatoonian, M. (2021). Oral manifestations of COVID-19 disease: A review article. Dermatologic therapy, 34(1), 14578.

Mathieu, E., Ritchie. H., Rodés-Guirao, L., Appel, C., Giattino, C., Hasell, J., & Roser, M. (2022). Coronavirus Pandemic (COVID-19). Recuperado de: https://ourworldindata.org/coronavirus

Ripa, M., Galli, L., Poli, A., Oltolini, C., Spagnuolo, V., Mastrangelo, A., & COVID-BioB study group (2021). Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors. Clinical microbiology and infection: the oficial publication of the Europe an Society of Clinical Microbiology and Infectious Diseases, 27(3), 451-457.

Santos, J. A, Normando, A., Carvalho da Silva, R. L., De Paula, R. M., Cembranel, A. C., Santos-Silva, A. R., & Guerra, E. (2020). Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations?. International jornal of infectious diseases: IJID: oficial publication of the International Society for Infectious Diseases, 97, 326-328.

Santos, J. A, Normando, A., Carvalho da Silva, R. L., Acevedo, A. C., De Luca Canto, G., Sugaya, N., & Guerra, E. (2021). Oral Manifestations in Patients with COVID-19: A 6-Month Update. Journal of dental research, 100(12), 1321-1329.

Soares, C. D., Carvalho, R. A., Carvalho, K. A., Carvalho, M. G., & Almeida, O. P. (2020). Letter to Editor: Oral lesions in a patient with Covid-19. Medicina oral, patologia oral y cirugia bucal, 25(4), 563-564.

Sheng, W. H., Liu, W. D., Wang, J. T., Chang, S. Y., & Chang, S. C. (2021). Dysosmia and dysgeusia in patients with COVID-19 in northern Taiwan. Journal of the Formosan Medical Association, 120(1 Pt 2), 311-317.

Villarroel-Dorrego, M., Chacón, L., Rosas, R., Barrios, V., Pernía, Y., & Vélez, H. (2022). Hallazgos bucales en pacientes COVID-19 [Oral Findings in Patients With COVID-19]. Actas dermo-sifiliograficas, 113(2), 183-186.

Zayet, S., Klopfenstein, T., Mercier, J., Kadiane-Oussou, N. J., Lan CheongWah, L., Royer, P. Y., &. Gendrin, V. (2021). Contribution of anosmia and dysgeusia for diagnostic of COVID-19 in out patients. Infection, 49(2), 361–365.

Zou, X., Chen, K., Zou, J., Han, P., Hao, J., & Han, Z. (2020). Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of diferente human organs vulnerable to 2019-nCoV infection. Frontiers of medicine, 14(2), 185–192.

Published

28/11/2022

How to Cite

BALZER, A. H. .; FERREIRA, M. D. .; SILVA, F. P. da .; CAROLINE WALCHAKI, V.; SANTOS, B. O. S. dos .; MARTINS, L. D. . Photodynamic Therapy in the treatment of oral lesions in patients with COVID-19 in the ICU: Two case reports. Research, Society and Development, [S. l.], v. 11, n. 16, p. e26111637436, 2022. DOI: 10.33448/rsd-v11i16.37436. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37436. Acesso em: 18 apr. 2024.

Issue

Section

Health Sciences