The indiscriminate use of antibiotics in the ICU




Antibiotics; Resistance; Rational use.


The indiscriminate use of antibiotics is one of the biggest public health problems in the world because it generates antimicrobial resistance and one of the factors of this generate this problem is the excessive prescription of antibiotics in ICU. Thus, the objective of this study is to address the in ICU indiscriminate use of antibiotics and the methodology chosen was an integrative literature review of recent studies on the subject, having as inclusion criteria studies for the development of research listing in scientific databases, dating from 2017 to 2022, in Portuguese and English, a bibliographic search was carried out between April and May 2022, using scientific journal articles as a data source and the following keywords as inclusion characters: Global health; Microbial drug resistance, Antibiotics in ICU, making a table with studies that deal with the subject, bringing their objectives and main results. It has been researched that the proper use of antibiotics in medical practice has been a point of discussion, as well as many studies in recent years, and they must be correctly implemented to bring benefits both in prophylactic and therapeutic capacity. But when these drugs are not used properly, especially routinely in patient care, there may be unnecessary exposure and possible risks of these agents; thus, it is necessary promotion of strategies, the improvement of communication skills with patients and the conduction of more studies about the subject.


Axente, C., Licker, M., Moldovan, R., Hogea, E., Muntean, D., Horhat, F.... Baditoiu, L. (2017). Antimicrobial consumption, costs and resistance patterns: a two year prospective study in a Romanian intensive care unit. BMC Infect Dis. 17 (1) 358.

Camins, B., King, M., Wells, J., Googe, H., Patel, M., Kourbatova, E., & Blumberg, H. (2019) Impact of an antimicrobial utilization program on antimicrobial use at a large teaching hospital: a randomized controlled trial. Infect Control Hosp Epidemiol. 30 (10) 931–938.

Duin D. & Paterson D. (2017) Multidrug Resistant Bacteria in the Community: Trends and Lessons Learned. Infect Dis Clin North Am. 30 (2) 377–390.

Esguerra, E M. (2017). Super Bugs and Antimicrobial Stewardship. Mo Med. 114 (6) 438–439.

Freires, M. & Rodrigues, O. M. Jr. (2022) Resistência bacteriana pelo uso indiscriminado da azitromicina frente a Covid-19: uma revisão integrativa. Society and Development. 11 (1) e31611125035.

Guimarães, D. O., Momesso, L.S. & Pupo M. T. (2010) Antibióticos: Importância Terapêuticas e perspectivas para a descoberta e desenvolvimento de novos agentes. Química Nova. 33 (3) 667-679.

Kadosaki, L. L., Sousa, S. F. & Borges J. C. M. (2018) Análise do uso e da resistência bacteriana aos antimicrobianos em nível hospitalar. Rev. Bras. Farm. 93 (2) 129-133

Kayambankadzanja R.K., Lihaka M., Barratt-Due A., Kachingwe M., Kumwenda W., Lester R., Bilima D., Eriksen T., Baker T. (2020) The use of antibiotics in the intensive care unit of a tertiary hospital in Malawi. BMC Infectious Diseases. 20 (1) 776.

Llor C. & Bierrum L. (2017) Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf. 5 (6) 229–241.

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & Prisma Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS med, 6(7), e1000097. doi: 10.1371/journal.pmed.1000097

Marshall, J. C., Bosco, L., Adhikari, N. K., Connolly, B., Diaz, J. V., Dorman, T., Fowler, R. A., Meyfroidt, G., Nakagawa, S., Pelosi, P., Vincent, J. L., Vollman, K. & Zimmerman, J. (2017). What is an intensive care unit? A report of the task force of the World Federation of Societies of Intensive and Critical Care Medicine. J Crit Care. 3(7), 270-6.

Minayo, M. C. S. O Desafio do Conhecimento: Pesquisa Qualitativa. (6a ed.), Hucitc, 2008.

Oliveira, P. M. N., Buonora, S. N., Souza, C. L. P., Simões Jr, R., Silva, T. C. D., Bom, G. J. T., Teixeira, C. H. D. S. & Silva, A. R. A. D. (2019). Surveillance of multidrug-resistant bacteria in pediatric and neonatal intensive care units in Rio de Janeiro State, Brazil. Revista da Sociedade Brasileira de Medicina Tropical. 5(52), e20190205. Recuperado

Oyemolade T. A, Malomo TA & Adeleye AO. (2019) Indiscriminate Use of Antibiotics in Neurotrauma Patients Referred for Expert Neurosurgical Care in a Developing Country. J Neurosci Rural Pract. 10 (4) 653-656.

Paiva, J., Mergulhão, P. & Salluh, J. I. F. (2020) O que todo intensivista precisa saber sobre gestão de antimibrobianos: suas armadilhas e desafios. Revista Brasileira de Terapia Intensiva. 32 (2) 207-212.

Sena, N. S., Costa, C. A., Santos, J. M., Lima, U. T., Nascimento, B. E., Lins, D. S. ... Santos, E. S. (2022). Infecções hospitalares em Unidade de Terapia Intensiva: Uma revisão integrativa. Research, Society and Development. 11 (10) e353111032591.

Silva, M. O. & Aquino, S. (2018) Resistência aos antimicrobianos: uma revisão dos desafios na busca por novas alternativas de tratamento. Revista de Epidemiologia e Controle de Infecção. 8(4) 472-482.

Silva, R. A., Oliveira, B. N., Silva, L. P., Oliveira, M. A. & Chaves, G. C. (2020) Resistência a Antimicrobianos: a formulação da resposta no âmbito da saúde global. Saúde em Debate. 44 (126) 607-623.

Souza, M. T. S., Silva, M. D, & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1), 102-6. http://astresmetodologias.c om/material/O_que_e_RIL.pdf

Santos, N. Q. (2004) A resistência bacteriana no contexto da infecção hospitalar. Texto & Contexto - Enfermagem. 13 (spe) 64-70.

Toyin A. O; Toluyemi A; Malomo A; Adeleye A. Indiscriminate Use of Antibiotics in Neurotrauma Patients Referred for Expert Neurosurgical Care in a Developing Country. J Neurosci Rural Pract, v. 10, n. 4, p. 653–656, 2019.

Vieira P. N & Vieira S. L. V. (2017) Uso irracional e resistência a antimicrobianos em hospitais. Arq. ciências saúde UNIPAR. 21 (3) 209-211.

Zhang , Z. G., Chen, F. & Ou, Y. (2017) Impact of an antimicrobial stewardship programme on antibiotic usage and resistance in a tertiary hospital in China. J Clin Pharm Ther. 42(5):579-584.

Zone, C. P., & Guide, S. (2017). Antimicrobial resistance and urinary tract infections in the community. Signs, 6, 3531-93. 10.4103/jrms.frms889-16



How to Cite

OLIVEIRA, C. S. .; PACHECO, T. P. .; OLIVEIRA, D. M. . The indiscriminate use of antibiotics in the ICU. Research, Society and Development, [S. l.], v. 11, n. 15, p. e500111537479, 2022. DOI: 10.33448/rsd-v11i15.37479. Disponível em: Acesso em: 23 mar. 2023.



Health Sciences