The role of immunonutrition in the fight against Covid-19: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i15.37489

Keywords:

Immunity; Covid-19; Immunonutrition.

Abstract

The goal of this review was to carry out a search on the evidences of the role of immunonutrition in patients fighting covid-19. concerns  an integrative literature review, as search sources were the databases: Scientific Eletronic Library Online (Scielo), National Library of Medicine (PubMed), Google Scholar. For the selection of the sample, original article criteria have been established indexed between the years 2019 to 2022, the choice of this period took into account the criterion of temporality, in which the cut-off of three years was considered, as it is a recent viral disease, in English and Portuguese. The studies analyzed the possible role of nutrients, glutamine, arginine, Omega-3 and vitamin C and D in the modulation of the immune system.  It is worth to emphysize that these nutrients are directly linked to the immune response that our body releases against infections, therefore, immunonutrition is an important instrument to be used against the viral infection of covid-19. Based on the results of the articles examined, it was observed that these nutrients had a positive effect on recovery, reduction of symptoms and mortality of patients with the disease, this is due to the fact that immunonutrients play a role in reducing inflammation caused by an exacerbated response of the body to fight the virus, concomitantly with this, these immunonutrients strengthened the immune system by modulating in a balanced way the immune responses released by the body.In this way, the modulation of the immune system through nutrition has a beneficial action for the recovery of patients with Covid-19.

References

Alcala-Diaz, J. F., Limia-Perez, L., Gomez-Huelgas, R., Martin-Escalante, M. D., Cortes-Rodriguez, B., Zambrana-Garcia, J. L., Entrenas-Castillo, M., Perez-Caballero, A. I., López-Carmona, M. D., Garcia-Alegria, J., Lozano Rodríguez-Mancheño, A., Arenas-de Larriva, M. del S., Pérez-Belmonte, L. M., Jungreis, I., Bouillon, R., Quesada-Gomez, J. M., & Lopez-Miranda, J. (2021). Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study. Nutrients, 13(6), 1760. https://doi.org/10.3390/nu13061760

Bansal, V., & Ochoa, J. B. (2003). Arginine availability, arginase, and the immune response. Current Opinion in Clinical Nutrition and Metabolic Care, 6(2), 223–228. https://doi.org/10.1097/00075197-200303000-00012

Bologna, C., & Pone, E. (2022). Clinical Study on the Efficacy and Safety of Arginine Administered Orally in Association with Other Active Ingredients for the Prevention and Treatment of Sarcopenia in Patients with COVID-19-Related Pneumonia, Hospitalized in a Sub-Intensive Care Unit. Healthcare, 10(1), 162. https://doi.org/10.3390/healthcare10010162

Calder, P. C. (2020). Nutrition, immunity and COVID-19. BMJ nutrition, prevention & health, 3(1), 74–92. https://doi.org/10.1136/bmjnph-2020-000085

Cengiz, M., Borku Uysal, B., Ikitimur, H., Ozcan, E., Islamoğlu, M. S., Aktepe, E., Yavuzer, H., & Yavuzer, S. (2020). Effect of oral l-Glutamine supplementation on Covid-19 treatment. Clinical Nutrition Experimental, 33, 24–31. https://doi.org/10.1016/j.yclnex.2020.07.003

De Niet, S., Trémège, M., Coffiner, M., Rousseau, A.-F., Calmes, D., Frix, A.-N., Gester, F., Delvaux, M., Dive, A.-F., Guglielmi, E., Henket, M., Staderoli, A., Maesen, D., Louis, R., Guiot, J., & Cavalier, E. (2022). Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 14(15), 3048. https://doi.org/10.3390/nu14153048

Doaei, S., Gholami, S., Rastgoo, S., Gholamalizadeh, M., Bourbour, F., Bagheri, S. E., Samipoor, F., Akbari, M. E., Shadnoush, M., Ghorat, F., Mosavi Jarrahi, S. A., Ashouri Mirsadeghi, N., Hajipour, A., Joola, P., Moslem, A., & Goodarzi, M. O. (2021). The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial. Journal of Translational Medicine, 19(1). https://doi.org/10.1186/s12967-021-02795-5

Fiorentino, G., Coppola, A., Izzo, R., Annunziata, A., Bernardo, M., Lombardi, A., Trimarco, V., Santulli, G., & Trimarco, B. (2021). Effects of adding L-arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis. EClinicalMedicine, 0(0). https://doi.org/10.1016/j.eclinm.2021.101125

Gao, D., Xu, M., Wang, G., Lv, J., Ma, X., Guo, Y., Zhang, D., Yang, H., Jiang, W., Deng, F., Xia, G., Lu, Z., Lv, L., & Gong, S. (2021). The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study. Aging, 13(5), 7020–7034. https://doi.org/10.18632/aging.202557

Galmés, S., Serra, F., & Palou, A. (2020). Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framework. Nutrients, 12(9). https://doi.org/10.3390/nu12092738

JamaliMoghadamSiahkali, S., Zarezade, B., Koolaji, S., SeyedAlinaghi, S., Zendehdel, A., Tabarestani, M., Sekhavati Moghadam, E., Abbasian, L., Dehghan Manshadi, S. A., Salehi, M., Hasannezhad, M., Ghaderkhani, S., Meidani, M., Salahshour, F., Jafari, F., Manafi, N., & Ghiasvand, F. (2021). Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial. European Journal of Medical Research, 26(1). https://doi.org/10.1186/s40001-021-00490-1

Ling, S. F., Broad, E., Murphy, R., Pappachan, J. M., Pardesi-Newton, S., Kong, M.-F., & Jude, E. B. (2020). High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study. Nutrients, 12(12). https://doi.org/10.3390/nu12123799

Majidi, N., Rabbani, F., Gholami, S., Gholamalizadeh, M., BourBour, F., Rastgoo, S., Hajipour, A., Shadnoosh, M., Akbari, M. E., Bahar, B., Ashoori, N., Alizadeh, A., Samipoor, F., Moslem, A., Doaei, S., & Suzuki, K. (2021). The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.717816

Mohajeri, M., Horriatkhah, E., & Mohajery, R. (2021). Correction to: The effect of glutamine supplementation on serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients: a case–control study. Inflammopharmacology, 30(1), 353–353. https://doi.org/10.1007/s10787-021-00898-5

O. de Almeida, J., T. de Oliveira, V. R., Lucas dos S. Avelar, J., Simões Moita, B., & Moreira Lima, L. (2020). COVID-19: Physiopathology and Targets for Therapeutic Intervention. Revista Virtual de Química. https://doi.org/10.21577/1984-6835.20200115

Oliveira, D. H. de S., Silva, M. I. de O., Fonseca, R. G., & Ferreira, J. C. de S. (2021). A importância de uma alimentação saudável como forma de aumento da imunidade através das vitaminas e minerais. Research, Society and Development, 10(12), e103101220305–e103101220305. https://doi.org/10.33448/rsd-v10i12.20305

Pimentel, R. F. W., Merces, M. C. das, Silva, D. A. R. da, Souza, M. C. de, Cerqueira, M. M. B. F., Figueiredo, P. C. M., Santana, A. I. C., Silva, D. de S. e, Fernandes, S. L., Maduro, I. P. de N. N., Soriano, E. de A., & Sousa, A. R. de. (2020). The role of oral supplementation with immunonutrients in the inflammatory response in patients with COVID-19. Research, Society and Development, 9(9), e126997115. https://doi.org/10.33448/rsd-v9i9.7115

Rocha, I. H. S. & Landim, L. A. dos S. R. (2021). Evidências científicas sobre a suplementação de vitamina D em pacientes acometidos por COVID-19: uma revisão bibliográfica integrativa. Research, Society and Development, 10(14), e485101422188. https://doi.org/10.33448/rsd-v10i14.22188

Saponaro, F., Franzini, M., Okoye, C., Antognoli, R., Campi, B., Scalese, M., Neri, T., Carrozzi, L., Monzani, F., Zucchi, R., Celi, A., Paolicchi, A., & Saba, A. (2021). Is There a Crucial Link Between Vitamin D Status and Inflammatory Response in Patients With COVID-19? Frontiers in Immunology, 12, 745713. https://doi.org/10.3389/fimmu.2021.745713

Silva, L. M. B. da, Oliveira, M. G. C. de, Nunes, A. C. da F., Silva, R. M. da, Felinto, R. da S., Soares, B. K. P., Araújo, F. D. de, Soares, A. de A., Lira, J. M. de, Silva, J. A., & Clemente, H. A. (2022). Influência da suplementação de micronutrientes em pacientes com COVID-19. Research, Society and Development, 11(4), e42811427601. https://doi.org/10.33448/rsd-v11i4.27601

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8, 102-106.

Sun, Y., Chatterjee, R., Ronanki, A., & Ye, K. (2022). Circulating polyunsaturated fatty acids and COVID-19: a prospective cohort study and Mendelian randomization analysis. https://doi.org/10.1101/2022.02.06.22270562

Sulli, A., Gotelli, E., Casabella, A., Paolino, S., Pizzorni, C., Alessandri, E., Grosso, M., Ferone, D., Smith, V., & Cutolo, M. (2021). Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients, 13(3), 717. https://doi.org/10.3390/nu13030717

Wiersinga, W. J., Rhodes, A., Cheng, A. C., Peacock, S. J., & Prescott, H. C. (2020). Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA, 324(8), 782–793. https://doi.org/10.1001/jama.2020.12839

Weber, T. K., Leandro-Merhi, V. A., Bernasconi, I., & Oliveira, M. R. M. de. (2020). Nutritional therapy in hospital care of in-patients with Covid-19: evidence, consensus and practice guidelines. Revista de Nutrição, 33. https://doi.org/10.1590/1678-9865202033e200212

Zhang, J., Rao, X., Li, Y., Zhu, Y., Liu, F., Guo, G., Luo, G., Meng, Z., Backer, D. D., Xiang, H., & Peng, Z.-Y. (2020). High-dose vitamin C infusion for the treatment of critically ill COVID-19. https://doi.org/10.21203/rs.3.rs-52778/v1

Published

18/11/2022

How to Cite

VASCONCELOS, D. M. de S. .; SILVA , A. J. da; LANDIM , L. A. dos S. R. . The role of immunonutrition in the fight against Covid-19: an integrative review. Research, Society and Development, [S. l.], v. 11, n. 15, p. e329111537489, 2022. DOI: 10.33448/rsd-v11i15.37489. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37489. Acesso em: 9 feb. 2023.

Issue

Section

Review Article