Momordica charantia L. in the treatment of diabetes melittus

Authors

DOI:

https://doi.org/10.33448/rsd-v9i7.3769

Keywords:

Alternative medicine; Medicinal plants; São Caetano melon.

Abstract

Introduction: Drugs of plant origin have been used since ancient times. The use of medicinal plants in disease control has grown due to therapeutic feasibility and successful clinical cases. Some plant species are used to combat the symptoms caused by diabetes mellitus in association or not with traditional medicine, among them, the São Caetano melon (Momordica charantia L.). Objective: The objective of this literature review is to analyze the main researches on the use of M. charantia L. in the treatment of diabetes mellitus. Methodology: The work consists of an integrative literature review based on original articles in the English language from the Google Scholar, Oxford Academic, Science Direct, Taylor & Francis and Web of Science databases. Results: Of the 31 articles selected for the research, only 5 were used (16.13%). It was observed that in the 5 articles used, M. charantia L. reduced glycemic levels, as well as providing other benefits. Conclusion: The prophylactic use of M. charantia L. is an alternative in the treatment of diabetes mellitus, as well as other diseases.

References

Abdalla, M. A., & Zidorn, C. (2019). The genus Tragopogon (Asteraceae): A review of its traditional uses, phytochemistry and pharmacological properties. Journal of Ethnopharmacology, 250 (25), 112466.

Alam, S., Asad, M., Asdaq, S. M. B., & Prasad, V. S. (2009). Antiulcer activity of methanolic extract of Momordica charantia L. in rats. Journal of enthnopharmacology, 123(3), 464-469.

Aslam, B., Wang, G. W., Arshad, M. I., Khurshid, M., Muzammil, S., Rasool, M. H., Nisar, M. A., Farooqalvi, R., Aslam, M. A., Qamar, M. U., Salamat, M. K. F., & Baloch, Z. (2018). Antibiotic resistance: a rundown of a global crisis. Infection and drug resistance, 11(1), 1645-1648.

Alvarenga, C. F., Lima, K. M. N., Mollica, L. R. Azevedo, L. O., & Carvalho, C. (2017). Uso de plantas medicinais para o tratamento do diabetes mellitus no Vale do Paraíba-SP. Revista Ciência e Saúde On-line, 2(2), 36-44.

Barbosa, M. O., Lacerda, G. M., Sousa, J. P., Lemos, I. C. S., Kerntopf, M. R., & Fernandes, G. P. (2017). Uso de recursos naturais para o tratamento de diabetes e de hipertensão em comunidades tradicionais. Revista Interdisciplinar, 10(2), 125-131.

Bhutkar, M. A., & Bhise, S. B. (2012). In vitro assay of α-amylase inhibitory activity of some indigenous plants. International Journal Chemistry Science, 10(1), 457-462.

Bubalo, J., Clark, R. K. Jr., Jiing, S. S., Johnson, N. B., Miller, K. A., Clemens-Shipman, C. J., & Sweet, A. L. (2010). Medication adherence: pharmacist perspective. Journal of the American Pharmacists Association, 50(3), 394–406.

Choudhary, S. K., Chhabra, G., Sharma, D., Vashishta, A., Ohri, S., & Dixit, A. (2012). Comprehensive evaluation of anti-hyperglycemic activity of fractionated Momordica charantia seed extract in alloxan-induced diabetic rats. Evidence-Based Complementary and Alternative Medicine, 1-10.

Deshaware, S., Gupta, S., Singhal, R. S., & Variyar, P. S. (2017). Enhancing anti-diabetic potential of bitter gourd juice using pectinase: A response surface methodology approach. LWT-Food Science and Technology, 86(1), 514-522.

Faria, H. T. G., Rodrigues, F. F. L., Zanetti, M. L., Araújo, M. F. M., & Damasceno, M. M. C. (2013). Fatores associados à adesão ao tratamento de pacientes com diabetes mellitus. Acta Paulista de Enfermagem, 26(3), 231-237.

Fernandes, N. P., Lagishetty, C. V., Panda, V. S., & Naik, S. R. (2007). An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complementary and Alternative Medicine, 7(1), 29.

Fuangchan, A., Sonthisombat, P., Seubnukarn, T., Chanouan, R., Chotchaisuwat, P., Sirigulsatien, V., Ingkaniman, K., Plianbangchang, P., & Hanes, S. T. (2011). Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients. Journal of Ethnopharmacology, 134(2), 422-428.

Gao, H., Wen, J. J., Hu, J. L., Nie, Q. X., Chen, H. H., Xiong, T., Nie, S. P., & Xie, M. (2018). Polysaccharide from fermented ameliorates type 2 diabetes in rats. Carbohydrate polymers, 2001(1), 624-633.

Grover, J. K., & Vats V. (2001). Shifting paradigm “from conventional to alternative medicine” – an introduction on tradicional indian medicine. Asia Pacific Biotech News, 5(1), 28-32.

Grover, J. K., & Yadav, S. P. (2004). Pharmacological actions and potential uses of Momordica charantia: a review. Journal of Ethnopharmacology, 93(1), 123-132.

Horax, R., Hettiarachchy, N., & Islam, S. (2005). Total phenolic contents and phenolic acid constituents in 4 varieties of bitter melons (Momordica charantia) and antioxidant activities of their extracts. Journal of Food Science, 70(4), 275-280.

Hsiao, P. C., Liaw, C. C., Hwang, S. Y., Cheng, H. L., Zhang, L. J., Shen, C. C., Hsu, F. L., & Kuo, Y. H. (2013). Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia. Journal of Agricultural and Food Chemistry, 61(12), 2979-2986.

Hu, F. B. (2011). Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes, 34(6), 1249-1257.

Joseph, B., & Jini, D. (2013). Antidiabetic effects of Momordica (bitter melon) and its medicinal potency. Asian Pacific Journal of Tropical Disease, 3(2), 93-102.

Kaur, M., Deep, G., Jain, A. K., Raina, K., Agarwal, C., Wempe, M. F., & Agarwall, R. (2013). Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells. Carcinogenesis, 34(7), 1585-1592.

King, H., Aubert, R. E., & Herman, W. H. (2008). Global Burden of Diabetes 1995-2025 prevalence, numerical estimates, and projections. Diabetes Care, 21(1), 1414-31.

Kolchraiber, F. C., Rocha, J. S., César, D. J., Monteiro, O. O., Frederico, G. A., & Gamba, M. A. (2018). Nível de atividade física em pessoas com diabetes mellitus tipo 2. Revista Cuidarte, 9(2), 2105-2116.

Kumar, D. S., Sharathnath, K. V., Yogeswaran, P., Harani, A., Sudhakar, K., Sudha, P., & Banji, D. A. (2010). A medicinal potency of Momordica charantia. International Journal of Pharmaceutical Sciences Review and Research, 1(2): 95-100.

Lessmann, J. C., Silva, D. M. G. V., & Nassar, S. M. (2011). Estresse em mulheres com Diabetes mellitus tipo 2. Revista Brasileira de Enfermagem, 64(3), 451-456.

Lorenzi, H. Plantas Daninhas do Brasil – terrestres, aquáticas, parasitas e tóxicas, 3ª ed. Instituto Plantarum. Nova Odessa – SP, 2000. 640p.

Lim, S. T., Jimeno, C. A., Razon-Gonzales, E. B., & Velasquez, E. N. (2010). The MOCHA DM study: The effect on Momordica charantia tablets on glucose and insulin levels during the postprandial state among patients with type 2 diabetes mellitus. Philippine Journal International Medicine, 48(1), 19-25.

Mahmoud, M. F., El Ashry, F. E. Z. Z., El Maraghy, N. N., & Fahmy, A. (2017). Studies on the antidiabetic activities of Momordica charantia fruit juice in streptozotocin-induced diabetic rats. Pharmaeutical Biology, 55(1), 758-765.

Moraes, S. A., Freitas, I. C., Gimeno, S. G., & Mondini, L. (2010). Prevalência de Diabetes mellitus e identificação de fatores associados em adultos residentes em área urbana de Ribeirão Preto, São Paulo, Brasil, 2006: Projeto OBEDIARP. Cadernos de Saúde Pública, 26(5), 929-41.

Jacomini, D., Martins, F. F., & Anderson, Q. K. (2018). Uso de fitoterápicos no município de Cascavel – PR: Assistência Faramacêutica. Extensão em Foco, 1(15), 71-85.

Onoja, S. O., Nnadi, C.O., Udem, S.C., & Anaga, A. O. (2020). Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annus L. leaves. Acta Pharmaceutica, 70(2), 215-226.

Panda, B. C., Mondal, S., Devi, K. S. P., Maiti, T. K., Khatua, S., Acharya, K., & Islam, S. S. (2015). Pectic polysaccharide from the green fruits of Momordica charantia (Karela): structural characterization and study of immunoenhancing and antioxidant properties. Carbohydrate research, 401(1), 24-31.

Patel, D. K., Prasad, S. K., Kumar, R., & Hemalatha, S. (2012). An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pacific Journal of Tropical Biomedicine, 2(4), 320-330.

Percin, P. S., Inanli, O., & Karakaya, S. (2018). In vitro α-amylase and α-glucosidase inhibitory activities of bitter melon (Momordica charantia) with different stage of maturity. International Journal of Nutrition and Food Engineering, 12(1).

Pinto, C., & Ribeiro, J. L. (2010). Avaliação de espiritualidade dos sobreviventes de cancro: implicações na qualidade de vida. Revista Portuguesa de Saúde Pública, 28(1), 49-56.

Rao, B. K., Kesavulu, M. M., & Apparo, C. H. (2001). Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats. Journal of Ethnopharmacology, 78(1), 67-71.

Santos, C. M. D. C., Pimenta, C. A. D. M., & Nobre, M. R. C. (2007). A estratégia PICO para a construção da pergunta de pesquisa e busca de evidências. Revista Latino-Americana de Enfermagem, 15 (3), 508-511.

Sales-Peres, S. H. C., Guedes, M. F. S., Sá, L. M., Negrato, C. A., & Lauris J. R. P. (2016). Estilo de vida em pacientes portadores de diabetes mellitus tipo 1: uma revisão sistemática. Ciência Saúde Coletiva, 21(4), 1197-1206.

SBD – Sociedade Brasileira de Diabetes (2014). Diretrizes da Sociedade Brasileira de Diabetes: 2014-2015. São Paulo: AC Farmacêutica.

Shan, B., Xie, J. H., Zhu, J. H., & Peng, Y. (2012) Ethanol modified supercritical carbon dioxide extraction of flavonoids from Momordica charantia L. and its antioxidant activity. Food and Bioproducts Processing, 90(3), 579-587.

Snee, L. S., Nerurkark, V. R., Dooley, D. A., Efird, J. T., Shovic, A. C., & Nerurkar, P. V. (2011). Strategies to improve palatability and increase consumption intentions for Momordica charantia (bitter melon): a vegetable commonly used for diabetes management. Nutrition Journal, 10(1), 78.

Sousa, I. M. C., Bodstein, R. C. D. A., Tesser, C. D., Santos, F. D. A. D. S., & Hortale, V. A. (2012). Práticas integrativas e complementares: oferta e produção de atendimentos no SUS e em municípios selecionados. Cadernos de Saúde Pública, 28(1), 2143-2154.

Torres, H. C., Pereira, F. R. L., & Alexandre, L. R. (2011). Avaliação das ações educativas na promoção do autogerenciamento dos cuidados em diabetes mellitus tipo 2. Revista da Escola de Enfermagem da USP, 45(5), 1077-1082.

Valarezo-García, C., Cartas, U. S., & Espinosa, P. V. (2019). Integración de la medicina alternativa en la malla curricular de las carreras de Medicina y Enfermaría de las universidade peruanas. Educacíon Médica, 20(2), 118-124.

Vinayagam, R., & Jayachandran, M., Xu, B. (2016). Antidiabetic effects of simple phenolic acids: a comprehensive review. Phytotherapy Research, 30(2), 184-199.

Xu, X., Shan, B., Liao, C. H., Xie, J. H., Wen, P. W., & Shi, J. Y. (2015). Anti-diabetic properties of Momordica charantia L. polysaccharide in alloxan-induced diabetic mice. International Journal of Biological Macromolecules, 81(1), 538-543.

Wang, X., Sun, W., Cao, J. Qu, H., Bi, X., & Zhao, Y. (2012). Structures of new triterpenoids and cytotoxicity activities of the isolated major compounds from the fruit of Momordica charantia L. Journal of Agricultural and Food Chemistry, 60(15), 3927-3933.

Wu, S. J., & Ng, L. T. (2008). Antioxidant and free radical scavenging activities of wild bitter melon (Momordica charantia Linn. var. abbreviate Ser.) in Taiwan. LWT-Food Science and Technology, 41(2), 323-330.

Zeng, K., He, Y. N., Yang, D., Cao, J. Q., Xia, X. C., Zhang, S. J., Bi, X. L., & Zhao, Y. Q. (2014). New compounds from acid hydrolyzed products of the fruits of Momordica charantia L. and their inhibitory activity against protein tyrosine phosphatas 1 B. European Journal of Medicinal Chemistry, 81 (1), 176-180.

Zhang, C., Chen, H., & Bai, W. (2018). Characterization of Momordica charantia L. polysaccharide and its protective effect on pancreatic cells injury in STZ-induced diabetic mice. International Journal of Biological Macromolecules, 115(1), 45-52.

Zhang, C., Huang, M., Hong, R., & Chen, H. (2019). Preparation of a Momordica charantia L. polysaccharide-chromium (III) complex and its anti-hyperglycemic activity in mice with streptozotocin-induced diabetes. International Journal of Biological Macromolecules, 122(1), 619-627.

Zhang, L. J., Liaw, C. C., Hsiao, P. C., Huang, H. C., Lin, M. J., Lin, Z. H., Hsu, F. L., & Kuo, Y. H. (2014) Cucurbitane-type glycosides from the fruits of Momordica charantia and their hypoglycemic and cytotoxic activities. Journal of Functional Foods, 6(1), 564-574.

Published

26/04/2020

How to Cite

CRUZ, R. R. P.; FREIRE, A. I.; PEREIRA, A. M.; RIBEIRO, R. P.; ALVES, M. M. Momordica charantia L. in the treatment of diabetes melittus. Research, Society and Development, [S. l.], v. 9, n. 7, p. e15973769, 2020. DOI: 10.33448/rsd-v9i7.3769. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/3769. Acesso em: 21 jan. 2022.

Issue

Section

Review Article