The study of the intestine-brain axis and its influence in neurodegenerative diseases - a literature review
DOI:
https://doi.org/10.33448/rsd-v11i16.38185Keywords:
Gut microbiota; Neurodegenerative Diseases; Gut-Brain Axis; Gastrointestinal microbiome.Abstract
The intestine plays a fundamental role in the relationship with the brain due to a bidirectional communication between both that connects the central nervous system to the so-called enteric nervous system, these systems are kept connected by the vagus nerve. The intestine has bacteria, viruses, fungi and protozoa responsible for the health of the intestinal microbiota and also produce and release neurotransmitters, your mental and physical health is directly related to the type of food used to feed these living beings of the intestinal microbiota. The objective of this work was to discuss the possible relationship between the intestinal microbiota and neurodegenerative diseases. The present study is a literature review on the gut-brain axis and its influence on neurodegenerative diseases. Databases such as Google academic, PUBMED, SciELO, SCIELO, Oxford academic, ingentaconnect, Europe PMC, Nature journal, Brazilian Journal were used. Books, journals or scientific journals and scientific research sites on the internet were reviewed and criteria used as the title of the article. Based on the 40 studies analyzed in the last eleven years , it was found that the intestinal microbiota has an influence on the gut-brain relationship, the association that exists between neurodegenerative diseases and the imbalance of the intestinal microbiota; and, as an aid in the management of these diseases, nutritional strategies.
References
Abdel-haq, R., Schlachetzki, M. C. J., Glass, K. C., & Mazmanian, K. S. (2019). Microbiome–microglia connections via the gut–brain axis. Journal of Experimental Medicine, 216(1), 41–59. https://rupress.org/jem/article/216/1/41/42450/Microbiome-microglia-connections-via-the-gut-brain
Al Assal, K. (2021). Permeabilidade intestinal , o que é e quais os riscos à saúde? Acesso em: 25 out, 2022 Disponível em: https://www.karinaalassal.com.br/post/serotonina-e-intestino-qual-a-rela%C3%A7%C3%A3o.
Al Assal, K. (2021). Serotonina e intestino - qual a relação? Acesso em: 25 out, 2022 Disponível em: https://www.karinaalassal.com.br/post/serotonina-e-intestino-qual-a-rela%C3%A7%C3%A3o
Alam, R., Abdolmaleky, M. H., & Zhou, Jin-Rong. (2017). Microbiome, inflammation, epigenetic alterations, and mental diseases. American Journal of Medical Genetics Part B, 174, 651– 660. https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.b.32567
Angelucci, F., Cechova, K., Amlerova, J., & Hort, J. (2019). Antibiotics, gut microbiota, and Alzheimer 's disease. Journal of Neuroinflammation, 16, 108. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530014/
Araújo, de Sousa. G. D., de Vasconcelos, F. P. L., Lima, da Silva. B. A., Martins, de Morais. A., de Sousa, E. E., & Vasconcelos, de Sousa, M. G. (2019). Alteração da microbiota intestinal e patologias associadas: importância do uso de prebióticos e probióticos no seu equilíbrio. Temas em saúde, 19(4), 8-26. https://temasemsaude.com/wp-content/uploads/2019/09/19401.pdf
Balbino, de Souza. C. (2021) A influência da alimentação no tratamento da doença de Alzheimer. Brazilian Journal of Health Review, 4(3), 10279-10293. doi:10.34119/bjhrv4n3-055
Bastiaanssen, S. F. T., Cussotto, S., Claesson, J. M., Clarke, G., Dinan, G. T., & Cryan, F. J. (2020). Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder. Harvard Review of Psychiatry, 28(1), 26-39. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012351/
Bonaz, B., Bazin, T., & Pellissier, S. (2018). The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Frontiers in Neuroscience, 12. https://www.frontiersin.org/articles/10.3389/fnins.2018.00049/full
Botelho, L. L. R., Cunha, C. C. A., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Gestão e Sociedade, 5(11), 121-136. http://www.spell.org.br/documentos/ver/10515/o-metodo-da-revisao-integrativa-nos-estudos-organizacionais
Calsolaro, V., & Edison, P. (2016). Neuroinflammation in Alzheimer's disease: Current evidence and future directions. Science direct, 12(6), 719-732. https://www.sciencedirect.com/science/article/pii/S1552526016301856
Carretta, B. M., & Scherer, S. (2012). Perspectivas atuais na prevenção da doença de Alzheimer. Estudos Interdisciplinares sobre o Envelhecimento, 17(1), 37-57. https://seer.ufrgs.br/index.php/RevEnvelhecer/article/view/14368/23187
Christofoletti, F. S. G., Paiva, do C. L. N., Pinheiro, J. G., & Ferreira, C. T. (2022). O microbioma intestinal e a interconexão com os neurotransmissores associados à ansiedade e depressão. Brazilian Journal of Health Review, 5(1), 3382-3408. https://brazilianjournals.com/ojs/index.php/BJHR/article/view/44339/pdf
Conhecendo as bactérias da microbiota intestinal. (2020). Biomehub. Acesso em 25 out. 2022. Disponível em: https://www.biome-hub.com/post/conhecendo-as-bact%C3%A9rias-da-microbiota-intestinal.
Cox, M. L., & Weiner, L. H. (2018). Microbiota Signaling Pathways that Influence Neurologic Disease. Neurotherapeutics, 15, 135–145. https://link.springer.com/article/10.1007/s13311-017-0598-8
Cryan, F. J., O´Riordan, J. K., Cowan, M. S. C., Sandhu, V. K., Bastiaanssen, S. F. T., Boehme, M. … Dinan, G. T. (2019) . The Microbiota-Gut-Brain Axis. Physiological Reviews, 99(4), 1877-2013. https://journals.physiology.org/doi/full/10.1152/physrev.00018.2018?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
Cuppari, L. (2019). Nutrição clínica no adulto 4a ed. (4th ed.). (pp. 94-415). Barueri, SP. Editora Manole. https://integrada.minhabiblioteca.com.br/books/9788520464106
da Paixão, A. L., & Castro, S. F. F. (2016). Colonização da microbiota intestinal e sua influência na saúde do hospedeiro. Universitas: Ciências da Saúde, 14(1), 85-96. https://www.cienciasaude.uniceub.br/cienciasaude/article/download/3629/3073
da Paz, G. E., Mendes, S. J. D., Brito, N. S., & Barbosa, O. W. (2021). Doenças neurodegenerativas em adultos e idosos: um estudo epidemiológico descritivo. Revistas Neurociências, 29, 1-11. https://periodicos.unifesp.br/index.php/neurociencias/article/view/12348/8854
Dinan, G. T., & Cryan, F. J. (2017). The microbiome-gut-brain axis in health and disease. Gastroenterology Clinics, 46(1), 77-89. https://www.gastro.theclinics.com/article/S0889-8553(16)30082-6/fulltext
DiSabato, J. D., Quan, N., & Godbout, P. J. (2016). Neuroinflammation: the devil is in the details. Journal of Neurochemistry, 139, 136-153. https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.13607
Dominguez, J. L., & Barbagallo, M. (2018). Nutritional prevention of cognitive decline and dementia. Acta Biomedica, 89(2), 276-290. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179018/
Endres, K. (2019). Ácido retinóico e a microbiota intestinal na doença de Alzheimer: lutando de um lado para o outro?. Current Alzheimer 's Research, 16(5), 405-417. https://www.ingentaconnect.com/content/ben/car/2019/00000016/00000005/art00004
Grosso, G., Pajak, A., Marventano, S., Castellano, S., Galvano, F., Bucolo, C. … Caraci, F. (2014). Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials. Plos One, 9(5), 1-18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013121/
Gubert, C., Kong, G., Renoir, T., & Hannan, J. A. (2020). Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases. Neurobiology of Disease, 134. https://www.sciencedirect.com/science/article/pii/S0969996119302967
Hammer, D. G., & Mcphee, J. S. (2015) Fisiopatologia da doença: uma introdução à medicina clínica. AMGH editora ltda.. pp. 340-341 Porto Alegre, RS.
Hu, X., Wang, T., & Jin, F. (2016). Alzheimer's disease and gut microbiota, Science China Life Sciences, 59(10), 1006-1023. https://pubmed.ncbi.nlm.nih.gov/27566465/#:~:text=Abstract,brain%20axis%2C%20including%20cognitive%20behavior.
Karl, P. J., Hatch, M. A., Arcidiacono, M. S., Pearce, C. S., Pantoja-F, G. I., Doherty, A. L., & Soares, W. J. (2018). Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota. Frontiers in Microbiology. https://www.frontiersin.org/articles/10.3389/fmicb.2018.02013/full?s=09
Keightley, C. P., Koloski, A. N., & Talley, J. N. (2015). Pathways in gut-brain communication: Evidence for distinct gut-to-brain and brain-to-gut syndromes. Australian & New Zealand Journal of Psychiatry, 49(3), 207-214. https://journals.sagepub.com/doi/full/10.1177/0004867415569801?casa_token=6ZkaJs2CZRIAAAAA%3AymDsYFP_00l-9NHmhAStzNex8-XGTg01yk078gg_8L199dRICUdU3snaoXNZbH6qXZYq
Kumar, A., Sidhu, J., Goyal, A., & Tsao, W. J. (2018). Alzheimer Disease. Stat Pearls. StatPearls Publishing. https://europepmc.org/article/nbk/nbk499922
Liu, S., Gao, J., Zhu, M., Liu, K., & Zang, H. L. (2020). Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment. Molecular Neurobiology, 57(12), 5026-5043. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541367/
Long, M. J., & Holtzman, M. D. (2019). Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Cell, 179(2), 312-339. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778042/
Lozupone, A. C., Stombaugh, I. J., Gordon, I. J., Jansson, K. J., & Knight, R. (2012). Diversity, stability and resilience of the human gut microbiota. Nature,489, 220–230. https://www.nature.com/articles/nature11550
Marese, M. C. A., Ficagna, J. E., Parizotto, A. R., & Linartevichi, F. V. (2019). Principais mecanismos que correlacionam a microbiota intestinal com a patogênese da depressão. FAG Journal of Health, 1(3), 232. https://fjh.fag.edu.br/index.php/fjh/article/view/40/109
Medeiros, E. G., Rosas, O. B., Lessa. N, S, A., de Carvalho, C. M. F., da Silva, P. C. D., Franco, M. B. J., & Serquiz, C. A. (2016). Perfil nutricional de idosos portadores de Alzheimer atendidos em home care. Revista Brasileira de Neurologia, 52(4), 5-17. https://www.brazilianjournals.com/index.php/BJHR/article/view/29583
Nesi, A. G., Franco, R. M., & Capel, M. M. L. (2020). A disbiose da microbiota intestinal, sua associação no desenvolvimento de doenças neurodegenerativas e seus possíveis tratamentos. Brazilian Journal of Development, 6(8), 63306-63326. https://www.brazilianjournals.com/index.php/BRJD/article/view/15856
Pistollato, F., Cano, S. S., Elio, I., Vergara, M. M., Giampieri, F., & Battino, M. (2016). Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease, Nutrition Reviews, 74(10), 624–634. https://academic.oup.com/nutritionreviews/article/74/10/624/2349955?login=false
Prince, M., Wimo, A., Guerchet, M., Ali, G., Wu, T., & Prina, M. (2015). The global impact of dementia. Alzheimer’s Disease International. https://www.alzint.org/u/WorldAlzheimerReport2015.pdf
Resumo Bactérias Gram-Negativas: definição, classificação e patologias. (2021). Sanarmed. Acesso em 25 de out, 2022. Disponível em: https://www.sanarmed.com/resumo-bacterias-gram-negativas-definicao-classificacao-e-patologias.
Rios, C. A., Maurya, K. P., Pedrini, M., Graiff-F, M., Asevedo, E., Mansur, B. R. … Brietzke, E. (2017). Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders. Reviews in the Neurosciences, 28(7), 739-749. https://doi.org/10.1515/revneuro-2017-0001https://www.degruyter.com/document/doi/10.1515/revneuro-2017-0001/html
Sampson, R. T., & Mazmanian, K. S. (2015). Control of brain development, function, and behavior by the microbiome. Cell Host Microbe, 17, 565–576. https://www.sciencedirect.com/science/article/pii/S1931312815001699
Savioli, Gisela. Intestino - Onde tudo começa e não onde tudo termina: Tudo o que você precisa saber sobre a saúde da microbiota intestinal para ter uma vida saudável e mais feliz. 1ª edição. São Paulo, SP: Academia, 2021.
Silverthorn, D. U. (2017). Fisiologia Humana: Uma Abordagem Integrada, 7ª edição,( pp. 664-667). Porto Alegre, RS: Artmed.
Strandwitz, P. (2018). Neurotransmitter modulation by the gut microbiota. Brain Research, 1693, 128-133. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005194/
Tonini, O. G. I., Vaz, S. S. D., & Mazur, E. C. (2020). Eixo intestino-cérebro: relação entre a microbiota intestinal e desordens mentais. Research, Society and Development, 9(7). 1-14. https://www.researchgate.net/publication/341608110_Eixo_intestino-cerebro_relacao_entre_a_microbiota_intestinal_e_desordens_mentais
Tortora, G. J., & Derrickson, B. (2016). Princípios de Anatomia e Fisiologia (14th ed.). (pp. 947-986). Rio de janeiro, RJ: Guanabara Koogan.
Tortora, G. J., Funke, B. R., & Case, C. L. (2017). Microbiologia (12th ed.). (pp. 290-310). Porto Alegre, RS: Artmed.
van Best, N., Hornef, M. W., Savelkoul, P. H., & Penders, J. (2015). On The Origin of species: factors shaping the establishment of infant's gut microbiota. BirthDefects Res C EmbryoToday, 105, 240-251. https://pubmed.ncbi.nlm.nih.gov/26607554/
Willyard, C. (2021). How gut microbes could drive brain disorders. Nature, 590, 22-25. https://www.nature.com/articles/d41586-021-00260-3
Zorzo, A. R. (2017). Impacto do microbioma intestinal no Eixo Cérebro-Intestino. International Journal of Nutrology, 10(1), 298-305. https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0040-1705652.pdf
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