Relationship between vitamin D and depression: literature review
DOI:
https://doi.org/10.33448/rsd-v11i16.38431Keywords:
Depression; Vitamin D; Mental health.Abstract
Depression is a mental disorder with a chronic and recurrent course, being one of the most common and fastest growing illnesses in the world. Vitamin D is a steroid hormone that acts mainly in the regulation of bone metabolism, however, in view of the presence of vitamin D receptors throughout the body, several studies have been and are being carried out in order to prove its role in other functions. The objective of this work is to demonstrate the relationship between blood concentration of vitamin D and depression through an integrative literature review. The research consisted of searching for scientific articles in the PubMed and Scielo electronic databases, using the following descriptors in English and Portuguese: “vitamin D”, “blood concentration” and depression. In all, 1588 articles were found in the databases, but only 07 were used in this research. The selected articles show a significant relationship between vitamin D levels and the clinical picture of depression, in which individuals with vitamin D deficiency had a higher risk of developing and maintaining a depressive state, as well as their supplementation seems to reduce this state. However, further studies are needed to elucidate the relationship between vitamin D and depression, in addition to generating new information that demonstrates the importance of monitoring this nutrient and its use in the treatment of this pathology.
References
Akpınar, Ş., & Karadağ, M. G. (2022). Is Vitamin D Important in Anxiety or Depression? What Is the Truth? Current Nutrition Reports, 1–7. Advance online publication. https://doi.org/10.1007/s13668-022-00441-0
Alavi, N. M., Khademalhoseini, S., Vakili, Z., & Assarian, F. (2019). Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial. Clinical Nutrition, 38(5), 2065–2070. https://doi.org/10.1016/j.clnu.2018.09.011
Alghamdi, S., Alsulami, N., Khoja, S., Alsufiani, H., Tayeb, H. O., & Tarazi, F. I. (2020). Vitamin D Supplementation Ameliorates Severity of Major Depressive Disorder. Journal of Molecular Neuroscience, 70(2), 230–235. https://doi.org/10.1007/s12031-019-01461-2
Bersani, F. S., Ghezzi, F., Maraone, A., Vicinanza, R., Cavaggioni, G., Biondi, M., & Pasquini, M. (2019). The relationship between Vitamin D and depressive disorders. Rivista di Psichiatria, 54(6), 229–234. https://doi.org/10.1708/3281.32541
Bizzaro, G., Antico, A., Fortunato, A., & Bizzaro, N. (2017). Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? The Israel Medical Association Jornal, 19(7), 438–443.
Brasil, Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Análise em Saúde e Vigilância de Doenças Não Transmissíveis.
Vigitel Brasil 2021: vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico: estimativas sobre frequência e distribuição sociodemográfica de fatores de risco e proteção para doenças crônicas nas capitais dos 26 estados brasileiros e no Distrito Federal em 2021. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/publicacoes-svs/vigitel/vigitel-brasil-2021-estimativas-sobre-frequencia-e-distribuicao-sociodemografica-de-fatores-de-risco-e-protecao-para-doencas-cronicas/@@download/file/vigitel-brasil-2021.pdf.
Brasil. Ministério da Saúde. (2022a). Depressão no adulto. https://linhasdecuidado.saude.gov.br/portal/depressao/definicao/.
Brasil. Ministério da Saúde. (2022b). Depressão: Saúde de A a Z. https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/d/depressao.
Brasil. Ministério da Saúde. (2022c). Depressão: Avaliação e conduta. https://linhasdecuidado.saude.gov.br/portal/depressao/unidade-hospitalar-especializada/avaliacao-conduta/
Botelho, L. L. R., Cunha, C. J. C. A., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Gestão e Sociedade, 5(1), 121-136. https://doi.org/10.21171/ges.v5i11.1220
Castro, L. C. G. (2011) O sistema endocrinológico vitamina D. Arquivos Brasileiros de Endocrinologia & Metabologia [online]. 55(8), 566- 575. https://doi.org/10.1590/S0004-27302011000800010
Chang, S. W., & Lee, H. C. (2019). Vitamin D and health - The missing vitamin in humans. Pediatrics and Neonatology, 60(3), 237–244. https://doi.org/10.1016/j.pedneo.2019.04.007
Eyles, D. W., Burne, T. H., & McGrath, J. J. (2013). Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Frontiers in Neuroendocrinology, 34(1), 47–64. https://doi.org/10.1016/j.yfrne.2012.07.001
Gonçalves, A. M. C., Teixeira, M. T. B., Gama, J. R. A., Lopes, C. S., Silva, G. A, Gamarra, C. J., Duque, K. C. D. D., & Machado, M. L. S. M. (2018) Prevalência de depressão e fatores associados em mulheres atendidas pela Estratégia de Saúde da Família. Jornal Brasileiro de Psiquiatria [online], 67(2), 101-109. https://doi.org/10.1590/0047-2085000000192.
Hansen, J. P., Pareek, M., Hvolby, A., Schmedes, A., Toft, T., Dahl, E., & Nielsen, C. T. (2019). Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep). BMC Research Notes, 12(1), 203. https://doi.org/10.1186/s13104-019-4218-z.
Holick, M. F., & Chen, T. C. (2008). Vitamin D deficiency: a worldwide problem with health consequences. The American Journal of Clinical Nutrition, 87(4), 1080S–6S. https://doi.org/10.1093/ajcn/87.4.1080S.
Jorge, A. J. L., Cordeiro, J. R., Rosa, M. L. G., & Bianchi, D. B. C. (2018). Vitamin D Deficiency and Cardiovascular Diseases. International Journal of Cardiovascular Sciences [online], 31(4), 422-432. https://doi.org/10.5935/2359-4802.20180025.
Kaviani, M., Nikooyeh, B., Zand, H., Yaghmaei, P., & Neyestani, T. R. (2020). Effects of vitamin D supplementation on depression and some involved neurotransmitters. Journal of Affective Disorders, 269, 28–35. https://doi.org/10.1016/j.jad.2020.03.029
Khan, B., Shafiq, H., Abbas, S., Jabeen, S., Khan, S. A., Afsar, T., Almajwal, A., Alruwaili, N. W., Al-Disi, D., Alenezi, S., Parveen, Z., & Razak, S. (2022). Vitamin D status and its correlation to depression. Annals of General Psychiatry, 21(1), 32. https://doi.org/10.1186/s12991-022-00406-1
Kratz, D., Silva, G., & Tefen, A. (2018). Deficiência de vitamina D (250H) e seu impacto na qualidade de vida: uma revisão de literatura. Revista Brasileira de Análises Clínicas, 50(2): 118-123. http:// doi.org/10.21877/2448-3877.201800686
Moreira, R. T., Rodrigues,L. A. R. L., Farias, L. M., Crisóstomo, J. M., Lavôr, L. C. C., Rodrigues Filho, O. S., & Frota, K. M. G. (2021). Effect of vitamin D supplementation on depression treatment. Revista da Associação Médica Brasileira [online],67(8), 1192-1197. https:// doi.org/10.1590/1806-9282.20210404
Omidian, M., Mahmoudi, M., Abshirini, M., Eshraghian, M. R., Javanbakht, M. H., Zarei, M., Hasani, H., & Djalali, M. (2019). Effects of vitamin D supplementation on depressive symptoms in type 2 diabetes mellitus patients: Randomized placebo-controlled double-blind clinical trial. Diabetes & Metabolic Syndrome, 13(4), 2375–2380. https://doi.org/10.1016/j.dsx.2019.06.011
OPAS. Organização Pan-Americana da Saúde. (2022) Depressão. Folha informativa. https://www.paho.org/pt/topicos/depressao.
Ronaldson, A., Arias de la Torre, J., Gaughran, F., Bakolis, I., Hatch, S. L., Hotopf, M., & Dregan, A. (2022). Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort. Psychological Medicine, 52(10), 1866–1874. https://doi.org/10.1017/S0033291720003657
Roy, N. M., Al-Harthi, L., Sampat, N., Al-Mujaini, R., Mahadevan, S., Al Adawi, S., Essa, M. M., Al Subhi, L., Al-Balushi, B., & Qoronfleh, M. W. (2021). Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD. Frontiers in Bioscience, 26(3), 566–611. https://doi.org/10.2741/4908
Sabir, M. S., Haussler, M. R., Mallick, S., Kaneko, I., Lucas, D. A., Haussler, C. A., Whitfield, G. K., & Jurutka, P. W. (2018). Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines. Genes & nutrition, 13, 19. https://doi.org/10.1186/s12263-018-0605-7
Sherchand, O., Sapkota, N., Chaudhari, R. K., Khan, S. A., Baranwal, J. K., Pokhrel, T., Das, B. K. L., & Lamsal, M. (2018). Association between vitamin D deficiency and depression in Nepalese population. Psychiatry research, 267, 266–271. https://doi.org/10.1016/j.psychres.2018.06.018
Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of Advanced Nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x
Wilkins, C. H., Sheline, Y. I., Roe, C. M., Birge, S. J., & Morris, J. C. (2006). Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. The American Journal of Geriatric Psychiatry, 14(12), 1032–1040. https://doi.org/10.1097/01.JGP.0000240986.74642.7c
Yalamanchili, V., & Gallagher, J. C. (2018). Dose ranging effects of vitamin D3 on the geriatric depression score: A clinical trial. The Journal of Steroid Biochemistry and Molecular Biology, 178, 60–64. https://doi.org/10.1016/j.jsbmb.2017.10.025
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Ravena Kevlar Alencar Magalhães Lobão; Paulo Víctor de Lima Sousa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
