Vitamin B12 deficiency and sublingual and intramuscular treatment: case report
DOI:
https://doi.org/10.33448/rsd-v11i17.38863Keywords:
Vitamin B12; Sublingual Administration; Intramuscular Injections; Case reports.Abstract
Vitamin B12 is an essential micronutrient for some metabolic processes. It is not synthesized by the body and is obtained from foods of animal origin. Its deficiency is frequent and can cause dermatological, hematological and neurological disorders. The deficiency must be diagnosed early and treatment started as soon as possible. There are oral, sublingual and intramuscular treatments and the choice should be based on the severity of the deficiency and factors that interfere with the absorption of this micronutrient. Objective this study is to report a case of a patient with vitamin B12 deficiency and the differences found by intramuscular and sublingual treatments. This is a case report in which laboratory data were collected in the reports of a private clinical analysis laboratory between the years 2019 to 2022. The patient presented vitamin B12 deficiencies in the years 2019 and 2022. In the year 2019, the patient was treated with intramuscular injections. In the year 2022, she was treated with sublingual pills. There were differences between the two interventions in post-treatment vitamin B12 dosage. The two treatments used by different routes proved to be efficacious, but the intramuscular treatment was more effective than the sublingual treatment. The investigation of vitamin B12 deficiency is an important conduct in the evaluation of patients, since early diagnosis can prevent neurological and hematological disorders, as well as provide a better quality of life. Each case must be evaluated to indicate the most appropriate treatment and restore normal vitamin parameters.
References
Benfica, M. E., Lovato, E. C. W., D’orsi, E., & França, V. F. (2022). Sintomas depressivos e níveis séricos das vitaminas B12 e folato em idosos de Florianópolis/SC – Estudo Epifloripa Idoso. Research, Society and Development, 11(4), e9811427090. https://doi.org/10.33448/rsd-v11i4.27090
Bensky, M. J., Ayalon-Dangur, I., Ayalon-Dangur, R., Naamany, E., Gafter-Gvili, A., Koren, G., & Shiber, S. (2019). Comparison of sublingual vs. intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency. Drug Delivery and Translational Research, 9(3), 625–630. https://doi.org/10.1007/s13346-018-00613-y
Brescoll, J., & Daveluy, S. (2015). A Review of Vitamin B12 in Dermatology. American Journal of Clinical Dermatology, 16(1), 27–33. https://doi.org/10.1007/s40257-014-0107-3
Fábregas, B. C., Vitorino, F. D., & Teixeira, A. L. (2011). Deficiência de vitamina B12 e transtorno depressivo refratário. Jornal Brasileiro de Psiquiatria, 60(2), 141–143. https://doi.org/10.1590/S0047-20852011000200010
Futterleib, A., & Cherubini, K. (2005). Importância da vitamina B12 na avaliação clínica do paciente idoso. Scientia Medica, 15(1), 74–78.
Gontijo, B., Rocha, D. M., & Flor, E. M. (2008). Relatos de caso: seu papel em um periódico médico. Anais Brasileiros de Dermatologia, 83(6), 561–565.
Kumar, R. R., Singh, L., Thakur, A., Singh, S., & Kumar, B. (2022). Role of Vitamins in Neurodegenerative Diseases: A Review. CNS & Neurological Disorders - Drug Targets, 21(9), 766–773. https://doi.org/10.2174/1871527320666211119122150
Langan, R. C., & Goodbred, A. J. (2017). Vitamin B12 Deficiency: Recognition and Management. American Family Physician, 96(6), 384–389. https://doi.org/10.1097/00129300-200206000-00001
Lauer, A. A., Grimm, H. S., Apel, B., Golobrodska, N., Kruse, L., Ratanski, E., & Grimm, M. O. W. (2022). Mechanistic Link between Vitamin B12 and Alzheimer’s Disease. Biomolecules, 12(1). https://doi.org/10.3390/biom12010129
Marley, J. (2000). Efficacy, effectiveness, efficiency. Australian Prescriber, 23(6), 114–115.
Menegardo, C. S., Friggi, F. A., Santos, A. D., Devens, L. T., Tieppo, A., & Morelato, R. L. (2020). Deficiência de vitamina B12 e fatores associados em idosos institucionalizados. Revista Brasileira de Geriatria e Gerontologia, 23(2), 1–8. https://doi.org/10.1590/1981-22562020023.200022
Miller, J. W. (2018). Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications. Advances in Nutrition, 9(4), 511S-518S. https://doi.org/10.1093/advances/nmy023
Orhan Kiliç, B., Kiliç, S., Şahin Eroğlu, E., Gül, E., & Belen Apak, F. B. (2021). Sublingual methylcobalamin treatment is as effective as intramuscular and peroral cyanocobalamin in children age 0–3 years. Hematology, 26(1), 1013–1017. https://doi.org/10.1080/16078454.2021.2010877
Paniz, C., Grotto, D., Schmitt, G. C., Valentini, J., Schott, K. L., Pomblum, V. J., & Garcia, S. C. (2005). Fisiopatologia da deficiência de vitamina B12 e seu diagnóstico laboratorial. Jornal Brasileiro de Patologia e Medicina Laboratorial, 41(5), 323–334. https://doi.org/10.1590/s1676-24442005000500007
Parente, R., de Oliveira, M. A. P., & Celeste, R. K. (2010). Relatos e Série de Casos na Era da Medicina Baseada em Evidência. Brazilian Journal of Videoendoscopic Surgery, 3(2), 67–70.
Pawlak, R., Lester, S. E., & Babatunde, T. (2014). The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature. European Journal of Clinical Nutrition, 68(5), 541–548. https://doi.org/10.1038/ejcn.2014.46
Pelling, M. M., Kimura, S. T., Han, E. J., & Shin, Y. M. (2022). Severe Vitamin B12 Deficiency Presenting as Pancytopenia, Hemolytic Anemia, and Paresthesia: Could Your B12 Be Any Lower? Cureus, 14(9), 10–14. https://doi.org/10.7759/cureus.29225
Riley, D. S., Barber, M. S., Kienle, G. S., Aronson, J. K., von Schoen-Angerer, T., Tugwell, P., & Gagnier, J. J. (2017). CARE guidelines for case reports: explanation and elaboration document. Journal of Clinical Epidemiology, 89, 218–235. https://doi.org/10.1016/j.jclinepi.2017.04.026
Rush, E. C., Katre, P., & Yajnik, C. S. (2014). Vitamin B12: One carbon metabolism, fetal growth and programming for chronic disease. European Journal of Clinical Nutrition, 68(1), 2–7. https://doi.org/10.1038/ejcn.2013.232
Shipton, M. J., & Thachil, J. (2015). Vitamin B12 deficiency - A 21st century perspective. Clinical Medicine, 15(2), 145–150. https://doi.org/10.7861/clinmedicine.15-2-145
Stabler, S. P., & Allen, R. H. (2004). Vitamin B12 Deficiency as a Worldwide Problem. Annual Review of Nutrition, 24(1), 299–326. https://doi.org/10.1146/annurev.nutr.24.012003.132440
Tuğba-Kartal, A., & Çağla-Mutlu, Z. (2020). Comparison of Sublingual and Intramuscular Administration of Vitamin B12 for the Treatment of Vitamin B12 Deficiency in Children. Revista de Investigacion Clinica, 72(6), 380–385. https://doi.org/10.24875/RIC.20000208
Viana, A. da S. T., Santos, L. S. dos, Pasqualotto, M. F., Ferreira, T. R. L., & Placido, G. R. (2022). Você sabia que a falta de vitamina B12 pode desencadear doenças neurológicas? Research, Society and Development, 11(3), 1–11. https://doi.org/10.33448/rsd-v11i3.26712
Vidal-Alaball, J., Butler, C. C., Cannings-John, R., Goringe, A., Hood, K., McCaddon, A., & Papaioannou, A. (2005). Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. The Cochrane Database of Systematic Reviews, (3), CD004655. https://doi.org/10.1002/14651858.CD004655.pub2
Wang, H., Li, L., Ll, Q., Song, Y., Th, L., Wang, H., & Th, L. (2018). Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency (Review). Cochrane Database of Systematic Reviews, (3), 1–56. https://doi.org/10.1002/14651858.CD004655.pub3
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