Updates on the influence of obesity on the onset of gestational diabetes and its complications for mother and fetus

Authors

DOI:

https://doi.org/10.33448/rsd-v11i17.38952

Keywords:

Gestational Diabetes Mellitus; Obesity; Postnatal physiologiacal changes.

Abstract

Variations in carbohydrate metabolism are evident during pregnancy to meet the needs of the fetus. However, when pregnant women present exacerbated physiological alterations of this mechanism associated with maternal predisposition, Gestational Diabetes Mellitus (GDM) is characterized. Pregnant women who have risk factors such as insulin resistance and overweight/obesity are more likely to develop the disease, favoring adverse outcomes for the fetus. Thus, the present study aims to find evidence in the literature of the relationship between overweight/obesity and the development of GDM, given the epidemiology of the disease and its higher prevalence as one of the main complications of the gestational period. The article consists of an integrative literature review, with a publication interval between 2020 and 2022. The following databases were used: Virtual Health Library (VHL); National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), EbscoHost. The results demonstrated a positive relationship between overweight/obesity and GDM, demonstrating that the complications of this relationship affect maternal and fetal health, and may progress to unfavorable outcomes in the infant and adult life of the conceptus. Therefore, the conclusion of this article is in agreement with recent findings in the literature, which show that obesity, when present in pregnant women, is directly related to several disorders both in the mother, such as the development of GDM, and in the fetus, increasing intrauterine and neonatal morbidity and mortality.

References

Arabiat, D., AL Jabery, M., Kemp, V., Jenkins, M., Whitehead, L. C., & Adams, G. (2021). Motor Developmental Outcomes in Children Exposed to Maternal Diabetes during Pregnancy: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 18(4), 1699.

Azeez, T. A., Abo-Briggs, T., & Adeyanju, A. S. (2021). A systematic review and meta-analysis of the prevalence and determinants of gestational diabetes mellitus in Nigeria. Indian journal of endocrinology and metabolism, 25(3), 182–190.

Berek, J. S. (2014). Tratado de Ginecologia (15th ed.). Grupo GEN.

Creanga, A., Catalano, P. M., Bateman, B. T. (2022). Obesity in Pregnancy. New England Journal of Medicine. 387 (3), 248-259.

Cunningham, F. G. (2021). Obstetrícia de Williams (25th ed.). Grupo A.

Davidson SJ, Barrett HL, Price SA, Callaway LK, Dekker Nitert M (2021). Probiotics for preventing gestational diabetes. Cochrane Database of Systematic Reviews, Issue 4. Art. No.: CD009951.

Decherney, A. H., Nathan, L., & Laufer, N. et al. (2014). CURRENT ginecologia e obstetrícia: diagnóstico e tratamento (11th ed.). Grupo A.

Dimas, A., Politi, A., Papaioannou, G., Barber, T. M., Weickert, M. O., Grammatopoulos, D. K., Kumar, S., Kalantaridou, S., & Valsamakis, G. (2022). The Gestational Effects of Maternal Appetite Axis Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review. International Journal of Molecular Sciences, 23(2), 695.

Eletri, L., & Mitanchez, D. (2022). How Do the Different Types of Maternal Diabetes during Pregnancy Influence Offspring Outcomes? Nutrients, 14(18), 3870.

Fakhraei, R., Denize, K., Simon, A., Sharif, A., Zhu-Pawlowsky, J., Dingwall-Harvey, A. L. J., Hutton, B., Pratt, M., Skidmore, B., Ahmadzai, N., Heslehurst, N., Hayes, L., Flynn, A. C., Velez, M. P., Smith, G., Lanes, A., Rybak, N., Walker, M., & Gaudet, L. (2022). Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review. International Journal of Environmental Research and Public Health, 19(4), 2063.

Foratori-Junior, G. A., Pereira, P. R., Gasparoto, I. A., de Carvalho Sales-Peres, S. H., de Souza, J. M. S., & Khan, S. (2022). Is overweight associated with periodontitis in pregnant women? Systematic review and meta-analysis. Japanese Dental Science Review, 58, 41-51.

Han, V.X., Patel, S., Jones, H.F. Jones, H. F., Nielsen T. C., Mohammad S. S., Hofer M. J., Gold W., Brilot F., Lain S. J., Nassar N., Dale R. C. (2021). A inflamação aguda e crônica materna na gravidez está associada a distúrbios comuns do neurodesenvolvimento: uma revisão sistemática. Transl Psiquiatria.11(7), 12.

Keller, A., Varela Vazquez, C., Dangol, R., Damm, P., Heitmann, B. L., & Händel, M. N. (2020). The role of vitamin D in the development of diabetes post gestational diabetes mellitus: A systematic literature review. Nutrients, 12(6), 1733.

Martins-Costa, S. (2017). Rotinas em Obstetrícia (7th ed.). Grupo A.

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., McGuinness, L. A., … Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical research ed.), 372, n71.

Pascual-Morena, C., Cavero-Redondo, I., Álvarez-Bueno, C., Lucerón-Lucas-Torres, M., Sanabria-Martínez, G., Poyatos-León, R., Rodríguez-Martín, B., & Martínez-Vizcaíno, V. (2021). Exercise versus Metformin to Improve Pregnancy Outcomes among Overweight Pregnant Women: A Systematic Review and Network Meta-Analysis. Journal of Clinical Medicine, 10(16), 3490.

Santos, C. M. C., Pimenta, C. A. M., Nobre, M. R. C. (2007). The PICO strategy for the research question construction and evidence search. Revista Latino-Americana de Enfermagem [online], v. 15, n. 3

Sociedade Brasileira De Diabetes (2019). Diretrizes da sociedade Brasileira de Diabetes 2019-2020. São Paulo: SBD, 489.

Sriboonvorakul, N., Hu, J., Boriboonhirunsarn, D., Ng, L. L., & Tan, B. K. (2022). Proteomics Studies in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 11(10), 2737.

Subramanian, A., Idkowiak, J., Toulis, K. A., Thangaratinam, S., Arlt, W., & Nirantharakumar, K. (2021). Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review. European journal of endocrinology, 184(1), 51-64.

Wang, C. C., Tung, Y. T., Chang, H. C., Lin, C. H., & Chen, Y. C. (2020). Effect of probiotic supplementation on newborn birth weight for mother with gestational diabetes mellitus or overweight/obesity: A systematic review and meta-analysis. Nutrients, 12(11), 3477.

Yao, D., Chang, Q., Wu, Q. J., Gao, S. Y., Zhao, H., Liu, Y. S., ... & Zhao, Y. H. (2020). Relationship between maternal central obesity and the risk of gestational diabetes mellitus: A systematic review and meta-analysis of cohort studies. Journal of diabetes research, 2020.

Published

24/12/2022

How to Cite

RESENDE, R. S. F. de .; BORBA, P. A. B. .; AMÂNCIO, N. de F. G. .; ALMEIDA, R. L. B. M. de . Updates on the influence of obesity on the onset of gestational diabetes and its complications for mother and fetus. Research, Society and Development, [S. l.], v. 11, n. 17, p. e185111738952, 2022. DOI: 10.33448/rsd-v11i17.38952. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/38952. Acesso em: 25 dec. 2024.

Issue

Section

Health Sciences