Insomnia: use of exogenous melatonina and its implications

Authors

DOI:

https://doi.org/10.33448/rsd-v12i3.39010

Keywords:

Insomnia; Melatonin; Sleep.

Abstract

This article aims to identify the main impacts of the use of exogenous melatonin as a sleep inducer in adults. The study comprised a systematic literature review based on the PubMed/MEDLINE database. The importance of sleep has been demonstrated in several ways and sleep deprivation is associated with physical and cognitive impairments. Insomnia is a sleep disorder characterized by difficulty falling or staying asleep. In this regard, many studies have sought to identify the effectiveness of the use of exogenous melatonin on sleep disorders, also evaluating the intrinsic adverse effects of this use. Very positive impacts related to the use of this exogenous melatonin were observed, as there was an increase in the total period of sleep and absence of dependence, tolerance, hangovers or even serious adverse effects. However, it is important to point out that more studies related to the subject are needed, which aim at a safer administration, considering the specificities of each person, such as age group, sex, preexisting diseases, possible drug interactions, among other aspects.

References

Amaral, F. G. D., & Cipolla-Neto, J. (2018). A brief review about melatonin, a pineal hormone. Archives of endocrinology and metabolism, 62(4), 472–479. https://doi.org/10.20945/2359-3997000000066

Bueno, A. P. R., Savi, F. M., Alves, I. A., & Bandeira, V. A. C. (2021). Regulatory aspects and evidences of melatonin use for sleep disorders and insomnia: an integrative review. Arquivos de neuro-psiquiatria, 79(8), 732–742. https://doi.org/10.1590/0004-282X-ANP-2020-0379

Chitimus, D. M., Popescu, M. R., Voiculescu, S. E., Panaitescu, A. M., Pavel, B., Zagrean, L., & Zagrean, A. M. (2020). Melatonin's Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease. Biomolecules, 10(9), 1211. https://doi.org/10.3390/biom10091211

Claustrat, B., & Leston, J. (2015). Melatonin: Physiological effects in humans. Neuro-Chirurgie, 61(2-3), 77–84. https://doi.org/10.1016/j.neuchi.2015.03.002

da Silva Júnior, P. R., Cabral, H. R., Gomes, A. L. O. R., Teófilo, P. B. E., & de Oliveira, T. K. B. (2019). Melatonina exógena e seus efeitos metabólicos: revisão da literatura. Anais da Faculdade de Medicina de Olinda, 1(3), 45-48.

Donato, H., & Donato, M. (2019). Etapas na Condução de uma Revisão Sistemática [Stages for Undertaking a Systematic Review]. Acta medica portuguesa, 32(3), 227–235. https://doi.org/10.20344/amp.11923

Foley, H. M., & Steel, A. E. (2019). Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence. Complementary therapies in medicine, 42, 65-81.

Guerrero, J. M., Carrillo-Vico, A., & Lardone, P. J. (2007). La melatonina. Investigación y ciencia, 373, 30-38.

Gunata, M., Parlakpinar, H., & Acet, H. A. (2020). Melatonin: A review of its potential functions and effects on neurological diseases. Revue neurologique, 176(3), 148–165. https://doi.org/10.1016/j.neurol.2019.07.025

Lent, R. (2005). Cem bilhões de neurônios: conceitos fundamentais de neurociência (Ed. rev. e atual). São Paulo: Atheneu.

Li, T., Jiang, S., Han, M., Yang, Z., Lv, J., Deng, C., Reiter, R. J., & Yang, Y. (2019). Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis. Frontiers in neuroendocrinology, 52, 22–28. https://doi.org/10.1016/j.yfrne.2018.06.004

Moroni, I., Garcia-Bennett, A., Chapman, J., Grunstein, R. R., Gordon, C. J., & Comas, M. (2021). Pharmacokinetics of exogenous melatonin in relation to formulation, and effects on sleep: A systematic review. Sleep Medicine Reviews, 57, 101431.

Neto, J. A. S., & Castro, B. F. D. (2008). Melatonina, ritmos biológicos e sono: uma revisão da literatura. Rev Bras Neurol, 44(1), 5-11.

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., McGuinness, L. A., & Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical research ed.), 372, n71. https://doi.org/10.1136/bmj.n71

Poza, J. J., Pujol, M., Ortega-Albás, J. J., Romero, O. en representación del Grupo de estudio de insomnio de la Sociedad Española de Sueño (SES). (2018). Melatonina nos distúrbios do sono. Melatonina en los trastornos de sueño. Neurologia (Barcelona, Espanha). https://doi.org/10.1016/j.nrl.2018.08.002

Riha R. L. (2018). The use and misuse of exogenous melatonin in the treatment of sleep disorders. Current opinion in pulmonary medicine, 24(6), 543–548. https://doi.org/10.1097/MCP.0000000000000522

Souza, J. C., & Reimão, R. (2004). Epidemiologia da insônia. Psicologia em Estudo, 9, 3-7.

Vasey, C., McBride, J., & Penta, K. (2021). Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin. Nutrients, 13(10), 3480. https://doi.org/10.3390/nu13103480

Voysey, Z. J., Barker, R. A., & Lazar, A. S. (2021). The Treatment of Sleep Dysfunction in Neurodegenerative Disorders. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18(1), 202–216. https://doi.org/10.1007/s13311-020-00959-7

Zisapel N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. British journal of pharmacology, 175(16), 3190–3199. https://doi.org/10.1111/bph.14116

Downloads

Published

08/03/2023

How to Cite

SANTOS, . I. M. de P. .; SILVA, I. Z. .; TOLEDO, A. J. F. de .; MARCIANO, B. R. .; DUARTE, G. G. de M. .; SOARES, E. A. .; GOMES, F. S. .; SANTOS, T. de S. .; MARTINS, J. de O. .; ZANETTI, G. T. . Insomnia: use of exogenous melatonina and its implications. Research, Society and Development, [S. l.], v. 12, n. 3, p. e19212339010, 2023. DOI: 10.33448/rsd-v12i3.39010. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/39010. Acesso em: 26 dec. 2024.

Issue

Vol. 12 No. 3

Section

Health Sciences

License

Copyright (c) 2023 Iris Motta de Paula Santos; Isadora Zanuto Silva; Ana Júlia Fretas de Toledo; Bárbara Rezende Marciano; Gema Galgani de Mesquita Duarte; Evelise Aline Soares; Fabrício Souza Gomes; Thayrine de Souza Santos; Janara de Oliveira Martins; Guilherme Totoli Zanetti

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.