Evaluation of vitamin D use in patients with asthma: an integrative review
DOI:
https://doi.org/10.33448/rsd-v11i17.39045Keywords:
Asthma; Vitamin D; Pneumology.Abstract
Background: Asthma is a chronic inflammatory disease of the airways in which the inflammatory process culminates in recurrent episodes of wheezing, dyspnea, chest tightness and coughing. Recent studies have linked low serum levels of 25-hydroxyvitamin D (vitamin D) to severe asthma exacerbations, decreased lung function, and reduced response to corticosteroids. Objectives: To analyze the effects of the use of vitamin D in patients with asthma, with or without defect in this vitamin. Methods: This is an integrative review, which used PUBMED, SciELO and LILACS databases. Inclusion criteria were: answering the guiding question, being available in Portuguese, English or Spanish, articles published in the last 5 years, of the clinical trial type, reports and case series, cohort studies and cross-sectional studies. After screening, 13 articles were selected. Results and discussion: The results were quite divergent regarding the effectiveness of vitamin D supplementation in asthmatic patients with or without its deficiency, although the majority indicated a strong correlation between vitamin D deficiency and the exacerbation of asthma attacks. Still, factors such as sample type and size and follow-up time can influence the results, showing that there is a more positive correlation in children than in adults. Conclusion: The divergent results in the available literature require that more primary studies be carried out, with a larger and more homogeneous sample, in order to reach more reliable results, which, in fact, support the effectiveness of vitamin D supplementation in these patients.
References
Brehm, J. M., Schuemann, B., Fuhlbrigge, A. L., Hollis, B. W., Strunk, R. C., Zeiger, R. S., Weiss, S. T., & Litonjua, A. A. (2010). Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. Journal of Allergy and Clinical Immunology, 126(1), 52-58.e5. https://doi.org/10.1016/j.jaci.2010.03.043
Camargo, C. A., Toop, L., Sluyter, J., Lawes, C. M. M., Waayer, D., Khaw, K.-T., Martineau, A. R., & Scragg, R. (2021). Effect of Monthly Vitamin D Supplementation on Preventing Exacerbations of Asthma or Chronic Obstructive Pulmonary Disease in Older Adults: Post Hoc Analysis of a Randomized Controlled Trial. Nutrients, 13(2), 521. https://doi.org/10.3390/nu13020521
Chang, S.-W., & Lee, H.-C. (2019). Vitamin D and health - The missing vitamin in humans. Pediatrics & Neonatology, 60(3), 237–244. https://doi.org/10.1016/j.pedneo.2019.04.007
Ducharme, F. M., Jensen, M., Mailhot, G., Alos, N., White, J., Rousseau, E., Tse, S. M., Khamessan, A., & Vinet, B. (2019). Impact of two oral doses of 100,000 IU of vitamin D3 in preschoolers with viral-induced asthma: a pilot randomised controlled trial. Trials, 20(1). https://doi.org/10.1186/s13063-019-3184-z
Fahy, J. V. (2014). Type 2 inflammation in asthma — present in most, absent in many. Nature Reviews Immunology, 15(1), 57–65. https://doi.org/10.1038/nri3786
Forno, E., Bacharier, L. B., Phipatanakul, W., Guilbert, T. W., Cabana, M. D., Ross, K., Covar, R., Gern, J. E., Rosser, F. J., Blatter, J., Durrani, S., Han, Y.-Y., Wisniewski, S. R., & Celedón, J. C. (2020). Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels. JAMA, 324(8), 752. https://doi.org/10.1001/jama.2020.12384
González-Diaz, S. N., Arias-Cruz, A., Villarreal-Pérez, J. Z., Guerra, D. S., & Monge-Ortega, O. P. (2018). Evaluación de los niveles séricos de vitamina D en adultos asmáticos y su relación con el control de asma. Revista Alergia México, 65(4), 362–371. https://doi.org/10.29262/ram.v65i4.386
Gupta, A., Sjoukes, A., Richards, D., Banya, W., Hawrylowicz, C., Bush, A., & Saglani, S. (2011). Relationship between Serum Vitamin D, Disease Severity, and Airway Remodeling in Children with Asthma. American Journal of Respiratory and Critical Care Medicine, 184(12), 1342–1349. https://doi.org/10.1164/rccm.201107-1239oc
Havan, M., Razi, C. H., Bulus, A. D., Köksal, A. O., & Andıran, N. (2017). Efectos de la concentración de 25-hidroxi vitamina D sobre la gravedad y el control del asma en pacientes asmáticos en edad escolar. Archivos Argentinos de Pediatria, 115(04). https://doi.org/10.5546/aap.2017.336
Hirai, K., Shirai, T., Suzuki, Y., Shimomura, T., & Itoh, K. (2019). Comparison of the Association between Circulating Vitamin D3 Levels and Clinical Outcomes in Patients with Asthma and Chronic Obstructive Pulmonary Disease: A Prospective Observational Study. Biological & Pharmaceutical Bulletin, 42(11), 1861–1866. https://doi.org/10.1248/bpb.b19-00385
Jat, K. R., Goel, N., Gupta, N., Gupta, C. P., Datta, S., Lodha, R., & Kabra, S. (2020). Efficacy of vitamin D supplementation in asthmatic children with vitamin D deficiency: a randomized controlled trial (ESDAC trial). Pediatric Allergy and Immunology, 32(3). https://doi.org/10.1111/pai.13415
Jolliffe, D. A., Greenberg, L., Hooper, R. L., Griffiths, C. J., Camargo, C. A., Kerley, C. P., Jensen, M. E., Mauger, D., Stelmach, I., Urashima, M., & Martineau, A. R. (2017). Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. The Lancet Respiratory Medicine, 5(11), 881–890. https://doi.org/10.1016/s2213-2600(17)30306-5
Lima, J. J., Castro, M., King, T. S., Lang, J. E., Ortega, V. E., Peters, S. P., Denlinger, L. C., Israel, E., Sorkness, C. A., Wechsler, M. E., Wenzel, S. E., & Smith, L. J. (2018). Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial. Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology, 121(4), 444-450.e1. https://doi.org/10.1016/j.anai.2018.06.001
Liu, J., Dong, Y.-Q., Yin, J., Yao, J., Shen, J., Sheng, G.-J., Li, K., Lv, H.-F., Fang, X., & Wu, W.-F. (2019). Meta-analysis of vitamin D and lung function in patients with asthma. Respiratory Research, 20(1). https://doi.org/10.1186/s12931-019-1072-4
Liu, M., Wang, J., & Sun, X. (2022). A Meta-Analysis on Vitamin D Supplementation and Asthma Treatment. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.860628
Marques, C. P. C., Bloise, R. F., Lopes, L. B. M., Godói, L. F., Souza, P. R. P. de, Rosa, I. M. S., Costa, S. de S., Barros, M. C., Souza, A. C. L. de, & Carvalho, B. M. M. de. (2022). Epidemiologia da Asma no Brasil, no período de 2016 a 2020. Research, Society and Development, 11(8), e5211828825. https://doi.org/10.33448/rsd-v11i8.28825
McHugh, M., Symanski, E., Pompeii, L., & Delclos, G. (2009). Prevalence of Asthma among Adult Females and Males in the United States: Results from the National Health and Nutrition Examination Survey (NHANES), 2001-2004. Journal of Asthma, 46(8), 759–766. https://doi.org/10.3109/02770900903067895
National Heart, Lung, and Blood Institute - NHLBI. (2019). Guidelines for the Diagnosis and Management of Asthma (EPR-3) | National Heart, Lung, and Blood Institute (NHLBI). Nih.gov. https://www.nhlbi.nih.gov/health-topics/guidelines-for-diagnosis-management-of-asthma
Ober, C., & Yao, T.-C. (2011). The genetics of asthma and allergic disease: a 21st century perspective. Immunological Reviews, 242(1), 10–30. https://doi.org/10.1111/j.1600-065x.2011.01029.x
Ogeyingbo, O. D., Ahmed, R., Gyawali, M., Venkatesan, N., Bhandari, R., Botleroo, R. A., Kareem, R., & Elshaikh, A. O. (2021). The Relationship Between Vitamin D and Asthma Exacerbation. Cureus, 13(8). https://doi.org/10.7759/cureus.17279
Rosser, F. J., Han, Y.-Y., Forno, E., Bacharier, L. B., Phipatanakul, W., Guilbert, T. W., Cabana, M. D., Ross, K., Blatter, J., Durrani, S., Luther, J., Wisniewski, S. R., & Celedón, J. C. (2022). Effect of vitamin D supplementation on total and allergen-specific IgE in children with asthma and low vitamin D levels. The Journal of Allergy and Clinical Immunology, 149(1), 440-444.e2. https://doi.org/10.1016/j.jaci.2021.05.037
Scaff, M. R. C., De-Souza, F. I. S., Sarni, R. O. S., Argani, I. L., & Wandalsen, N. F. (2019). Concentrações de vitamina D em lactentes sibilantes e crianças asmáticas: relação com a condição nutricional e o controle da doença. Brazilian Journal of Allergy and Immunology (BJAI), 3(4). https://doi.org/10.5935/2526-5393.20190060
Schramm Neto, F. A. R., Faria, C. D. de, Oliveira, L. de O. e, Barbosa, C. E. da S., Rosa, B. S. G., Oliveira, G. B., Castro, P. C., Andrade, V. C. F. de, Cardoso, I. R. M., & Costa, S. F. da. (2022). Asma e seus aspectos fisiopatológicos: revisão integrativa da literatura. Research, Society and Development, 11(14), e186111436267. https://doi.org/10.33448/rsd-v11i14.36267
Searing, D. A., Zhang, Y., Murphy, J. R., Hauk, P. J., Goleva, E., & Leung, D. Y. M. (2010). Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. Journal of Allergy and Clinical Immunology, 125(5), 995–1000. https://doi.org/10.1016/j.jaci.2010.03.008
Sluyter, J. D., Camargo, C. A., Waayer, D., Lawes, C. M. M., Toop, L., Khaw, K.-T., & Scragg, R. (2017). Effect of Monthly, High-Dose, Long-Term Vitamin D on Lung Function: A Randomized Controlled Trial. Nutrients, 9(12). https://doi.org/10.3390/nu9121353
Sociedade Brasileira de Pneumologia e Tisiologia - SBPT. (2014, June 10). Asma. Sociedade Brasileira de Pneumologia E Tisiologia. https://sbpt.org.br/portal/espaco-saude-respiratoria-asma/
Thakur, C., Kumar, J., Kumar, P., Goyal, J. P., Singh, K., & Gupta, A. (2021). Vitamin‐D supplementation as an adjunct to standard treatment of asthma in children: A randomized controlled trial (ViDASTA Trial). Pediatric Pulmonology, 56(6), 1427–1433. https://doi.org/10.1002/ppul.25287
Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of Advanced Nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x
Win, S. S., Camargo, C. A., Khaw, K.-T., Lawes, C. M. M., Sluyter, J., Waayer, D., Toop, L., & Scragg, R. (2019). Cross-sectional associations of vitamin D status with asthma prevalence, exacerbations, and control in New Zealand adults. The Journal of Steroid Biochemistry and Molecular Biology, 188, 1–7. https://doi.org/10.1016/j.jsbmb.2018.11.016
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Andressa Raiany Henrique Pinto; Gustavo Pinto dos Santos; Saulo Prado da Costa; Pedro Henrique Fernandes Pólvora Santos; Georthon Pereira Lacerda; Natália Caroline Coelho dos Santos Almeida; Michel Patrik de Sousa Arruda; Beatriz Rodrigues Paz; Mariana de Jesus Oliveira; Rodrigo Daniel Zanoni
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
