Microplatistics and Nanoplastic and their relevance in human health: literature review





Microplastic; Nanoplastic; Heath.


Plastic fragments, more specifically microplastics (MPS) and nanoplastics (NPS) are present and produced in large quantities and on global scales. They are found virtually everywhere in seawater, food and air. Thus, considering the forms of human contact such as consumption itself or breathing and biological effects, chemical effects of these fragments, it becomes necessary to discuss the relevance and possible effects of this material on the individuals' bodies. This study aims to understand the possible relationship between harmful effects to the body related to contact with such plastic fragments, observing their effects. Using the integrative exploratory literature review, 22 articles were used, with eight articles being excluded due to non-compliance with the inclusion criteria. The consumption of MPS and NPS can induce harmful effects on organisms either through physical, chemical or biological phenomena. In the first, there is an association with physical barriers that induce inflammation processes. The biological role addresses the association of MPS with some possibly pathogenic beings to humans. Finally, the chemical role related to the phenomenon of adsorption of harmful proves to be a generation of possible harm. Therefore, it is essential to carry out new studies on the effects of MPS and NPS in human, due to their high coverage on a worldwide scale and the report that, although there are few studies carried out recently, they present alarming pictures about the action harmful of these compounds to humans.


Bamai, Y. A., et al (2014). Associations of phthalate concentrations in floor dust and multi-surface dust with the interior materials in Japanese dwellings. Science of the total environment, 468, 147-157. https://pubmed.ncbi.nlm.nih.gov/24012901/.

Bakir, A., et al (2014). Enhanced desorption of persistent organic pollutants from microplastics under simulated physiological conditions. Environmental pollution, 185, 16-23. https://pubmed.ncbi.nlm.nih.gov/24212067/.

Banco mundial (2019) Brasil é o 4º maior produtor de lixo plástico do mundo e recicla apenas 1%.


Bardin, L. (2011) Análise de conteúdo. Edições 70.

Blackburn, K., & Green, D. (2021). The potential effects of microplastics on human health: What is known and what is unknown. Ambio, 1-13. https://pubmed.ncbi.nlm.nih.gov/34185251/.2021.

Boucher, J. & Friot, D. (2017) .Primary Microplastics in the Oceans: A Global Evaluation of Sources Gland, Switzerland.IUCN, 43,21.https://www.wwf.org.br/?70222/Brasil-e-o-4-pais-do-mundo-que-mais-gera-lixo-plastico.

BBC (2022) Microplastics found in human breast milk for the first time. The guardian..https://www.theguardian.com/environment/2022/oct/07/microplastics-human-breast-milk-first-time.

Caixeta, D.et al (2022). Microplásticos como indicadores de poluição ambiental e seus efeitos sobre os organismos. Enciclopedia biosferA, 19(40). https://conhecer.org.br/ojs/index.php/biosfera/article/view/5479.

Domenech, J. et al (2021). Long-term effects of polystyrene nanoplastics in human intestinal Caco-2 cells. Biomolecules, 11(10), 1442. https://pubmed.ncbi.nlm.nih.gov/34680075/.

Endo, S.; Yuyama; M., & Takada, H. (2013). Desorption kinetics of hydrophobic organic contaminants from marine plastic pellets. Marine pollution bulletin, 74(1), 125-131.https://www.sciencedirect.com/science/article/abs/pii/S0025326X13003871.

Fapesp (2021). Respirando microplásticos. Pesquisa FAPESP, 63 ,305. https://revistapesquisa.fapesp.br/wp-content/uploads/2021/06/062-063_microplasticos_305.pdf.

Galvão CM, Sawada NO & Mendes IA. (2003) A busca das melhores evidências. Rev Esc Enferm USP. ; 37(4): 43-50. https://www.scielo.br/j/tce/a/XzFkq6tjWs4wHNqNjKJLkXQ/#.

Gesamp (2015). Sources, fate and effects of microplastics in the marine environment: part 2 of a global assessment.international maritime organization. 11.http://www.gesamp.org/site/assets/files/1275/sources-fate-and-effects-of-microplastics-in-the-marine-environment-part-2-of-a-global-assessment-en.pdf.

Groh, K. J., et al (2019). Overview of known plastic packaging-associated chemicals and their hazards. Science of the total environment, 651, 3253-3268.Overview of Known Plastic Packaging-Associated Chemicals and Their Hazards.

Hwang, J., et al (2019). An assessment of the toxicity of polypropylene microplastics in human derived cells. Science of the Total Environment, 684, 657-669. https://doi.org/10.1016/J.SCITOTENV.2019.05.071.

Horvatits, T et al (2022). Microplastics detected in cirrhotic liver tissue. EBioMedicine, 82, 104147.https://pubmed.ncbi.nlm.nih.gov/35835713/#:~:text=Six%20different%20microplastic%20polymers%20ranging,those%20without%20underlying%20liver%20disease.

Jenner, L. C., et al (2022). Detection of microplastics in human lung tissue using μFTIR spectroscopy. Science of The Total Environment, 831, 154907. https://www.sciencedirect.com/science/article/pii/S0048969722020009.

Karami, A., et al (2017). The presence of microplastics in commercial salts from different countries. Scientific Reports, 7(1), 1-11. lhttps://www.nature.com/articles/srep46173.

Kershaw, P. J., et al. (2019). Guidelines for the monitoring and assessment of plastic litter and microplastics in the ocean. http://www.gesamp.org/publications/guidelines-for-the-monitoring-and-assessment-of-plastic-litter-in-the-ocean.

Liang, B., et al (2021). Underestimated health risks: polystyrene micro-and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis. Particle and fibre toxicology, 18(1), 1-19. https://link.springer.com/article/10.1186/s12989-021-00414-1.

Li, J., et al (2019). Using mussel as a global bioindicator of coastal microplastic pollution. Environmental pollution, 244, 522-533.https://doi.org/10.1016/j.envpol.2018.10.032.

López-vázquez, J., et al (2022). Mimicking human ingestion of microplastics: Oral bioaccessibility tests of bisphenol A and phthalate esters under fed and fasted states. Science of the Total Environment, 826, 154027.https://www.sciencedirect.com/science/article/pii/S0048969722011196.

Lucio, F. T., et al (2019). Disponibilidade e influência dos microplásticos nos seres vivos e ambiente: uma revisão. Conexão Ci. Formiga, Minas Gerais, 14(1), 47-55. https://www.science.org/doi/full/10.1126/sciadv.abd1211.

Massos, A., & Turner, A. (2017). Cadmium, lead and bromine in beached microplastics. Environmental Pollution, 227, 139-145. https://pubmed.ncbi.nlm.nih.gov/28458244/.

Mason, S. A., et al (2018). Synthetic polymer contamination in bottled water. Frontiers in chemistry, 407.https://pubmed.ncbi.nlm.nih.gov/30255015/.

Montagner, C. C., et al (2021). Microplásticos: Ocorrência Ambiental e Desafios Analíticos. Química Nova, 44, 1328-1352.https://www.scielo.br/j/qn/a/VJ58TBjHVqDZsvWLckcFbTQ/.

Napper, I. E., et al (2015). Characterisation, quantity and sorptive properties of microplastics extracted from cosmetics. Marine pollution bulletin, 99(1-2), 178-185. https://www.sciencedirect.com/science/article/abs/pii/S0025326X1500449X.

Nelms, S. E., et al (2018). Investigating microplastic trophic transfer in marine top predators. Environmental pollution, 238, 999-1007.https://www.sciencedirect.com/science/article/pii/S0269749117343294.

Mohamed Nor, N. H., Kooi, M., Diepens, N. J., & Koelmans, A. A. (2021). Lifetime Accumulation of Microplastic in Children and Adults. Environmental science & technology, 55(8), 5084–5096. https://doi.org/10.1021/acs.est.0c07384.

Outram, L., et al (2020). No evidence of microplastic consumption by the copepod, Temora longicornis (Müller, 1785) in Chichester Harbour, United Kingdom. Nauplius, 28. https://www.scielo.br/j/nau/a/jzQBQqSmhFRcW59YQChzk4D/?lang=en.

ONU (2022). 1/3 do plástico produzido no Brasil pode chegar aos oceanos, mostra estudo.Exame.


Page, M. J., et al. (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Research Methods and Reporting.BMJ: first published as 10.

Park, C., et al (2020). The mixture effects of bisphenol derivatives on estrogen receptor and androgen receptor. Environmental Pollution, 260, 114036. https://www.sciencedirect.com/science/article/pii/S0269749119348511.

Peng, X., et al (2018). Microplastics contaminate the deepest part of the world’s ocean. Geochemical Perspectives Letters, 9(1), 1-5. https://doi.org/10.7185/geochemlet.1829.

Peretz, J., et al (2014). Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environmental health perspectives, 122(8), 775-786. https://pubmed.ncbi.nlm.nih.gov/24896072/.

Prata J.C. et al. (2018) Airborne microplastics: Consequences to human health. / Environmental Pollution 234 .https://www.sciencedirect.com/science/article/abs/pii/S0269749117307686?via%3Dihub.

Prata, J. C., et al (2020). Environmental exposure to microplastics: An overview on possible human health effects. Science of the total environment, 702, 134455.https://www.sciencedirect.com/science/article/abs/pii/S0048969719344468?Via%3Dihub.

Ragusa, A., (2021). Plasticenta: First evidence of microplastics in human placenta. Environment International, 146, 106274. https://www.sciencedirect.com/science/article/pii/S0160412020322297.2021.

Ragusa, A., et al (2022). Raman microspectroscopy detection and characterisation of microplastics in human breastmilk. Polymers, 14(13), 2700. https://www.mdpi.com/2073-4360/14/13/2700.

Rahman, A., et al (2021). Potential human health risks due to environmental exposure to nano-and microplastics and knowledge gaps: a scoping review. Science of the Total Environment, 757, 143872.https://doi.org/10.1016/j.scitotenv.2020.143872.

Ryan, P. G., et al (2020). Monitoring marine plastics-will we know if we are making a difference? South African Journal of Science, 116(5-6), 1-9. http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0038-23532020000300006.

Santillo, D., et al (2017). Microplastics as contaminants in commercially important seafood species. Integrated environmental assessment and management, 13(3), 516-521. https://setac.onlinelibrary.wiley.com/doi/10.1002/ieam.1909.

Santos, C.M.D.C.; Pimenta, C.A.D.M. & Nobre, M.R.C. (2007). The PICO strategy for the research question construction and evidence search. Revista Latino-Americana de Enfermagem, 15, 508-511.

Sanchez-gutierrez, F. O. (2021). Retos pos pandemia en la gestión de residuos sólidos. CienciAmérica, 10(1), 11-23. dx.doi. org/10.33210/ca.v10i1.354.Acesso em:15 de novembro de 2022.

Sindplast (2022). Os plásticos. http://www.sindiplast.org.br/os-plasticos/#:~:text=Pl%C3%A1stico%2C%20tem%20seu%20nome%20origin%C3%A1rio,de%2Da%C3%A7%C3%BAcar%20ou%20o%20milho.

Shruti, VC, F.et al (2020). Primeiro estudo desse tipo sobre a contaminação microplástica de refrigerantes, chá frio e bebidas energéticas – pesquisas futuras e considerações ambientais. Ciência do Meio Ambiente Total726: 138580. https://doi.org/ 10.1016/j.scitotenv.2020.138580.

Valente, J. V., et al (2021). Avaliação do potencial citotóxico de microplásticos em linhas celulares intestinais, hepáticas e neuronais. Revista Captar: Ciência e Ambiente para Todos, 10, 4-4. https://proa.ua.pt/index.php/captar/article/view/23950/18678.

Vilca-quispe, W., et al (2021). Residuos Biocontaminantes, otro Legado del COVID-19. Producción+ Limpia, 16(2), 197-211. http://www.scielo.org.co/pdf/pml/v16n2/1909-0455-pml-16-02-197.pdf.

Visalli, G., et al (2021). Acute and sub-chronic effects of microplastics (3 and 10 µm) on the human intestinal cells HT-29. International journal of environmental research and public health, 18(11), 5833. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198674/.

Wardrop, P., et al (2016). Chemical pollutants sorbed to ingested microbeads from personal care products accumulate in fish. Environmental science & technology, 50(7), 4037-4044. https://pubmed.ncbi.nlm.nih.gov/26963589/.Acessoem: 15 de novembro de 2022.

Walczak, A. P., et al (2015). Translocation of differently sized and charged polystyrene nanoparticles in in vitro intestinal cell models of increasing complexity. Nanotoxicology, 9(4), 453-461. https://pubmed.ncbi.nlm.nih.gov/25093449/.

W.h.o. Microplastics in drinking-water. .2019. https://www.who.int/publications-detail-redirect/9789241516198.

Wu, P., et al (2020). Consequential fate of bisphenol-attached PVC microplastics in water and simulated intestinal fluids. Environmental Science and Ecotechnology, 2, 100027. https://pubmed.ncbi.nlm.nih.gov/36160922/.

Xiong, X., et al (2018). Sources and distribution of microplastics in China's largest inland lake–Qinghai Lake. Environmental pollution, 235, 899-906. https://doi.org/10.1016/J.ENVPOL.2017.12.081.

Yang, D., et al (2022). Polystyrene micro-and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis. Environment International, 166, 107362. https://pubmed.ncbi.nlm.nih.gov/35749991/.

Yee, M. S. L., et al (2021). Impact of microplastics and nanoplastics on human health. Nanomaterials, 11(2), 496. https://www.mdpi.com/2079-4991/11/2/496.

Zettler, E. R., et al (2013). Life in the “plastisphere”: microbial communities on plastic marine debris. Environmental science & technology, 47(13), 7137-7146. https://pubs.acs.org/doi/abs/10.1021/es401288x.

Zhang, E., et al (2022). Association of zoonotic protozoan parasites with microplastics in seawater and implications for human and wildlife health. Scientific reports, 12(1), 1-11. https://doi.org/10.1038/s41598-022-10485-5.



How to Cite

BUGATTI, C.; ALMEIDA, K. C. de .; GUIMARÃES, M. S. de A. .; AMÂNCIO, N. de F. G. . Microplatistics and Nanoplastic and their relevance in human health: literature review. Research, Society and Development, [S. l.], v. 12, n. 1, p. e6712139302, 2023. DOI: 10.33448/rsd-v12i1.39302. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/39302. Acesso em: 3 feb. 2023.



Review Article