Use of platelet-rich fibrin (PRF) in dental surgical procedures




Platelet-rich fibrin; Tooth extraction; Regeneração.


The aim of this study is to evaluate the use and applicability of Platelet-rich Fibrin (PRF) in surgical procedures of exodontia. The methodology was to perform an integrative literature review that was developed in six phases, in which the guiding question was elaborated by means of the PICo strategy. Thus bibliographic searches were performed in the electronic portals PubMed, LILACS and Cochrane Library, with the keywords Platelet-Rich Fibrin, Extraction and Regeneration, in which 20 articles were selected for the development of this review. he PRF has been increasingly effective in its various applications, especially in soft tissue healing, post-exodontia, contributing to the healing time, morbidity and amount of analgesics needed to reduce pain. Given the above, it is clear that PRF has a high capacity for the stimulation and regeneration of the natural healing process of tissues at extraction sites. Recent findings indicate that PRP can be considered as an efficient, cost-effective and simple therapeutic support for extraction procedures. Furthermore, the use of PRF in surgical procedures for tooth extraction has been shown to be advantageous in terms of tissue healing and bone regeneration, as well as having an expressive role in reducing the risk of delay in the recovery of patients undergoing therapies with oral bisphosphonates. Improvements in the techniques used with PRF can be summed up, as well as further studies and clinical trials with larger samples may confirm the results discussed in this work.


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Malhotra, A., Kapur, I., Das, D., Sharma, A., Gupta, M., & Kumar, M. (2020). Comparative evaluation of bone regeneration with platelet-rich fibrin in mandibular third molar extraction socket: A randomized split-mouth study. National Journal of Maxillofacial Surgery, 11(2), 241.

Mourão, C. F. D. A. B., de Mello-Machado, R. C., Javid, K., & Moraschini, V. (2020). The use of leukocyte-and platelet-rich fibrin in the management of soft tissue healing and pain in post-extraction sockets: A randomized clinical trial. Journal of Cranio-Maxillofacial Surgery, 48(4), 452-457.

Tambella, A. M., Bartocetti, F., Rossi, G., Galosi, L., Catone, G., Falcone, A., & Vullo, C. (2020). Effects of autologous platelet-rich fibrin in post-extraction alveolar sockets: a randomized, controlled split-mouth trial in dogs with spontaneous periodontal disease. Animals, 10(8), 1343.

Sharma, A., Ingole, S., Deshpande, M., Ranadive, P., Sharma, S., Kazi, N., & Rajurkar, S. (2020). Influence of platelet-rich fibrin on wound healing and bone regeneration after tooth extraction: A clinical and radiographic study. Journal of oral biology and craniofacial research, 10(4), 385-390.

Sybil, D., Sawai, M., Faisal, M., Singh, S., & Jain, V. (2020). Platelet-rich fibrin for hard-and soft-tissue healing in mandibular third molar extraction socket. Annals of maxillofacial surgery, 10(1), 102.

Witek, L., Tian, H., Tovar, N., Torroni, A., Neiva, R., Gil, L. F., & Coelho, P. G. (2020). The effect of platelet‐rich fibrin exudate addition to porous poly (lactic‐co‐glycolic acid) scaffold in bone healing: An in vivo study. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108(4), 1304-1310.

Afat, I. M., Akdoğan, E. T., & Gönül, O. (2019). Effects of leukocyte-and platelet-rich fibrin alone and combined with hyaluronic acid on early soft tissue healing after surgical extraction of impacted mandibular third molars: A prospective clinical study. Journal of Cranio-Maxillofacial Surgery, 47(2), 280-286.

Areewong, K., Chantaramungkorn, M., & Khongkhunthian, P. (2019). Platelet‐rich fibrin to preserve alveolar bone sockets following tooth extraction: A randomized controlled trial. Clinical Implant Dentistry and Related Research, 21(6), 1156-1163.

Ritto, F. G., Pimentel, T., Canellas, J. V. S., Junger, B., Cruz, M., & Medeiros, P. J. (2019). Randomized double-blind clinical trial evaluation of bone healing after third molar surgery with the use of leukocyte-and platelet-rich fibrin. International journal of oral and maxillofacial surgery, 48(8), 1088-1093.

Ustaoğlu, G., Bulut, D. G., & Gümüş, K. Ç. (2020). Evaluation of different platelet-rich concentrates effects on early soft tissue healing and socket preservation after tooth extraction. Journal of Stomatology, Oral and Maxillofacial Surgery, 121(5), 539-544.

Asmael, H. M., Jamil, F. A., & Hasan, A. M. (2018). Novel application of platelet-rich fibrin as a wound healing enhancement in extraction sockets of patients who smoke. Journal of Craniofacial Surgery, 29(8), e794-e797.

Clark, D., Rajendran, Y., Paydar, S., Ho, S., Cox, D., Ryder, M., ... & Kao, R. T. (2018). Advanced platelet‐rich fibrin and freeze‐dried bone allograft for ridge preservation: a randomized controlled clinical trial. Journal of periodontology, 89(4), 379-387.

Daugela, P., Grimuta, V., Sakavicius, D., Jonaitis, J., & Juodzbalys, G. (2018). Influence of leukocyte-and platelet-rich fibrin (L-PRF) on the outcomes of impacted mandibular third molar removal surgery: A split-mouth randomized clinical trial. Quintessence International, 49(5).

Jeyaraj, P. E., & Chakranarayan, A. (2018). Soft tissue healing and bone regeneration of impacted mandibular third molar extraction sockets, following postoperative incorporation of platelet-rich fibrin. Annals of maxillofacial surgery, 8(1), 10.

Kapse, S., Surana, S., Satish, M., Hussain, S. E., Vyas, S., & Thakur, D. (2019). Autologous platelet-rich fibrin: can it secure a better healing?. Oral surgery, oral medicine, oral pathology and oral radiology, 127(1), 8-18.

Unsal, H., & Erbasar, G. N. H. (2018). Evaluation of the effect of platelet-rich fibrin on the alveolar osteitis incidence and periodontal probing depth after extracting partially erupted mandibular third molars extraction. Nigerian journal of clinical practice, 21(2), 201-205.

Asaka, T., Ohga, N., Yamazaki, Y., Sato, J., Satoh, C., & Kitagawa, Y. (2017). Platelet-rich fibrin may reduce the risk of delayed recovery in tooth-extracted patients undergoing oral bisphosphonate therapy: a trial study. Clinical oral investigations, 21(7), 2165-2172.

Asutay, F., Yolcu, Ü. M. İ. T., Geçör, O., Acar, A. H., Öztürk, S. A., & Malkoç, S. (2017). An evaluation of effects of platelet‑rich‑fibrin on postoperative morbidities after lower third molar surgery. Nigerian journal of clinical practice, 20(12), 1531-1536.

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How to Cite

ARAÚJO, A. M.; MESQUITA, K. B. N. de .; AZEVEDO, M. W. C. de .; RIBEIRO, E. G. M.; BRÍGIDO, K. G. R.; BRÍGIDO, J. A. . Use of platelet-rich fibrin (PRF) in dental surgical procedures. Research, Society and Development, [S. l.], v. 12, n. 2, p. e2512239811, 2023. DOI: 10.33448/rsd-v12i2.39811. Disponível em: Acesso em: 7 jun. 2023.



Review Article