The threshold between pharmacy and food: Microencapsulation of vitamin B12 for enrichment of plant-based foods

Authors

DOI:

https://doi.org/10.33448/rsd-v12i3.40354

Keywords:

Pharmacokinetics; Absorption; Microtechnology; Fortified Foods; Cobamides; Drug liberation.

Abstract

Vitamin B12 is a micronutrient not synthesized by the human body, in which it is of fundamental importance in reactions essential to the formation of new tissues in the body. Found primarily in animal foods, vegetarians and vegans are susceptible to this micronutrient deficiency. Thus, the consumption of vitamin B12 via fortified foods favors accessibility for this public. Vitamin B12 deficiency is reported worldwide and can cause hematological, neurological and cardiovascular disorders, and microencapsulation of the vitamin with prospective applications in food may provide a solution to this problem. The present study aimed to evaluate the viability of microencapsulation of vitamin B12 by spray drying for enrichment of plant-based foods through online and printed bibliographic routes, in the time lapse 1998 to 2023, using descriptors such as: “Vitamin B12”, “Microencapsulation”, “Vegetarian”, “Food Plant-Based”, extracted from several databases such as: Science Direct, Scielo and PubMed, through qualitative content analysis. Thus, it was observed that the isolated subjects that support the hypothesis are well developed and indicate the viability of the proposed objective, but when the search is narrowed, the content is scarce, suggesting too much relevance for this work.

References

Aditya, N. P., & Ko, S. (2015). Solid lipid nanoparticles (SLNs): delivery vehicles for food bioactives. RSC Advances, 5(39), 30902–30911. https://doi.org/10.1039/c4ra17127f

Araújo, C. d. S., Vimercati, W. C., Macedo, L. L., Saraiva, S. H., Teixeira, L. J. Q., da Costa, J. M. G., & Pimenta, C. J. (2022). Encapsulation of phenolic and antioxidant compounds from spent coffee grounds using spray‐drying and freeze‐drying and characterization of dried powders. Journal of Food Science. https://doi.org/10.1111/1750-3841.16281

Aschemann-Witzel, J., Gantriis, R. F., Fraga, P., & Perez-Cueto, F. J. A. (2020). Plant-based food and protein trend from a business perspective: markets, consumers, and the challenges and opportunities in the future. Critical Reviews in Food Science and Nutrition, 1–10. https://doi.org/10.1080/10408398.2020.1793730

Atilgan, M. R., & Bayraktar, O. (2020). Utilization of Natural Compounds. Journal of Food Processing and Preservation. https://doi.org/10.1111/jfpp.15197

Bajaj, S. R., Marathe, S. J., & Singhal, R. S. (2021). Co-encapsulation of vitamins B12 and D3 using spray drying: Wall material optimization, product characterization, and release kinetics. Food Chemistry, 335, 127642. https://doi.org/10.1016/j.foodchem.2020.127642

Bernardo, W. M., Nobre, M. R. C., & Jatene, F. B. (2004). A prática clínica baseada em evidências: parte II - buscando as evidências em fontes de informação. Revista da Associação Médica Brasileira, 50(1), 104–108. https://doi.org/10.1590/s0104-42302004000100045

Bizerra, A.; Silva, V. (2016). Sistemas de liberação controlada: Mecanismos e aplicações. Revista Saúde e Meio Ambiente, 3(2), 1-12.

Brasil. (2022). Alimentos plantbased: Relatório das oficinas virtuais para identificação do problema regulatório e dos agentes afetados. ANVISA. 1-12.

Brasil. Instrução Normativa n° 28 (2018). Estabelece as listas de constituintes, de limites de uso, de alegações e de rotulagem complementar dos suplementos alimentares. Diário Oficial da União. 1-48.

Brasil. Portaria no 1.122 (2020). Define as prioridades, no âmbito do Ministério da Ciência, Tecnologia, Inovações e Comunicações (MCTIC), no que se refere a projetos de pesquisa, de desenvolvimento de tecnologias e inovações, para o período 2020 a 2023. Diário Oficial da União. 1-3.

Caregnato, R. C. A., & Mutti, R. (2006). Pesquisa qualitativa: análise de discurso versus análise de conteúdo. Texto & Contexto - Enfermagem, 15(4), 679–684. https://doi.org/10.1590/s0104-07072006000400017

Correia L. F., Faraoni A. S. & Pinheiro-Sant’ana H. M. (2018). Effects of industrial foods processing on vitamins stability. Alim Nutr, 83-95.

Couceiro, P., Slywitch, E., & Lenz, F. (2008). Padrão alimentar da dieta vegetariana. Einstein, 6(3), 365-373.

Del Bo’, C., Riso, P., Gardana, C., Brusamolino, A., Battezzati, A., & Ciappellano, S. (2019). Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: A randomized controlled trial. Clinical Nutrition, 38(2), 575–583. https://doi.org/10.1016/j.clnu.2018.02.008

Demartini, E., Vecchiato, D., Finos, L., Mattavelli, S., & Gaviglio, A. (2022). Would you buy vegan meatballs? The policy issues around vegan and meat-sounding labelling of plant-based meat alternatives. Food Policy, 111, 102310. https://doi.org/10.1016/j.foodpol.2022.102310

Dhakal, S. P., & He, J. (2020). Microencapsulation of vitamins in food applications to prevent losses in processing and storage: A review. Food Research International, 109326. https://doi.org/10.1016/j.foodres.2020.109326

Estevinho, B. N., Carlan, I., Blaga, A., & Rocha, F. (2016). Soluble vitamins (vitamin B12 and vitamin C) microencapsulated with different biopolymers by a spray drying process. Powder Technology, 71–78. https://doi.org/10.1016/j.powtec.2015.11.019

Estevinho, B. N., Mota, R., Leite, J. P., Tamagnini, P., Gales, L., & Rocha, F. (2019). Application of a cyanobacterial extracellular polymeric substance in the microencapsulation of vitamin B12. Powder Technology, 343, 644–651. https://doi.org/10.1016/j.powtec.2018.11.079

Fennema, O. R; Damodaran, S, Parkin, K. L. (2010). Química Alimentar de Fennema. (4ª ed.). Artmed, 399-401.

Ferrigno, M. (2012). Veganismo e Libertação Animal: um estudo etnográfico. Dissertação (Mestrado), UEC. 1-294.

Giuntini, E. B.; Franco, M. (2005). Tabela brasileira de composição de alimentos (TBCA). USP.

Gonçalves, A., Estevinho, B. N., & Rocha, F. (2016). Microencapsulation of vitamin A: A review. Trends in Food Science & Technology, 51, 76–87. https://doi.org/10.1016/j.tifs.2016.03.001

González-Montaña, J.-R., Escalera-Valente, F., Alonso, A. J., Lomillos, J. M., Robles, R., & Alonso, M. E. (2020). Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update. Animals, 10(10), 1855. https://doi.org/10.3390/ani10101855

Green, R. (2013). Vitamin B12: Physiology, Dietary Sources, and Requirements. Encyclopedia of Human Nutrition, 351–356. doi:10.1016/b978-0-12-375083-9.00056-8

Gregório, J. F. (2008). Vitaminas. In: Química de alimentos de Fennema (4ª ed.). CRC Press.

Labuschagne, P. (2018). Impact of wall material physicochemical characteristics on the stability of encapsulated phytochemicals: A review. Food Research International, 107, 227–247. https://doi.org/10.1016/j.foodres.2018.02.026

Li, Y. O., González, V. P. D., & Diosady, L. L. (2014). Microencapsulation of Vitamins, Minerals, and Nutraceuticals for Food Applications. In Microencapsulation in the Food Industry, 501–522. https://doi.org/10.1016/b978-0-12-404568-2.00038-8

Li, Y. O., González, V. P. D., & Diosady, L. L. (2023). Microencapsulation of vitamins, minerals, and nutraceuticals for food applications. In Microencapsulation in the Food Industry, 507–528. https://doi.org/10.1016/b978-0-12-821683-5.00027-3

Li, B. L., Zhang, J., Jin, W., Chen, X.-Y., Yang, J.-M., Chi, S.-M., Ruan, Q., & Zhao, Y. (2022). Oral administration of pH-responsive polyamine modified cyclodextrin nanoparticles for controlled release of anti-tumor drugs. Reactive and Functional Polymers, 172, 105175. https://doi.org/10.1016/j.reactfunctpolym.2022.105175

Lima, M.; Costa, R.; Lameiras, J.; Botelho, G. (2021). Alimentação à base de plantas: uma revisão narrativa. Acta Portuguesa de Nutrição, 1(26), 1-7. http://dx.doi.org/10.21011/apn.2021.2607.

Lopes, S. C., Gadelha, D. D., Carvalho, M. D. d., Fernandes, V. O., & Montenegro Junior, R. M. (2019). Vitamin B12 deficiency: metabolic effects, clinical evaluation, and treatment. Revista de Medicina da UFC, 59(2), 40. https://doi.org/10.20513/2447-6595.2019v59n2p40-49

Maciel Neto, P., Nascimento, C. P. F., Zambelli, R. A., & Eça, K. S. (2020). Alimentos plant-based: estudo dos critérios de escolha do consumidor. Research, Society and Development, 9(7), Artigo e984974980. https://doi.org/10.33448/rsd-v9i7.4980

Martens, H. Barg, M. Warren, D. Jah, J. H. (2002). Microbial production of vitamin B 12. Applied Microbiology and Biotechnology, 58(3), 275–285. https://doi.org/10.1007/s00253-001-0902-7

Masters, K. (1985). Manual de secagem por pulverização. George Godwin Ltd., (4a ed.). 1- 696.

Mazzocato, M. C.; Trindade, C. S. F. (2016). Caracterização de micropartículas lipídicas sólidas carregadas com vitamina B12 e produzidas pela técnica de spray chilling. sbCTA-RS.

Monteiro, D. S.; Gianezini, M. (2021). Alimentos à base de plantas: revisão bibliométrica sobre produtos alternativos à carne. Seminário de Ciências Sociais Aplicadas, 7(7)1–3.

Naddaf, L.; Avalo, B.; Oliveros, M. (2012). Spray-dried natural orange juice encapsulants using maltodextrin and gum arabic. Revista Técnica Ingeniería Universidad del Zulia, 1(35), 20-27.

Nair, M. K. (2011). Metabolism of iron, folic acid and vitamin B12. Public Health In Developing Countries, 607-637. http://dx.doi.org/10.1533/9780857093905.607.

Nascimento Filho, E. d., Barroca Silva, N. N., Converti, A., Ferreira Grosso, C. R., Pinheiro Santos, A. M., Silva Ribeiro, D., & Maciel, M. I. S. (2022). MICROENCAPSULATION OF ACEROLA (Malpighia emarginata DC) AND CIRIGUELA (Spondias purpurea L) MIXED JUICE WITH DIFFERENT WALL MATERIALS. Food Chemistry Advances, 100046. https://doi.org/10.1016/j.focha.2022.100046

Oliveira, O. W., & Petrovick, P. R. (2010). Secagem por aspersão (spray drying) de extratos vegetais: bases e aplicações. Revista Brasileira de Farmacognosia, 20(4), 641–650. https://doi.org/10.1590/s0102-695x2010000400026

Padovani, R. M., Amaya-Farfán, J., Colugnati, F. A. B., Domene, S. M. A. (2006). Dietary reference intakes: application of tables in nutritional studies. Revista Nutrição, 19(6), 741-760.

Paniz, C., Grotto, D., Schmitt, G. C., Valentini, J., Schott, K. L., Pomblum, V. J., & Garcia, S. C. (2005). Fisiopatologia da deficiência de vitamina B12 e seu diagnóstico laboratorial. Jornal Brasileiro de Patologia e Medicina Laboratorial, 41(5). https://doi.org/10.1590/s1676-24442005000500007

Pereira, K. C., Ferreira, D. C. M., Alvarenga, G. F., Pereira, M. S. S., Barcelos, M. C. S., & Costa, J. M. G. d. (2018). Microencapsulação e liberação controlada por difusão de ingredientes alimentícios produzidos através da secagem por atomização: revisão. Brazilian Journal of Food Technology, 21. https://doi.org/10.1590/1981-6723.08317

Ribeiro, A. M., Shahgol, M., Estevinho, B. N., & Rocha, F. (2020). Microencapsulation of Vitamin A by spray-drying, using binary and ternary blends of gum arabic, starch and maltodextrin. Food Hydrocolloids, 108, 106029. https://doi.org/10.1016/j.foodhyd.2020.106029.

Ribeiro, L. S. (2010). Dieta vegetariana: o que falta saber sobre o papel do selénio na proteção contra doenças?. Mérito acadêmico do Centro Vegetariano, 1-2.

Rigon, R. T., & Zapata Noreña, C. P. (2015). Microencapsulation by spray-drying of bioactive compounds extracted from blackberry (rubus fruticosus). Journal of Food Science and Technology, 53(3), 1515–1524. https://doi.org/10.1007/s13197-015-2111-x

Rojas, M. L., Alvim, I. D., & Augusto, P. E. D. (2019). Incorporation of microencapsulated hydrophilic and lipophilic nutrients into foods by using ultrasound as a pre-treatment for drying: A prospective study. Ultrasonics Sonochemistry, 153–161. https://doi.org/10.1016/j.ultsonch.2019.02.004.

Sadler, M. J. (2004). Alternativas à carne - evolução do mercado e benefícios para a saúde. Tendências em Alimentos Ciência e Tecnologia, 5(15), 250–260.

Salvim, M. O., Thomazini, M., Pelaquim, F. P., Urbano, A., Moraes, I. C. F., & Favaro-Trindade, C. S. (2015). Production and structural characterization of solid lipid microparticles loaded with soybean protein hydrolysate. Food Research International, 76, 689–696. https://doi.org/10.1016/j.foodres.2015.08.003

Santos, M. B. de Carvalho, C. W. P., & Garcia-Rojas, E. E. (2021). Microencapsulation of vitamin D3 by complex coacervation using carboxymethyl tara gum (Caesalpinia spinosa) and gelatin A. Food Chemistry, 128529. https://doi.org/10.1016/j.foodchem.2020.128529.

Santos, F. H. d., Silveira, B. M. P. e., Souza, L. L. d., Duarte, A. K. C., Ribeiro, M. C., Pereira, K. C., & Costa, J. M. G. d. (2020). Influence of wall materials on the microencapsulation of pequi oil by spray drying. Brazilian Journal of Food Technology, 23. https://doi.org/10.1590/1981-6723.13219

Suave, J.; Dall’agnol, E. C.; Pezzin, A. P. T.; Silva, D. A. K.; Meier, M. M.; Soldi, V. (2006). Microencapsulação: Inovação em diferentes áreas. Health and Environment Journal, 2(7)1-9.

Sucupira, N. R.; Xerez, A. C. P.; De Sousa, P. H. M. (2012). Perdas vitamínicas durante o tratamento térmico de alimentos. Journal of Health Sciences, 2(14), 1-8.

Tamnak, S., Mirhosseini, H., Tan, C. P., Ghazali, H. M., & Muhammad, K. (2016). Physicochemical properties, rheological behavior and morphology of pectin-pea protein isolate mixtures and conjugates in aqueous system and oil in water emulsion. Food Hydrocolloids, 56, 405–416. https://doi.org/10.1016/j.foodhyd.2015.12.033

Taufik, D., Bouwman, E. P., Reinders, M. J., & Dagevos, H. (2022). A reversal of defaults: Implementing a menu-based default nudge to promote out-of-home consumer adoption of plant-based meat alternatives. Appetite, 106049. https://doi.org/10.1016/j.appet.2022.106049

Thame, G., Shinohara, E. M. G., Santos, H. G. d., & Moron, A. F. (1998). Folato, vitamina B12 e ferritina sérica e defeitos do tubo neural. Revista Brasileira de Ginecologia e Obstetrícia, 20(8), 449–453. https://doi.org/10.1590/s0100-72031998000800004

Tucker, K. L., Rich, S., Rosenberg, I., Jacques, P., Dallal, G., Wilson, P. W., & Selhub, J. (2000). Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study. The American Journal of Clinical Nutrition, 71(2), 514–522. https://doi.org/10.1093/ajcn/71.2.514

Viana, A. d. S. T., Santos, L. S. d., Pasqualotto, M. F., Ferreira, T. R. L., & Placido, G. R. (2022). Você sabia que a falta de vitamina B12 pode desencadear doenças neurológicas? Research, Society and Development, 11(3), Artigo e43311326712. https://doi.org/10.33448/rsd-v11i3.26712

Willett, W., Rockström, J., Loken, B., Springmann, M., Lang, T., Vermeulen, S., Garnett, T., Tilman, D., DeClerck, F., Wood, A., Jonell, M., Clark, M., Gordon, L. J., Fanzo, J., Hawkes, C., Zurayk, R., Rivera, J. A., De Vries, W., Majele Sibanda, L., ... Murray, C. J. L. (2019). Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems. The Lancet, 393(10170), 447–492. https://doi.org/10.1016/s0140-6736(18)31788-4

Williamson, M. A., & Snyder, L. M. (2016). Interpretação de exames laboratoriais (10a ed.). Guanabara Koogan. 1086-1087.

Yellepeddi, V. (2018). Princípios da terapia farmacológica – Farmacocinética. Manual de farmacologia e Terapeutica de Goodman e Gilman (2ª ed.), 1-1216.

Published

17/02/2023

How to Cite

LIMA, N. G. .; LIMA, G. N. .; ABREU, V. G. da C. .; COSTA, J. M. G. da . The threshold between pharmacy and food: Microencapsulation of vitamin B12 for enrichment of plant-based foods. Research, Society and Development, [S. l.], v. 12, n. 3, p. e1912340354, 2023. DOI: 10.33448/rsd-v12i3.40354. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40354. Acesso em: 8 may. 2024.

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Review Article