Development of a Y-incompatibility guide for intravenous drugs in a University Hospital in Sergipe
DOI:
https://doi.org/10.33448/rsd-v12i3.40717Keywords:
Drug Utilization; Drug Incompatibility; Patient safety.Abstract
The present study aims to describe the development of a practical guide on compatibility between drugs administered in Y. This is a descriptive study of the experience report type, which was developed in the period from March to August 2022 at the University Hospital of Lagarto (HUL), based on the survey of standardized intravenous drugs in the hospital. For the development of the instrument, a narrative bibliographical review was desenvolved and consultations with guides and manuals were published by other specialized hospital units and medicine package inserts. The drugs that had incompatibilities were listed in a table, as well as those that did not present information from compatibility tests. After a careful review of the standardized items in the HUL, 123 drugs were selected to compose the Y-incompatibility guide, because they represent those with intravenous administration. The guide was structured based on the standard model of materials produced by the HUL Hospital Pharmacy Sector. For drugs with insufficient data in the literature, warnings about few tests, no tests, and mixtures with other drugs are not indicated or no information was found in the references, as appropriate. The drugs that had more data in the literature about incompatibilities were phenytoin and diazepam. With this work, it was possible to demonstrate the importance of research focusing on strategies that minimize the potential damage caused by drug incompatibility.
References
Abdelkader, A., Fathi, H. A., Hamad, M. A., & Elsabahy, M. (2020). Nanomedicine: a new paradigm to overcome drug incompatibilities. Journal of Pharmacy and Pharmacology, 72(10), 1289–1305. https://doi.org/10.1111/jphp.13292
Benlabed, M., Perez, M., Gaudy, R., Genay, S., Lannoy, D., Barthélémy, C., Odou, P., Lebuffe, G., & Décaudin, B. (2019). Clinical implications of intravenous drug incompatibilities in critically ill patients. Anaesthesia Critical Care & Pain Medicine, 38(2), 173–180. https://doi.org/10.1016/j.accpm.2018.04.003
Brasil. (2013). Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Anexo 03: Protocolo de segurança na prescrição, uso e administração de medicamentos. Brasília, 2013. https://www.hospitalsantalucinda.com.br/downloads/prot_meficamentos.pdf.
Cardoso, D. S., Matos, L. E. O., Barros, I. M. da C., Lisboa, J. S., Fernandes, S. S. S., & Lima, T. C. (2022). Desenvolvimento de um protocolo de inibidor de bomba de prótons na profilaxia de lesão aguda de mucosa gástrica: relato de experiência. Research, Society and Development, 11(8), e25211830865. https://doi.org/10.33448/rsd-v11i8.30865.
Castells Lao, G., Rodríguez Reyes, M., Roura Turet, J., Prat Dot, M., Soy Muner, D., & López Cabezas, C. (2020). Compatibilidad de los fármacos administrados en «Y» en las unidades de cuidados intensivos: revisión sistemática. Medicina Intensiva, 44(2), 80–87. https://doi.org/10.1016/j.medin.2018.08.004
Castro, M. da S., Camerini, F. G., Henrique, D. de M., Marins, A. L. C., & Fassarella, C. S. (2021). Análise das incompatibilidades medicamentosas em uma unidade cardiointensiva: estudo transversal. Enfermería Global, 20(2), 65–108. https://doi.org/10.6018/eglobal.438931
Correia, G. B., & Batista, A. M. (2021). Levantamento de informações para elaboração de guia de estabilidade de medicamentos injetáveis pós reconstituição e diluição em hospital materno-infantil. Infarma - Ciências Farmacêuticas, 33(1), 81–85. https://doi.org/10.14450/2318-9312.v33.e1.a2021.pp81-85.
Freitas, G. R. De, Vieira-De-Melo, J. Í., & Pessanha, C. M. (2022). Erros na administração de medicamentos pela via parenteral: um convite à reflexão. Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, 13(4), 881. https://doi.org/10.30968/rbfhss.2022.134.0881.
Garcia, J. H., Crespo, J. C. L., Handa, A. Y., Padilha, K. G., & Secoli, S. R. (2021). In(compatibility) of intravenous drugs in critical units: adult cohort. Revista Brasileira de Enfermagem, 74(2), e20200501. https://doi.org/10.1590/0034-7167-2020-0501
Leal, K. D. B., Leopoldino, R. W. D., Martins, R. R., & Veríssimo, L. M. (2016). Potencial de Incompatibilidade de Medicamentos Intravenosos em uma Unidade Pediátrica. Einstein. 14(2), 185-189. https://doi.org/10.1590/S1679-45082016AO3723.
Leopoldino, R. W., Costa, H. T., Costa, T. X., Martins, R. R., & Oliveira, A. G. (2018). Potential drug incompatibilities in the neonatal intensive care unit: a network analysis approach. BMC Pharmacology and Toxicology, 19(1), 83. https://doi.org/10.1186/s40360-018-0265-7
Madrigal-Cadavid, J., & Amariles, P. (2017). Incompatibilidad de medicamentos intravenosos: revisión estructuradaurada. Ces Medicina, 31(1), 58–69. https://doi.org/10.21615/cesmedicina.31.1.6
Maison, O., Tardy, C., Cabelguenne, D., Parat, S., Ducastelle, S., Piriou, V., Lepape, A., & Lalande, L. (2019). Drug incompatibilities in intravenous therapy: evaluation and proposition of preventive tools in intensive care and hematology units. European Journal of Clinical Pharmacology, 75(2), 179–187. https://doi.org/10.1007/s00228-018-2602-6
Marsilio, N. R., da Silva, D., & Bueno, D. (2016). Drug incompatibilities in the adult intensive care unit of a university hospital. Revista Brasileira de Terapia Intensiva, 28(2), 147–153. https://doi.org/10.5935/0103-507X.20160029
Mendes, J. R., Lopes, M. C. B. T., Vancini-Campanharo, C. R., Okuno, M. F. P., & Batista, R. E. A. (2018). Types and frequency of errors in the preparation and administration of drugs. Einstein (Sao Paulo, Brazil), 16(3), eAO4146. https://doi.org/10.1590/S1679-45082018AO4146
Moraes, R. S. de, & Almeida, O. A. E. de. (2021). Tecnologia para preparo e administração de medicamentos injetáveis usados no contexto hospitalar: contribuições da enfermagem. Enfermagem Em Foco, 12(7.SUPL.1), 158–162. https://doi.org/10.21675/2357-707X.2021.v12.n7.SUPL.1.5207
Moraes, K. D., Gomes, I. V., Lima, O. P., Reis, R. L., Souza, M. N., Freire, N. D., Barros, J. F., Medeiros, F. S., & Nunes, D. M. (2021). Analysis of drug compatibility in Y in intravenous therapy: preparation of a preventive tool for a university hospital in Petrolina – PE. Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, 12(1), 521. https://doi.org/10.30968/rbfhss.2021.121.0521
Nezvalova-Henriksen, K., Holm, T. H., Nilsson, N., Kjønniksen, I., & Tho, I. (2022). Frequently acquired drugs in neonatal intensive care and their physical compatibility. Acta Paediatrica, International Journal of Paediatrics, 111(12), 2307–2314. https://doi.org/10.1111/apa.16526
Paes, G. O., Moreira, S. O., Moreira, M. B., & Martins, T. G. (2017). Incompatibilidade medicamentosa em terapia intensiva: revisão sobre as implicações para a prática de enfermagem. Revista Eletrônica de Enfermagem, 19. https://doi.org/10.5216/ree.v19.38718
Paixão, F. M. da, Camerini, F. G., Fassarella, C. S., Henrique, D. de M., & Castro, M. da S. (2020). Gravidade clínica das incompatibilidades medicamentosas em pacientes críticos. Research, Society and Development, 9(6), e177963533. https://doi.org/10.33448/rsd-v9i6.3533
Paixão, F. M., Camerini, F. G., Fassarella, C. S., Henrique, D. de M., Assad, L. G., & Radighieri, A. R. (2019). Gravidade das incompatibilidades medicamentosas em pacientes críticos: Uma revisão integrativa. Saúde Coletiva (Barueri), 9(51), 1907–1912. https://doi.org/10.36489/saudecoletiva.2019v9i51p1907-1912
Pereira, C. S. (2018). Desenvolvimento de tabela de diluição para medicamentos antimicrobianos injetáveis: uma estratégia para o uso racional em pediatria. Academus Revista Científica Da Saúde, 3(1), 60–75. https://doi.org/10.24118/reva1806.9495.3.1.2018.384.
Perez, M., Maiguy-Foinard, A., Barthélémy, C., Décaudin, B., & Odou, P. (2016). Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients. Pharmaceutical Technology in Hospital Pharmacy, 1(2), 91–103. https://doi.org/10.1515/pthp-2016-0004
Prelhacoski, D., Silva, D. M., & Comarella, L. (2014). Incompatibilidade Medicamentosa em Unidade de Terapia Intensiva Pediátrica. Rev. Uniandrade. 16(2), 73-81. http://dx.doi.org/10.18024/1519-5694/revuniandrade.v16n2p73-81.
Rojas Marín, M. Z., Castillo Penagos, C. D., Orduz Diaz, Y. D., & Segura Suárez, M. A. (2021). Estrategias para la prevención de errores en la administración de medicamentos intravenosos. Investigación En Enfermería: Imagen y Desarrollo, 23. https://doi.org/10.11144/javeriana.ie23.epea.
Sriram, S., Aishwarya, S., Moithu, A., Sebastian, A., & Kumar, A. (2020). Intravenous drug incompatibilities in the intensive care unit of a tertiary care hospital in India: Are they preventable? Journal of Research in Pharmacy Practice, 9(2), 106. https://doi.org/10.4103/jrpp.JRPP_20_11
Trissel, L. A. (2013). Handbook on injectable drugs. 17th ed. Maryland: American Society of Health-System Pharmacists; 2013. (Livro)
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Gilvaneza Piedade Santos; Izadora Menezes da Cunha Barros; Damaris Santana Cardoso; Luiz Eduardo Oliveira Matos; Thaisa Calumby Lima; Mayra Auxiliadora Teixeira de Jesus Valença; Júlia Santana Lisboa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
