The pathogenesis of disseminated intravascular coagulation and the role of microparticles and tissue factor in acute promyelocytic leukemia

Authors

DOI:

https://doi.org/10.33448/rsd-v12i3.40757

Keywords:

Acute promyelocytic leukemia; Disseminated intravascular coagulation; Hypogranular promyelocytic leukemia; Hypergranular promyelocytic leukemia; Tissue factor; Microparticles.

Abstract

Objective: To perform an integrative review of the literature in order to raise data that clarify the pathogenesis of Disseminated Intravascular Coagulation (DIC) and the role of microparticles and tissue factor in Acute Promyelocytic Leukemia (APL). Method: This study is an integrative literature review that is based on the search of articles in databases, Pub Med, Science Direct, Scielo, journals and websites, with the following descriptors in "Acute Promyelocytic Leukemia", "Disseminated Intravascular Coagulation", "Hypogranular Promyelocytic Leukemia", "Hypergranular Promyelocytic Leukemia", "Microparticles", "Tissue Factor", using articles of original research between the years 2002 to 2022. This literature survey was conducted in the period from 02/01/2022 to 12/23/2022. Results: From a total of 137 articles identified, the following were excluded: 57 for not fitting the inclusion criteria, 32 by title analysis, and 14 by abstract analysis. Thirty-four articles remained that were analyzed in their entirety, of which 29 were excluded, thus, only 5 were included in the study. Discussion: The analysis of the studies selected in the review shows that the relationship between the pathophysiology of coagulopathy associated with ALI is complex, and the main mechanism is mediated by specific properties of the leukemic cell itself, which releases several mediators capable of activating the VSD. Conclusion: It is concluded that the CIVD that occurs in ALI patients is due to the activation of hemostasis by microparticles that carry tissue factor and are present in the promyelocytes. This understanding is critical to establishing effective treatment protocols.

Author Biography

Railson Henneberg, Universidade Federal do Paraná

Possui graduação em Farmácia e Bioquímica pela Universidade Estadual de Ponta Grossa (1996), mestrado em pela Universidade Estadual Paulista Júlio de Mesquita Filho (2003) e doutorado em Ciências Farmacêuticas pela Universidade Federal do Paraná (2013). Atualmente é professor associado 1 da Universidade Federal do Paraná. Tem experiência na área de Bioquímica, com ênfase em Anemias, atuando principalmente nos seguintes temas: anemias, hematologia, parasitoses, medicamentos e saúde do servidor.

References

Almeida, S. C. (2015). Leucemia Promielocítica Aguda: clínica, diagnóstico e abordagem terapêutica. https://estudogeral.uc.pt/bitstream/10316/36531/1/Tese de Mestrado LPA - final.pdf

Arbuthnot, C., & Wilde, J. T. (2006). Haemostatic problems in acute promyelocytic leukaemia. Blood Reviews, 20(6), 289–297. https://doi.org/10.1016/j.blre.2006.04.001

Breen, K. A., Grimwade, D., & Hunt, B. J. (2012). The pathogenesis and management of the coagulopathy of acute promyelocytic leukaemia. British Journal of Haematology, 156(1), 24–36. https://doi.org/10.1111/j.1365-2141.2011.08922.x

Elshazzly, M. E., Hammo, B., & Buhtoiarov, I. N. (2021). A Case of Subacute Brain Hemorrhage and Disseminated Intravascular Coagulation Secondary to Acute Promyelocytic Leukemia in a Pediatric Patient. Cureus, 13(5). https://doi.org/10.7759/cureus.14922

Falanga, A. (2017). Predicting APL lethal bleeding in the ATRA era. Blood, 129(13), 1739–1740. https://doi.org/10.1182/blood-2017-02-763490

Gheldof, D., Chatelain, C., Dogné, J.-M., & Mullier, F. (2014). Microparticle-associated tissue factor activity and overt disseminated intravascular coagulation in patients with acute myelocytic leukemia. Thrombosis Research, 134(1), 213–214. https://doi.org/10.1016/j.thromres.2014.05.001

Gurnari, C., Voso, M. T., Girardi, K., Mastronuzzi, A., & Strocchio, L. (2021). Acute Promyelocytic Leukemia in Children: A Model of Precision Medicine and Chemotherapy-Free Therapy. International Journal of Molecular Sciences, 22(2), 642. https://doi.org/10.3390/ijms22020642

Haferlach, T., Kohlmann, A., Schnittger, S., Dugas, M., Hiddemann, W., Kern, W., & Schoch, C. (2005). AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes. Genes, Chromosomes and Cancer, 43(2), 113–127. https://doi.org/10.1002/gcc.20175

Hey, A. C., Azambuja, A. P., Schluga, Y. C., Nunes, E. C., Bendlin, R. M., & Jamur, V. R. (2019). Acute promyelocytic leukemia: evaluation of diagnostic tests from 2000 to 2018 in a public hospital. Jornal Brasileiro de Patologia e Medicina Laboratorial, 55(6), 580–597. https://doi.org/10.5935/1676-2444.20190052

Ikezoe, T. (2014). Pathogenesis of disseminated intravascular coagulation in patients with acute promyelocytic leukemia, and its treatment using recombinant human soluble thrombomodulin. International Journal of Hematology, 100(1), 27–37. https://doi.org/10.1007/s12185-013-1463-0

Jácomo, R. H., Figueiredo-Pontes, L. L. de, & Rego, E. M. (2008). Do paradigma molecular ao impacto no prognóstico: uma visão da leucemia promielocítica aguda. Revista Da Associação Médica Brasileira, 54(1), 82–89. https://doi.org/10.1590/S0104-42302008000100026

Langer, F., Spath, B., Haubold, K., Holstein, K., Marx, G., Wierecky, J., Brümmendorf, T. H., Dierlamm, J., Bokemeyer, C., & Eifrig, B. (2008). Tissue factor procoagulant activity of plasma microparticles in patients with cancer-associated disseminated intravascular coagulation. Annals of Hematology, 87(6), 451–457. https://doi.org/10.1007/s00277-008-0446-3

Leal, A. M., Kumeda, C. A., & Velloso, E. D. R. P. (2009). Características genéticas da leucemia promielocítica aguda de novo. Revista Brasileira de Hematologia e Hemoterapia, 31(6), 454–462. https://doi.org/10.1590/S1516-84842009005000088

Levi, M., & Sivapalaratnam, S. (2018). Disseminated intravascular coagulation: an update on pathogenesis and diagnosis. Expert Review of Hematology, 11(8), 663–672. https://doi.org/10.1080/17474086.2018.1500173

Levi, M., & van der Poll, T. (2014). A Short Contemporary History of Disseminated Intravascular Coagulation. Seminars in Thrombosis and Hemostasis, 40(08), 874–880. https://doi.org/10.1055/s-0034-1395155

Liso, V., & Bennett, J. (2003). Morphological and cytochemical characteristics of leukaemic promyelocytes. Best Practice & Research Clinical Haematology, 16(3), 349–355. https://doi.org/10.1016/S1521-6926(03)00061-6

Ma, G., Liu, F., Lv, L., Gao, Y., & Su, Y. (2013). Increased promyelocytic-derived microparticles: a novel potential factor for coagulopathy in acute promyelocytic leukemia. Annals of Hematology, 92(5), 645–652. https://doi.org/10.1007/s00277-013-1676-6

Sagrillo, M. R., Cardoso, S. H., Silva, L. R. J., Graça, C. H. N., Ferreira, E., Hamerschlak, N., Guerra, J. C. C., Bacal, N. S., Andrade, J. A. D., & Borovik, C. L. (2005). Leucemia promielocítica aguda: caracterização de alterações cromossômicas por citogenética tradicional e molecular (FISH). Revista Brasileira de Hematologia e Hemoterapia, 27(2), 94–101. https://doi.org/10.1590/S1516-84842005000200008

Steffenello-durigon, G. (2014). leucemia promielocítica aguda: avaliação retrospectiva dos casos diagnosticados e tratados pelo serviço de hematologia do hospital universitário da universidade federal de santa catarina entre 2001 e 2013. 1 a 158. https://repositorio.ufsc.br/handle/123456789/128944

Stinghen, A. E. M., Gonçalves, S. M., Martines, E. G., Nakao, L. S., Riella, M. C., Aita, C. a., & Pecoits-Filho, R. (2009). Increased plasma and endothelial cell expression of chemokines and adhesion molecules in chronic kidney disease. Nephron - Clinical Practice, 111(2), 117–126. https://doi.org/10.1159/000191205

Tallman, M., Abutalib, S., & Altman, J. (2007). The Double Hazard of Thrombophilia and Bleeding in Acute Promyelocytic Leukemia. Seminars in Thrombosis and Hemostasis, 33(4), 330–338. https://doi.org/10.1055/s-2007-976168

Yilmaz, M., Kantarjian, H., & Ravandi, F. (2021). Acute promyelocytic leukemia current treatment algorithms. Blood Cancer Journal, 11(6), 123. https://doi.org/10.1038/s41408-021-00514-3

Zhao, H., Sun, J., Yan, L., Jin, B., Hou, W., Cao, F., Li, H., Zhou, J., & Zhang, Y. (2021). Tissue factor–bearing microparticles are a link between acute promyelocytic leukemia cells and coagulation activation: a human subject study. Annals of Hematology, 100(6), 1473–1483. https://doi.org/10.1007/s00277-021-04533-9

Zhang YM, Chen B, Wu LY, Hou JX, Fu JY. Role of Microparticles Derived from Acute Promyelocytic Leukemia Cells in Coagulopathy. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Jun;25(3):693-698. Chinese. doi: 10.7534/j.issn.1009-2137.2017.03.011. PMID: 28641620.

Zhou LL, Han Y, Zhu Q, Hu LP, Zhao SX, Zhu MQ, Dai L, Shen WH, Chen L, Wu DP. Detection of tissue factor-positive microparticles and its clinical significance in the haemostatic disorder. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Aug;20(4):937-40. Chinese. PMID: 22931659.

Zhou LL, Han Y, Zhu Q, Hu LP, Zhao SX, Zhu MQ, Dai L, Shen WH, Chen L, Wu DP. Detection of tissue factor-positive microparticles and its clinical significance in the haemostatic disorder. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Aug;20(4):937-40. Chinese. PMID: 22931659.

Published

20/03/2023

How to Cite

GABIATO, A. B. .; CARDOSO , M. R. .; GREGÓRIO, P. C.; HENNEBERG, R. . The pathogenesis of disseminated intravascular coagulation and the role of microparticles and tissue factor in acute promyelocytic leukemia. Research, Society and Development, [S. l.], v. 12, n. 3, p. e28412340757, 2023. DOI: 10.33448/rsd-v12i3.40757. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40757. Acesso em: 26 nov. 2024.

Issue

Section

Review Article