Botulinum toxin in the treatment of patients with myofascial pain: a scoping review
DOI:
https://doi.org/10.33448/rsd-v12i4.40996Keywords:
Temporomandibular Joint Dysfunction Syndrome; Botulinum Toxins, Type A; Myofascial pain syndromes.Abstract
Temporomandibular disorders (TMD) can be classified as alterations that affect the temporomandibular joint, the masticatory muscles, and associated structures, being divided into two large groups: TMD of muscular origin and joint origin, being those of muscular origin more frequent. Despite existing studies, the etiology and treatment of these alterations have not yet been fully clarified, and among the treatment modalities, the use of botulinum toxin type A (TXA) in myofascial pain, a TMD of muscular origin, has been discussed. This study aims to review the literature on the effectiveness of using TXA for the treatment of myofascial pain. A search was carried out in the PubMed and SciELO databases using the descriptors “Botulinum Toxin”, “Temporomandibular” and “Myofascial Pain”, from 2012 to 2022. One hundred sixty-seven articles were found, but only 11 met the established inclusion criteria. It was observed that the use of TXA for the treatment of myofascial pain proved to be, in most studies, equally effective when compared to other less invasive treatment methods, but there are still few studies on the subject, especially randomized controlled clinical trials. Therefore, more randomized controlled trials with high methodological rigor and long-term follow-up are needed to support the indication of TXA in the treatment of TMD-related myofascial pain.
References
Al-Moraissi, E. A., Farea, R., Qasem, K. A., Al-Wadeai, M. S., Al-Sabahi, M. E., & Al-Iryani, G. M. (2020). Effectiveness of occlusal splint therapy in the management of temporomandibular disorders: network meta-analysis of randomized controlled trials. International Journal of Oral and Maxillofacial Surgery, 49(8), 1042–1056. https://doi.org/10.1016/j.ijom.2020.01.004
Armijo-Olivo, S., Pitance, L., Singh, V., Neto, F., Thie, N., & Michelotti, A. (2016). Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis. Physical Therapy, 96(1), 9–25. https://doi.org/10.2522/ptj.20140548
Chaurand, J., Pacheco-Ruíz, L., Orozco-Saldívar, H., & López-Valdés, J. (2017). Efficacy of botulinum toxin therapy in treatment of myofascial pain. Journal of Oral Science, 59(3), 351–356. https://doi.org/10.2334/josnusd.16-0614
Costa, Y. M., Conti, P. C. R., de Faria, F. A. C., & Bonjardim, L. R. (2017). Temporomandibular disorders and painful comorbidities: clinical association and underlying mechanisms. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 123(3), 288–297. https://doi.org/10.1016/j.oooo.2016.12.005
de Barros Pascoal, A. L., de Freitas, R. F. C. P., da Silva, L. F. G., Oliveira, A. G. R. C., & Dos Santos Calderon, P. (2020). Effectiveness of Counseling on Chronic Pain Management in Patients with Temporomandibular Disorders. Journal of Oral & Facial Pain and Headache, 34(1), 77–82. https://doi.org/10.11607/ofph.2163
De Carli, B. M. G., Magro, A. K. D., Souza-Silva, B. N., Matos, F. de S., De Carli, J. P., Paranhos, L. R., & Magro, E. D. (2016). The effect of laser and botulinum toxin in the treatment of myofascial pain and mouth opening: A randomized clinical trial. Journal of Photochemistry and Photobiology. B, Biology, 159, 120–123. https://doi.org/10.1016/j.jphotobiol.2016.03.038
De la Torre Canales, G., Alvarez-Pinzon, N., Muñoz-Lora, V. R. M., Vieira Peroni, L., Farias Gomes, A., Sánchez-Ayala, A., Haiter-Neto, F., Manfredini, D., & Rizzatti-Barbosa, C. M. (2020). Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial. Toxins, 12(6), 395. https://doi.org/10.3390/toxins12060395
De La Torre Canales, G., Câmara-Souza, M. B., Muñoz Lora, V. R. M., Guarda-Nardini, L., Conti, P. C. R., Rodrigues Garcia, R. M., Del Bel Cury, A. A., & Manfredini, D. (2018). Prevalence of psychosocial impairment in temporomandibular disorder patients: A systematic review. Journal of Oral Rehabilitation, 45(11), 881–889. https://doi.org/10.1111/joor.12685
De La Torre Canales, G., Câmara-Souza, M. B., Poluha, R. L., Grillo, C. M., Conti, P. C. R., Sousa, M. da L. R. de, Rodrigues Garcia, R. C. M., & Rizzatti-Barbosa, C. M. (2021). Botulinum toxin type A and acupuncture for masticatory myofascial pain: a randomized clinical trial. Journal of Applied Oral Science : Revista FOB, 29, e20201035. https://doi.org/10.1590/1678-7757-2020-1035
De la Torre Canales, G., Poluha, R. L., Lora, V. M., Araújo Oliveira Ferreira, D. M., Stuginski-Barbosa, J., Bonjardim, L. R., Cury, A. A. D. B., & Conti, P. C. R. (2019). Botulinum toxin type A applications for masticatory myofascial pain and trigeminal neuralgia: what is the evidence regarding adverse effects? Clinical Oral Investigations, 23(9), 3411–3421. https://doi.org/10.1007/s00784-019-03026-4
Denglehem, C., Maes, J.-M., Raoul, G., & Ferri, J. (2012). [Botulinum toxin A: analgesic treatment for temporomandibular joint disorders]. Revue de Stomatologie et de Chirurgie Maxillo-Faciale, 113(1), 27–31. https://doi.org/10.1016/j.stomax.2011.12.003
Fernandes, A., Moura, D., Da Silva, L., De Almeida, E., & Barbosa, G. (2017). Acupuncture in Temporomandibular Disorder Myofascial Pain Treatment: A Systematic Review. Journal of Oral & Facial Pain and Headache, 31(3), 225–232. https://doi.org/10.11607/ofph.1719
Freitas Júnior, W. J. L. de, Marcos, Â. M. da S., Maranhão, A. R. M., Lira, M. L. G. de O., Mendonça, G. L. de, Travassos, R. M. C., Cardoso, M. S. O., & Milhomens Filho, J. A. (2022). Toxina botulínica e Odontologia: revisão integrativa. Research, Society and Development, 11(11), e561111134081. https://doi.org/10.33448/rsd-v11i11.34081
Góes, K. R. B., Grangeiro, M. T. V., & De Figueiredo, V. M. G. (2018). Epidemiologia da disfunção temporomandibular: uma revisão de literatura. Journal of Dentistry & Public Health, 9(2), 115–120. https://doi.org/10.17267/2596-3368dentistry.v9i2.1813
Greene, C. S., Klasser, G. D., & Epstein, J. B. (2010). Revision of the American Association of Dental Research’s Science Information Statement about Temporomandibular Disorders. Journal (Canadian Dental Association), 76, a115. http://www.ncbi.nlm.nih.gov/pubmed/20943030
Guarda-Nardini, L., Stecco, A., Stecco, C., Masiero, S., & Manfredini, D. (2012). Myofascial pain of the jaw muscles: comparison of short-term effectiveness of botulinum toxin injections and fascial manipulation technique. Cranio : The Journal of Craniomandibular Practice, 30(2), 95–102. https://doi.org/10.1179/crn.2012.014
Han, Z. A., Song, D. H., Oh, H. M., & Chung, M. E. (2016). Botulinum toxin type A for neuropathic pain in patients with spinal cord injury. Annals of Neurology, 79(4), 569–578. https://doi.org/10.1002/ana.24605
Hong, S. W., & Kang, J. H. (2020). Decreased mandibular cortical bone quality after botulinum toxin injections in masticatory muscles in female adults. Scientific Reports, 10(1), 1–12. https://doi.org/10.1038/s41598-020-60554-w
Kaya, D. I., & Ataoglu, H. (2021). Botulinum toxin treatment of temporomandibular joint pain in patients with bruxism: A prospective and randomized clinical study. Nigerian Journal of Clinical Practice, 24(3), 412–417. https://doi.org/10.4103/njcp.njcp_251_20
Kim, H.-S., Yun, P.-Y., & Kim, Y.-K. (2016). A clinical evaluation of botulinum toxin-A injections in the temporomandibular disorder treatment. Maxillofacial Plastic and Reconstructive Surgery, 38(1), 5. https://doi.org/10.1186/s40902-016-0051-7
Kim, K. S., Byun, Y. S., Kim, Y. J., & Kim, S. T. (2009). Muscle Weakness After Repeated Injection of Botulinum Toxin Type A Evaluated According to Bite Force Measurement of Human Masseter Muscle. Dermatologic Surgery, 35(12), 1902–1907. https://doi.org/10.1111/j.1524-4725.2009.01319.x
Lee, H. J., Kim, S. J., Lee, K. J., Yu, H. S., & Baik, H. S. (2017). Repeated injections of botulinum toxin into the masseter muscle induce bony changes in human adults: A longitudinal study. Korean Journal of Orthodontics, 47(4), 222–228. https://doi.org/10.4041/kjod.2017.47.4.222
Levac, D., Colquhoun, H., & O’Brien, K. K. (2010). Scoping studies: advancing the methodology. Implementation Science : IS, 5, 69. https://doi.org/10.1186/1748-5908-5-69
Lopes, T. S., Oliveira, E. M. de, Paiva, C. L. de O. C., Santos, T. J. S. dos, Araújo, I. dos S., Cavalcante, V. F., Nascimento, A. C. C. do, Lima, A. P. de, Fiamengui, L. M. S. P., & Chaves, H. V. (2022). Associação entre distúrbios gastrointestinais e disfunção temporomandibular: uma revisão integrativa. Research, Society and Development, 11(15), e30111536910. https://doi.org/10.33448/rsd-v11i15.36910
Machado, E., Santos, L. Z. dos, Custódio, L. G., & Cunali, P. A. (2012). Botulinum toxin for treating muscular temporomandibular disorders: a systematic review. Dental Press Journal of Orthodontics, 17(6), 167–171. https://doi.org/10.1590/S2176-94512012000600029
Montes-Carmona, J.-F., Gonzalez-Perez, L.-M., & Infante-Cossio, P. (2020). Treatment of Localized and Referred Masticatory Myofascial Pain with Botulinum Toxin Injection. Toxins, 13(1), 6. https://doi.org/10.3390/toxins13010006
Munguia, F., Jang, J., Salem, M., Clark, G., & Enciso, R. (2018). Efficacy of Low-Level Laser Therapy in the Treatment of Temporomandibular Myofascial Pain: A Systematic Review and Meta-Analysis. Journal of Oral & Facial Pain and Headache, 32(3), 287–297. https://doi.org/10.11607/ofph.2032
Padula, J. H., Cunali, P. A., Zwir, L. F., & Teixeira, R. E. (2016). Declaração Oficial da Sociedade Brasileira de Disfunção Temporomandibular e Dor Orofacial – SBDOF sobre a utilização da toxina botulínica na especialidade de DTM e Dor Orofacial. SBDOF. https://sbdof.com.br/download.php?f=913a414977ce03917c6f45e98d121b8a
Park, H. U., Kim, B. I., Kang, S. M., Kim, S. T., Choi, J. H., & Ahn, H. J. (2013). Changes in masticatory function after injection of botulinum toxin type A to masticatory muscles. Journal of Oral Rehabilitation, 40(12), 916–922. https://doi.org/10.1111/joor.12111
Patel, J., Cardoso, J. A., & Mehta, S. (2019). A systematic review of botulinum toxin in the management of patients with temporomandibular disorders and bruxism. British Dental Journal, 226(9), 667–672. https://doi.org/10.1038/s41415-019-0257-z
Raphael, K. G., Tadinada, A., Bradshaw, J. M., Janal, M. N., Sirois, D. A., Chan, K. C., & Lurie, A. G. (2014). Osteopenic consequences of botulinum toxin injections in the masticatory muscles: A pilot study. Journal of Oral Rehabilitation, 41(8), 555–563. https://doi.org/10.1111/joor.12180
Sales, J. M., Lavôr, T. F. A. de, Marinho, S. A., Vasconcelos, R. G., & Vasconcelos, M. G. (2020). Toxina botulínica como opçãoo no tratamento da disfunção temporomandibular. Rev. Salusvita (Online), 39(1), 229–254. https://secure.unisagrado.edu.br/static/biblioteca/salusvita/salusvita_v39_n1_2020/salusvita_v39_n1_2020_art_17.pdf
Schiffman, E., Ohrbach, R., Truelove, E., Look, J., Anderson, G., Goulet, J.-P., List, T., Svensson, P., Gonzalez, Y., Lobbezoo, F., Michelotti, A., Brooks, S. L., Ceusters, W., Drangsholt, M., Ettlin, D., Gaul, C., Goldberg, L. J., Haythornthwaite, J. A., Hollender, L., … Orofacial Pain Special Interest Group, I. A. for the S. of P. (2014). Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†. Journal of Oral & Facial Pain and Headache, 28(1), 6–27. https://doi.org/10.11607/jop.1151
Shah, J. P., Thaker, N., Heimur, J., Aredo, J. V, Sikdar, S., & Gerber, L. (2015). Myofascial Trigger Points Then and Now: A Historical and Scientific Perspective. PM & R : The Journal of Injury, Function, and Rehabilitation, 7(7), 746–761. https://doi.org/10.1016/j.pmrj.2015.01.024
Vier, C., Almeida, M. B. de, Neves, M. L., Santos, A. R. S. Dos, & Bracht, M. A. (2019). The effectiveness of dry needling for patients with orofacial pain associated with temporomandibular dysfunction: a systematic review and meta-analysis. Brazilian Journal of Physical Therapy, 23(1), 3–11. https://doi.org/10.1016/j.bjpt.2018.08.008
Zhang, L.-D., Liu, Q., Zou, D.-R., & Yu, L.-F. (2016). Occlusal force characteristics of masseteric muscles after intramuscular injection of botulinum toxin A(BTX - A)for treatment of temporomandibular disorder. The British Journal of Oral & Maxillofacial Surgery, 54(7), 736–740. https://doi.org/10.1016/j.bjoms.2016.04.008
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Copyright (c) 2023 Renato Daniel de Freitas; Bernadete Azevedo de Abreu; Felipe Dantas Silveira; Lívia Maria Sales Pinto Fiamengui; Mirna Marques Bezerra; Hellíada Vasconcelos Chaves
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