Cerebellar pilocytic astrocytoma: literature review and case report of a young patient with anatomopathological correlation
DOI:
https://doi.org/10.33448/rsd-v9i7.4115Keywords:
Central nervous System neoplasms; Magnetic resonance; Cerebellum.Abstract
Pilocytic astrocytoma (PA) is a typically circumscribed, slow-growing tumor, being the most common glioma in children, usually originating in the cerebellum; there are few reports of this tumor in adults, but it has a good prognosis. Here, we report an PA diagnosis in an adolescent patient whose only complaint was progressive headache and presyncope. Given that it is essential to recognize the image pattern of a little aggressive pilocytic astrocytoma (grade 1), as it can be similar to high-grade gliomas, leading to more aggressive treatments mistakenly, we review the role of imaging methods in the diagnosis of PA.
References
Antonelli M, Fadda A, Loi E, Moi L, Zavattari C, Sulas P, Gentilini D, Cameli C, Bacchelli E, Badiali M, Arcella A, Morra I, Giangaspero F & Zavattari P. (2018). Integrated DNA methylation analysis identifies topographical and tumoral biomarkers in pilocytic astrocytomas. Oncotarget. Feb 12;9(17):13807-13821. DOI: 10.18632/oncotarget.24480.
Bell D, Chitnavis BP, Al-Sarraj S, Connor S, Sharr MM & Gullan RW. Pilocytic astrocytoma of the adult--clinical features, radiological features and management. Br J Neurosurg. 2004 Dec;18(6):613-6.
Burger PC & Scheithauer BW. The brain: tumors. In: Burger P, Scheithauer B, eds. Surgical pathology of the nervous system and its coverings. 4th ed. Philadelphia, Pa: Churchill Livingstone, 2002; 203-215.
Burger PC, Scheithauer BW, Paulus W, Szymas J, Giannini C & Kleihues P. Pilocytic astrocytoma. In: Kleihues P, Cavenee W, eds. Pathology and genetics of tumours of the nervous system. Lyon, France: IARC, 2000; 45-51.
Dirks PB, Jay V, Becker LE, et al. Development of anaplastic changes in low-grade astrocytomas of childhood. Neurosurgery 1994; 34:68-78.
Haaga, JR. TC & RM: Uma Abordagem Do Corpo Humano Completo. 5ª Edição [H. Lederman, trad.]. Clevland. Haaga. 2010.
Kelly K. Koeller, Elisabeth J. Rushing. From the Archives of the AFIP Pilocytic Astrocytoma: Radiologic-Pathologic Correlation1. RadioGraphics, 2004, Vol.24: 1693-1708. 10.1148/rg.246045146.
Korgün Koral, Derek Mathis, Barjor Gimi, Lynn Gargan, Bradley Weprin, Daniel C. Bowers, Linda Margraf. Common Pediatric Cerebellar Tumors: Correlation between Cell Densities and Apparent Diffusion Coefficient Metrics. Radiology, 2013, Vol.268: 532-537, 10.1148/radiol.13121362.
Kuroiwa T, Ohta T, Tsutsumi A. Malignant pilocytic astrocytoma in the medulla oblongata: case report. Brain Tumor Pathol 1999; 16:81-85.
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW & Kleihues P. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007 Aug;114(2):97-109.
Murahashi T, Sato K, Ito T, Ozaki Y, Sugio H, Nakamura H & Tanaka S. A case of pilocytic astrocytoma in an adult. No Shinkei Geka. 2012 Sep;40(9):793-7.
Ostrom QT, Gittleman H, Truitt G, Boscia A, Kruchko C & Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015. Neuro Oncol. 2018 Oct 1;20(suppl_4):iv1-iv86.
Pagni CA, Giordana MT & Canavero S. Benign recurrence of a pilocytic cerebellar astrocytoma 36 years after radical removal: case report.Neurosurgery 1991; 28:606-609.
Robbins, SL. Patologia – Bases Patológicas das Doenças. 7ª Edição [JL. Santos, trad.]. Chicago. 2004.
Pereira, AS, Shitsuka, DM, Parreira, FJ & Shitsuka, R. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Disponível em: https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.
Rocha, AJ. Série Colégio Brasileiro de Radiologia e Diagnóstico por Imagem: Encéfalo. São Paulo. CBR Encéfalo. 2012.
Shaya MR, Fowler MR, Nanda A. Pilocytic astrocytoma presenting as an intrinsic brainstem tumor: case report and review of the literature. J La State Med Soc. 2004 Jan-Feb;156(1):33-6.
Schneider JH, Jr, Raffel C, McComb JG. Benign cerebellar astrocytomas of childhood. Neurosurgery 1992; 30:58-63.
Sutton LN, Wang Z & Gusnard D, et al. Proton magnetic resonance spectroscopy of pediatric brain tumors. Neurosurgery 1992; 31:195-202.
White JB, Piepgras DG, Scheithauer BW & Parisi JE. Rate of spontaneous hemorrhage in histologically proven cases of pilocytic astrocytoma. J Neurosurg. 2008 Feb;108(2):223-6.
Yoshida Y, Tsukada T, Hashimoto M & Hayashi Y. Pilocytic astrocytoma of the cerebrum presenting in an elderly patient: a case report. No Shinkei Geka. 2011 Sep;39(9):865-9.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
