Periodontal tratment and drug-induced gingival hyperplasia: Systematc literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i7.41421

Keywords:

Hyperplasia; Gingiva; Periodontitis.

Abstract

Gingival hyperplasia is an abnormal growth of the gingival tissue, which may start in the anterior gingival tissues and then move on to affect the entire posterior part. In some cases, the gums can hyperplasia and compromise almost the entire tooth surface. Faced with the need to obtain targeted information with up-to-date evidence on the indications and effectiveness of the treatment of hyperplasia, this study aimed to carry out a systematic review of the literature on periodontal treatment and drug-induced gingival hyperplasia. Search strategies were constructed for each of the following databases: PubMed, Embase, Scopus and LiLACS. The gray literature search was performed on Pubmed Central. The keywords used were Periodontitis, Periodontal Desease, Gingival hyperplasia drug, Cyclosporine, Phenytoin, periodontal treatment, periodontal parameters. The search totaled 675 studies. After removing duplicates and considering the eligibility criteria, 5 studies were selected for this systematic review. The risk of bias was assessed independently by two review authors. The RevMan Software was used to generate the summary and graph of the risk of bias of the selected studies that patients who use drugs that induce gingival hyperplasia are followed up by a dental surgeon, since several studies state that no matter how much a hygiene correctly, gingival enlargement will almost always occur. According to the development of the case, it may even undergo some surgical procedures, such as gingivoplasty or a gingivectomy.

References

Amit, B. & Shalu, B. V. (2012). Gingival enlargement induced by anticonvulsants, calcium channel blockers and immunosuppressants: A review. International Research Journal of Pharmacy. 3(7), 116-9.

Bharti, V. & Bansal, C. (2013). Supercrescimento gengival induzido por drogas: o inimigo da gengiva desvendado. Jornal da Sociedade Indiana de Periodontologia. 17(2), 182.

Blluon, P. et al. (1994). Clinical assessment of gingival hyperplasia in patients treated with nifedipine. Journal of Clinical Periodontology. 21(4), 256-9.

Dannewitz, B., Holtfreter, B. & Eickholz, P. (2021). Parodontitis–Therapie einer Volkskrankheit. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz. 64(8), 931-940.

Darbar, U. R. et al. (1996). Combined treatment approach to gingival overgrowth due to drug therapy. Journal of clinical periodontology. 23(10), 941-944.

Dongari, A., Mcdonnell, H. T. & Langlais, R. P. (1993). Drug-induced gingival overgrowth. Oral surgery, oral medicine, oral pathology. 76(4), 543-548.

Santos, F. A., Carvalho, C. A & Pochapski, M. T. (2001). Crescimento gengival associado ao uso da fenitoína. Relato de um caso clínico (gingival overgrowth associated to use of phenytoin. a case report). Publicatio UEPG: Ciências Biológicas e da Saúde. 7(1).

Doufexi, A., Mina, M. & Ioannidou, E. (2005). Gingival overgrowth in children: epidemiology, pathogenesis, and complications. A literature review. Journal of periodontology. 76(1), 3-10.

Dragan, Y. P. et al. (1993). The initiation-promotion-progression model of rat hepatocarcinogenesis. Proceedings of the Society for Experimental Biology and Medicine. 202(1), 16-24.

Foroozan, R. (2018). Vigabatrin: lessons learned from the United States experience. Journal of Neuro-Ophthalmology. 38(4), 442-450.

Guimarães, J. (2007). Hiperplasia gengival medicamentosa: parte I. Journal of Epilepsy and Clinical Neurophysiology. 13, 33-36.

Kilpatrick, N. M. et al. (1997). Gingival overgrowth in pediatric heart and heart-lung transplant recipients. The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation. 16(12), 1231-1237.

Kimball, O. P. (1939). The treatment of epilepsy with sodium diphenyl hydantoinate. Journal of the American Medical Association. 112(13), 1244-1245.

Kinane, D. F., Stathopoulou, P. G. & Papapanou, P. N. (2017). Periodontal diseases. Nature reviews Disease primers. 3(1), 1-14.

Kopp, C. M. C. et al. (2008). Behavior problems in children with tuberous sclerosis complex and parental stress. Epilepsy & Behavior. 13(3), 505-510.

KWAN, P. & BRODIE, M. J. (2004). Drug treatment of epilepsy: when does it fail and how to optimize its use? CNS spectrums. 9(2), 110-119.

Lin, K. Guilhoto, L. M. F. F. & Yacubian, E. M. T. (2007). Drug-induced gingival enlargement-Part II. Antiepileptic drugs: not only phenytoin is involved. Journal of Epilepsy and Clinical Neurophysiology. 13, 83-88.

Lopes, A. M. (2009). Hiperplasia gengival associada ao uso da fenitoína. Journal of Epilepsy and Clinical Neurophysiology.

Maior, T. C. P. S., Furquim, M. & Kempinski, E. M. B. C. (2008). Distúrbios associados à paralisia cerebral e a abordagem da equipe interdisciplinar. Uningá Journal. 15(1).

Manuelli, M. et al. (2019). Oral mucosal complications in orthodontic treatment. Minerva Stomatologica. 68(2), 84-88.

Marshall, R. I. & Bartold, P. M. (1998). Medication induced gingival overgrowth. Oral diseases. 4(2), 130-151.

Mcnamara, J. O. (1994). Cellular and molecular basis of epilepsy. Journal of Neuroscience. 14(6), 3413-3425.

Meraw, S. J. & Sheridan, P. J. (1998). Medically induced gingival hyperplasia. Mayo Clinic Proceedings. Elsevier. 1196-1199.

Messer, R. & Knupp, K. G. (2020). Infantile spasms: opportunities to improve care. Seminars in Neurology. 236-245.

Nery, E. B. et al. (1995). Prevalence of nifedipine‐induced gingival hyperplasia. Journal of periodontology. 66(7), 572-578.

Pesaturo, K. A., Spooner, L, M. & Belliveau, P. (2011). Vigabatrin for infantile spasms. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 31(3), 298-311.

Piattelli, A., Petrelli, I. & Fanci, P. (1993). Regression following reduction of the daily drug dosage in cyclosporin A-induced gingival overgrowth in bone marrow transplant recipients. Acta stomatologica Belgica. 90(3), 171-176.

Rateitschak‐Plüss, E. M. et al. (1983). Initial observation that cyclosporin‐A induces gingival enlargement in man. Journal of clinical periodontology. 10(3), 237-246.

Rees, T. D. & Levine, R. A. (1995). Systematic drugs as a risk factor for periodontal disease initiation and progression. Compendium. 16(1), 20.

Ristic, M. et al. (2008). Effects of fixed orthodontic appliances on subgingival microflora. International journal of dental hygiene. 6(2), 129-136.

Rocha, G. P., Batista, B. H. & Nunes, M. L. (2004). Orientações ao pediatra sobre o manejo das drogas psicoativas e antiepilépticas. Jornal de Pediatria. 80(2), 45-55.

Santos, M. E. S. M. & Costa, W. R. M. (2004). Terapêutica cirúrgica da hiperplasia fibrosa inflamatória-relato de caso/ surgical therapy of fibrous inflammatory hyperplasia: a case report. Revista de Cirurgia e Traumatologia Buco-Maxilo-Facial. 4(4), 241-245.

Seymour, R. A. & Jacobs, D. J. (1992). Cyclosporin and the gingival tissues. Journal of clinical periodontology. 19(1), 1-11.

Sherman, L. G. & Liang, C. (1983). Nifedipine in chronic stable angina: a double-blind placebo-controlled crossover trial. The American Journal of Cardiology. 51(5), 706-711.

Sohal, G., Dave, M. & Patel, N. (2021). Dental implications of some commonly prescribed medicines. Drug and Therapeutics Bulletin. 59(9), 135-138.

Steele, R. M., Schuna, A. A. & Schreiber, R. T. (1994). Calcium antagonist-induced gingival hyperplasia. Annals of internal medicine. 120(8), 663-664.

Tyldesley, W. R. & Rotter, E. (1984). Gingival hyperplasia induced by cyclosporin-A. British dental jornal. 157(9), 305-309.

Usinger, R. L., Olivera, G. & Dirschnabel, A. J. (2016). Hiperplasia gengival induzida por fármacos. Ação Odonto. 1.

Varona, J., Escribano, E. & Martín-Calderón, J. L. (2001). Fenobarbital: farmacocinética, toxicología y monitorización por el laboratorio. Revista de Diagnóstico Biológico. 50(1), 13-16.

Published

09/07/2023

How to Cite

MONTE, F. M. M. .; FURTADO, M. A. M. . Periodontal tratment and drug-induced gingival hyperplasia: Systematc literature review . Research, Society and Development, [S. l.], v. 12, n. 7, p. e2912741421, 2023. DOI: 10.33448/rsd-v12i7.41421. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41421. Acesso em: 21 nov. 2024.

Issue

Section

Health Sciences