Palliative care and schizophrenia: a reflection on the difficulty of palliative care in patients with schizophrenia

Authors

DOI:

https://doi.org/10.33448/rsd-v12i5.41427

Keywords:

Palliative care; Mental health; Schizophrenia.

Abstract

Introduction: Schizophrenia is a chronic and serious psychiatric illness, in addition to being extremely debilitating and which carries with it a very large stigma for its carriers. It is one of the diseases that causes the most disability and therefore the patient needs comprehensive care, aiming not only at resolving the psychiatric condition, but also at improving well-being and reducing suffering. Objective: This work aims to review the literature on palliative care in patients with schizophrenia and identify the applicability and importance of such a practice. Method: narrative literature review, using the databases: Scientific Electronic Library Online (ScieELO), UpToDate and Medical Literature Analysis and Retrieval System Online (MEDLINE). Using the following keywords: “Palliative Care”, “Schizophrenia” and “Mental Health”. Inclusion and exclusion criteria were applied and a total of 61 articles were used. Results and Discussion: Schizophrenia is a serious chronic mental illness that results in marginalization and stigma for patients. Approximately four to seven million people worldwide suffer from severe treatment-resistant schizophrenia. These patients may have a high level of negative symptoms, leading to impaired quality of life and social functioning. The range of palliative care approaches in medicine is very wide, from targeted short-term measures for the relief of distressing symptoms to palliative sedation. Palliative care services for people with schizophrenia must adopt an inclusive approach. Conclusion: Palliative care can offer comfort to patients with schizophrenia and their families, especially to marginalized people.

References

Arksey, H. & O’Malley, L. (2005). Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 8(1):19–32.

Backer, T. E., & Howard, E. A. (2007). Cognitive impairments and the prevention of homelessness: research and practice review. The journal of primary prevention, 28(3-4), 375–388. https://doi.org/10.1007/s10935-007-0100-1

Baez, M. A., & Avery, J. D. (2010). Terminally ill schizophrenic patients: an ignored population. Journal of palliative medicine, 13(3), 237. https://doi.org/10.1089/jpm.2009.0328

Bassirpour, G., Mahr, G., Lee, B., & Torres, M. (2011). The use of hospice care in end-stage psychiatric patients. Journal of palliative medicine, 14(1), 107–108. https://doi.org/10.1089/jpm.2009.0431

Berk, M., Berk, L., Udina, M., Moylan, S., Stafford, L., Hallam, K., Goldstone, S., & McGorry, P. D. (2012). Palliative models of care for later stages of mental disorder: maximizing recovery, maintaining hope, and building morale. The Australian and New Zealand journal of psychiatry, 46(2), 92–99. https://doi.org/10.1177/0004867411432072

Block S. D. (2006). Psychological issues in end-of-life care. Journal of palliative medicine, 9(3), 751–772. https://doi.org/10.1089/jpm.2006.9.751

Bonnot, O., Anderson, G. M., Cohen, D., Willer, J. C., & Tordjman, S. (2009). Are patients with schizophrenia insensitive to pain? A reconsideration of the question. The Clinical journal of pain, 25(3), 244–252. https://doi.org/10.1097/AJP.0b013e318192be97

Buhagiar, K., Parsonage, L., & Osborn, D. P. (2011). Physical health behaviours and health locus of control in people with schizophrenia-spectrum disorder and bipolar disorder: a cross-sectional comparative study with people with non-psychotic mental illness. BMC psychiatry, 11, 104. https://doi.org/10.1186/1471-244X-11-104

Candilis, P. J., Foti, M. E., & Holzer, J. C. (2004). End-of-life care and mental illness: a model for community psychiatry and beyond. Community mental health journal, 40(1), 3–16. https://doi.org/10.1023/b:comh.0000015214.24404.cc

Cai, X., Cram, P., & Li, Y. (2011). Origination of medical advance directives among nursing home residents with and without serious mental illness. Psychiatric services (Washington, D.C.), 62(1), 61–66. https://doi.org/10.1176/ps.62.1.pss6201_0061

Caraceni, A., Nanni, O., Maltoni, M., Piva, L., Indelli, M., Arnoldi, E., Monti, M., Montanari, L., Amadori, D., & De Conno, F. (2000). Impact of delirium on the short term prognosis of advanced cancer patients. Italian Multicenter Study Group on Palliative Care. Cancer, 89(5), 1145–1149. https://doi.org/10.1002/1097-0142(20000901)89:5<1145::aid-cncr24>3.0.co;2-x

Charlson, F. J., Ferrari, A. J., Santomauro, D. F., Diminic, S., Stockings, E., Scott, J. G., McGrath, J. J., & Whiteford, H. A. (2018). Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016. Schizophrenia bulletin, 44(6), 1195–1203. https://doi.org/10.1093/schbul/sby058

Chochinov, H. M., Martens, P. J., Prior, H. J., & Kredentser, M. S. (2012). Comparative health care use patterns of people with schizophrenia near the end of life: a population-based study in Manitoba, Canada. Schizophrenia research, 141(2-3), 241–246. https://doi.org/10.1016/j.schres.2012.07.028

Chong, H. Y., Teoh, S. L., Wu, D. B., Kotirum, S., Chiou, C. F., & Chaiyakunapruk, N. (2016). Global economic burden of schizophrenia: a systematic review. Neuropsychiatric disease and treatment, 12, 357–373. https://doi.org/10.2147/NDT.S96649

Chwastiak, L. A., & Tek, C. (2009). The unchanging mortality gap for people with schizophrenia. Lancet (London, England), 374(9690), 590–592. https://doi.org/10.1016/S0140-6736(09)61072-2

Craig, T. K., Rus-Calafell, M., Ward, T., Leff, J. P., Huckvale, M., Howarth, E., Emsley, R., & Garety, P. A. (2018). AVATAR therapy for auditory verbal hallucinations in people with psychosis: a single-blind, randomised controlled trial. The lancet. Psychiatry, 5(1), 31–40. https://doi.org/10.1016/S2215-0366(17)30427-3

Davie, E. (2006). A social work perspective on palliative care for people with mental health problems. Eur J Palliat Care. 13(1):26-28.

Dickerson, F., Origoni, A., Schroeder, J., Adamos, M., Katsafanas, E., Khushalani, S., Savage, C. L. G., Schweinfurth, L. A. B., Stallings, C., Sweeney, K., & Yolken, R. (2018). Natural cause mortality in persons with serious mental illness. Acta psychiatrica Scandinavica, 137(5), 371–379. https://doi.org/10.1111/acps.12880

De Roo, M. L., Leemans, K., Claessen, S. J., Cohen, J., Pasman, H. R., Deliens, L., Francke, A. L., & EURO IMPACT (2013). Quality indicators for palliative care: update of a systematic review. Journal of pain and symptom management, 46(4), 556–572. https://doi.org/10.1016/j.jpainsymman.2012.09.013

Engels, G., Francke, A. L., van Meijel, B., Douma, J. G., de Kam, H., Wesselink, W., Houtjes, W., & Scherder, E. J. (2014). Clinical pain in schizophrenia: a systematic review. The journal of pain, 15(5), 457–467. https://doi.org/10.1016/j.jpain.2013.11.005

Ferris, F. D., Balfour, H. M., Bowen, K., Farley, J., Hardwick, M., Lamontagne, C., Lundy, M., Syme, A., & West, P. J. (2002). A model to guide patient and family care: based on nationally accepted principles and norms of practice. Journal of pain and symptom management, 24(2), 106–123. https://doi.org/10.1016/s0885-3924(02)00468-2

Folsom, D. P., Hawthorne, W., Lindamer, L., Gilmer, T., Bailey, A., Golshan, S., Garcia, P., Unützer, J., Hough, R., & Jeste, D. V. (2005). Prevalence and risk factors for homelessness and utilization of mental health services among 10,340 patients with serious mental illness in a large public mental health system. The American journal of psychiatry, 162(2), 370–376. https://doi.org/10.1176/appi.ajp.162.2.370

Gillum L. A. (2015). Palliative care and neurology: time for a paradigm shift. Neurology, 84(11), 1184. https://doi.org/10.1212/WNL.0000000000001384

Griffith L. J. (2007). Brief Supportive Psychotherapy for a Patient with Chronic Schizophrenia Who is Dying. Psychiatry (Edgmont (Pa. : Township)), 4(12), 49–54.

Howard, L. M., Barley, E. A., Davies, E., Rigg, A., Lempp, H., Rose, D., Taylor, D., & Thornicroft, G. (2010). Cancer diagnosis in people with severe mental illness: practical and ethical issues. The Lancet. Oncology, 11(8), 797–804. https://doi.org/10.1016/S1470-2045(10)70085-1

Irwin, K. E., Henderson, D. C., Knight, H. P., & Pirl, W. F. (2014). Cancer care for individuals with schizophrenia. Cancer, 120(3), 323–334. https://doi.org/10.1002/cncr.28431

Lanzoni, G.M.M. & Meirelles, B.H.S. (2011). Leadership of the nurse: an integrative literature review. Revista Latino-Americana de Enfermagem. v. 19, n. 3 <https://doi.org/10.1590/S0104-11692011000300026>. Epub 07 Mar 2012. ISSN 1518-8345. https://doi.org/10.1590/S0104-11692011000300026.

Lavin, K., Davydow, D. S., Downey, L., Engelberg, R. A., Dunlap, B., Sibley, J., Lober, W. B., Okimoto, K., Khandelwal, N., Loggers, E. T., Teno, J. M., & Curtis, J. R. (2017). Effect of Psychiatric Illness on Acute Care Utilization at End of Life From Serious Medical Illness. Journal of pain and symptom management, 54(2), 176–185.e1. https://doi.org/10.1016/j.jpainsymman.2017.04.003

Lawrence, D., & Kisely, S. (2010). Inequalities in healthcare provision for people with severe mental illness. Journal of psychopharmacology (Oxford, England), 24(4 Suppl), 61–68. https://doi.org/10.1177/1359786810382058

Lindblad, A., Helgesson, G., & Sjöstrand, M. (2019). Towards a palliative care approach in psychiatry: do we need a new definition?. Journal of medical ethics, 45(1), 26–30. https://doi.org/10.1136/medethics-2018-104944

Martens, P. J., Chochinov, H. M., & Prior, H. J. (2013). Where and how people with schizophrenia die: a population-based, matched cohort study in Manitoba, Canada. The Journal of clinical psychiatry, 74(6), e551–e557. https://doi.org/10.4088/JCP.12m08234

Massie M. J. (2004). Prevalence of depression in patients with cancer. Journal of the National Cancer Institute. Monographs, (32), 57–71. https://doi.org/10.1093/jncimonographs/lgh014

McCasland, L.A. (2007). Providing hospice and palliative care to the seriously and persistently mentally ill. J Hosp Palliat Nurs. 9(6):305–315.

McGinty, E. E., Baller, J., Azrin, S. T., Juliano-Bult, D., & Daumit, G. L. (2015). Quality of medical care for persons with serious mental illness: A comprehensive review. Schizophrenia research, 165(2-3), 227–235. https://doi.org/10.1016/j.schres.2015.04.010

McNamara, B., Same, A., Rosenwax, L., & Kelly, B. (2018). Palliative care for people with schizophrenia: a qualitative study of an under-serviced group in need. BMC palliative care, 17(1), 53. https://doi.org/10.1186/s12904-018-0309-1

Meier, D. E., & Brawley, O. W. (2011). Palliative care and the quality of life. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(20), 2750–2752. https://doi.org/10.1200/JCO.2011.35.9729

Meyer, A. A., Hwang, M., Farasatpour, M., Janardhan, R., Margenthaler, J. A., Virgo, K. S., & Johnson, F. E. (2013). Metastatic breast cancer in patients with schizophrenia. Molecular and clinical oncology, 1(2), 359–364. https://doi.org/10.3892/mco.2012.44

Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., Kahn, R., Krebs, M. O., Leboyer, M., Lewis, D., Marin, O., Marin, P., Meyer-Lindenberg, A., McGorry, P., McGuire, P., Owen, M. J., … Weinberger, D. (2016). Altering the course of schizophrenia: progress and perspectives. Nature reviews. Drug discovery, 15(7), 485–515. https://doi.org/10.1038/nrd.2016.28

Miovic, M., & Block, S. (2007). Psychiatric disorders in advanced cancer. Cancer, 110(8), 1665–1676. https://doi.org/10.1002/cncr.22980

Mitchell, A. J., Chan, M., Bhatti, H., Halton, M., Grassi, L., Johansen, C., & Meader, N. (2011). Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. The Lancet. Oncology, 12(2), 160–174. https://doi.org/10.1016/S1470-2045(11)70002-X

Miyamoto, S., Jarskog, L. F., & Fleischhacker, W. W. (2015). Schizophrenia: when clozapine fails. Current opinion in psychiatry, 28(3), 243–248. https://doi.org/10.1097/YCO.0000000000000159

Relyea, E., MacDonald, B., Cattaruzza, C., & Marshall, D. (2019). On the Margins of Death: A Scoping Review on Palliative Care and Schizophrenia. Journal of palliative care, 34(1), 62–69. https://doi.org/10.1177/0825859718804108

Saha, S., Chant, D., & McGrath, J. (2007). A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?. Archives of general psychiatry, 64(10), 1123–1131. https://doi.org/10.1001/archpsyc.64.10.1123

Shalev, D., Brewster, K. K., & Levenson, J. A. (2017). End-of-Life Care for Patients with Schizophrenia #332. Journal of palliative medicine, 20(7), 787–788. https://doi.org/10.1089/jpm.2017.0164

Shalev, D., Brewster, K., Arbuckle, M. R., & Levenson, J. A. (2017). A staggered edge: End-of-life care in patients with severe mental illness. General hospital psychiatry, 44, 1–3. https://doi.org/10.1016/j.genhosppsych.2016.10.004

Simeone, J. C., Ward, A. J., Rotella, P., Collins, J., & Windisch, R. (2015). An evaluation of variation in published estimates of schizophrenia prevalence from 1990─2013: a systematic literature review. BMC psychiatry, 15, 193. https://doi.org/10.1186/s12888-015-0578-7

Stienstra, D., & Chochinov, H. M. (2012). Palliative care for vulnerable populations. Palliative & supportive care, 10(1), 37–42. https://doi.org/10.1017/S1478951511000563

Stoll, J., Mathew, A., Venkateswaran, C., Prabhakaran, A., Westermair, A. L., & Trachsel, M. (2022). Palliative Psychiatry for Patients With Severe and Persistent Mental Illness: A Survey on the Attitudes of Psychiatrists in India Compared to Psychiatrists in Switzerland. Frontiers in psychiatry, 13, 858699. https://doi.org/10.3389/fpsyt.2022.858699

Strand, M., Sjöstrand, M., & Lindblad, A. (2020). A palliative care approach in psychiatry: clinical implications. BMC medical ethics, 21(1), 29. https://doi.org/10.1186/s12910-020-00472-8

Swiss Academy of Medical Sciences (SAMS). (2013). Medical-ethical guidelines and recommendations on palliative care. Basel, Switzerland; 2006, Swiss Academy of Medical Sciences (SAMS).

Tajima-Pozo, K., de Castro Oller, M. J., Lewczuk, A., & Montañes-Rada, F. (2015). Understanding the direct and indirect costs of patients with schizophrenia. F1000Research, 4, 182. https://doi.org/10.12688/f1000research.6699.2

Temel, J. S., Greer, J. A., Muzikansky, A., Gallagher, E. R., Admane, S., Jackson, V. A., Dahlin, C. M., Blinderman, C. D., Jacobsen, J., Pirl, W. F., Billings, J. A., & Lynch, T. J. (2010). Early palliative care for patients with metastatic non-small-cell lung cancer. The New England journal of medicine, 363(8), 733–742. https://doi.org/10.1056/NEJMoa1000678

Terpstra, T. L., Williamson, S., & Terpstra, T. (2014). Palliative care for terminally ill individuals with schizophrenia. Journal of psychosocial nursing and mental health services, 52(8), 32–38. https://doi.org/10.3928/02793695-20140522-01

Teunissen, S. C., Wesker, W., Kruitwagen, C., de Haes, H. C., Voest, E. E., & de Graeff, A. (2007). Symptom prevalence in patients with incurable cancer: a systematic review. Journal of pain and symptom management, 34(1), 94–104. https://doi.org/10.1016/j.jpainsymman.2006.10.015

Trachsel, M., Irwin, S. A., Biller-Andorno, N., Hoff, P., & Riese, F. (2016). Palliative psychiatry for severe persistent mental illness as a new approach to psychiatry? Definition, scope, benefits, and risks. BMC psychiatry, 16, 260. https://doi.org/10.1186/s12888-016-0970-y

Trachsel, M., Irwin, S. A., Biller-Andorno, N., Hoff, P., & Riese, F. (2016). Palliative psychiatry for severe and persistent mental illness. The lancet. Psychiatry, 3(3), 200. https://doi.org/10.1016/S2215-0366(16)00005-5

Vita, A., & Barlati, S. (2018). Recovery from schizophrenia: is it possible?. Current opinion in psychiatry, 31(3), 246–255. https://doi.org/10.1097/YCO.0000000000000407

Webber, T. (2012) End of life care for people with mental illness. J Ethics Ment Health. 7:1–4.

Westermair, A. L., Buchman, D. Z., Levitt, S., Perrar, K. M., & Trachsel, M. (2022). Psiquiatria paliativa em um sentido estreito e amplo: Um esclarecimento de conceito. A revista de psiquiatria da Austrália e Nova Zelândia, 56(12), 1535–1541. https://doi.org/10.1177/00048674221114784

World Health Organization (WHO). (2014). WHO definition of palliative care. www.who.int/cancer/palliative/definition/en/

World Health Organization (WHO) 2016. Schizophrenia. Fact sheet. http://www.who.int/mediacentre/factsheets/fs397/en/

Published

23/04/2023

How to Cite

TAKATORI, M. M. O. .; RIGO, R. S. . Palliative care and schizophrenia: a reflection on the difficulty of palliative care in patients with schizophrenia . Research, Society and Development, [S. l.], v. 12, n. 5, p. e0512541427, 2023. DOI: 10.33448/rsd-v12i5.41427. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41427. Acesso em: 21 nov. 2024.

Issue

Section

Health Sciences