The gut microbiota, associated diseases and possible treatments: A narrative review
DOI:
https://doi.org/10.33448/rsd-v13i1.41719Keywords:
Microorganisms; Microbiome; Pathologies; Dysbiosis; Neurotransmitters.Abstract
The microbiota is made up of several microorganisms, bacteria, viruses and fungi that inhabit the human body, carrying out mutualistic processes. This mechanism directly interferes with the digestion and absorption of nutrients, protection against pathogenic organisms, regulation of the immune system, and enzymatic functions that act as stimulators and precursors of substances involved in various metabolic processes of the host. This review aims to describe the functions of the gut microbiota, together with the existing microorganisms of the human gut, which is one of the largest in diversity, number and functions performed. Studies were analyzed using databases such as Periódico CAPES, SciELO and LILACS and PubMed, covering publications between 1990 and 2022. The gut microbiota is responsible for maintaining gut homeostasis, in which it prevents the development of pathogens and infectious agents. There is a relationship between increased inflammatory rates and gut dysbiosis, which may be associated with improper diets, consumption of toxic and chemical products, as well as genetic and environmental factors that can suppress or trigger the increase in harmful bacteria. The determinants of the gut microbiota were addressed. The relationship between the brain and the gut and the influence of the microbiota on obesity, the immune system, the development of neurological diseases and cancer were discussed. The role of the microbiota in pseudomembranous colitis has been presented. It was possible to understand that dysbiosis triggers several innate and adaptive immune responses that can develop the formation of several harmful processes for the host. It is concluded that the intestinal microbiota plays an essential role in maintaining the homeostasis of the intestine through the host's immune system, and evolves with it, influencing the metabolism, physiology and development of the immune system, while disruption of the microbial community can result in chronic diseases.
References
Abdelsalam, N. A., Ramadan, A. T., ElRakaiby, M. T., & Aziz, R. K. (2020). Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics. Frontiers in pharmacology, 11, 390. https://doi.org/10.3389/fphar.2020.00390
Almeida, J. R. M., Collares, D., & Barbosa, P. (2015). Bioprospecção microbiana. Embrapa Agroenergia. https://ainfo.cnptia.embrapa.br/digital/bitstream/item/137596/1/bioprospeccao-microbiana-web.pdf.
Almeida, K. A., Strunz, C. M. C., Maranhão, R. C. & Mansur, A. P. (2007). Polimorfismo S447X da lipase lipoprotéica: influência sobre a incidência de doença arterial coronariana prematura e sobre os lípides plasmáticos. Arquivos Brasileiros de Cardiologia, 88(3), 297-303. https://doi.org/10.1590/S0066-782X2007000300008
Altveş, S., Yildiz, H. K. & Vural, H. C. (2020). Interaction of the microbiota with the human body in health and diseases. Biosci Microbiota Food Health, 39(2), 23-32. https://doi.org/10.12938/bmfh.19-023.
Anderson, N. B. & Armstead, C. A. (1995). Toward understanding the association of socioeconomic status and health: a new challenge for the biopsychosocial approach. Psychosom. Med., 57(3), 213–25. https://journals.lww.com/psychosomaticmedicine/abstract/1995/05000/toward_understanding_the_association_of.3.aspx
Andrucioli, M. C. D., Faria, G., Nelson-Filho, P., Romano, F. L. & Matsumoto, M. A. N. (2017). Influence of resin-modified glass ionomer and tropical fluoride on levels of Streptococcus mutans in saliva and biofilm adjacent to metallic brackets. Journal of Applied Oral Science, 25(2),196-202. https://doi.org/10.1590/1678-77572016-0231
Bajinka, O., Darboe, A., Tan, Y., Abdelhalim, K. A. & Cham, L. B. (2020). Gut microbiota and the human gut physiological changes. Annals of Microbiology, 70(65), 1-9. https://doi.org/10.1186/s13213-020-01608-2.
Barbosa, F. H. F. Martins, F. S. Barbosa, L. P. J. L. & Nico, J. R. (2010). Microbiota indígena do trato gastrintestinal. Revista de Biologia e Ciência da Terra, Aracaju, 10(1), 78-93. https://www.redalyc.org/articulo.oa?id=50016930008
Bodén, S., Myte, R., Wennberg, M., Harlid, S., Johansson, I. et al. (2019). The inflammatory potential of diet in determining cancer risk; A prospective investigation of two dietary pattern scores. PloS One, 14(4), 1-16. https://doi.org/10.1371/journal.pone.0214551
Bull, M. J. & Plummer, N. T. (2014). Part 1: The Human Gut Microbiome in Health and Disease. Integr Med (Encinitas), 13(6), 17–22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566439/
Butler, M. I., Mörkl, S., Sandhu, K. V., Cryan, J. F. & Dinan, T. G. (2019). The gut microbiome and mental health: what should we tell our patients? The Canadian Journal of Psychiatry, 64(11), 747–760. https://doi.org/10.1177/0706743719874168
Campos, H. S. (2018). Papel do microbioma na resposta imune e na asma. Arq Asma Alerg Imunol., 2(2), 238-246. http://aaai-asbai.org.br/detalhe_artigo.asp?id=872
Cani, P. D. & Delzonne, N. M. (2007). Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care, 10(6), 729-734. https://doi.org/10.1097/MCO.0b013e3282efdebb
Chen, Y., Xu, J., & Chen, Y. (2021). Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders. Nutrients, 13(6), 2099. https://doi.org/10.3390/nu13062099
Clark, A. & Mach, N. (2016). Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes. Journal of the International Society of Sports Nutrition, 13, 43. https://doi.org/110.1186/s12970-016-0155-6
Clemente, J. C., Ursell, L. K., Parfrey, L. W. & Knight, R. (2012). The impact of the gut microbiota on human health: An integrative view. Cell, 148(6), 1258-1270.
Costa, C. S. G. (2021). A Importância da microbiota intestinal na saúde e em estados de disbiose – revisão narrativa. Dissertação (Mestrado em Ciências Farmacêuticas), Universidade Fernando Pessoa, Porto, 1-58. https://bdigital.ufp.pt/bitstream/10284/10461/1/PPG_39681.pdf
Costa, S. E. & Varavallo, A. M. (2011). Probióticos e Prebióticos: Relações com a imunidade e promoção da saúde. Revista Científica do ITPAC, 4(2), 4-11. https://assets.unitpac.com.br/arquivos/Revista/42/6.pdf
Cotrim, M. A., Marzano, L. A. S., Batista, J. P. T., Lira, M. L. C. & Fraga, C. L. (2020). O papel da microbiota intestinal na patogênese das doenças inflamatórias intestinais. Brazilian Journal of Health Review, 3(3), 4558–4565. https://doi.org/10.34119/bjhrv3n3-052
Cryan, J. F. & O'mahony, S. M. (2011). The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol Motil, 23(3), 187-192. https://doi.org/10.1111/j.1365-2982.2010.01664.x
Cryan, J. F., O'riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S. et al. (2019). The microbiota–gut–brain axis. Physiol., 99, 1877–2013. https://doi.org/10.1152/physrev.00018.2018
Cullin, N., Azevedo Antunes, C., Straussman, R., Stein-Thoeringer, C. K. & Elinav, E. (2021). Microbiome and cancer. Cancer cell, 39(10), 1317–1341. https://doi.org/10.1016/j.ccell.2021.08.006
Czepiel, J., Dróżdż, M., Pituch, H., Kuijper, E. J., Perucki, W., Mielimonka, A., Goldman, S., Wultańska, D., Garlicki, A., & Biesiada, G. (2019). Clostridium difficile infection: review. European journal of clinical microbiology & infectious diseases, 38(7), 1211–1221. https://doi.org/10.1007/s10096-019-03539-6
Daisley, B. A., Monachese, M., Trinder M., Bisanz, J. E., Chmiel, J. A., Burton, J. P. & Reida, G. (2019). Immobilization of cadmium and lead by Lactobacillus rhamnosus GR-1 mitigates apical-to-basolateral heavy metal translocation in a Caco-2 model of the intestinal epithelium. Gut Microbes, 10, 321–33. https://doi.org/10.1080/19490976.2018.1526581
El-Enshasy, H. A. & Yang, S. T. (2021). Probiotics, the Natural Microbiota in Living Organisms: Fundamentals and Applications. Boca Raton: CRC Press. https://doi.org/10.1201/9781351027540
Faintuch, J. (2017). Microbioma, disbiose, probióticos e bacterioterapia. Barueri, SP: Editora Manole LTDA.
Fan, X., Alekseyenko, V., Wu, J., Peters, B. A., Jacobs, E., Gapstur, S. M. et al. (2018). Human oral microbiota and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut, 67(1), 120–27.
Farooq, P. D., Urrunaga, N. H., Tang, D. M., & von Rosenvinge, E. C. (2015). Pseudomembranous colitis. Disease-a-month : DM, 61(5), 181–206. https://doi.org/10.1016/j.disamonth.2015.01.006
Fatima, R. & Aziz, M. (2019). The Hypervirulent Strain of Clostridium Difficile: NAP1/B1/027 - A Brief Overview. Cureus, 11(1), e3977. https://doi.org/10.7759/cureus.3977
Fernández, M. F., Reina-Pérez, I., Astorga, J. M., Rodríguez-Carrillo, A., Plaza-Díaz, J. & Fontana, L. Breast Cancer and Its Relationship with the Microbiota. International journal of environmental research and public health, 15(8), 1747. https://doi.org/110.3390/ijerph15081747
Fonseca, P. C. & Pinheiro, M. S. (2019). Influência da microbiota intestinal no desenvolvimento da obesidade: artigo de revisão. Caderno De Graduação - Ciências Biológicas E Da Saúde, Aracaju, 5(2), 193-212. https://periodicos.set.edu.br/cadernobiologicas/article/view/6664
Forsythe, P. (2013). Gut microbes as modulators of neuro-immuno-endocrine system. PharmaNutrition, 1(4), 115–122. https://doi.org/10.1016/j.phanu.2013.05.003
Forsythe, P., Sudo, N., Dinan, T., Taylor, V. & Bienenstock, J. (2010). Mood and gut feelings. Brain, Behavior, and Immunity, 24, 1, 9-16. https://doi.org/10.1016/j.bbi.2009.05.058
Foster, J. & Neufeld, K. M. (2013). Gut-brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences, 36(5), 305-312. https://doi.org/10.1016/j.tins.2013.01.005
Furuhashi, M., Tuncman, G., Görgün, C. Z., Makowski, L., Atsumi, G. et al. (2007). Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature, 21(447), 959-65. https://doi.org/10.1038/nature05844
Garrett, W. S. (2015). Cancer and the microbiota. Science, 3(348), 80-6. https://doi.org/10.1126/science.aaa4972
Gaudino, S. J. & Kuma, P. (2019). Cross-Talk Between Antigen Presenting Cells and T Cells Impacts Intestinal Homeostasis, Bacterial Infections, and Tumorigenesis. Front Immunol., 6(10), 360. https://doi.org/10.3389/fimmu.2019.00360
Geuking, M. B., Köller, Y., Rupp, S. & Mccoy, K. D. (2014). The interplay between the gut microbiota and the immune system. Gut Microbes, 5(3), 411–418. https://doi.org/10.4161/gmic.29330
Gonçalves, P. A. M. (2014). Microbiota – implicações na imunidade e no metabolismo. Dissertação de Mestrado em Ciências Farmacêuticas). Universidade Fernando Pessoa, Porto, Portugal.
Guarner, F. (2007). Papel de la flora intestinal en la salud y en la enfermedad. Nutrición Hospitalaria, Madrid, 22(2), 14-19. http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112007000500003&lng=es&tlng=es
Hadrich, D. (2018). Microbiome research is becoming the key to better understanding health and nutrition. Frontiers in genetics, 9, 212. https://doi.org/10.3389/fgene.2018.00212
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Bjorkholm, B., Samuelsson, A. et al. (2011). Normal gut microbiota modulates brain development and behavior. Proc. Natl. Acad. Sci. USA, 108(7), 3047-3052. https://doi.org/10.1073/pnas.1010529108
Hvas, C. L., Baunwalla, S. M. D., & Erikstrup, C. (2020). Faecal microbiota transplantation: A life-saving therapy challenged by commercial claims for exclusivity. EClinicalMedicine, 24, 100436.
Karkman, A., Lehtimäki, J. & Ruokolainen, L. (2017). The ecology of human microbiota: dynamics and diversity in health and disease. Annals of the New York Academy of Sciences, 1399(1), 78–92. https://doi.org/10.1111/nyas.13326.
Kim, K. O. & Gluck, M. (2019). Fecal Microbiota Transplantation: An Update on Clinical Practice. Clinical endoscopy, 52(2), 137–143. https://doi.org/10.5946/ce.2019.009
Koren, O., Knights, D., Gonzalez, A., Waldron, L., Segata, N., Knight, R. et al. (2013). A guide to enterotypes across the human body: meta-analysis of microbial community structures in human microbiome datasets. PLoS Comput Biol., 9(1), e1002863. https://doi.org/10.1371/journal.pcbi.1002863
Korman, T. M. (2015). Diagnosis and management of Clostridium difficile infection. Semin Respir Crit Care Med., 36(1), 31-43. https://doi.org/10.1055/s-0034-1398741
Ley R. E., Backhed F., Turbanugh, P., Lozupone, C. A., Knight, R. D. & Gordon, J. I. (2005). Obesity alters gut microbial ecology. Nature USA, 102(31), 1022-23. https://doi.org/10.1073/pnas.0504978102
Ley, R. E., Turnbaugh, P. J., Klein, S. & Gordon, J. I. (2006). Human gut microbes associated with obesity. Nature, 444(7122), 1022–1023. https://doi.org/10.1038/4441022a
Longo, W. E., & Oliver, G.C. (2007). Less-common Benign Disorders of the Colon and Rectum. In: Wolff, B.G., et al. The ASCRS Textbook of Colon and Rectal Surgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-36374-5_43
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K. & Knight, R. (2012). Diversity, stability and resilience of the human gut microbiota. Nature, 489(7415), 220-230. https://doi.org/10.1038/nature11550
Magalhães-Guedes, K. T., Anunciação, T. A. & Nascimento, A. S. M. (2020). Psicobióticos na saúde mental contra transtorno da ansiedade e depressão. cap. 13, 105-110. Castro, L. H. A., Pereira, T. T., Oesterreich, S. A. (Orgs). In: Ciências da saúde: campo promissor em pesquisa. (vol. 1, 1ª ed, 2020). Ponta Grossa, PR: Atena. https://doi.org/10.22533/at.ed.89920110213
Margolis, K. G., Cryan, J. F., & Mayer, E. A. (2021). The Microbiota-Gut-Brain Axis: From Motility to Mood. Gastroenterology, 160(5), 1486–1501. https://doi.org/10.1053/j.gastro.2020.10.066
Markowiak, P. & Śliżewska, K. (2017). Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients, 9(9), 1021. https://doi.org/10.1155/2014/572754
Marmot, M. (2006). Smoking and inequalities. The Lancet, 368(9533), 341–42. https://doi.org/10.1016/S0140-6736(06)68976-9
Martin, R., Nauta, A. J., Ben Amor, K., Knippels, L. M. J., Knol, J. & Garssen, J. (2010). Early life: gut microbiota and immune development in infancy. Beneficial Microbes, 1(4), 367-382. https://doi.org/10.3920/BM2010.0027
Martins, D. C., Baptista, C. & Carrilho, C. (2018). Microbiota intestinal e diabetes mellitus: associações intrínsecas. Rev Port Endocrinol Diabetes Metab., 13(2). https://doi.org/10.1016/j.rpedm.2016.10.0XXX
Meng, C., Bai, C., Brown, T. D., Hood, L. E. & Tian, Q. (2018). Human Gut Microbiota and Gastrointestinal Cancer. Genomics, proteomics & bioinformatics, 16(1), 33–49. https://doi.org/10.1016/j.gpb.2017.06.002
Microbiology By Numbers. (2011). Nature reviews microbiology, 9, 628. https://doi.org/10.1038/nrmicro2644
Morais, L. H., Schreiber, H. L. & Mazmanian, S. K. (2021). The gut microbiota–brain axis in behaviour and brain disorders. Nature reviews microbiology, 19, 241–255. https://doi.org/10.1038/s41579-020-00460-0
Nishijima, S., Suda, W., Oshima, K., Kim, S. W., Hirose, Y., Morita, H. & Hattori, M. (2016). The gut microbiome of healthy Japanese and its microbial and functional uniqueness. DNA Res., 23, 125–33. https://doi.org/10.1093/dnares/dsw002
Pandey, K. R., Naik, S. R. & Vakil, B. V. (2015). Probiotics, prebiotics and synbiotics- a review. Journal of Food Science and Technology, 52(12), 7577–7587. https://doi.org/10.1007/s13197-015-1921-1
Peters, B. A., Wu, J., Pei, Z., Yang, L., Purdue, M. P., Freedman, N. D. et al. (2017). Oral microbiome composition reflects prospective risk for esophageal cancers. Cancer Res., 77(23), 6777–87. https://doi.org/10.1158/0008-5472.CAN-17-1296
Postelli, G. & Costa, C. (2010). Bactérias intestinais e obesidade. Revista saúde e pesquisa, 3(1), 115-119. https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1412
Rossen, N. G., Macdonald, J. K., De Vries, E. M., D’haens, G. R., De Vos, W. M. et al. (2015). Fecal microbiota transplantation as novel therapy in gastroenterology: a systematic review. World J Gastroenterol., 21(17), 5359-71. https://doi.org/10.3748/wjg.v21.i17.5359
Santos, K. E. R. & Ricci, G. C. L. (2016). Microbiota intestinal e a obesidade. Revista UNINGÁ Review, 26(1),74-82. https://revista.uninga.br/uningareviews/article/view/1794
Santos, L. A. (2018). A Microbiota intestinal e sua relação com o sistema imunológico. Revista da Universidade Vale do Rio Verde, 16(1), 1-9. http://dx.doi.org/10.5892/ruvrd.v16i2.4342
Santos, R. & Varavalho, M. (2011). A importância de probiótico para o controle e/ou reestruturação da microbiota intestinal. Revista Científica do ITPAC, São Paulo, 4(1), 40-49. https://assets.unitpac.com.br/arquivos/Revista/41/5.pdf
Sender R., Fuchs S. & Milo R. (2016). Revised estimates for the number of human and bacteria cells in the body. PLoS biology, 14(8), e1002533. https://doi.org/10.1371/journal.pbio.1002533
Signorello, L. B., Cohen, S. S., Williams, D. R., Munro, H. M., Hargreaves, M. K. & Blot, W. J. (2014). Socioeconomic status, race, and mortality: a prospective cohort study. Am. J. Public Health, 104(12), 98–107. https://doi.org/10.2105/AJPH.2014.302156
Sommer, F. & Backhed, F. (2013). The gut microbiota - masters of host development and physiology. Nature reviews microbiology, 11, 227–238. https://doi.org/10.1038/nrmicro2974
Tan, P., Li, X., Shen, J., & Feng, Q. (2020). Fecal Microbiota Transplantation for the Treatment of Inflammatory Bowel Disease: An Update. Frontiers Pharmacology, 11:574533. doi: 10.3389/fphar.2020.574533
Tan, H. E. (2023). The microbiota-gut-brain axis in stress and depression. Frontiers in neuroscience, 17, 1151478. https://doi.org/10.3389/fnins.2023.1151478
Tang, W. W. H., Bäckhed, F., Landmesser, U. L. F & Hazen, S. L. (2019). Intestinal Microbiota in Cardiovascular Health and Disease: JACC State-of-the-Art Review. J Am Coll Cardiol., 73(16), 2089–2105. https://doi.org/10.1016/j.jacc.2019.03.024
Terrier, M. C. Z., Simonet, Ml, B. P. & Frossard, J. L. (2014). Recurrent Clostridium difficile infections: the importance of the intestinal microbiota. World J Gastroenterol., 20(23), 7416-23. https://doi.org/10.3748/wjg.v20.i23.7416
The Integrative Hmp (iHMP). (2019). Research Network Consortium. The Integrative Human Microbiome Project. Nature, 569, 641–648. https://doi.org/10.1038/s41586-019-1238-8
Tsukumo, D. M., Carvalho, B. M., Carvalho-Filho, M. A. & Saad, M. J. A. (2009). Translational research into gut microbiota: new horizons in obesity treatment. Arq Bras Endocrinol Metabol., 53(2), 139-44. https://doi.org/10.1590/2359-3997000000029
Wachsmuth, H.R., Weninger, S.N. & Duca, F.A. (2022). Role of the gut–brain axis in energy and glucose metabolism. Experimental & Molecular Medicine, 54, 377–392. https://doi.org/10.1038/s12276-021-00677-w
Waclawiková, B., Codutti, A., Alim, K., & El Aidy, S. (2022). Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies. Gut microbes, 14(1), 1997296. https://doi.org/10.1080/19490976.2021.1997296
Wilson, I. D. & Nicholson, J. K. (2017). Gut microbiome interactions with drug metabolism, efficacy, and toxicity. Transl. Res., 179, 204–22. https://doi.org/10.1016/j.trsl.2016.08.002
Zahran, S. A., Ali-Tammam, M., Hashem, A. M., Aziz, R. K. & Ali, A. E. (2019). Azoreductase activity of dye-decolorizing bacteria isolated from the human gut microbiota. Scientific reports, 9(1), 5508. https://doi.org/10.1038/s41598-019-41894-8
Zhou, X., Qiao, K., Wu, H., & Zhang, Y. (2023). The Impact of Food Additives on the Abundance and Composition of Gut Microbiota. Molecules (Basel, Switzerland), 28(2), 631. https://doi.org/10.3390/molecules28020631
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