Adverse events with the use of hyaluronic acid in HOF – A narrative literature review
DOI:
https://doi.org/10.33448/rsd-v12i5.41854Keywords:
Hyaluronic acid; Face; Adverse effects.Abstract
With the increase in people looking for aesthetic procedures, especially facial procedures, numerous techniques and materials have emerged in the Orofacial Harmonization market. Among the materials, filling with the use of injectable hyaluronic acid stands out. Being a natural substance found in the human body itself, its applicability has gained scale and supporters. Due to its short half-life, purification and cross-linking techniques were added by the industry, providing products with greater density, purity and durability. Inevitably, the scalar increase in the use of this substance has proportionally increased the number of reports of adverse effects. Among the causes of these adversities stand out the inability of operators, incorrect application techniques, lack of knowledge of the products, in addition to organic factors inherent to the individual. Adverse effects are classified as early and late, the most common being: edema, erythema, ecchymosis, hematoma, infection, nodules, necrosis, vascular complications, granulomas, allergic reactions and scars. Cryotherapy, compress, use of antibiotics, systemic and intralesional corticoids, in addition to hyaluronidase, are part of the range of procedures that are part of the treatment to combat these adverse effects.
References
Abduljabbar, M. H., & Basendwh, M. A. (2016). Complications of hyaluronic acid fillers and their managements. Journal of Dermatology & Dermatologic Surgery, 20(2): 100-106.
Bailey, S. H., Cohen, J. L., & Kenkel, J. M. (2011). Etiology, prevention, and treatment of dermal filler complications. Aesthetic surgery journal, 31(1), 110–121.
Carle, M. V., Roe, R. H., & Novack, R. L. (2015). Occlusion caused by cosmetic facial filler injection - reply. JAMA ophthalmology, 133(2), 225.
Carruthers, J. D. A., Fagien, S., Rohrich, R. J., Weinkle, S., & Carruthers, A. (2014). Blindness caused by cosmetic filler injection: a review of cause and therapy. Plastic and reconstructive surgery, 134(6), 1197–1201.
Cavalcanti, A. N., Azevedo, J. F., & Mathias, P. (2017). HOF: a Odontologia além do sorriso. Journal of Dentistry & Public Health (inactive/archive only), 8(2): 35-36.
Cavallieri, F. A. et al. (2017). Edema tardio intermitente e persistente ETIP: reação adversa tardia ao preenchedor de AH. Surgical & Cosmetic Dermatology, 9(3): 218-2222.
Cohen, J. L., Biesman, B. S., Dayan, S. H., DeLorenzi, C., Lambros, V. S., Nestor, M. S., Sadick, N., & Sykes, J. (2015). Treatment of Hyaluronic Acid Filler-Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations. Aesthetic surgery journal, 35(7), 844–849.
Coimbra, D. A., Uribe, N. C., & De Oliveira, B. S. (2014). “Quadralização facial” no processo do envelhecimento. Surgical & Cosmetic Dermatology, 6(1): 65-71.
Crocco, E. I., Alves, R. O., & Alessi, C. (2012). Eventos adversos do AH injetável. Surgical & cosmetic dermatology, 4(3): 259-263.
Daher, J. et al. Complicações vasculares dos preenchimentos faciais com AH: confecção de protocolo de prevenção e tratamento. Revista Brasileira de Cirurgia Plástica, 35(1): 2-7.
Dantas, S. F. I. M. et al. (2019). As eficácias a curto e longo prazo do preenchimento com AH no rejuvenescimento facial. Saúde & Ciência em Ação, 5(1): 63-81.
Almeida, A. D. et al. (2017). Diagnóstico e tratamento dos eventos adversos do AH: recomendações de consenso do painel de especialistas da América Latina. Surgical & Cosmetic Dermatology, 9(3): 204-213.
DeLorenzi C. (2013). Complications of injectable fillers, part I. Aesthetic surgery journal, 33(4), 561–575.
Garbin, A. J. I. et al. (2019). HOF e suas implicações na odontologia. BJSCR, 27(2): 116-22.
Gilbert, E., Hui, A., Meehan, S., & Waldorf, H. A. (2012). The basic science of dermal fillers: past and present Part II: adverse effects. Journal of drugs in dermatology: JDD, 11(9), 1069–1077.
Gladstone, H. B., & Cohen, J. L. (2007). Adverse effects when injecting facial fillers. Seminars in cutaneous medicine and surgery, 26(1), 34–39.
Gutmann, I. E., & Dutra, R. T. (2018). Reações adversas associadas ao uso de preenchedores faciais com AH. Rev. eletr. biociências, biotecnologia e saúde, 11(20): 07-17.
Hwang C. J. (2016). Periorbital Injectables: Understanding and Avoiding Complications. Journal of cutaneous and aesthetic surgery, 9(2), 73–79.
Kang, B. K., Kang, I. J., Jeong, K. H., & Shin, M. K. (2016). Treatment of glabella skin necrosis following injection of hyaluronic acid filler using platelet-rich plasma. Journal of cosmetic and laser therapy: official publication of the European Society for Laser Dermatology, 18(2), 111–112.
Kapoor, K. M., Kapoor, P., Heydenrych, I., & Bertossi, D. (2020). Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature. Aesthetic plastic surgery, 44(3), 929–944.
Karp, B. I., & Alter, K. (2016). Botulinum Toxin Treatment of Blepharospasm, Orofacial/Oromandibular Dystonia, and Hemifacial Spasm. Seminars in neurology, 36(1), 84–91.
Lafaille, P., & Benedetto, A. (2010). Fillers: contraindications, side effects and precautions. Journal of cutaneous and aesthetic surgery, 3(1), 16–19.
Laglenne, E. (2004). Letter to the editor: in response to: case report: episodes of angioedema of the face with nodules and foreign body granulomas two years after injection of a product for filling wrinkles: New-Fill probably the responsible agent. Nouv Dermatol, 23: 223-4.
Lee, J. M., & Kim, Y. J. (2015). Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment. Archives of plastic surgery, 42(2), 232–239.
Mamelak, A. J., Katz, T. M., Goldberg, L. H., Graves, J. J., Kaye, V. N., & Friedman, P. M. (2009). Foreign body reaction to hyaluronic acid filler injection: in search of an etiology. Dermatologic surgery: official publication for American Society for Dermatologic Surgery [et al.], 35 Suppl 2, 1701–1703.
Matarasso S. L. (2007). Injectable collagens: lost but not forgotten--a review of products, indications, and injection techniques. Plastic and reconstructive surgery, 120(6 Suppl), 17S–26S.
Mccann M. (2019). Intravenous Hyaluronidase for Visual Loss Secondary to Filler Injection: A Novel Therapeutic Approach. The Journal of clinical and aesthetic dermatology, 12(12), 25–27.
Morris, C. L., Stinnett, S. S., & Woodward, J. A. (2008). Patient-preferred sites of restylane injection in periocular and facial soft-tissue augmentation. Ophthalmic plastic and reconstructive surgery, 24(2), 117–121.
Murray, G., Convery, C., Walker, L., & Davies, E. (2021). Guideline for the Safe Use of Hyaluronidase in Aesthetic Medicine, Including Modified High-dose Protocol. The Journal of clinical and aesthetic dermatology, 14(8), E69–E75.
Naini, F. B., & Gill, D. S. (2008). Facial aesthetics: 2. Clinical assessment. Dental update, 35(3), 159–170.
Narins, R. S., & Bowman, P. H. (2005). Injectable skin fillers. Clinics in plastic surgery, 32(2), 151–162.
Parada, M. B. et al. (2016). Manejo de complicações de preenchedores dérmicos. Surgical & Cosmetic Dermatology, 8(4): 342-351.
Park, T. H., Seo, S. W., Kim, J. K., & Chang, C. H. (2011). Clinical experience with hyaluronic acid-filler complications. Journal of plastic, reconstructive & aesthetic surgery: JPRAS, 64(7), 892–896.
López Pérez V. (2022). COVID-19 and Dermal Fillers: Should We Really Be Concerned? COVID y rellenos faciales ¿realmente debemos preocuparnos?. Actas dermo-sifiliograficas, 113(9), 888–894.
Philipp-Dormston, W. G., Wong, C., Schuster, B., Larsson, M. K., & Podda, M. (2018). Evaluating Perceived Naturalness of Facial Expression After Fillers to the Nasolabial Folds and Lower Face With Standardized Video and Photography. Dermatologic surgery: official publication for American Society for Dermatologic Surgery [et al.], 44(6), 826–832.
Requena, L., Requena, C., Christensen, L., Zimmermann, U. S., Kutzner, H., & Cerroni, L. (2011). Adverse reactions to injectable soft tissue fillers. Journal of the American Academy of Dermatology, 64(1), 1–36.
Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paul. Enferm, 20(2).
Rousso, J. J., & Pitman, M. J. (2010). Enterococcus faecalis complicating dermal filler injection: a case of virulent facial abscesses. Dermatologic surgery: official publication for American Society for Dermatologic Surgery [et al.], 36(10), 1638–1641.
Sánchez-Carpintero, I., Candelas, D., & Ruiz-Rodríguez, R. (2010). Materiales de relleno: tipos, indicaciones y complicaciones. Actas Dermo-Sifiliográficas, 101(5): 381-393.
Selyanin, M. A. (2015). et al. The history of hyaluronic acid discovery, foundational research and initial use. Hyaluronic Acid: Preparation, Properties, Application in Biology and Medicine, 1-8.
Signorini, M., Liew, S., Sundaram, H., De Boulle, K. L., Goodman, G. J., Monheit, G., Wu, Y., Trindade de Almeida, A. R., Swift, A., Vieira Braz, A., & Global Aesthetics Consensus Group (2016). Global Aesthetics Consensus: Avoidance and Management of Complications from Hyaluronic Acid Fillers-Evidence- and Opinion-Based Review and Consensus Recommendations. Plastic and reconstructive surgery, 137(6), 961e–971e.
Urdiales-Gálvez, F., Delgado, N. E., Figueiredo, V., Lajo-Plaza, J. V., Mira, M., Ortíz-Martí, F., Del Rio-Reyes, R., Romero-Álvarez, N., Del Cueto, S. R., Segurado, M. A., & Rebenaque, C. V. (2017). Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report. Aesthetic plastic surgery, 41(3), 667–677.
Vasconcelos, S. C. B. et al. (2020). O uso do AH no rejuvenescimento facial. Revista brasileira militar de ciências, 6(14).
Wang, C., Sun, T., Yu, N., & Wang, X. (2020). Herpes reactivation after the injection of hyaluronic acid dermal filler: A case report and review of literature. Medicine, 99(24), e20394.
Wollina, U., & Goldman, A. (2020). Facial vascular danger zones for filler injections. Dermatologic therapy, 33(6), e14285.
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