Profile of limonoids isolated from andiroba (Carapa Guianensis Aubl): Systematic review
DOI:
https://doi.org/10.33448/rsd-v12i6.42018Keywords:
Isolation; Limonoids; Carapa; Guianensis.Abstract
Introduction: Carapa guianensis Aubl is a member of the Meliaceae family. This species contains alkaloids and terpenoids, especially limonoids. These substances have broad spectrum biological activities, in particular, anti-inflammatory and insecticidal action. Objective: To characterize the main limonoids extracted from andiroba (Carapa guianensis Aubl), in relation to botany, phytochemistry and biological action. Methodology: Systematic review study. Results: Sixteen articles were selected to respond to the objectives established in this systematic review. Therefore, information addressing the biological action and phytochemical determination of isolated limonoids was described, these being experimental in vitro studies. Among these articles, there was a significant number that verified the effectiveness of the inhibitory activity of NO (Nitric Oxide), having anti-inflammatory potential in the macrophage-like lineage RAW 264.7. And in other articles it was possible to identify cytotoxic activity in P388, L1210 and HL-60 strains. Conclusion: It was possible to compare existing limonoids with new ones and identify their differences in the structural formula and biological action of isolated limonoids, which were described and confirmed by articles found in the literature. Although there are important and specific studies in this review, it is clear to the authors the need for new studies and experimental tests in vitro and in vivo, with Carapa guianensis, since it shows a promising analgesic and anti-inflammatory action, in addition to presenting activity insecticide and antimalarial.
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