Pharmaceutical care in the misuse of drugs for weight loss: systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i6.42133

Keywords:

Pharmaceutical attention; Liraglutide; Fluoxetine; Orlistat; Weight loss.

Abstract

Introduction: The high search for short-term weight loss leads to the misuse of weight loss drugs without the supervision of a health professional, which can cause physical dependence, intoxication and serious side effects. Objective: To present the forms of intervention by the pharmacist in the misuse of weight loss drugs. Methodology: This is a systematic review following Prisma criteria, using the database of online virtual libraries BVS, Scielo and Pubmed. Inclusion criteria are: publications of articles in the last 10 years (2012-2022) that are available in Portuguese and English in the informed databases, easily accessible articles on appetite suppressants. Results: The main effects reported in the use of these drugs are: dehydration, chronic diarrhea and constipation, metabolic acidosis, hypokalemia, cardiac arrhythmia; hemorrhagic and ischemic stroke; renal and hepatic failure. The main pharmacological indication for obesity is for those who have profiles with more serious consequences, such as hypertension, diabetes, among other comorbidities who have not been successful in losing weight only with changes in lifestyle. Pharmacists are directly involved in dispensing weight loss products, providing useful information about their use and their main adverse effects. Conclusions: It is essential that the patient seeks professional guidance before starting the use of weight loss drugs, so that they are aware of the contraindications, side effects and that the administration of these drugs is done correctly.

References

Andrade, T. B., Andrade, G.B., Honorato, J. J., & Silva J. N. (2019). O farmacêutico frente aos riscos do uso de inibidores de apetite: a sibutramina. Revista da Faculdade de Educação e Meio Ambiente - FAEMA, Ariquemes, 10(1), 81-92.

Ard, J., Fitch, A., Fruh, S., & Herman, L. (2021). Weight Loss and Maintenance Related to the Mechanism of Action of Glucagon-Like Peptide 1 Receptor Agonists. Adv Ther.

Azevedo, F. R. & Brito, B. C. (2018). Influência das variáveis nutricionais e da obesidade sobre a saúde e o metabolismo. Revista da Associação Médica Brasileira (English Edition). 58(6): 714-23.

Bersoux, S., Byun, T. H., Chaliki, S. S., & Poole, K. G. (2017). Pharmacotherapy for obesity: What you need to know.

Beyea, M. M., Garg, A. X., & Weir, M. A. (2012). Does orlistat cause acute kidney injury? Doi: 10.1177/2042098611429985

Dastjerdi, A. G., Akhgari, M., Kamali, A., & Mousavi, Z. (2018). Principal component analysis of synthetic adulterants in herbal supplements advertised as weight loss drugs. Doi: 10.1016/j.ctcp.2018.03.007

Denyer, D, &Tranfield, D. (2006). Using qualitative research synthesis to build an actionable knowledge base. Management Decision, 44,213-227. DOI: 10,1108 / 00251740610650201.

Domecq, J. P., et al. (2015). Clinical review: Drugs commonly associated with weight change: a systematic review and meta-analysis. Doi: 10.1210/jc.2014-3421

Douglas, I. J., Bhaskaran, K., Batterham, R. L., & Smeeth, L. (2015). The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort. DOI: 10.1111/bcp.12578

Fakih, S., Marriott, J.L., Boardman, H. et al. (2014). Comparing women pharmacy consumers’ experiences with weight loss treatment in Victoria and Nottingham: a cross-sectional study.

Felix, H. C., & West, D. S. (2013). Effectiveness of weight loss interventions for obese older adults. Doi: 10.4278/ajhp.110617-LIT-259

Hijazi, M. A., Shatila, H., El-Lakany, A., Al Rifai. H., Aboul-Ela, M., & Naja, F. (2020). Role of community pharmacists in weight management: results of a national study in Lebanon.

Inch, J., Avenell, A., Aucott, L., & Watson, M. C. (2018). A mixed-methods evaluation of a community pharmacy signposting service to a commercial weight-loss provider.

Khera, R., Murad, M. H., Chandar, A. K., et al. (2016). Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis. Doi: 10.1001/jama.2016.7602

Manning, S., Pucci, A., & Finer N. (2014). Pharmacotherapy for obesity: novel agents and paradigms.

Mead, E., Atkinson, G., Richter, B., Metzendorf, M., Baur, L., Finer, N., Corpeleijn, E., O'Malley, C., Ells, L. J. (2016). Drug interventions for the treatment of obesity in children and adolescents. Doi :10.1002/14651858.CD012436

Neto, B. B. C., et al. (2021). Uso de medicamentos para emagrecimento por estudantes de cursos superiores da área da saúde, em uma instituição de ensino privada na cidade de cajazeiras, Paraíba, Brasil. Revista Saúde e Meio Ambiente, 12(1), 167-179.

Pomeranz, J. L., Taylor, L. M., & Austin, S. B. (2013). Over-the-counter and out-of-control: legal strategies to protect youths from abusing products for weight control.

Salim, N., Rahman, M. N. A., & Wahab, D. A. (2019) A systematic literature review of internal capabilities for enhancing eco-innovation performance ofmanufacturing firms. ournal of Cleaner Production, v. 209, p. 1445-1460. DOI: https://doi.org/10.1016/j.jclepro.2018.11.105.

Silva, J. R., Oliveira, E. N. F., & Ferreira, A. G. (2012). Avaliação do consumo de anorexígenos derivados de anfetamina em cidades de Goiás-GO. Ensaios e Ciência: C. Biológicas, Agrárias e da Saúde, 76(3).

Squadrito, F., et al. (2020). Anti-obesity drug therapy in clinical practice: Evidence of a poor prescriptive attitude. Biomed Pharmacother.

Tranfield, D., Denyer, D., & Smart, P. (2003). Towards a methodology for developing evidence-informed management knowledge by means of systematic review. British Journal Management, 14,207-222. DOI: https://doi.org/10.1111/1467-8551.00375

Um, I. S., Armour, C., Krass, I., Gill, T., & Chaar, B. B. (2014). Consumer perspectives about weight management services in a community pharmacy setting in NSW, Australia. Health Expect.

Verma, R. K., Chong, W. W., Taha, N. A., & Paraidathathu T. (2021). A Qualitative Study Exploring Community Pharmacists' Experiences and Views About Weight Management Interventions and Services in Klang Valley, Malaysia.

Downloads

Published

11/06/2023

How to Cite

SOUZA, A. P. de; OLIVEIRA, B. M. de; SILVA, E. F. L. da .; ROCHA, G. da S. .; ALMEIDA, A. C. G. de; BRITO, M. A. M. . Pharmaceutical care in the misuse of drugs for weight loss: systematic review. Research, Society and Development, [S. l.], v. 12, n. 6, p. e10712642133, 2023. DOI: 10.33448/rsd-v12i6.42133. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/42133. Acesso em: 23 nov. 2024.

Issue

Vol. 12 No. 6

Section

Review Article

License

Copyright (c) 2023 Andreia Portilho de Souza; Bianca Moreira de Oliveira; Evelyn Fernanda Lima da Silva; Gabriel da Silva Rocha; Anne Cristine Gomes de Almeida; Marcelo Augusto Mota Brito

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.