The correlation between bone fractures and obesity: a literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i7.42450

Keywords:

Obesity; Bones fractures; Complications.

Abstract

Introduction: The discussion between the existence or not of influence of obesity on the incidence of bone fractures raises an extremely relevant physiological clash in the endocrine and orthopedic scenario, and it is essential to deepen this medical correlation. Objective: The present study aimed to evaluate the clinical and epidemiological aspects, and the correlation between obesity and bone fractures in general. Materials and Methods: This is an integrative literature review of the physiological aspects of bone tissue and the pathophysiological aspects of obesity, seeking to obtain a correlation between them in the context of bone fractures. The PICO strategy was used to prepare the guiding question. Furthermore, the descriptors “Obesity” were crossed; “Bone Fractures”; “Complications”, in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Ebscohost, Google Scholar and Virtual Health Library (BVS) databases. Results and Discussion: A significant portion of the articles demonstrated that there is a correlation between bone fractures and obesity, although its protective role, which was established, is currently questioned. Conclusion: It was possible to perceive that there are points of metabolic convergence between the pathophysiology of obesity and the physiology of bone tissue, highlighting the theoretical possibility of greater bone fragility in obese patients.

Author Biography

Marilene Rivany Nunes, Centro Universitário de Patos de Minas

Doutora em enfermagem em saúde pública. EERP- USP.

References

Ayagara, A. R., Langlet, A., & Hambli, R. (2019). On dynamic behavior of bone: Experimental and numerical study of porcine ribs subjected to impact loads in dynamic three-point bending tests. Journal of the Mechanical Behavior of Biomedical Materials, 98, 336–347. https://doi.org/10.1016/j.jmbbm.2019.05.031

Bandeira, F. (2007). A obesidade realmente fortalece os ossos? Arquivos brasileiros de endocrinologia e metabologia, 51(6), 895–897. https://doi.org/10.1590/s0004-27302007000600001

Bredella, M. A., Torriani, M., Ghomi, R. H., Thomas, B. J., Brick, D. J., Gerweck, A. V., Rosen, C. J., Klibanski, A., & Miller, K. K. (2011). Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women. Obesity (Silver Spring, Md.), 19(1), 49–53. https://doi.org/10.1038/oby.2010.106

Cao, J. J. (2011). Effects of obesity on bone metabolism. Journal of Orthopaedic Surgery and Research, 6(1), 30. https://doi.org/10.1186/1749-799X-6-30

Cobayashi, F., Lopes, L. A., & Taddei, J. A. A. C. (2005). Densidade mineral óssea de adolescentes com sobrepeso e obesidade. Jornal de pediatria, 81(4), 337–342. https://doi.org/10.1590/s0021-75572005000500013

Côpes, R. M. (2014). Impacto da obesidade nas fraturas ósseas em mulheres na pós-menopausa: um estudo de base populacional em Santa Maria. Universidade Federal de Santa Maria.

Costa, J., Porolnik, S., Amaral, T. F., Petter, G. do N., Pivetta, H. M. F., & Braz, M. M. (2022). Risco de quedas de idosas obesas. Conjecturas, 22(2), 974–986. https://doi.org/10.53660/conj-797-e19

De Jesus, C. F., De Jesus, L. S., & Dos Santos, M. C. (2022). Processo inflamatório na obesidade: papel modulador da nutrição. Imersão: Revista Científica do Sertão Baiano, 59–77.

Feitosa, V. M. C., Araújo, D. K. L. de, & Sousa, M. N. A. de. (2022). Risco de osteoporose em pacientes submetidos à cirurgia bariátrica. Revista Contemporânea, 2(3), 446–468. https://doi.org/10.56083/rcv2n3-021

Fjeldstad, C., Fjeldstad, A. S., Acree, L. S., Nickel, K. J., & Gardner, A. W. (2008). The influence of obesity on falls and quality of life. Dynamic Medicine: DM, 7(1), 4. https://doi.org/10.1186/1476-5918-7-4

Gasques, L. S., Abrão, R. M., Diegues, M. E. M., & Gonçalves, T. S. A. (2022). Obesidade genética não sindrômica: histórico, fisiopatologia e principais genes. Arquivos de Ciências da Saúde da UNIPAR, 26(2). https://doi.org/10.25110/arqsaude.v26i2.2022.8737

Gomes, T. P., Veloso, F. L. de M., Antunes Filho, J., Mourão, F. C., Nascif, N. H. T., Loures, E. D. A., Labronici, P. J., & Mendes Júnior, A. F. (2019). Obesidade, Diabetes Mellitus tipo 2 e fragilidade óssea: uma revisão narrativa. HU Revista, 44(2), 241–249. https://doi.org/10.34019/1982-8047.2018.v44.14058

Guerra, J. (2019). Diabetes e Osso: da Prevenção à Terapêutica. Universidade de Lisboa.

Júnior, W. de, Teixeira, L. S., Benevides, P. H. S., Rezende, L. C. B., & Coelho, D. L. M. (2022). Perfil epidemiológico de pacientes com fratura de fêmur proximal submetidos a tratamento cirúrgico. Revista Eletrônica Acervo Saúde, 15(12), e11321. https://doi.org/10.25248/reas.e11321.2022

Kojima, K. E., & Ferreira, R. V. (2011). Fraturas da diáfise da tíbia. Revista Brasileira de Ortopedia, 46(2), 130–135. https://doi.org/10.1590/s0102-36162011000200002

Loi, F., Córdova, L. A., Pajarinen, J., Lin, T.-H., Yao, Z., & Goodman, S. B. (2016). Inflammation, fracture and bone repair. Bone, 86, 119–130. https://doi.org/10.1016/j.bone.2016.02.020

Morgan, E. F., Barnes, G. L., & Einhorn, T. A. (2010). The bone organ system: Form and function. Em Fundamentals of Osteoporosis (p. 1–23). Elsevier.

Mota, A., & Schraiber, L. B. (2014). Medicina sob as lentes da História: reflexões teórico-metodológicas. Ciencia & saude coletiva, 19(4), 1085–1094. https://doi.org/10.1590/1413-81232014194.16832013

Picelli, J. P. (2021). Influência da obesidade na reparação óssea em ratos (Rattus novergicus). Universidade de Uberaba - UNIUBE.

Premaor, M. O., Comim, F. V., & Compston, J. E. (2014). Obesity and fractures. Arquivos Brasileiros de Endocrinologia e Metabologia, 58(5), 470–477. https://doi.org/10.1590/0004-2730000003274

Sandøe, P., Palmer, C., Corr, S., Astrup, A., & Bjørnvad, C. R. (2014). Canine and feline obesity: a One Health perspective. The Veterinary Record, 175(24), 610–616. https://doi.org/10.1136/vr.g7521

Savvidis, C., Tournis, S., & Dede, A. D. (2018). Obesity and bone metabolism. Hormones (Athens, Greece), 17(2), 205–217. https://doi.org/10.1007/s42000-018-0018-4

Silva, S. S. da, Silva, S. H., Aguiar, G. A., Batista, S. O., Santos, A. C. M., Bandeira, F. L. C., Alves, M. T., Silva, Á. G. F. da, Sousa, V. A. de, Rodrigues, C. N. da S., Silva, N. C. da, Souza, L. A. de, Oliveira, T. R. J., Cardoso, B. S., & Gonçalves, J. B. da S. (2022). A atuação neuroendócrina no controle da fome e saciedade e sua relação com a obesidade. Research, Society and Development, 11(2), e33311225621. https://doi.org/10.33448/rsd-v11i2.25621

Torres, M. R. dos S., Oliveira, L. B. de, & Peixoto, M. I. (2020). Associação entre sarcopenia e história de fraturas em pacientes idosos com diabetes tipo 2. Medicina (Ribeirao Preto Online), 53(4), 389–397. https://doi.org/10.11606/issn.2176-7262.v53i4p389-397

Walsh, J. S., & Vilaca, T. (2017). Obesity, type 2 diabetes and bone in adults. Calcified tissue international, 100(5), 528–535. https://doi.org/10.1007/s00223-016-0229-0

World Health Organization. (2023). Obesity. Obesity. http://www.who.int/topics/obesity/en/

Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z., & Morrison, S. J. (2016). Leptin receptor promotes adipogenesis and reduces osteogenesis by regulating mesenchymal stromal cells in adult bone marrow. Cell Stem Cell, 18(6), 782–796. https://doi.org/10.1016/j.stem.2016.02.015

Published

08/07/2023

How to Cite

ALMEIDA, S. L. .; NUNES, M. R. . The correlation between bone fractures and obesity: a literature review. Research, Society and Development, [S. l.], v. 12, n. 7, p. e2112742450, 2023. DOI: 10.33448/rsd-v12i7.42450. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/42450. Acesso em: 21 nov. 2024.

Issue

Section

Health Sciences