Development of a quality of life instrument to evaluate oral mucositis in cancer patients
DOI:
https://doi.org/10.33448/rsd-v12i7.42468Keywords:
Mucositis; Surveys and questionnaires; Indicators of quality of life; Oncology.Abstract
Oral mucositis is a side effect of cancer treatments, a limiting condition and of great impact on quality of life (QOL). The objective was to develop an instrument to evaluate QoL related to oral mucositis. Research through mixed methods, starting with qualitative interviews analyzed by the Bardin method and Reinert method, with the IRaMuTeQ software, followed by the Delphi method in four rounds of interviews and discussions with experts. The first version of the instrument underwent a pre-test with 10 patients, with quantitative and qualitative analysis, followed by another round of experts. The material of the qualitative interviews pointed out the terms pain and feeding as central in the experience of oral mucositis, besides providing several keywords for definition of constructs. Then 4 experts formulated 34 questions sent to 10 other experts from different regions and Brazilian institutions who analyzed the clarity, spelling and need of each question for the questionnaire. The relevant changes were made, reviewed and discussed again. The first version of the Oral Mucositis Impact Scale in Cancer Patients (EIMOPO) was presented to 10 patients who did not participate in the qualitative interviews and answered the degree of understanding and need of each question. The final analysis of the pre-test reformulated some tenses and words difficult to understand, forming the final version of the instrument. Although there are good instruments to measure QoL and oral mucositis, we present new questions about financial impacts, treatment interruption, saliva alteration, weight loss directly related to oral mucositis and psychosocial aspects.
References
Aguilar-Ponce J. L., Granados-García M., Cruz López J. C., Maldonado-Magos F., Alvarez-Avitia M. A., Arrieta O., et al. (2013). Alternating chemotherapy: gemcitabine and cisplatin with concurrent radiotherapy for treatment of advanced head and neck cancer. Oral Oncol. 49:249-54.
Aldhouse N. V. J., Kitchen H., Knight S., Macey J., Nunes F. P., Dutronc Y., et al. (2020). "'You lose your hair, what's the big deal?' I was so embarrassed, I was so self-conscious, I was so depressed:" a qualitative interview study to understand the psychosocial burden of alopecia areata. J Patient Rep Outcomes. 4:76.
Antunes J. L., Biazevic M. G., de Araujo M. E., Tomita N. E., Chinellato L. E., & Narvai P. C. (2001). Trends and spatial distribution of oral cancer mortality in São Paulo, Brazil, 1980-1998. Oral Oncol.;37:345-50.
Antunes J. L., Biazevic M. G., de Araujo M. E., Tomita N. E., Chinellato L. E., & Narvai P. C. (2001). Trends and spatial distribution of oral cancer mortality in São Paulo, Brazil, 1980-1998. Oral Oncol.;37:345-50.
Arditi C., Walther D., Gilles I., et al. (2020). Computer-assisted textual analysis of free-text comments in the Swiss Cancer Patient Experiences (SCAPE) survey. BMC Health Serv Res. 20:1029.
Ariyawardana, A., Cheng, K. K. F., Kandwal, A., Tilly, V., Al-Azri, A. R., Galiti, D. et al. (2019). Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 27: 3985-35.
Bardin L. (2016). Content Analysis. Edições 70.
Boulkedid R., Abdoul H., Loustau M., Sibony O., & Alberti C. (2011). Using and reporting the Delphi method for selecting healthcare quality indicators: a systematic review. PLoS One. 6:e20476.
Carrera P.M & Olver I. (2015). The financial hazard of personalized medicine and supportive care. Support Care Cancer. 23:3399-401.
Creswell J. W, Klassen A. C., Plano Clark V. L., & Smith K. C. (2011). Best practices for mixed methods research in the health sciences. National Institutes of Health; Available from: https://obssr.od.nih.gov/sites/obssr/files/Best_Practices_for_Mixed_Methods_Research.pdf
Fayers, P. M., & Machin D. (2007). Scores and measurements: validity, reliability, sensitivity. In: Quality of Life: the assessment, analysis and interpretation of patient-reported outcomes. New Jersey:Wiley.
Fontenele B. M. N., & Pedrosa M. D. S. (2021). Xerostomia and Taste Alterations in COVID-19. Ear Nose Throat J.186S-187S.
Gilam G., Gross J. J., Wager T. D., Keefe F. J., & Mackey S. C. (2020). What Is the Relationship between Pain and Emotion? Bridging Constructs and Communities. Neuron.107:17-21.
Greenhalgh J, Gooding K, Gibbons E, Dalkin S, Wright J, Valderas J, et al. (2018). How do patient reported outcome measures (PROMs) support clinician-patient communication and patient care? A realist synthesis. J Patient Rep Outcomes. 2:42.
Harrison R. L., Reilly T. M., & Creswell J. W. (2020). Methodological rigor in mixed methods: an application in management studies. Journal of Mixed Methods Research.14:473-95.
Hovan A. J, Williams P. M., Stevenson-Moore P., Wahlin Y. B., Ohrn K. E, Elting L. S., et al. (2010). A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer.1081-7.
Kolator, M., Kolator, P. & Zatoński, T. (2018). Assessment of quality of life in patients with laryngeal cancer: a review of articles. Adv Clin Exp Med. 27: 711-5.
Linstone H. A & Turf, M. (1975). The Delphi method: techniques and applications. Boston:Addison-Wesley.
Lo Monaco G., & Bonetto E. (2019). Social representations and culture in food studies. Food Res Int.,115:474-479.
Mehraeen E., Behnezhad F., Salehi M. A., Noori T., Harandi H., & SeyedAlinaghi S. (2021). Olfactory and gustatory dysfunctions due to the coronavirus disease (COVID-19): a review of current evidence. Eur Arch Otorhinolaryngol. 278:307-312.
Oba, M. K., Innocentini, L. M. A. R., Viani, G., Ricz, H. M. A., de Carvalho Reis, T., Ferrari, T. C. et al. (2021). Evaluation of the correlation between side effects to oral mucosa, salivary glands, and general health status with quality of life during intensity-modulated radiotherapy for head and neck cancer. Support Care Cancer. 29: 127-34.
Pereira N. F., Silva P. V. R. D., Fukuoka C. Y., Michel-Crosato E., Gonçalves A. S., Alves F. A., et al. (2018). Measurement of oral health quality of life among patients who underwent haematopoietic stem-cell transplantation. Braz Oral Res. 32:e78.
Silva A. H.& Fossá M. I. T. (2015). Análise de conteúdo: exemplo de aplicação da técnica para análise de dados qualitativos. Qualitas Rev Eletrônica. 16.1
Sonis S. T., Peterson R. L., Edwards L. J., Lucey C. A., Wang L., Mason L. et al. (2000). Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucositis in hamsters. Oral Oncol. 36(4):373-81.
Trakman G. L., Forsyth A., Hoye R., & Belski R. (2017). Developing and validating a nutrition knowledge questionnaire: key methods and considerations. Public Health Nutr., 20:2670-9.
Whiting P. F., Rutjes A. W., Westwood M. E., Mallett S., Deeks J. J., Reitsma J. B., et al. (2011). QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 155:529-36.
Wiseman M. J. (2019). Nutrition and cancer: prevention and survival. J Nutr.122:481-487.
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