Botulinum toxin: Intercurrences and complications in the application
DOI:
https://doi.org/10.33448/rsd-v12i7.42697Keywords:
Botulinum toxins, type A; Injection site reaction; Iatrogenic disease.Abstract
The search for beauty and rejuvenation has become a widely discussed subject in today's society, both by women and men. In this context, treatment with botulinum toxin has gained prominence in aesthetics due to its durability and low occurrence of side effects. Botulinum toxin, a neurotoxin produced by a gram-positive anaerobic bacterium, has seven different serotypes, with botulinum toxin A being the most used for aesthetic purposes. Wrinkles are the result of repetitive contractions of certain muscles, and botulinum toxin A acts by reducing muscle tension, being indicated for various aesthetic procedures, such as shaping the eyebrows and nose, smoothing dynamic wrinkles on the forehead, lifting the corners of the mouth and correcting of facial asymmetries. However, it is important to emphasize that any aesthetic procedure presents risks, and it is essential that professionals have a broad anatomical, muscular and subcutaneous knowledge of the face, in addition to precise manual skills. Although it is considered a relatively simple and safe procedure, the use of botulinum toxin requires adequate care. This work aims to address the intercurrences and complications associated with the application of botulinum toxin, aiming to provide guidance to specialists and promote an aesthetic treatment with a minimum of adverse events.
References
Alster, T. S., & Harrison, I. S. (2020). Alternative Clinical Indications of Botulinum Toxin. American journal of clinical dermatology, 21(6), 855–880.
Anandan, C., & Jankovic, J. (2021). Botulinum Toxin in Movement Disorders: An Update. Toxins, 13(1), 42.
Andalécio, M. M., Andrade, R. S., Lima, L. C. S., Carvalho, T. de A., & Silva, I. A. P. S. (2021). A utilização da toxina botulínica no tratamento da paralisia facial periférica. Research, Society and Development, 10(9), e8510917935.
Bellows, S., & Jankovic, J. (2019). Immunogenicity Associated with Botulinum Toxin Treatment. Toxins, 11(9), 491.
Borba, A., Matayoshi, S., & Rodrigues, M. (2022). Avoiding Complications on the Upper Face Treatment With Botulinum Toxin: A Practical Guide. Aesthetic plastic surgery, 46(1), 385–394.
Choudhury, S., Baker, M. R., Chatterjee, S., & Kumar, H. (2021). Botulinum Toxin: An Update on Pharmacology and Newer Products in Development. Toxins, 13(1), 58.
Feroze, K. B., & Kaufman, E. J. (2023). Xerophthalmia. In StatPearls. StatPearls Publishing.
Francisco Filho, M. L., Suguihara, R. T., Muknicka, D. P. (2023). Mecanismos de ação e indicações da Toxina Botulínica. Research, Society and Development, 12(6), e15712642223.
Gómez de Liaño R. (2019). The Use of Botulinum Toxin in Strabismus Treatment. Journal of binocular vision and ocular motility, 69(2), 51–60.
Guo, X., Li, T., Wang, Y., & Jin, X. (2021). Sub-acute hypersensitive reaction to botulinum toxin type A following Covid-19 vaccination: Case report and literature review. Medicine, 100(49), e27787.
Heydenrych I. (2020). The Treatment of Facial Asymmetry with Botulinum Toxin: Current Concepts, Guidelines, and Future Trends. Indian journal of plastic surgery, 53(2), 219–229.
Koka, K., & Patel, B. C. (2023). Ptosis Correction. In StatPearls. StatPearls Publishing.
Kroumpouzos, G., Kassir, M., Gupta, M., Patil, A., & Goldust, M. (2021). Complications of Botulinum toxin A: An update review. Journal of cosmetic dermatology, 20(6), 1585–1590.
Lee, W., Ahn, T. H., Cheon, G. W., Lee, M. J., & Yang, E. J. (2021). Comparative analysis of botulinum toxin injection after corrective rhinoplasty for deviated nose and alar asymmetry. Journal of cosmetic dermatology, 20(2), 451–456.
Matak, I., Bölcskei, K., Bach-Rojecky, L., & Helyes, Z. (2019). Mechanisms of Botulinum Toxin Type A Action on Pain. Toxins, 11(8), 459.
Nestor, M. S., Han, H., Gade, A., Fischer, D., Saban, Y., & Polselli, R. (2021). Botulinum toxin-induced blepharoptosis: Anatomy, etiology, prevention, and therapeutic options. Journal of cosmetic dermatology, 20(10), 3133–3146.
Ramos, M. L. S., Teixeira, L. de A. C., Bastos, B. T. S. S., Gebara, M. G. O., Silva, M. B. da, & Costa, D. H. (2022). A importância da conscientização sobre o uso da toxina botulínica tanto na atuação terapêutica, como na harmonização orofacial para cirurgiões dentistas. E-Acadêmica, 3(3), e4433344.
Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paul. Enferm, 20(2).
Serrera-Figallo, M. A., Ruiz-de-León-Hernández, G., Torres-Lagares, D., Castro-Araya, A., Torres-Ferrerosa, O., Hernández-Pacheco, E., & Gutierrez-Perez, J. L. (2020). Use of Botulinum Toxin in Orofacial Clinical Practice. Toxins, 12(2), 112.
Sethi, N., Singh, S., DeBoulle, K., & Rahman, E. (2021). A Review of Complications Due to the Use of Botulinum Toxin A for Cosmetic Indications. Aesthetic plastic surgery, 45(3), 1210–1220.
Swift, A., Liew, S., Weinkle, S., Garcia, J. K., & Silberberg, M. B. (2021). The Facial Aging Process From the "Inside Out". Aesthetic surgery journal, 41(10), 1107–1119.
Tiwari, A., & Nagalli, S. (2022). Clostridium botulinum Infection. In StatPearls. StatPearls Publishing.
Yi, K. H., Lee, J. H., Hu, H. W., & Kim, H. J. (2022). Anatomical Proposal for Botulinum Neurotoxin Injection for Glabellar Frown Lines. Toxins, 14(4), 268.
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