Therapeutic properties of Moringa oleífera Lam. in the treatment of diabetes mellitus

Authors

DOI:

https://doi.org/10.33448/rsd-v9i7.4270

Keywords:

Moringa oleífera; Diabetes mellitus; Hypoglycemic agents.

Abstract

The Moringa oleifera is a species of perennial plant, native to the western and southern Himalayas and northeast India. Its nutritional and phytochemical richness has been the target of several studies, as they have relevant therapeutic effects, such as anticancer, antiallergic, anti-inflammatory, immunomodulatory, antifungal, antibacterial, hepatoprotective and antidiabetic. In this context, the present study aimed to explain the therapeutic potential of oil Moringa in the treatment of diabetes mellitus. For this, a systematic search was carried out in the PubMed, ScienceDirect and SciELO databases. For the search, the following descriptors were used: Moringa oleifera; Diabetes Mellitus and Hypoglycemic Drugs. All selected from the Health Sciences Descriptors (DeCS) and used in the languages: Portuguese and English. At first, 501 publications were found and after applying the predetermined inclusion and exclusion criteria, 18 pertinent publications remained, which served as the basis for the construction of the work. It was observed that Moringa oleífera has, among numerous benefits, important hypoglycemic activity, an action attributed, above all, to the abundance of nutrients and secondary metabolites capable of positively influencing serum glucose levels. For example, some bioactive compounds such as isothiocyanates, quercetin, gallic acid, ellagic acid and chlorogenic acid, are cited as relevant hypoglycemic agents, as they are able to inhibit enzymes related to carbohydrate degradation in the gastrointestinal tract. In addition to these metabolites, Moringa oleífera contains protein fractions similar to insulin, which in addition to controlling blood glucose levels and improving oral tolerance, has greater stability and activity time in the body. It has also been shown that Moringa oleífera has been used as a therapeutic alternative, not only in the control of diabetes itself, but also in the treatment of diseases associated with this pathology, such as diabetic nephropathy, oxidative stress, impaired healing, endothelial dysfunction and cardiovascular diseases. In addition, the literature suggests that this species has no significant toxicity. Thus, it can be concluded that Moringa oleifera proved to be important on hyperglycemia, as well as on the damage caused by it. However, the use of this plant as a therapeutic resource for diabetes is not yet recommended, given the scarcity of studies that demonstrate its effects on humans.

References

Ahmad, I, Khan, I, & Blundell, R. (2019). Moringa oleifera and glycemic control: a review of current evidence and possible mechanisms: A review of current evidence and possible mechanisms. Phytotherapy Research, 33(11), 2841-2848.

Aju, B.Y, Rajalakshmi, R & Mini, S. (2019). Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats. Heliyon, 5(12), 1-7.

Almeida, M.S.M (2018), Moringa oleifera Lam. seus benefícios medicinais, nutricionais e avaliação de toxicidade. Dissertação de Mestrado, Universidade de Coimbra, Coimbra, Portugal.

Alencar, E.M. et al. (2019). Estudo etnobotânico do conhecimento e uso das plantas medicinais no município de Buriticupu, Maranhão, Brasil. Revista Ibero-Americana de Ciências Ambientais, 10 (6), 328-338.

Alvarenga, C.F. et al. (2017). Uso De Plantas Medicinais Para O Tratamento Do Diabetes Mellitus No Vale Do Paraíba-SP. Revista Ciência e Saúde On-line, 2(2), 36-44.

Amelia, D. (2018). et al. Effects of Moringa oleifera on Insulin Levels and Folliculogenesis in Polycystic Ovary Syndrome Model with Insulin Resistance. Immunology, Endocrine & Metabolic Agents In Medicinal Chemistry, 18(1), 22-30.

American Diabetes Association (ADA). (2014). Diagnosis and classification of diabetes mellitus. Diabetes care, 37(1), 81-90.

Anwar, F. et al. (2006). Moringa oleifera: a food plant with multiple medicinal uses: a food plant with multiple medicinal uses . Phytotherapy Research, 21(1), 17-25.

Arora, D.S, Onsare , J.G & Kaur, .H. (2013). Bioprospecting of Moringa (Moringaceae): Microbiological Perspective. Journal of Pharmacognosy and Phytochemistry, 1(6), 193-215.

Asiedu-gyekye, I.J. et al. (2014). Micro- and Macroelemental Composition and Safety Evaluation of the Nutraceutical Moringa oleífera Leaves. Journal Of Toxicology, 2014(1), 1-13.

Azad, S.B. et al. (2017). Anti-hyperglycaemic activity of Moringa oleifera is partly mediated by carbohydrase inhibition and glucose-fibre binding. Bioscience reports, 37 (3), 1-11.

Azevedo, Í.M. et al. (2018). Wound healing of diabetic rats treated with Moringa oleifera extract. Acta cirúrgica brasileira, 33(9), 799-805.

Bertonhi, L.G & Dias, J.C.R. (2018). Diabetes mellitus tipo 2: aspectos clínicos, tratamento e conduta dietoterápica. Revista Ciências Nutricionais Online, 2(2), 1-10.

Bezerra, A.M.E, Momenté, V.G & Medeiros, F.S. (2004). Germinação de sementes e desenvolvimento de plântulas de moringa (Moringa oleifera Lam) em função do peso da semente e do tipo de substrato. Horticultura Brasileira, 22(2), 295-299.]

Carneiro, F.M. et al. (2014). Tendências dos estudos com plantas medicinais no Brasil. Revista Sapiência: sociedade, saberes e práticas educacionais, 3(2), 44-75.

Cheng, D. et al. (2019). Moringa Isothiocyanate Activates Nrf2: potential role in diabetic nephropathy: Potential Role in Diabetic Nephropathy. The Aaps Journal, 21(2), 1-23.

Cortez, D.N. et al. (2015). Complicações e o tempo de diagnóstico do diabetes mellitus na atenção primária. Acta Paulista de Enfermagem, 28(3), 250-255.

Ferreira, L.T. et al. (2011). Diabetes melito: hiperglicemia crônica e suas complicações. Arquivos Brasileiros de Ciências da Saúde, 36(3), 182-188.

Gopalakrishnan, L, Doriya, K & Kumar, D.S. (2016). Moringa oleifera: a review on nutritive importance and its medicinal application: A review on nutritive importance and its medicinal application. Food Science And Human Wellness, 5(2), 49-56.

Goyal, B.R. et al. (2007). Phyto-pharmacology of Moringa oleifera Lam An overview. Natural Product Radiance, , 6(4), 347-353.

Jimoh, T.O. (2018). Enzymes inhibitory and radical scavenging potentials of two selected tropical vegetable (Moringa oleifera and Telfairia occidentalis) leaves relevant to type 2 diabetes mellitus. Revista Brasileira de Farmacognosia, 28(1), 73-79.

Klein, E.C. (2015.). Diabetes Mellitus Tipo 1 Adquirido Na Infância, E A Importância Do Profissional Farmacêutico. FACIDER-Revista Científica, 1(7), 1-17.

Kou, X. et al. (2018). Nutraceutical or pharmacological potential of Moringa oleifera Lam. Nutrients, 10(3), 343.

Koul, B & Chase, N. (2015). Moringa oleifera Lam: panacea to several maladies: Panacea to several maladies. Journal Of Chemical And Pharmaceutical Research, 7(6), 687-707.

Kumssa, D.B. et al. (2017.). Challenges and opportunities for Moringa growers in southern Ethiopia and Kenya. Plos One, 12(11), 1-15.

Leone, A. et al. (2018). Effect of Moringa oleifera leaf powder on postprandial blood glucose response: In vivo study on Saharawi people living in refugee camps. Nutrients, 10 (10), 1494.

Lunyera, J. et al. (2016). Traditional medicine practices among community members with diabetes mellitus in Northern Tanzania: an ethnomedical survey. BMC complementary and alternative medicine, 16(1), 282.

Magaji, U.F., Sacan, O & Yanardag, R. (2020). Alpha amylase, alpha glucosidase and glycation inhibitory activity of Moringa oleifera extracts. South African Journal Of Botany, 128(1), 225-230.

Morais, A.M. et al. (2019). Perfil e conhecimento de gestantes sobre o diabetes mellitus gestacional. Revista de Epidemiologia e Controle de Infecção, V 9(2), 134-141.

Muhammad, A.A. et al. (2016.). Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. Drug design, development and therapy, 10(1), 1715.

Muhammad, H.I. et al. (2016.). A review on promising phytochemical, nutritional and glycemic control studies on Moringa oleifera Lam in tropical and sub-tropical regions. Asian Pacific Journal Of Tropical Biomedicine, 6(10), 896-902.

Neves, C. et al. (2017). Diabetes Mellitus Tipo 1. Revista Portuguesa de Diabetes, 12(4), 159-167.

Newsholme, P. et al. (2014.). Nutrient regulation of insulin secretion and action. Journal of Endocrinology, 221(3), 105-120.

Okiki, P.A. et al. (2015). Evaluation of Proximate, Minerals, Vitamins and Phytochemical Composition of Moringa oleifera Lam Cultivated in Ado Ekiti, Nigeria . Advances In Biological Research, 9(6), 436-443.

Omodanisi, E, Aboua, Y & Oguntibeju, O. (2017). Assessment of the Anti-Hyperglycaemic, Anti-Inflammatory and Antioxidant Activities of the Methanol Extract of Moringa oleifera in Diabetes-Induced Nephrotoxic Male Wistar Rats. Molecules, 22(4), 1-16.

Padayachee, B & Baijnath, H. (2019). An updated comprehensive review of the medicinal, phytochemical and pharmacological properties of Moringa oleifera . South African Journal Of Botany, 1(1), 1-13.

Paula, P.C. et al. (2017). A protein isolate from Moringa oleifera leaves has hypoglycemic and antioxidant effects in alloxan-induced diabetic mice. Molecules, 22(2), 271.

Paula, P.C. et al. (2016). Insulin-like plant proteins as potential innovative drugs to treat diabetes—The Moringa oleifera case study. New Biotechnology, 39 (1), 99-109.

Pina, J.C. (2018). Influência de diferentes substratos na produção de fitoconstituintes de Moringa oleifera Lam cultivada a pleno sol. Ciência Florestal, 28(3), 1076-1097.

Rangel, M.S.A. (1999). Moringa oleifera Uma Planta de Uso Múltiplo. Embrapa Tabuleiros Costeiros, 1(1), 41.

Saidu, Y. (2017). In vitro screening for protein tyrosine phosphatase 1B and dipeptidyl peptidase IV inhibitors from selected Nigerian medicinal plants. Journal of intercultural ethnopharmacology, 6(2), 154.

Sánchez, K.V, Jaramillo, E.G & Reyes, R.E.G. (2019). Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies. Nutrients, 11(12), 1-19.

SOCIEDADE BRASILEIRA DE DIABETES. (2019). Diretrizes da Sociedade Brasileira de Diabetes 2019-2020. Editora Clannad.

Sousa R.A.L. et al. (2018). Consequences of gestational diabetes to the brain and behavior of the offspring. Anais da Academia Brasileira de Ciências, 90(2), 2279-2291.

Sousa, D.N. (2016) Levantamento de patentes sobre a planta Moringa oleifera no Brasil e no mundo. 79 f. Dissertação de Mestrado, Curso de Inovação Tecnológica, Instituto de Ciências Exatas e Tecnológicas, Universidade Federal do Triângulo Mineiro, Uberaba.

Souza, T.M.A. et al. (2015). Crescimento e desenvolvimento inicial da cultura da moringa (Moringa oleifera Lam) submetida à fertilização orgânica. Revista Verde de Agroecologia e Desenvolvimento Sustentável, 10(3), 103-107.

Taweerutchana, R. et al. (2017). Effect of Moringa oleifera leaf capsules on glycemic control in therapy-naive type 2 diabetes patients: A randomized placebo controlled study. Evidence-Based Complementary and Alternative Medicine, 2017(1), 1-6.

Vargas-Sánchez, K, Garay-Jaramillo, E & González-Reyes, R.E. (2019). Effects of Moringa oleifera on Glycaemia and Insulin Levels: a review of animal and human studies: A Review of Animal and Human Studies. Nutrients, 12(12), 1-19.

Villarruel-López, A. et al. (2018). Effect of Moringa oleifera consumption on diabetic rats. BMC complementary and alternative medicine, 18(1), 1-10.

Waterman, C. et al. (2015.). Isothiocyanate‐rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice . Molecular nutrition & food research, 59(6), 1013-1024.

World health organization , W.H.O. (2014). Global status report on noncommunicable diseases 2014. (1 ed.). Genebra: Who Library Cataloguing-in-publication data.

Zainab, B. (2020). In-silico elucidation of Moringa oleifera phytochemicals against diabetes mellitus. Saudi Journal Of Biological Sciences, 1(1), 1-9.

Zaku, S.G. (2015). Moringa oleifera: an underutilized tree in nigeria with amazing versatility: An underutilized tree in Nigeria with amazing versatility. African Journal Of Food Science, 9(9), 456-461.

Published

23/05/2020

How to Cite

ANDRADE, J. I. A.; FERNANDES, D. P.; GALVÃO, J. G. F. M.; SILVA, D. R.; NÓBREGA, R. de O. Therapeutic properties of Moringa oleífera Lam. in the treatment of diabetes mellitus. Research, Society and Development, [S. l.], v. 9, n. 7, p. e485974270, 2020. DOI: 10.33448/rsd-v9i7.4270. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/4270. Acesso em: 27 dec. 2024.

Issue

Section

Health Sciences