Gut-brain axis: relationship between intestinal microbiota and mental disorders

Authors

  • Ingrid Gabriela de Oliveira Tonini Centro Universitário Campo Real https://orcid.org/0000-0003-2568-8721
  • Diana Souza Santos Vaz Universidade Estadual de Campinas
  • Caryna Eurich Mazur Universidade Estadual do Centro-Oeste Guarapuava

DOI:

https://doi.org/10.33448/rsd-v9i7.4303

Keywords:

Anxiety; Depression; Gastrointestinal microbiome; Mental disorders.

Abstract

The term “gut-brain axis” has been widely used in the study of communication between the gastrointestinal tract and the central nervous system, a vital relationship for the maintenance of homeostasis and whose imbalance can result in changes in the response to stress and in behavior. This review aims to present and discuss the findings of studies about the gut-brain axis and the possible relationship between intestinal dysbiosis and mental disorders. The guiding question was: "How can intestinal health affect the brain and its functioning?" Of fifty articles found, seven were selected to integrate this review, all published in English. The findings of all articles discussed in this review demonstrate a direct and significant impact of the intestinal microbiota on the central nervous system, observing behaviors related to anxiety, depression and stress in the face of changes in the microbiota.

References

Barbosa, FT, Cunha, RM, Pinto, ALCLT. (2008). Delirium pós-operatório em idosos. Rev Bras Anestesiol, 58(6).

Bastiaanssen, TFS, Cussotto, S, Claesson, MJ, Clarke, G, Dinan, TG & Cryan, JF. (2020). Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder. Harvard Review of Psychiatry, 28(1), 26-39.

Bourassa, MW, Alim, I, Bultman, SJ & Ratan, RR. (2016). Butyrate, neuroepigenetics and the gut microbiome: Can a high fiberdiet improve brain health? Neuroscience Letters, 625, 56-63.

Burokas, A, Arboleya, S, Moloney, RD, Peterson, VL, Murphy, K, Clarke, G, Stanton, C, Dinan, TG, Cryan, JF. (2017). Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressantlike Effects and Reverse the Impact of Chronic Stress in Mice. Biological Psychiatry, 82(7), 472-487.

Cerejeira, J, Firmino, H & Vaz-Serra, A. (2010). The neuroinflammatory hypothesis of delirium. Acta Neuropathol, 119(6), 737-754.

Clarke, G, Grenham, S, Scully, P, Fitzgerald, P, Moloney, RD, Shanahan, F, Dinan, TG, Cryan, JF. (2013). The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular Psychiatry, 18(6), 666-673.

Cryan, JF, O’Mahony, SM. (2011). The microbiome‐gut‐brain axis: from bowel to behavior. Neurogastroenterol Motil, 23(3), 187-192.

Del’arco, APWT, Magalhães, P, Quilici, FA. (2017). SIM Brasil study – Women’s Gastrointestinal Health: gastrointestinal symptoms and impact on the Brazilian women quality of life. Arq Gastroenterol, 54(2), 115-122.

Dinan, TG, Cryan, JF. (2017). The Microbiome-Gut-Brain Axis in Health and Disease. Gastroenterol Clin North Am., 46(1), 77-89.

Dinan, TG, Stanton, C, Cryan, JF. (2013). Psychobiotics: a novel class of psychotropic. Biol Psychiatry, 74(10), 720-6.

Dinan, TG, Stilling, RM, Stanton, C, Cryan, JF. (2015). Collective unconscious: How gut microbes shape human behavior. Journal of Psychiatric Research, 63, 1-9.

Gareau, MG, Wine, E, Rodrigues, DM, Cho, JH, Whary, MT, Philpott, DJ, Macqueen, G, Sherman, PM. (2011). Bacterial infection causes stress-induced memory dysfunction in mice. Gut, 60(3), 307-17.

Gershon, MD, Tack, J. (2007). The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology, 132(1), 397-414.

Heym, N, Heasman, BC, Hunter, K, Blanco, SR, Wang, GY, Siegert, R, Cleare, A, Gibson, Kumari, V, Sumich, AL. (2019). The role of microbiota and inflammation in self-judgement and empathy: implications for understanding the brain-gut-microbiome axis in depression. Psychopharmacology, 236(5), 1459-1470.

Kelly, JR, Clarke, G, Cryan, JF, Dinan, TG. (2016). Brain-Gut-Microbiota axis: Challenges for Translation in Psychiatry. Annals of Epidemiology, 26(5), 366-72.

Kelly, JR, Borre, Y, O’Brien, C, Patterson, E, El Aidy, S, Deane, J, Kennedy, PJ, Beers, S, Scott, K, Fitzgerald, P, Ross, P, Stanton, C, Clarke, G, Cryan, JF, Dinan, TG. (2016). Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research, 82, 109-18.

Kelly, JR, Kennedy, PJ, Cryan, JF, Dinan, TG, Clarke, G & Hyland, NP. (2015). Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci, 9, 392.

Lach, G, Morais, LH, Costa, APR, Hoeller, AA. (2017). Envolvimento da flora intestinal na modulação de doenças psiquiátricas. Vittalle – Revista de Ciências da Saúde, 29(1), 64-82.

Liu, P, Peng, G, Zhang, N, Wang, B, Luo, B. (2019). Crosstalk Between the Gut Microbiota and the Brain: An Update on Neuroimaging Findings. Front Neurol, 10, 883.

Liu, Q. F., Kim, H. M., Lim, S., Chung, M. J., Lim, C. Y., Koo, B. S., Kang, S. S. (2020). Effect of probiotic administration on gut microbiota and depressive behaviors in mice. DARU J Pharm Sci.

Ministério da Saúde. Biblioteca Virtual em Saúde. (2015). Ansiedade. Retrieved February 04, from http://bvsms.saude.gov.br/dicas-em-saude/470-ansiedade.

Organização Pan-Americana de Saúde. Organização Mundial da Saúde. (2018). Folha informativa – Transtornos mentais. Retrieved February 04, from https://www.paho.org/bra/index.php?option=com_content&view=article&id=5652:folha-informativa-transtornos-mentais&Itemid=839.

Ozan, ZT, Tanik, N, Inan, LE. (2019). Constipation is associated with tension type headache in women. Arq Neuropsiquiatr, 77(3), 161-165.

Pan, JX, Deng, FL, Zeng, BH, Zheng, P, Liang, WW, Yin, BM, Wu, J, Dong, MX, Luo, Y. Y, Wang, HY, Wei, H & Xie, P. (2019). Absence of gut microbiota during early life affects anxiolytic Behaviors and monoamine neurotransmitters system in the hippocampal of mice. Journal of the Neurological Sciences, 400, 160-168.

Reigstad, CS, Salmonson, CE, Rainey, JF, Szurszewski, JH, Linden, DR, Sonnenburg, JL, Farrugia, G & Kashyap, PC. (2015). Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J, 29(4), 1395-1403.

Schmidt, K, Cowen, PJ, Harmer, CJ, Tzortzis, G, Errington, S, Burnet, PWJ. (2015). Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology (Berl), 232(10), 1793-801.

Stilling, RM, Dinan, TG, Cryan, JF. (2014). Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis. Genes, Brain and Behavior, 13(1), 69-86.

World Health Organization. (2017). Depression and Other Common Mental Disorders: Global Health Estimates. Retrieved February 04, from https://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf.

Xiao, HW, Ge, C, Feng, GX, Li, Y, Luo, D, Dong, JL, Li, H, Wang, H, Cui, M & Fan, SJ. (2018). Gut microbiota modulates alcohol withdrawal-induced anxiety in mice. Toxicology Letters, 287, 23-30.

Yano, JM, Yu, K, Donaldson, GP, Shastri, GG, Ann, P, Ma, L, Nagler, CR, Ismagilov, RF, Mazmanian, SK & Hsiao, EY. (2015). Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis. Cell, 161(2), 264-276.

Zhang, J, Bi, JJ, Guo, GJ, Yang, L, Zhu, B, Zhan, GF, Li, S, Huang, NN, Hashimoto, K, Yang, C & Luo, AL. (2019). Abnormal composition of gut microbiota contributes to delirium‐like behaviors after abdominal surgery in mice. CNS Neurosci Ther, 25(6), 685-696.

Published

23/05/2020

How to Cite

TONINI, I. G. de O.; VAZ, D. S. S.; MAZUR, C. E. Gut-brain axis: relationship between intestinal microbiota and mental disorders. Research, Society and Development, [S. l.], v. 9, n. 7, p. e499974303, 2020. DOI: 10.33448/rsd-v9i7.4303. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/4303. Acesso em: 8 nov. 2024.

Issue

Section

Review Article