Gut-brain axis: relationship between intestinal microbiota and mental disorders
DOI:
https://doi.org/10.33448/rsd-v9i7.4303Keywords:
Anxiety; Depression; Gastrointestinal microbiome; Mental disorders.Abstract
The term “gut-brain axis” has been widely used in the study of communication between the gastrointestinal tract and the central nervous system, a vital relationship for the maintenance of homeostasis and whose imbalance can result in changes in the response to stress and in behavior. This review aims to present and discuss the findings of studies about the gut-brain axis and the possible relationship between intestinal dysbiosis and mental disorders. The guiding question was: "How can intestinal health affect the brain and its functioning?" Of fifty articles found, seven were selected to integrate this review, all published in English. The findings of all articles discussed in this review demonstrate a direct and significant impact of the intestinal microbiota on the central nervous system, observing behaviors related to anxiety, depression and stress in the face of changes in the microbiota.
References
Barbosa, FT, Cunha, RM, Pinto, ALCLT. (2008). Delirium pós-operatório em idosos. Rev Bras Anestesiol, 58(6).
Bastiaanssen, TFS, Cussotto, S, Claesson, MJ, Clarke, G, Dinan, TG & Cryan, JF. (2020). Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder. Harvard Review of Psychiatry, 28(1), 26-39.
Bourassa, MW, Alim, I, Bultman, SJ & Ratan, RR. (2016). Butyrate, neuroepigenetics and the gut microbiome: Can a high fiberdiet improve brain health? Neuroscience Letters, 625, 56-63.
Burokas, A, Arboleya, S, Moloney, RD, Peterson, VL, Murphy, K, Clarke, G, Stanton, C, Dinan, TG, Cryan, JF. (2017). Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressantlike Effects and Reverse the Impact of Chronic Stress in Mice. Biological Psychiatry, 82(7), 472-487.
Cerejeira, J, Firmino, H & Vaz-Serra, A. (2010). The neuroinflammatory hypothesis of delirium. Acta Neuropathol, 119(6), 737-754.
Clarke, G, Grenham, S, Scully, P, Fitzgerald, P, Moloney, RD, Shanahan, F, Dinan, TG, Cryan, JF. (2013). The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular Psychiatry, 18(6), 666-673.
Cryan, JF, O’Mahony, SM. (2011). The microbiome‐gut‐brain axis: from bowel to behavior. Neurogastroenterol Motil, 23(3), 187-192.
Del’arco, APWT, Magalhães, P, Quilici, FA. (2017). SIM Brasil study – Women’s Gastrointestinal Health: gastrointestinal symptoms and impact on the Brazilian women quality of life. Arq Gastroenterol, 54(2), 115-122.
Dinan, TG, Cryan, JF. (2017). The Microbiome-Gut-Brain Axis in Health and Disease. Gastroenterol Clin North Am., 46(1), 77-89.
Dinan, TG, Stanton, C, Cryan, JF. (2013). Psychobiotics: a novel class of psychotropic. Biol Psychiatry, 74(10), 720-6.
Dinan, TG, Stilling, RM, Stanton, C, Cryan, JF. (2015). Collective unconscious: How gut microbes shape human behavior. Journal of Psychiatric Research, 63, 1-9.
Gareau, MG, Wine, E, Rodrigues, DM, Cho, JH, Whary, MT, Philpott, DJ, Macqueen, G, Sherman, PM. (2011). Bacterial infection causes stress-induced memory dysfunction in mice. Gut, 60(3), 307-17.
Gershon, MD, Tack, J. (2007). The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology, 132(1), 397-414.
Heym, N, Heasman, BC, Hunter, K, Blanco, SR, Wang, GY, Siegert, R, Cleare, A, Gibson, Kumari, V, Sumich, AL. (2019). The role of microbiota and inflammation in self-judgement and empathy: implications for understanding the brain-gut-microbiome axis in depression. Psychopharmacology, 236(5), 1459-1470.
Kelly, JR, Clarke, G, Cryan, JF, Dinan, TG. (2016). Brain-Gut-Microbiota axis: Challenges for Translation in Psychiatry. Annals of Epidemiology, 26(5), 366-72.
Kelly, JR, Borre, Y, O’Brien, C, Patterson, E, El Aidy, S, Deane, J, Kennedy, PJ, Beers, S, Scott, K, Fitzgerald, P, Ross, P, Stanton, C, Clarke, G, Cryan, JF, Dinan, TG. (2016). Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research, 82, 109-18.
Kelly, JR, Kennedy, PJ, Cryan, JF, Dinan, TG, Clarke, G & Hyland, NP. (2015). Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci, 9, 392.
Lach, G, Morais, LH, Costa, APR, Hoeller, AA. (2017). Envolvimento da flora intestinal na modulação de doenças psiquiátricas. Vittalle – Revista de Ciências da Saúde, 29(1), 64-82.
Liu, P, Peng, G, Zhang, N, Wang, B, Luo, B. (2019). Crosstalk Between the Gut Microbiota and the Brain: An Update on Neuroimaging Findings. Front Neurol, 10, 883.
Liu, Q. F., Kim, H. M., Lim, S., Chung, M. J., Lim, C. Y., Koo, B. S., Kang, S. S. (2020). Effect of probiotic administration on gut microbiota and depressive behaviors in mice. DARU J Pharm Sci.
Ministério da Saúde. Biblioteca Virtual em Saúde. (2015). Ansiedade. Retrieved February 04, from http://bvsms.saude.gov.br/dicas-em-saude/470-ansiedade.
Organização Pan-Americana de Saúde. Organização Mundial da Saúde. (2018). Folha informativa – Transtornos mentais. Retrieved February 04, from https://www.paho.org/bra/index.php?option=com_content&view=article&id=5652:folha-informativa-transtornos-mentais&Itemid=839.
Ozan, ZT, Tanik, N, Inan, LE. (2019). Constipation is associated with tension type headache in women. Arq Neuropsiquiatr, 77(3), 161-165.
Pan, JX, Deng, FL, Zeng, BH, Zheng, P, Liang, WW, Yin, BM, Wu, J, Dong, MX, Luo, Y. Y, Wang, HY, Wei, H & Xie, P. (2019). Absence of gut microbiota during early life affects anxiolytic Behaviors and monoamine neurotransmitters system in the hippocampal of mice. Journal of the Neurological Sciences, 400, 160-168.
Reigstad, CS, Salmonson, CE, Rainey, JF, Szurszewski, JH, Linden, DR, Sonnenburg, JL, Farrugia, G & Kashyap, PC. (2015). Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J, 29(4), 1395-1403.
Schmidt, K, Cowen, PJ, Harmer, CJ, Tzortzis, G, Errington, S, Burnet, PWJ. (2015). Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology (Berl), 232(10), 1793-801.
Stilling, RM, Dinan, TG, Cryan, JF. (2014). Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis. Genes, Brain and Behavior, 13(1), 69-86.
World Health Organization. (2017). Depression and Other Common Mental Disorders: Global Health Estimates. Retrieved February 04, from https://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf.
Xiao, HW, Ge, C, Feng, GX, Li, Y, Luo, D, Dong, JL, Li, H, Wang, H, Cui, M & Fan, SJ. (2018). Gut microbiota modulates alcohol withdrawal-induced anxiety in mice. Toxicology Letters, 287, 23-30.
Yano, JM, Yu, K, Donaldson, GP, Shastri, GG, Ann, P, Ma, L, Nagler, CR, Ismagilov, RF, Mazmanian, SK & Hsiao, EY. (2015). Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis. Cell, 161(2), 264-276.
Zhang, J, Bi, JJ, Guo, GJ, Yang, L, Zhu, B, Zhan, GF, Li, S, Huang, NN, Hashimoto, K, Yang, C & Luo, AL. (2019). Abnormal composition of gut microbiota contributes to delirium‐like behaviors after abdominal surgery in mice. CNS Neurosci Ther, 25(6), 685-696.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.