Clinical and epidemiological profile of COVID-19 patients hospitalized in the North of Mato Grosso: A cross-sectional study

Authors

DOI:

https://doi.org/10.33448/rsd-v12i9.43112

Keywords:

COVID-19; SARS-CoV-2; Overweight; Obesity.

Abstract

Objective: Studies have shown that obesity, age, presence of chronic disease, respiratory disease and cancer are risk factors for COVID-19, increasing the risk of hospitalization, complications, and the mortality rate. Thus, the objective of this study was to compare and evaluate the clinical and epidemiological profile of COVID-19 patients admitted to the nursery or Intensive Care Unit (ICU) of the Hospital Regional Jorge de Abreu (HRJA) in Sinop-MT. Methods: This was a cross-sectional study with data collected from medical records of patients diagnosed with COVID-19 and admitted between March 2020 and March 2021. Results: Data from 399 patients hospitalized in a nursery and 389 in ICU were evaluated. Days of symptoms, age and body weight were significantly higher in ICU patients compared to nursery. Furthermore, it was observed that patients admitted to the ICU had a higher prevalence of obesity, diabetes, cardiovascular diseases, and other non-transmitted chronic diseases (NTCD). There was no difference between the groups regarding the presence of previous respiratory diseases. 82.2% of ICU patients and 18.8% of nursery patients required assisted mechanical ventilation. Percentage of patients requiring tracheostomy and presenting complications was also higher in the ICU. The mortality rate was significantly higher in ICU patients (75.2%) compared to nursery patients (13.9%). Conclusion: It was observed that the clinical and epidemiological profile of COVID-19 patients admitted to the ICU was more severe compared to those admitted to the nursery which can be associated with age, obesity and NTCD in these patients.

References

Andrade, O. R. (2020). Os efeitos da Covid-19. Rev pesquisa FAPESP, 295. https://revistapesquisa.fapesp.br/os-efeitos-da-covid-19.

Babbie, E. (2015). The Practice of Social Research. Cengage Learning.

Brasil. (2020). Guia de Vigilância Epidemiológica. Emergência de Saúde Pública de importância nacional pela doença pelo Coronavírus 2019: Vigilância de Síndromes Respiratórias Agudas: COVID-19. Brasília, DF. Ministério da Saúde. Secretaria de Vigilância em Saúde. https://portalarquivos.saude.gov.br/images/af_gvs_coronavirus_6ago20_ajustes-finais- 2.pdf.

Bellini, B., Cresci, B., Cosentino, C., Profili, F. et al. (2020). Obesity as a risk factor for hospitalization in Coronavirus Disease-19 (COVID-19) patients: Analysis of the Tuscany regional database. Nutr Metab Cardiovasc Dis, 31, p. 769-773. https://doi.org/10.1016/j.numecd.2020.11.030.

Cai, Q., Chen, F., Wang, T. et al. (2020). Obesity and Severity of COVID-19 at a Designated Hospital in Shenzhen, China. Diabetes care. 43, 1392-1398.

Castro, M. L. et al. (2021) Profile of patients in an adult intensive care unit in a municipality in Paraíba. Enfermería Actual de Costa Rica, (40), 42910, https://dx.doi.org/10.15517/revenf.v0i40.42910.

Cavalcante, J. R. & Abreu, A. J. (2020). COVID-19 in the city of Rio de Janeiro: spatial analysis of the first confirmed cases and deaths. Epidemiologia e Serviços de Saúde. 29 (3), e2020204. https://doi.org/10.5123/S1679-49742020000300007.

Chen, N., Zhou, M., Dong, X., et al. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 395, 507-513.

Dholia, N., & Yadav, U. C. S. (2018). Lipid mediator leukotriene D (4) induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway. Prostaglandins & Other Lipid Mediators, 136, 55-63.

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Fei, Z., et al. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, 395, 1054-1062.

Fernandes, L. R., et al. (2022). Epidemiological profile of COVID-19 cases in a city in northwest São Paulo. Boletim Epidemiológico Paulista, 19 (217).

Federação Mundial da Obesidade (FMO). (2019). Prevalence of obesity. England and Wales, GB. https://www.worldobesity.org/about/about-obesity/prevalence-of-obesity.

Filho, E. R. A., Reis, I. P., Sandim, L. S., Ramos, R. O. et al. (2020). Profile of Covid-19 notified and confirmed cases in the period from April and May 2020 in the Federal District. REVISA, 9, 646-655. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1128837.

Huang, C., et al. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395, 497-506.

Hussain, A., et al. (2020). COVID-19 and diabetes: knowledge in progress. Diabetes Research and Clinical Practice, 162. e108142. https:// 10.1016/j.diabres.2020.108142.

Iqbal, A., et al. (2019). Effect of hypoglycemia on inflammatory responses and the response to low-dose endotoxemia in humans. The Journal of Clinical Endocrinology & Metabolism, 104(4), 1187-1199.

Klokner, S. G. M., et al. (2021). Epidemiological profile and risk factors for COVID-19 in southern Brazil. Research, Society and Development, 10 (3), e e17710313197.

Ko, J., et al. (2021). Risk Factors for COVID-19-associated hospitalization: COVID-19-Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System. Clinical Infectious Diseases, 1 (72), e695-703.

Kreutz, R., et al. (2020). Hypertension, the renin-angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19. Cardiovascular Research, 1(1), 1-12.

Lopes R. D. et al. (2021). Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial. Lancet. 12 (397), 2253-2263. https://10.1016/S0140-6736(21)01203-4.

Mendonça, K. D. S., et al. (2020). Risk factors for worsening COVID-19 in young individuals. Enfermagem em Foco, 11(2), 37-45.

Nascimento, G. M. I., et al. (2022). Clinical-epidemiological profile of hospitalization cases due to COVID-19 in the ninth health region of Paraíba, Brazil. Research, Society and Development, 11(1). e29011124761. http://dx.doi.org/10.33448/rsd-v11i1.24761.

Nesello, K., et al. (2022). Epidemiological profile, risk of worsening and death from COVID-19 in patients with heart disease in Brazil. Journal Health NPEPS, 7(1), e620.

Organização Pan-Americana de Saúde (OPAS). (2020). Folha informativa COVID-19. Brasília, DF. https://www.paho.org/bra/index.php?option=com_content&view=article&id=6101:covid19&Itemid=875#risco.

Paiva, C. I., et al. (2020). Epidemiological profile of COVID-19 in the State of Paraná. Revista de Saúde Pública do Paraná, 3, 39-61.

Pontes, L., et al. (2022). Clinical profile and factors associated with death of COVID-19 patients in the first months of the pandemic. Escola Anna Nery, 26, e20210203.

Ryan, P. MC., & Caplice, N. M. (2020). Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019? Obesity. 28(7), 1191-1194. https://10.1002/oby.22843

Saltiel, A. R., & Olefsky, J. M. (2017). Mechanisms linking obesity and metabolic disease. Journal of Clinical Investigation, 127, 1-4.

Sociedade Brasileira de Infectologia (SBI). (2021). Covid 19. São Paulo, SP. https://infectologia.org.br/?s=covid+19.

Shi, Y., et al. (2020). Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 causes outside Wuhan. Critical Care, 24(1), 108.

Silva, A. W. C., et al. (2020). Clinical characterization and epidemiology of 1560 cases of COVID-19 in Macapá/AP, extreme north of Brazil. Research, Society and Development, 9(8), e150985499. https://10.33448/rsd-v9i8.5499.

Silva, E. O., et al. (2022). Epidemiological profile of COVID-19 cases in the VIII health region of Pernambuco, Brazil. Revista de Saúde Coletiva da UEFS, 12(1), e7520.

Simonnet, A., Chetboun, M., Poissy, et al. (2020). High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation. Obesity Journal, 28, 1195-1199.

Souza, T. A., et al. (2021). Vulnerabilidade e fatores de risco associados para COVID-19 em idosos institucionalizados. Revista Eletrônica Acervo Saúde, 13(2), e5947. https://doi.org/10.25248/reas.e5947.2021.

Spiteri, G., et al. (2020). First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region. Euro Surveillance, 25(9), e2000178. http://10.2807/1560-7917.ES.2020.25.9.2000178.

Stefan, N., Häring, H. U., & Schulze, M. B. (2018). Metabolically healthy obesity: the low-hanging fruit in obesity treatment? Diabetes & Endocrinology, 6, 249-258.

Tao, C., et al. (2020). Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ, 368(1091). https://doi.org/10.1136/bmj.m1091

Tobias, G., & Teixeira, C. (2021). Epidemiological profile of confirmed cases of COVID-19 in the state of Goiás. In: Siqueira, Samylla. COVID-19: The work of health professionals in times of a pandemic. São Paulo: Editora Científica Digital.

Wang, A., et al. (2020). Timely blood glucose management for the outbreak of 2019 novel coronavirus disease (COVID-19) is urgently needed. Diabetes Research and Clinical Practice, 162, e 108118. https://10.1016/j.diabres.2020.108118.

World Health Organization (WHO) (2021). COVID-19 clinical management: living guidance. https://www.who.int/news-room/q-a-detail/coronavirus-disease-covid-19.

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Published

06/09/2023

How to Cite

SANTOS, K. K. P. M. dos .; MATTAR, V. T. R. .; COSTA, F. C. de O. .; GARCIA, R. M. .; VALLE, B. M. B. do .; CABRAL, M. A. A. S. K. .; QUEIROZ, D. A. de .; NASCIMENTO, A. F. do .; LUVIZOTTO, R. de A. M. .; QUEIROZ, E. A. I. F. de . Clinical and epidemiological profile of COVID-19 patients hospitalized in the North of Mato Grosso: A cross-sectional study. Research, Society and Development, [S. l.], v. 12, n. 9, p. e1712943112, 2023. DOI: 10.33448/rsd-v12i9.43112. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/43112. Acesso em: 12 nov. 2024.

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Health Sciences