Epidemiological profile of newborns diagnosed with COVID-19 in a private maternit hospital in the Northeast between january 2020 and december 2021

Authors

DOI:

https://doi.org/10.33448/rsd-v12i10.43465

Keywords:

COVID-19; Newborn; Epidemiology.

Abstract

Objective: To evaluate the epidemiological profile of newborns (NB) diagnosed with COVID-19 by RT-PCR between January 2020 and December 2021, to obtain information on symptoms and risk factors associated with infection and patient prognosis. Methods: This is an observational, analytical, and descriptive cross-sectional study that investigated the epidemiological profile of 17 newborns (NB) diagnosed with COVID-19 by reviewing medical records. Results: The majority of the newborns under consideration were born full-term, with a median gestacional age of 38 weeks, to mothers without any previous comorbidities or complications during pregnancy. The primary indicators for a potential COVID-19 infection included fever at 52.9%, respiratory distress at 35.2%, diarrhoea at 11.7%, and contact with persons suspected of being infected at 11.7%. The disease's progression was relatively mild, with asymptomatic NB representing 29.4% of the sample and symptomatic NB presenting with non-severe symptoms such as abdominal distension (17.6%), bloody stools (11.7%) and tachycardia (35.9%). The study found that hospital discharge occurred in 88.2% of newborns, while death was observed in 11.7% of the sample. Notably, one death (5.88%) was attributed directly to COVID-19 infection. Conclusion: The epidemiologic results found in our study were similar to the vast majority of published studies on this topic, including reports and case series. However, there is still a need for more studies with larger sample sizes.

References

Bulbul, A., Agirgol, E., Uslu, S., Elitok, G. K., Tellioglu, A., Avsar, H., Divarci, A., Bas, E. K., & Unal, E. T. (2020). COVID-19 management in newborn babies in the light of recent data: Breastfeeding, rooming-in and clinical symptoms. SiSli Etfal Hastanesi Tip Bulteni / The Medical Bulletin of Sisli Hospital, 54(3), 261–270. https://doi.org/10.14744/SEMB.2020.90267

Cao, W., & Li, T. (2020). COVID-19: towards understanding of pathogenesis. Cell Research, 30(5), 367–369. https://doi.org/10.1038/s41422-020-0327-4

Coronavirus disease (COVID-19) – World Health Organization. (2020). Disponível em: https://www.who.int/emergencies/diseases/novel-coronavirus-2019

Duran, P., Berman, S., Niermeyer, S., Jaenisch, T., Forster, T., Gomez Ponce de Leon, R., De Mucio, B., & Serruya, S. (2020). COVID-19 and newborn health: systematic review. Revista Panamericana de Salud Publica [Pan American Journal of Public Health], 44, e54. https://doi.org/10.26633/RPSP.2020.54

García, H., Allende-López, A., Morales-Ruíz, P., Miranda-Novales, G., & Villasis-Keever, M. Á. (2022). COVID-19 in neonates with positive RT-PCR test. Systematic review. Archives of Medical Research, 53(3), 252–262. https://doi.org/10.1016/j.arcmed.2022.03.001

Gupta, A., Kamity, R., Sharma, R., Caprio, M., Mally, P., & Verma, S. (2022). Mother to newborn transmission of SARS-CoV-2 infection: Evolution of evidence in 1.5 years of COVID-19 pandemic. American Journal of Perinatology, 39(16), 1764–1778. https://doi.org/10.1055/s-0042-1749635

Kallem, V. R., & Sharma, D. (2022). COVID 19 in neonates. The Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 35(8), 1610–1618. https://doi.org/10.1080/14767058.2020.1759542

Kim, D.-H. (2021). Clinical implications of coronavirus disease 2019 in neonates. Clinical and Experimental Pediatrics, 64(4), 157–164. https://doi.org/10.3345/cep.2020.01795

Liguoro, I., Pilotto, C., Bonanni, M., Ferrari, M. E., Pusiol, A., Nocerino, A., Vidal, E., & Cogo, P. (2020). SARS-COV-2 infection in children and newborns: a systematic review. European Journal of Pediatrics, 179(7), 1029–1046. https://doi.org/10.1007/s00431-020-03684-7

Lim, K. H., Soong, F. S. J., Low, Y. F., Goh, X. L., Amin, Z., & Ng, Y. P. M. (2021). Clinical features and outcomes of neonatal COVID-19: A systematic review. Journal of Clinical Virology: The Official Publication of the Pan American Society for Clinical Virology, 139(104819), 104819. https://doi.org/10.1016/j.jcv.2021.104819

Lu, Q., & Shi, Y. (2020). Coronavirus disease (COVID-19) and neonate: What neonatologist need to know. Journal of Medical Virology, 92(6), 564–567. https://doi.org/10.1002/jmv.25740

Morty, R. E., & Ziebuhr, J. (2020). Call for papers: The pathophysiology of COVID-19 and SARS-CoV-2 infection. American Journal of Physiology. Lung Cellular and Molecular Physiology, 318(5), L1016–L1019. https://doi.org/10.1152/ajplung.00136.2020

Nanavati, R., Mascarenhas, D., Goyal, M., Haribalakrishna, A., & Nataraj, G. (2021). A single-center observational study on clinical features and outcomes of 21 SARS-CoV-2-infected neonates from India. European Journal of Pediatrics, 180(6), 1895–1906. https://doi.org/10.1007/s00431-021-03967-7

Nayak, M., Panda, S., Pradhan, J. B., & Mohakud, N. K. (2020). Coronavirus disease 2019 in neonates - what is known and what needs to be known. Cureus, 12(8), e10171. https://doi.org/10.7759/cureus.10171

Pereira A. S. et al. (2018). Metodologia da pesquisa científica. UFSM.

Ponprabha, R., Thiagarajan, S., Balamurugesan, K., & Davis, P. (2022). A clinical retrospective study on the transmission of COVID-19 from mothers to their newborn and its outcome. Cureus, 14(1), e20963. https://doi.org/10.7759/cureus.20963

Raschetti, R., Vivanti, A. J., Vauloup-Fellous, C., Loi, B., Benachi, A., & De Luca, D. (2020). Synthesis and systematic review of reported neonatal SARS-CoV-2 infections. Nature Communications, 11(1), 5164. https://doi.org/10.1038/s41467-020-18982-9

Sánchez-Cruz A, L.-M. E. (2020). COVID-19, implicaciones para el recién nacido. Revisión de la literatura. Rev Med Inst Mex Seguro Soc.

Savić, D., Simović, A., Ristić, D., Stojković, T., Živojinović, S., Prodanović, T., Pavlović, S., Stojković, A., Igrutinović, Z., & Pavlović, R. (2021). Fatal outcome of COVID-19 in a newborn. Indian Journal of Pediatrics, 88(9), 949. https://doi.org/10.1007/s12098-021-03860-z

Schwartz, D. A. (2020). An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: Maternal Coronavirus infections and pregnancy outcomes. Archives of Pathology & Laboratory Medicine, 144(7), 799–805. https://doi.org/10.5858/arpa.2020-0901-SA

Secretaria de Vigilância em Saúde (SVS): Guia de Vigiläncia Epidemiológica do COVID-19. (2021).

Sh, Y., Kang, J. M., & Jg, A. (2020). Clinical outcomes of 201 neonates born to mothers with COVID-19: a systematic review. Eur Rev Med Pharmacol Sci.

Souza, D., Nadal, T. H., Nogueira, J. A., Pereira, R., & Brandão Mb, R. M. (2020). Clinical manifestations of children with COVID-19: A systematic review. Pediatr Pulmonol.

Trevisanuto, D., Cavallin, F., Cavicchiolo, M. E., Borellini, M., Calgaro, S., & Baraldi, E. (2021). Coronavirus infection in neonates: a systematic review. Archives of Disease in Childhood. Fetal and Neonatal Edition, 106(3), 330–335. https://doi.org/10.1136/archdischild-2020-319837

Zhang, L., Peres, T. G., Silva, M. V. F., & Camargos, P. (2020). What we know so far about Coronavirus Disease 2019 in children: A meta-analysis of 551 laboratory-confirmed cases. Pediatric Pulmonology, 55(8), 2115–2127. https://doi.org/10.1002/ppul.24869

Published

08/10/2023

How to Cite

CARVALHO, A. S. de .; ALMEIDA, L. R. B. de .; PAVIONE, M. A. . Epidemiological profile of newborns diagnosed with COVID-19 in a private maternit hospital in the Northeast between january 2020 and december 2021. Research, Society and Development, [S. l.], v. 12, n. 10, p. e60121043465, 2023. DOI: 10.33448/rsd-v12i10.43465. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/43465. Acesso em: 22 nov. 2024.

Issue

Section

Health Sciences