Use of botulinum toxin in the treatment of bruxism: A comprehensive analysis of diagnosis, treatment and their clinical correlations

Authors

DOI:

https://doi.org/10.33448/rsd-v12i11.43690

Keywords:

Botulinum toxin; Bruxism; Stomatognathic diseases.

Abstract

The search for the use of botulinum toxin has increased exponentially in recent years due to its versatility in various aesthetic and therapeutic treatments. In Dentistry, the search for less invasive and more comfortable treatments has generated innovation in relation to the creation of new protocols and techniques, aiming for aesthetic and functional gains for patients. Among the various reasons for this search for the use of botulinum toxin is bruxism, which is characterized by teeth grinding or excessive compression, involving masticatory muscles such as the temporalis and masseter. This parafunctional habit can occur during sleep or while awake and causes a lot of damage to the stomatognathic system as a whole. The central objective of this work is to address the effectiveness of botulinum toxin in the treatment of bruxism. To this end, a literature review was carried out through scientific articles that addressed the toxin as a treatment option for this parafunction. The platforms were used: Pub Med, Google Scholar and Scielo, using the descriptors: botulinum toxin, bruxism, therapeutic and their effectiveness and possible adverse effects were discussed.

References

Ågren, M., Sahin, C., & Pettersson, M. (2020). The effect of botulinum toxin injections on bruxism: A systematic review. Journal of oral rehabilitation, 47(3), 395–402. https://doi.org/10.1111/joor.12914

Almeida-Leite, C. M., Stuginski-Barbosa, J., & Conti, P. C. R. (2020). How psychosocial and economic impacts of COVID-19 pandemic can interfere on bruxism and temporomandibular disorders? Journal of applied oral science : revista FOB, 28, e20200263. https://doi.org/10.1590/1678-7757-2020-0263

Allergan, produtos farmacêuticos ltda. (2014). BOTOX, Bula para o profissional da saúde. https://www.allergan.com.br/

Anand, K. S; Juneja, A. et al. (2021). Effectiveness of Onabotulinum Toxin-A in Treatment of Sleep Bruxism. Mar Neurology, 2(1), 1-6 10.1212/WNL.0000000000004951

Asutay, F., Atalay, Y., Asutay, H., & Acar, A. H. (2017). The Evaluation of the Clinical Effects of Botulinum Toxin on Nocturnal Bruxism. Pain research & management, 2017, 6264146. https://doi.org/10.1155/2017/6264146

Bader, G., & Lavigne, G. (2000). Sleep bruxism; an overview of an oromandibular sleep movement disorder. REVIEW ARTICLE. Sleep medicine reviews, 4(1), 27–43. https://doi.org/10.1053/smrv.1999.0070

Bae, J. H., Choi, D. Y., Lee, J. G., Seo, K. K., Tansatit, T., & Kim, H. J. (2014). The risorius muscle: anatomic considerations with reference to botulinum neurotoxin injection for masseteric hypertrophy. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 40(12), 1334–1339. https://doi.org/10.1097/DSS.0000000000000223

Balanta-Melo, J., Toro-Ibacache, V., Kupczik, K., & Buvinic, S. (2019). Mandibular Bone Loss after Masticatory Muscles Intervention with Botulinum Toxin: An Approach from Basic Research to Clinical Findings. Toxins, 11(2), 84. https://doi.org/10.3390/toxins11020084

Beddis, H., Pemberton, M., & Davies, S. (2018). Sleep bruxism: an overview for clinicians. British dental journal, 225(6), 497–501. https://doi.org/10.1038/sj.bdj.2018.757

Behr, M., Hahnel, S., Faltermeier, A., Bürgers, R., Kolbeck, C., Handel, G., & Proff, P. (2012). The two main theories on dental bruxism. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 194(2), 216–219. https://doi.org/10.1016/j.aanat.2011.09.002

Kumar, A., & Spivakovsky, S. (2018). Bruxism- is botulinum toxin an effective treatment?. Evidence-based dentistry, 19(2), 59. https://doi.org/10.1038/sj.ebd.6401311

De la Torre Canales, G., Alvarez-Pinzon, N., Muñoz-Lora, V. R. M., Vieira Peroni, L., Farias Gomes, A., Sánchez-Ayala, A., Haiter-Neto, F., Manfredini, D., & Rizzatti-Barbosa, C. M. (2020). Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial. Toxins, 12(6), 395. https://doi.org/10.3390/toxins12060395

Colhado, O. C. G., Boeing, M., Ortega, L. B. (2009). Toxina Botulínica no Tratamento da Dor. Revista Brasileira de Anestesiologia, 59(3), 366-381. https://www.scielo.br/j/rba/a/9FZzDfrZwV6Yd8D9VspBM5p/?format=pdf

Choudhury, S., Baker, M. R., Chatterjee, S., & Kumar, H. (2021). Botulinum Toxin: An Update on Pharmacology and Newer Products in Development. Toxins, 13(1), 58. https://doi.org/10.3390/toxins13010058

Dall’Antonia, M., et al. (2013). Dor miofascial dos músculos da mastigação e toxina botulínica. Revista Dor, 14(1), 52-57. https://doi.org/10.1590/S1806-00132013000100013

De la Torre Canales, G., Poluha, R. L., Pinzón, N. A., Da Silva, B. R., Almeida, A. M., Ernberg, M., Manso, A. C., Bonjardim, L. R., & Rizzatti-Barbosa, C. M. (2022). Efficacy of Botulinum Toxin Type-A I in the Improvement of Mandibular Motion and Muscle Sensibility in Myofascial Pain TMD Subjects: A Randomized Controlled Trial. Toxins, 14(7), 441. https://doi.org/10.3390/toxins14070441

Dworkin S. F.; & LeResche L. (1992) Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. J Craniomandib Disord. 6(4):301-55.

Ernberg, M., Hedenberg-Magnusson, B., List, T., Svensson, P. (2011). Efficacy of botulinum toxin type A for treatment of persistent myofascial TMD pain: a randomized, controlled, double-blind multicenter study. Pain, 152(9), 1988-1996. doi: 10.1016/j.pain.2011.03.036.

Fernández-Núñez, Amghar-Maach e Gay-Escoda. et al. (2019). Efficacy of botulinum toxin in the treatment of bruxism: Systematic review. Medicina Oral Patologia Oral y Cirugia Bucal, 24(4), 416-424. doi: 10.4317/medoral.22923.

Francisco Filho, M. L., Suguihara, R. T., & Muknicka, D. P. (2023). Mecanismos de ação e indicações da Toxina Botulínica. Research, Society and Development, 12(6), e15712642223. https://doi.org/10.33448/rsd-v12i6.42223

Gama, E., Andrade, A. de O., Campos, R. M. (2013). Bruxismo: Uma revisão da literatura. Ciência Atual, 1(1), 16-22. https://revista.saojose.br/index.php/cafsj/article/view/2

Gimenes, M. C. M. (2004). Bruxismo: aspectos clínicos e tratamento. Artigo publicado em jan. 2004. Retrieved from: http://revodonto.bvsalud.org/scielo.php?script=sci_arttext&pid=S1677-38882012000300003

Glaros, A. G., & Rao, S. M. (1977). Effects of bruxism: a review of the literature. The Journal of prosthetic dentistry, 38(2), 149–157. https://doi.org/10.1016/0022-3913(77)90280-3

Guarda-Nardini, L., Manfredini, D., Salamone, M., Salmaso, L., Tonello, S., & Ferronato, G. (2008). Efficacy of botulinum toxin in treating myofascial pain in bruxers: a controlled placebo pilot study. Cranio : the journal of craniomandibular practice, 26(2), 126–135. https://doi.org/10.1179/crn.2008.017

Jadhao, V. A., Lokhande, N., Habbu, S. G., Sewane, S., Dongare, S., & Goyal, N. (2017). Efficacy of botulinum toxin in treating myofascial pain and occlusal force characteristics of masticatory muscles in bruxism. Indian journal of dental research : official publication of Indian Society for Dental Research, 28(5), 493–497. https://doi.org/10.4103/ijdr.IJDR_125_17

Jokubauskas, L., Baltrušaitytė, A., & Pileičikienė, G. (2018). Oral appliances for managing sleep bruxism in adults: a systematic review from 2007 to 2017. Journal of oral rehabilitation, 45(1), 81–95. https://doi.org/10.1111/joor.12558

Kef K. (2021). Application of Botulinum Toxin in Patients with Secondary Otalgia Caused by Bruxism. Journal of pain research, 14, 1051–1059. https://doi.org/10.2147/JPR.S292550

Klasser, G. D., Rei, N., & Lavigne, G. J. (2015). Sleep bruxism etiology: the evolution of a changing paradigm. Journal (Canadian Dental Association), 81, f2. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/25633110/

Azam, A., Manchanda, S., Thotapalli, S., & Kotha, S. B. (2015). Botox therapy in dentistry: A Review. Journal of international oral health: JIOH, 7(Suppl 2), 103.PMID: 26668495; PMCID: PMC4672850.

Kwon, K. H., Shin, K. S., Yeon, S. H., & Kwon, D. G. (2019). Application of botulinum toxin in maxillofacial field: part I. Bruxism and square jaw. Maxillofacial plastic and reconstructive surgery, 41(1), 38. https://doi.org/10.1186/s40902-019-0218-0

Fonseca, Isabel Lüscher. (2008). A Regulamentação da Toxina Botulínica no Brasil: uma controvérsia em análise. http://www.necso.ufrj.br/esocite2008/resumos/36188.htm.

Lavigne, G. J., Manzini, C., Kato, T. (2005). Principles and practice of sleep medicine. Elsevier Saunders. 26(3). https://doi.org/10.26843/ro_unicid.v26i3.308

Kim, N. H., Park, R. H., & Park, J. B. (2010). Botulinum toxin type A for the treatment of hypertrophy of the masseter muscle. Plastic and reconstructive surgery, 125(6), 1693–1705. https://doi.org/10.1097/PRS.0b013e3181d0ad03

Lee, S. J., McCall, W. D., Jr, Kim, Y. K., Chung, S. C., & Chung, J. W. (2010). Effect of botulinum toxin injection on nocturnal bruxism: a randomized controlled trial. American journal of physical medicine & rehabilitation, 89(1), 16–23. https://doi.org/10.1097/PHM.0b013e3181bc0c78

Mor N, Tang C, Blitzer A. Temporomandibular Myofacial Pain Treated with Botulinum Toxin Injection. Toxins (Basel). 2015 Jul 24;7(8):2791-800. 10.3390/toxins7082791. PMID: 26213970; PMCID: PMC4549724.

Nagarale, R., et al. (s. d.). Efeitos da toxina botulínica no bruxismo noturno. https://repositorio.unicamp.br/Busca/Download?codigoArquivo=479297

Nikolis, A., Enright, K. M., Masouri, S., Bernstein, S., & Antoniou, C. (2018). Prospective evaluation of incobotulinumtoxinA in the management of the masseter using two different injection techniques. Clinical, cosmetic and investigational dermatology, 11, 347–356. https://doi.org/10.2147/CCID.S164848

Nikolis, A., Enright, K. M., Rudolph, C., & Cotofana, S. (2020). Temporal volume increase after reduction of masseteric hypertrophy utilizing incobotulinumtoxin type A. Journal of cosmetic dermatology, 19(6), 1294–1300. https://doi.org/10.1111/jocd.13434

Ondo, W. G., Simmons, J. H., Shahid, M. H., Hashem, V., Hunter, C., & Jankovic, J. (2018). Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled study. Neurology, 90(7), e559–e564. https://doi.org/10.1212/WNL.0000000000004951

Ortega-Ruiz, Rosario & Elipe, Paz & Mora-Merchan, Joaquin & Calmaestra, Juan & Vega, Esther. (2009). The Emotional Impact on Victims of Traditional Bullying and Cyberbullying A Study of Spanish Adolescents. Zeitschrift für Psychologie. 217. 197-204. 10.1027/0044-3409.217.4.197.

Patel, J., Cardoso, J. A., & Mehta, S. (2019). A systematic review of botulinum toxin in the management of patients with temporomandibular disorders and bruxism. British dental journal, 226(9), 667–672. https://doi.org/10.1038/s41415-019-0257-z

Patil, S., Willett, O., Thompkins, T., Hermann, R., Ramanathan, S., Cornett, E. M., Fox, C. J., & Kaye, A. D. (2016). Botulinum Toxin: Pharmacology and Therapeutic Roles in Pain States. Current pain and headache reports, 20(3), 15. https://doi.org/10.1007/s11916-016-0545-0

Pereira, R. P. A., et al. (2006). Bruxismo e qualidade de vida. Revista Odonto Ciência, 21(52), 185-190. https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/1071

Polmann, H., Domingos, F. L., Melo, G., Stuginski-Barbosa, J., Guerra, E. N. D. S., Porporatti, A. L., Dick, B. D., Flores-Mir, C., & De Luca Canto, G. (2019). Association between sleep bruxism and anxiety symptoms in adults: A systematic review. Journal of oral rehabilitation, 46(5), 482–491. https://doi.org/10.1111/joor.12785

Raphael, K. G., Tadinada, A., Bradshaw, J. M., Janal, M. N., Sirois, D. A., Chan, K. C., & Lurie, A. G. (2014). Osteopenic consequences of botulinum toxin injections in the masticatory muscles: a pilot study. Journal of oral rehabilitation, 41(8), 555–563. https://doi.org/10.1111/joor.12180

Rosar, J. V., Barbosa, T. S., Dias, I. O. V., Kobayashi, F. Y., Costa, Y. M., Gavião, M. B. D., Bonjardim, L. R., & Castelo, P. M. (2017). Effect of interocclusal appliance on bite force, sleep quality, salivary cortisol levels and signs and symptoms of temporomandibular dysfunction in adults with sleep bruxism. Archives of oral biology, 82, 62–70. https://doi.org/10.1016/j.archoralbio.2017.05.018

Sellin, L. C., & Thesleff, S. (1981). Pre- and post-synaptic actions of botulinum toxin at the rat neuromuscular junction. The Journal of physiology, 317, 487–495. https://doi.org/10.1113/jphysiol.1981.sp013838

Serrera-Figallo, M. A., Ruiz-de-León-Hernández, G., Torres-Lagares, D., Castro-Araya, A., Torres-Ferrerosa, O., Hernández-Pacheco, E., & Gutierrez-Perez, J. L. (2020). Use of Botulinum Toxin in Orofacial Clinical Practice. Toxins, 12(2), 112. https://doi.org/10.3390/toxins12020112

Shackleton, T., Ram, S., Black, M., Ryder, J., Clark, G. T., & Enciso, R. (2016). The efficacy of botulinum toxin for the treatment of trigeminal and postherpetic neuralgia: a systematic review with meta-analyses. Oral surgery, oral medicine, oral pathology and oral radiology, 122(1), 61–71. https://doi.org/10.1016/j.oooo.2016.03.003

Shim, Y. J., Lee, M. K., Kato, T., Park, H. U., Heo, K., & Kim, S. T. (2014). Effects of botulinum toxin on jaw motor events during sleep in sleep bruxism patients: a polysomnographic evaluation. Journal of clinical sleep medicine: JCSM: official publication of the American Academy of Sleep Medicine, 10(3), 291–298. https://doi.org/10.5664/jcsm.3532

Srivastava, S., Kharbanda, S., Pal, U. S., & Shah, V. (2015). Applications of botulinum toxin in dentistry: A comprehensive review. National journal of maxillofacial surgery, 6(2), 152–159. https://doi.org/10.4103/0975-5950.183860

Smith, T. J., Hill, K. K., & Raphael, B. H. (2015). Historical and current perspectives on Clostridium botulinum diversity. Research in microbiology, 166(4), 290–302. DOI: 10.1016/j.resmic.2014.09.007

Sumodjo, P. R. P. A., Suguhihara, R. T., & Muknicka, D. P. (2023). O envelhecimento facial e a harmonização orofacial – uma revisão narrativa da literatura. Research, Society and Development, 12(5), e15312541591. 10.33448/rsd-v12i5.41591

Tinastepe, N., Küçük, B. B., & Oral, K. (2015). Botulinum toxin for the treatment of bruxism. Cranio : the journal of craniomandibular practice, 33(4), 291–298. https://doi.org/10.1080/08869634.2015.1097296

Tsai, C. Y., Huang, R. Y., Lee, C. M., Hsiao, W. T., & Yang, L. Y. (2010). Morphologic and bony structural changes in the mandible after a unilateral injection of botulinum neurotoxin in adult rats. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 68(5), 1081–1087. https://doi.org/10.1016/j.joms.2009.12.009

Yurttutan, M. E., Tütüncüler Sancak, K., & Tüzüner, A. M. (2019). Which Treatment Is Effective for Bruxism: Occlusal Splints or Botulinum Toxin? Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 77(12), 2431–2438. https://doi.org/10.1016/j.joms.2019.06.005

Xie, Y., Zhou, J., Li, H., Cheng, C., Herrler, T., & Li, Q. (2014). Classification of masseter hypertrophy for tailored botulinum toxin type A treatment. Plastic and reconstructive surgery, 134(2), 209e–218e. https://doi.org/10.1097/PRS.0000000000000371

Zhang, L. D., Liu, Q., Zou, D. R., & Yu, L. F. (2016). Occlusal force characteristics of masseteric muscles after intramuscular injection of botulinum toxin A(BTX - A)for treatment of temporomandibular disorder. The British journal of oral & maxillofacial surgery, 54(7), 736–740. https://doi.org/10.1016/j.bjoms.2016.04.008

Published

25/10/2023

How to Cite

D’DALARPONIO, P. de A. T. .; FARIA, H. V. dos S. .; DUARTE, P. B. .; MARTELLI , T. N.; ALEIXO, S. L. L. .; COSTA, M. F. M.; OLIVEIRA, T. G. de; PEREIRA, L. G. .; MELO, M. M.; DUARTE , A. F. .; GIRUNDI, R. P. Use of botulinum toxin in the treatment of bruxism: A comprehensive analysis of diagnosis, treatment and their clinical correlations. Research, Society and Development, [S. l.], v. 12, n. 11, p. e47121143690, 2023. DOI: 10.33448/rsd-v12i11.43690. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/43690. Acesso em: 23 dec. 2024.

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Section

Health Sciences