The use of Cannabis as a risk factor for the development/progression of Schizophrenia: A literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i11.43869

Keywords:

Schizophrenia; Cannabis; Psychoses; Risk factors; THC.

Abstract

Introduction: Cannabis is the third most used psychoactive substance in the world. Its use, in addition to other comorbidities, has an impact on mental health, with emphasis on schizophrenic conditions, since around 26.6% of these patients suffer from Cannabis Use Disorder (CUD). The use of this drug is frequent in patients with psychotic disorders, such as schizophrenia, and it also seems to stimulate isolated psychotic conditions. The objective of the work is to elucidate the association between the use of cannabis and its impact on the establishment/progression of schizophrenia Methodology: This is an integrative review on the impact of cannabis use in the context of schizophrenia. Data from the Virtual Health Library (VHL), Scientific Electronic Library Online (SciELO) and National Library of Medicine (PubMed) databases were used, by crossing the descriptors “Schizophrenia”, “Endocannabinoid system”, “Cannabis”, “THC” and “Cannabis psychosis”, to answer the question formulated through the PICO strategy. Results and discussion: The association between the two entities appears to be contained in a multifactorial genetic-behavioral relationship, in which early and exaggerated exposure to high concentrations of the drug, as well as family history and the polymorphism of some genes, appears to provide the individual with a condition of vulnerability to the earlier and more severe development of schizophrenia and/or psychotic events. Conclusion: The use of cannabis provides a more severe symptomatology, with early onset, with a high relapse rate, an early first hospital admission and recurrent psychotic conditions, this action being apparently provided by the interaction of THC with the endocannabinoid system.

Author Biographies

Thales Henrique do Prado Orlandi Pereira, Faculdade de Medicina de Itajubá

Acadêmico de Medicina

 

Renan Chaparro Rodrigues Alves Barbosa Coelho, Faculdade de Medicina de Itajubá

Possui graduação em Medicina pela Faculdade de Medicina de Itajubá - FMIT (2010). Tem experiência na área de Medicina, com ênfase em Medicina de Família e Comunidade e pós-graduado em Psiquiatria. Atualmente, atua como Médico de Família e Comunidade, Saúde Mental, além de professor na Faculdade de Medicina de Itajubá nas áreas de Medicina de Família e Comunidade e Saúde Mental.

References

Alabaf, S., Kirkpatrick, B., Chen, S., Cardinal, R. N., & Fernandez-Egea, E. (2022). Early versus late risk factors for deficit and nondeficit schizophrenia. Revista de Psiquiatría Y Salud Mental, 15(1), 38–46. https://doi.org/10.1016/j.rpsm.2021.03.002

AMERICAN PSYCHIATRIC ASSOCIATION DSM-5 ®. (2014). https://www.institutopebioetica.com.br/documentos/manual-diagnostico-e-estatistico-de-transtornos-mentais-dsm-5.pdf

Álvarez, G, L., Gomar, J. J., García-Portilla, M. P., & Bobes, J. (2019). Consumo de cannabis y alteraciones cognitivas en esquizofrenia y primeros episodios psicóticos. Adicciones, 31(2), 89. https://doi.org/10.20882/adicciones.1328

Bastos, F. (2019). III Levantamento Nacional sobre uso de Drogas pela População Brasileira. https://www.arca.fiocruz.br/bitstream/handle/icict/34614/III%20LNUD%20Suplemento_II.p?sequence=4

Britto, L. R. de, Araújo, A. N. de, Araújo, R. P. C. de, & Sena, E. P. de. (2016). Associações entre o uso de cannabis e esquizofrenia: uma revisão da literatura. Revista de Ciências Médicas E Biológicas, 15(1), 95. https://doi.org/10.9771/cmbio.v15i1.16156

Connor, J. P., Stjepanović, D., Le Foll, B., Hoch, E., Budney, A. J., & Hall, W. D. (2021). Cannabis use and cannabis use disorder. Nature Reviews Disease Primers, 7(1). https://doi.org/10.1038/s41572-021-00247-4

Cristino, L., Bisogno, T., & Di Marzo, V. (2019). Cannabinoids and the expanded endocannabinoid system in neurological disorders. Nature Reviews Neurology, 16(1), 9–29. https://doi.org/10.1038/s41582-019-0284-z

De Souza, T. M., Da Silva, D. M., De Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1). https://doi.org/10.1590/S1679-45082010RW1134

Díaz-Soto, C. M., Castaño-Pérez, G. A., & Pineda-Salazar, D. A. (2020). Cannabis, esquizofrenia y cognición, aportes de la conectividad cerebral. Adicciones. https://doi.org/10.20882/adicciones.1307

Hájková, M., Knížková, K., Siroňová, A., Keřková, B., Jonáš, J., Šustová, P., Dorazilová, A., & Rodriguez, M. (2021). Cognitive performance and lifetime cannabis use in patients with first-episode schizophrenia spectrum disorder. Cognitive Neuropsychiatry, 26(4), 257–272. https://doi.org/10.1080/13546805.2021.1924649

Hasan, A., von Keller, R., Friemel, C. M., Hall, W., Schneider, M., Koethe, D., Leweke, F. M., Strube, W., & Hoch, E. (2019). Cannabis use and psychosis: a review of reviews. European Archives of Psychiatry and Clinical Neuroscience, 270(4), 403–412. https://doi.org/10.1007/s00406-019-01068-z

Hashemi, D., & Gray, K. (2022). Cannabis Use Disorder in Adolescents. Child and Adolescent Psychiatric Clinics of North America. https://doi.org/10.1016/j.chc.2022.06.001

Horcajadas, A, F., Dávila Píriz, J. R., Parra González, A., Sánchez Romero, S., Sánchez-Morla, E., Ampuero Sánchez, I., & Ramos Atance, J. A. (2023). Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population. El gen del receptor cannabinoide tipo 2 se asocia con la comorbilidad entre esquizofrenia y dependencia de cannabis y el gen de la enzima amidohidrolasa de ácidos grasos se asocia con la dependencia de cannabis en población española. Adicciones, 35(1), 33–46. https://doi.org/10.20882/adicciones.1587

Kayir, H., Ruffolo, J., McCunn, P., & Khokhar, J. Y. (2022). The Relationship Between Cannabis, Cognition, and Schizophrenia: It’s Complicated. Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework, 437–461. https://doi.org/10.1007/7854_2022_396

Lu, H.-C., & Mackie, K. (2020). Review of the Endocannabinoid System. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(6). https://doi.org/10.1016/j.bpsc.2020.07.016

Ortiz-Medina, M. B., Perea, M., Torales, J., Ventriglio, A., Vitrani, G., Aguilar, L., & Roncero, C. (2018). Cannabis consumption and psychosis or schizophrenia development. International Journal of Social Psychiatry, 64(7), 690–704. https://doi.org/10.1177/0020764018801690

Pereira, I. D., & Girotto, J. R. (2023). Relação entre uso de cannabis e a esquizofrenia: uma revisão de literatura. Brazilian Journal of Health Review, 6(5), 22694–22700. https://doi.org/10.34119/bjhrv6n5-295

Peres, F. F., Diana, M. C., Levin, R., Suiama, M. A., Almeida, V., Vendramini, A. M., Santos, C. M., Zuardi, A. W., Hallak, J. E. C., Crippa, J. A., & Abílio, V. C. (2018). Cannabidiol Administered During Peri-Adolescence Prevents Behavioral Abnormalities in an Animal Model of Schizophrenia. Frontiers in Pharmacology, 9. https://doi.org/10.3389/fphar.2018.00901

Rentero Martín, D., Arias, F., Sánchez-Romero, S., Rubio, G., & Rodríguez-Jiménez, R. (2020). Psicosis inducida por cannabis: características clínicas y su diferenciación con la esquizofrenia con y sin consumo de cannabis asociado. Adicciones, 33(2), 95. https://doi.org/10.20882/adicciones.1251

Stilo, S. A., & Murray, R. M. (2019). Non-Genetic Factors in Schizophrenia. Current Psychiatry Reports, 21(10). https://doi.org/10.1007/s11920-019-1091-3

Vera, R. C. M, Solorzano, R., Lozano Aveiga, J. A., & Peña Cordero, B. E. (2023). Cannabis as a precursor of psychosis and its relationship with schizophrenia. Salud Ciencia Y Tecnología. https://doi.org/10.56294/saludcyt2023262

Published

04/11/2023

How to Cite

ZONARO, J. M. D. .; PEREIRA, T. H. do P. O. .; COELHO, R. C. R. A. B. . The use of Cannabis as a risk factor for the development/progression of Schizophrenia: A literature review. Research, Society and Development, [S. l.], v. 12, n. 11, p. e122121143869, 2023. DOI: 10.33448/rsd-v12i11.43869. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/43869. Acesso em: 13 nov. 2024.

Issue

Section

Health Sciences