The use of Cannabis as a risk factor for the development/progression of Schizophrenia: A literature review
DOI:
https://doi.org/10.33448/rsd-v12i11.43869Keywords:
Schizophrenia; Cannabis; Psychoses; Risk factors; THC.Abstract
Introduction: Cannabis is the third most used psychoactive substance in the world. Its use, in addition to other comorbidities, has an impact on mental health, with emphasis on schizophrenic conditions, since around 26.6% of these patients suffer from Cannabis Use Disorder (CUD). The use of this drug is frequent in patients with psychotic disorders, such as schizophrenia, and it also seems to stimulate isolated psychotic conditions. The objective of the work is to elucidate the association between the use of cannabis and its impact on the establishment/progression of schizophrenia Methodology: This is an integrative review on the impact of cannabis use in the context of schizophrenia. Data from the Virtual Health Library (VHL), Scientific Electronic Library Online (SciELO) and National Library of Medicine (PubMed) databases were used, by crossing the descriptors “Schizophrenia”, “Endocannabinoid system”, “Cannabis”, “THC” and “Cannabis psychosis”, to answer the question formulated through the PICO strategy. Results and discussion: The association between the two entities appears to be contained in a multifactorial genetic-behavioral relationship, in which early and exaggerated exposure to high concentrations of the drug, as well as family history and the polymorphism of some genes, appears to provide the individual with a condition of vulnerability to the earlier and more severe development of schizophrenia and/or psychotic events. Conclusion: The use of cannabis provides a more severe symptomatology, with early onset, with a high relapse rate, an early first hospital admission and recurrent psychotic conditions, this action being apparently provided by the interaction of THC with the endocannabinoid system.
References
Alabaf, S., Kirkpatrick, B., Chen, S., Cardinal, R. N., & Fernandez-Egea, E. (2022). Early versus late risk factors for deficit and nondeficit schizophrenia. Revista de Psiquiatría Y Salud Mental, 15(1), 38–46. https://doi.org/10.1016/j.rpsm.2021.03.002
AMERICAN PSYCHIATRIC ASSOCIATION DSM-5 ®. (2014). https://www.institutopebioetica.com.br/documentos/manual-diagnostico-e-estatistico-de-transtornos-mentais-dsm-5.pdf
Álvarez, G, L., Gomar, J. J., García-Portilla, M. P., & Bobes, J. (2019). Consumo de cannabis y alteraciones cognitivas en esquizofrenia y primeros episodios psicóticos. Adicciones, 31(2), 89. https://doi.org/10.20882/adicciones.1328
Bastos, F. (2019). III Levantamento Nacional sobre uso de Drogas pela População Brasileira. https://www.arca.fiocruz.br/bitstream/handle/icict/34614/III%20LNUD%20Suplemento_II.p?sequence=4
Britto, L. R. de, Araújo, A. N. de, Araújo, R. P. C. de, & Sena, E. P. de. (2016). Associações entre o uso de cannabis e esquizofrenia: uma revisão da literatura. Revista de Ciências Médicas E Biológicas, 15(1), 95. https://doi.org/10.9771/cmbio.v15i1.16156
Connor, J. P., Stjepanović, D., Le Foll, B., Hoch, E., Budney, A. J., & Hall, W. D. (2021). Cannabis use and cannabis use disorder. Nature Reviews Disease Primers, 7(1). https://doi.org/10.1038/s41572-021-00247-4
Cristino, L., Bisogno, T., & Di Marzo, V. (2019). Cannabinoids and the expanded endocannabinoid system in neurological disorders. Nature Reviews Neurology, 16(1), 9–29. https://doi.org/10.1038/s41582-019-0284-z
De Souza, T. M., Da Silva, D. M., De Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1). https://doi.org/10.1590/S1679-45082010RW1134
Díaz-Soto, C. M., Castaño-Pérez, G. A., & Pineda-Salazar, D. A. (2020). Cannabis, esquizofrenia y cognición, aportes de la conectividad cerebral. Adicciones. https://doi.org/10.20882/adicciones.1307
Hájková, M., Knížková, K., Siroňová, A., Keřková, B., Jonáš, J., Šustová, P., Dorazilová, A., & Rodriguez, M. (2021). Cognitive performance and lifetime cannabis use in patients with first-episode schizophrenia spectrum disorder. Cognitive Neuropsychiatry, 26(4), 257–272. https://doi.org/10.1080/13546805.2021.1924649
Hasan, A., von Keller, R., Friemel, C. M., Hall, W., Schneider, M., Koethe, D., Leweke, F. M., Strube, W., & Hoch, E. (2019). Cannabis use and psychosis: a review of reviews. European Archives of Psychiatry and Clinical Neuroscience, 270(4), 403–412. https://doi.org/10.1007/s00406-019-01068-z
Hashemi, D., & Gray, K. (2022). Cannabis Use Disorder in Adolescents. Child and Adolescent Psychiatric Clinics of North America. https://doi.org/10.1016/j.chc.2022.06.001
Horcajadas, A, F., Dávila Píriz, J. R., Parra González, A., Sánchez Romero, S., Sánchez-Morla, E., Ampuero Sánchez, I., & Ramos Atance, J. A. (2023). Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population. El gen del receptor cannabinoide tipo 2 se asocia con la comorbilidad entre esquizofrenia y dependencia de cannabis y el gen de la enzima amidohidrolasa de ácidos grasos se asocia con la dependencia de cannabis en población española. Adicciones, 35(1), 33–46. https://doi.org/10.20882/adicciones.1587
Kayir, H., Ruffolo, J., McCunn, P., & Khokhar, J. Y. (2022). The Relationship Between Cannabis, Cognition, and Schizophrenia: It’s Complicated. Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework, 437–461. https://doi.org/10.1007/7854_2022_396
Lu, H.-C., & Mackie, K. (2020). Review of the Endocannabinoid System. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(6). https://doi.org/10.1016/j.bpsc.2020.07.016
Ortiz-Medina, M. B., Perea, M., Torales, J., Ventriglio, A., Vitrani, G., Aguilar, L., & Roncero, C. (2018). Cannabis consumption and psychosis or schizophrenia development. International Journal of Social Psychiatry, 64(7), 690–704. https://doi.org/10.1177/0020764018801690
Pereira, I. D., & Girotto, J. R. (2023). Relação entre uso de cannabis e a esquizofrenia: uma revisão de literatura. Brazilian Journal of Health Review, 6(5), 22694–22700. https://doi.org/10.34119/bjhrv6n5-295
Peres, F. F., Diana, M. C., Levin, R., Suiama, M. A., Almeida, V., Vendramini, A. M., Santos, C. M., Zuardi, A. W., Hallak, J. E. C., Crippa, J. A., & Abílio, V. C. (2018). Cannabidiol Administered During Peri-Adolescence Prevents Behavioral Abnormalities in an Animal Model of Schizophrenia. Frontiers in Pharmacology, 9. https://doi.org/10.3389/fphar.2018.00901
Rentero Martín, D., Arias, F., Sánchez-Romero, S., Rubio, G., & Rodríguez-Jiménez, R. (2020). Psicosis inducida por cannabis: características clínicas y su diferenciación con la esquizofrenia con y sin consumo de cannabis asociado. Adicciones, 33(2), 95. https://doi.org/10.20882/adicciones.1251
Stilo, S. A., & Murray, R. M. (2019). Non-Genetic Factors in Schizophrenia. Current Psychiatry Reports, 21(10). https://doi.org/10.1007/s11920-019-1091-3
Vera, R. C. M, Solorzano, R., Lozano Aveiga, J. A., & Peña Cordero, B. E. (2023). Cannabis as a precursor of psychosis and its relationship with schizophrenia. Salud Ciencia Y Tecnología. https://doi.org/10.56294/saludcyt2023262
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 João Marcelo Defanti Zonaro; Thales Henrique do Prado Orlandi Pereira; Renan Chaparro Rodrigues Alves Barbosa Coelho
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.