A silent threat, the growth of oral Trypanossoma Cruzi infections: An integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v13i2.45108

Keywords:

Chagas Disease; Infections; Humans.

Abstract

In recent years, the transmission of Trypanosoma cruzi has intensified, due to the growth of oral infections, more specifically in Latin American countries. This type of contagion is related to the development of Acute Chagas disease (ACD). From this perspective, an integrative review was conducted, which was carried out through the analysis of articles published in the Pubmed, LILACS, Scopus and Embase databases. From the establishment of inclusion and exclusion criteria, 17 results were selected from 422 articles found to construct this scientific material. Although vector transmission of Trypanosoma cruzi trypomastigotes has attenuated in Latin America, oral infections have silently spread over the years. In this scenario, several epidemiological surveillance actions have already been adopted by countries, however, some aspects related to the increase in ACD still need to be clarified. Therefore, the objective of this article is to analyze which factors trigger the increase in oral infections by Trypanosoma cruzi.

References

Blanchet, D., Brenière, S. F., Schijman, A. G., Bisio, M., Simon, S., Véron, V., Mayence, C., Demar-Pierre, M., Djossou, F. & Aznar, C. (2014). First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up. Infection, Genetics and Evolution, 28, 245-50.

Cardoso, L. P., Paiva, T. R., Nogueira, L. M. V., Guimarães, R. J. P. S., Rodrigues, I. L. A. & André, S. R. (2020). Spatial distribution of Chagas disease and its correlation with health services. Revista da Escola de Enfermagem, 54, e03565.

Costa, E. D. G., dos Santos, S. O. D., Sojo-Milano, M., Amador, E. E. C., Tatto. E., Souza, D. S. M., Costa, F. A. & Póvoa, R. M. S. (2017). Epidemiological features of acute Chagas disease in the Brazilian Amazon: Epidemiological and clinical features. International Journal of Cardiology, 235, 176-178.

de Noya, B. A., Colmenares, C., Díaz-Bello, Z., Ruiz-Guevara, R., Medina, K., Muñoz-Calderón, A., Mauriello, L., Cabrera, E., Montiel, L., Losada, S., Martínez, J., Espinosa, R. & Abate, T. (2016). Orally-transmitted Chagas disease: Epidemiological, clinical, serological and molecular outcomes of a school microepidemic in Chichiriviche de la Costa, Venezuela. Parasite Epidemiology and Control, 1(2), 188-198.

de Sousa, D. R. T., Guerra, J. A. O., Ortiz, J. V., Couceiro, K. N., Silva, M. R. H. S., Brandão, A. R. J., Guevara, E., Arcanjo, A. R. L., Júnior, E. F. O., Smith-Doria S., Mwangi, V. I., Morais, R. F., Silva, G. A. V., Molina, I., Silveira, H., Ferreira, J. M. B. B. & Guerra, M. G. V. B. (2023). Acute Chagas disease associated with ingestion of contaminated food in Brazilian western Amazon. Tropical Medicine and International Health, 28(7), 541–550.

de Souza-Lima, R. de C., Barbosa, M. das G. V., Coura, J. R., Arcanjo, A. R. L., Nascimento, A. da S., Ferreira, J. M. B. B., Magalhães, L. K., de Albuquerque, B. C., Araújo, G. A. N. & Guerra, J. A. de O. (2013). Outbreak of acute Chagas disease associated with oral transmission in the Rio Negro region, Brazilian Amazon. Revista da Sociedade Brasileira de Medicina Tropical, 46(4), 510–4.

dos Santos, M. L. F., Tavares, O. H. M., Colares, G. G., da Silva, M. F. N., Damasceno, H. A., da Silva, C. G., Maciel, L. H. G., Yakubu, M. N., Gonçalves, R. de O. & Maciel, M. G. (2023). Distribuição Espacial dos Casos Agudos de Doença de Chagas Notificados de 2010 a 2020 no Estado do Amazonas. Arquivos de ciências da saúde UNIPAR, 27(2), 1038-1046.

dos Santos, V. R. C., Antunes, D., de Souza, D. do S. M., Moreira, O. C., Lima, I. C. de A., Farias-de-Oliveira, D. A., Lobo, J. P., de Meis, E., Coura, J. R., Savino, W., Junqueira A. C. V. & de Meis, J. (2020). Human acute chagas disease: Changes in factor vii, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará state (Brazilian Amazon). Memórias do Instituto Oswaldo Cruz, 115, e190364.

dos Santos, V. R. C. de Meis, J., Savino, W., Andrade, J. A. A., Vieira, J. R. dos S., Coura, J. R. & Junqueira, A. C. V. (2018). Acute chagas disease in the state of Pará, amazon region: Is it increasing? Memórias do Instituto Oswaldo Cruz, 113(5), e170298.

Echeverria, L. E., Suarez, E. U., Zambrano, P., Cucunuba, Z. M., Rojas, L. Z., Rueda, O. L., Lopez, M. & Bazarra, M. F. (2014). Chagas disease and its oral transmission in Colombia: chronicles of an epidemia. Description of eight outbreaks (2008-2010). European Journal of Heart Failure, 16, 36-37.

Ferreira, R. T. B., Melandre, A. M., Cabral, M. L., Branquinho, M. R. & Cardarelli-Leite, P. (2016). Extraction of trypanosoma cruzi DNA from food: A contribution to the elucidation of acute Chagas disease outbreaks. Revista da Sociedade Brasileira de Medicina Tropical, 49(2), 190–5.

Hernández, C. Vera, M. J., Cucunubá, Z., Flórez, C., Cantillo, O., Buitrago, L. S., González, M. S., Ardila, S., Dueñas, L. Z., Tovar, R., Forero, L. R. & Ramíres, J. D. (2016). High-Resolution Molecular Typing of Trypanosoma cruzi in 2 Large Outbreaks of Acute Chagas Disease in Colombia. (2016). Journal of Infectious Diseases, 214(8), 1252–5.

Marques, J. Mendoza, I., Noya, B., Acquatella, H. Palacios, I. & Marques-Mejias, M. (2013). As manifestações de ECG do maior surto da doença de Chagas devido a infecção oral na América Latina. Arquivos Brasileiros de Cardiologia, 101(3), 249–254.

Monsalve-Lara, J., Lilioso, M., Valença-Barbosa, C., Thyssen, P. J., Miguel, D. C., Limeira, C., Gadelha, F. R., Fontes, F. V. H. M., Pires-Silva, D., Dornak, L. L., Lima, M. M., Donalisio, M. R. & Almeida, C. E. (2021). The risk of oral transmission in an area of a Chagas disease outbreak in the Brazilian northeast evaluated through entomological, socioeconomic and schooling indicators. Acta Tropica, 215, e105803.

Muñoz-Calderón, A. Díaz-Bello, Z., Valladares, B., Noya, O., López, M. C., de Noya, B. A. & Thomas, M. C. (2013). Oral transmission of Chagas disease: Typing of Trypanosoma cruzi from five outbreaks occurred in Venezuela shows multiclonal and common infections in patients, vectors and reservoirs. Infection, Genetics and Evolution, 17, 113–122.

Ramírez, J. D., Montilla, M., Cucunubá, Z. M., Floréz, A. C., Zambrano, P. & Guhl, F. (2013). Molecular epidemiology of human oral Chagas disease outbreaks in Colombia. PLOS Neglected Tropical Diseases, 7(2), e2041.

Sampaio, G. H. F., da Silva, A. N. B., Brito, C. R. do N., Honorato, N. R. M., de Oliveira, L. M., da Câmara, A. C. J. & Galvão, L. M. da C. (2020). Epidemiological profile of acute chagas disease in individuals infected by oral transmission in Northern Brazil. Revista da Sociedade Brasileira de Medicina Tropical, 53, e20200088.

Santana, R. A. G., Guerra, M. G. V. B., Sousa, D. R., Couceiro, K., Ortiz, J. V., Oliveira, M., Ferreira, L. S., Souza, K. R., Tavares, I. C., Morais, R. F., Silva, G. A. V., Melo, G. C., Vergel, G. M., Albuquerque, B. C., Arcanjo, A. R. L., Monteiro, W. M., Ferreira, J. M. B. B., Lacerda, M. V. G., Silveira, H. & Guerra, J. A. O. (2019). Oral transmission of Trypanosoma cruzi, Brazilian Amazon. Emerging Infectious Diseases, 25(1), 132–135.

Soto, H., Tibaduiza, T., Montilla, M., Triana, O., Suárez, D. C., Torres, M. T., Arias, M. T. & Lugo, L. (2014). Investigación de vectores y reservorios en brote de Chagas agudo por posible transmisión oral en Aguachica, Cesar, Colombia. Cadernos de Saúde Pública, 30(4), 746-756.

Vargas, A., Malta, J. M. A. S., da Costa, V. M., Cláudio, L. D. G., Alves, R. V., Cordeiro, G. S., Aguiar, L. M. A. & Percio, J. (2018). Investigação de surto de doença de Chagas aguda na região extra-amazônica, Rio Grande do Norte, Brasil, 2016. Cadernos de Saúde Pública, 34(1), e00006517.

Published

25/02/2024

How to Cite

SOBRAL, M. A. F. .; ROSSIN, P. L. F. .; SÁ, C. D. B. de; VÉRAS, A. A.; KUEHN, C. C. A silent threat, the growth of oral Trypanossoma Cruzi infections: An integrative review. Research, Society and Development, [S. l.], v. 13, n. 2, p. e11213245108, 2024. DOI: 10.33448/rsd-v13i2.45108. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/45108. Acesso em: 16 nov. 2024.

Issue

Section

Health Sciences