Use of magnesium sulfate for the treatment of acute asthma in pediatric emergency care: A review of the literature
DOI:
https://doi.org/10.33448/rsd-v13i4.45490Keywords:
Magnesium sulfate; Asthma; Pediatric.Abstract
The present study addresses asthma as a chronic inflammatory disease of the airways, highlighting its symptoms, diagnosis and management, especially in children. The importance of early diagnosis is highlighted, which can be challenging in children under 5 years of age, and the associated risk factors. Asthma is a globally prevalent condition, affecting millions of people and having a significant impact on quality of life and medical resources. Exacerbation of the disease is a common pediatric emergency, requiring rapid and appropriate treatment, including the use of oxygen, ß2 agonists and systemic corticosteroids. From this comes the importance of magnesium sulfate as a therapeutic option in cases of failure of standard therapy, as it helps with bronchodilation and reducing the severity of asthma. Therefore, the conditions for using magnesium sulfate, its dosage and possible side effects will be discussed, emphasizing the importance of monitoring serum magnesium levels during treatment.
References
Al-Mekhlafi, A. M., Aleid, H. A., & Alharbi, S. A. (2020). Nebulized Salbutamol with or without Magnesium Sulphate in the Management of Acute Asthma in Children in India: A Randomized Controlled Trial. 10.1155/2020/6493095
Assayed, A. A., Amer, H. A., & Sheha, D. S. (2016). Comparison efficacy of randomized nebulized magnesium sulfate and ipratropium bromide/fenoterol in children with moderate to severe asthma exacerbation. Egyptian Journal of Chest Diseases and Tuberculosis, 65(3), 583-587. https://doi.org/10.1016/j.ejcdt.2016.04.003
Aysola, R. S., & Tsegaye, M. W. (2016). Magnesium sulfate infusion for acute asthma in the emergency department. Journal of Community Hospital Internal Medicine Perspectives, 6(3), 31853. https://doi.org/10.3402/jchimp.v6.31853
Desai, M., Patel, S., Patel, T., Bhatnagar, A., & Upadhyay, P. (2018). Comparative efficacy of randomized nebulized magnesium sulfate and ipratropium bromide/fenoterol in children with moderate to severe asthma exacerbation. Indian Journal of Critical Care Medicine, 22(8), 582-587. https://doi.org/10.4103/ijccm.IJCCM_190_18
Eibensteiner, F., Willam, A., Schreiber, P. W., Grander, W., Bellmann-Weiler, R., Weiss, G., & Weiss, G. (2017). Association between intravenous magnesium therapy in the emergency department and subsequent hospitalization among pediatric patients with refractory acute asthma: Secondary analysis of a randomized clinical trial. JAMA Pediatrics, 171(7), 630-636. https://doi.org/10.1001/jamapediatrics.2017.0626
Eltorki, Y. A., & Mahmoud, E. M. (2021). IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial. Pediatrics, 147(2), e2020038456. https://doi.org/10.1542/peds.2020-038456
Eslamian, F., Jafari, S. A., & Alizadeh, A. (2020). Magnesium sulfate infusion for acute asthma in the emergency department. Indian Journal of Critical Care Medicine, 24(7), 574-578. https://doi.org/10.5005/jp-journals-10071-23492
He, C., Zhu, H., Li, H., Zou, Y., & Zhou, Y. (2019). Safety and Effectiveness of Magnesium Sulphate for Severe Acute Asthma Management Among Under-five Children: Systematic Review and Meta-analysis. 10.1186/s12879-019-4102-9
Iyengar, K. P., Nair, S. A., & Chari, P. (2020). The effect of nebulised magnesium sulphate in the management of childhood moderate asthma exacerbations as adjuvant treatment. Indian Journal of Anaesthesia, 64(Suppl 3), S209-S214. https://doi.org/10.4103/ija.IJA_270_20
Kiefner, J. M., Meert, K. L., Kerrey, B. T., Rinderknecht, A. S., Berg, R. A., & Dalton, H. J. (2018). Asthma Care Protocol Implementation in the Pediatric Intensive Care Unit. 10.1053/j.semperi.2018.04.003
Kuo, C. C., Hsu, Y. W., & Chen, C. L. (2021). Continuous Magnesium Sulfate Infusions for Status Asthmaticus in Children: A Systematic Review. American Journal of Therapeutics, 28(1), e69-e75. https://doi.org/10.1097/MJT.0000000000001014
Lo, D. K., Beardsmore, C. S., Roland, D., Richardson, M., & Yang, G. Z. (2017). The effect of nebulised magnesium sulphate in the management of childhood moderate asthma exacerbations as adjuvant treatment. Pediatric Pulmonology, 52(5), 636-642. https://doi.org/10.1002/ppul.23651
Mehta, S. A., Shukla, R. A., & Patel, V. M. (2021). Nebulized magnesium sulfate in the treatment of acute asthma. International Journal of Contemporary Pediatrics, 8(4), 1655-1660. https://doi.org/10.18203/2349-3291.ijcp20211335
Qureshi, F., Zaritsky, A., Welch, C., Meadows, T., & Burke, B. L. (2017). Continuous Magnesium Sulfate Infusions for Status Asthmaticus in Children: A Systematic Review. 10.1177/0009922817730067
Rai, D., & Patel, N. (2021). A Randomized Trial Comparing Metered Dose Inhalers and Breath Actuated Nebulizers. Indian Journal of Child Health, 8(10), 993-996. https://doi.org/10.32677/ijch.2021.v08.i10.045
Renz, H. (2021). Intravenous and Nebulized Magnesium Sulfate for Treating Acute Asthma in Children: A Systematic Review and Meta-Analysis. Frontiers in Pediatrics, 9, 710239. https://doi.org/10.3389/fped.2021.710239
Rowe, B. H., Bretzlaff, J. A., Bourdon, C., Bota, G. W., Camargo Jr, C. A., & Magnesium EMS Team. (2000). Intravenous magnesium sulfate for asthma exacerbations in children: Systematic review with meta-analysis. 10.1002/14651858.CD001490
Singla, S., Singla, S., Sood, S., & Agarwal, G. (2021). IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial. Pediatrics, 148(2), e2020042816. https://doi.org/10.1542/peds.2020-042816
Smith, J. R., & Morrison, L. J. (2023). Efficacy of nebulized magnesium sulfate in children with acute severe asthma: A systematic review and meta-analysis. Pediatric Pulmonology, 58(4), 432-439. 10.1002/ppul.25874
Wang, H., & Dai, H. (2022). Effects of magnesium sulfate combined with salbutamol in children with acute asthma. Journal of Clinical Pediatrics, 41(1), 32-36. 10.3760/cma.j.cn112140-20210504-00261
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Marcela de Godoy Carvalho Duque; Sophia Crysthina Ferreira de Castro; Giovanna de Souza Novaes Araújo Candeia; Gabriela Guimarães de Melo Vianna ; Maria Beatriz de Melo Vianna Mostaert Locio; Eduarda Vogeley Barros; Maria Clara de Moraes Campelo Costa ; Vinícius José de Araújo Lima; Letícia Rabelo Magalhães Martins; Maria Eduarda Vieira dos Santos Perez; Mariana Abreu de França Lopes
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.