Epidemiological profile of deaths from leukemia in Brazil from 2018 to 2023
DOI:
https://doi.org/10.33448/rsd-v13i5.45648Keywords:
Leukemia; Lymphoid leukemia; Myeloid leukemia.Abstract
Leukemias are neoplasms that affect hematopoietic tissue. These neoplasms do not have a completely known etiology, however, it is known that they are related to a complex set of factors, which include various mutations, infections, environmental exposure and lifestyle habits. Leukemias are classified according to the cell lineage affected and how the disease progresses. This diverse group of neoplasms is related to several deaths annually throughout the world. The objective of this study was to epidemiologically characterize leukemia deaths recorded in Brazil during the period from January 2018 to October 2023. For this study, mortality data were collected from the Department of Informatics of the Unified Health System (DATASUS). The data were tabulated and descriptive statistics were performed. The five regions of the country were considered (north, south, central-west, southeast and northeast), male and female sexes, age groups from 0 to over 80 years old and races/color (white, brown, black, without information, yellow and indigenous). From data analysis, it was observed that the highest number of deaths was concentrated in the southeast region. Other factors such as male sex and older age group were associated with higher mortality from leukemia. Regarding the assessment of races, more deaths were observed among white individuals. It is possible that the socioeconomic differences present between different regions of the country and races have an impact on access to health services, adequate diagnosis and notification.
References
Bailey, N. G., & Elenitoba-Johnson, K. S. J. (2020). Impact of Genetics on Mature Lymphoid Leukemias and Lymphomas. Cold Spring Harbor Perspectives in Medicine, a035444. https://doi.org/10.1101/cshperspect.a035444
Bispo, J. A. B., Pinheiro, P. S., & Kobetz, E. K. (2020). Epidemiology and Etiology of Leukemia and Lymphoma. Cold Spring Harbor Perspectives in Medicine, 10(6). https://doi.org/10.1101/cshperspect.a034819
Borim, L. N. B., Ruiz, M. A., Conte, A. C. F., & Camargo, B. (2000). Estado nutricional como fator prognóstico em crianças portadoras de Leucemia Linfocítica Aguda. Revista Brasileira de Hematologia E Hemoterapia, 22(1). https://doi.org/10.1590/s1516-84842000000100007
Bousfield Da Silva, D., & Povaluk, P. (n.d.). Epidemiologia das Leucemias em crianças de um Centro de Referência Estadual. Retrieved January 1, 2024, from https://www.acm.org.br/acm/revista/pdf/artigos/19.pdf
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492
Carvalho, T., Santiago-Neto, J., Cavalcante, T., Linhares, G., Lopes, C., Filho, R., Trevia, G., Sousa, C., Parente, A., Santos, F., & Santos, F. (2022). Taxa de mortalidade por leucemias no Brasil: um estudo epidemiológico. Hematology, Transfusion and Cell Therapy, 44, S652–S653. https://doi.org/10.1016/j.htct.2022.09.1121
Chiorazzi, N., Chen, S.-S., & Rai, K. R. (2020). Chronic Lymphocytic Leukemia. Cold Spring Harbor Perspectives in Medicine, a035220. https://doi.org/10.1101/cshperspect.a035220
Cortes, J., Pavlovsky, C., & Saußele, S. (2021). Chronic myeloid leukaemia. The Lancet, 398(10314). https://doi.org/10.1016/S0140-6736(21)01204-6
D. Preisler, H. (1994). The leukemias. Disease-a-Month, 40(10), 529–579. https://doi.org/10.1016/0011-5029(94)90015-9
De Kouchkovsky, I., & Abdul-Hay, M. (2016). “Acute myeloid leukemia: a comprehensive review and 2016 update.” Blood Cancer Journal, 6(7), e441–e441. https://doi.org/10.1038/bcj.2016.50
Dong, Y., Shi, O., Zeng, Q., Lu, X., Wang, W., Li, Y., & Wang, Q. (2020). Leukemia incidence trends at the global, regional, and national level between 1990 and 2017. Experimental Hematology & Oncology, 9(1). https://doi.org/10.1186/s40164-020-00170-6
Du, M., Chen, W., Liu, K., Wang, L., Hu, Y., Mao, Y., Sun, X., Luo, Y., Shi, J., Shao, K., Huang, H., & Ye, D. (2022). The Global Burden of Leukemia and Its Attributable Factors in 204 Countries and Territories: Findings from the Global Burden of Disease 2019 Study and Projections to 2030. Journal of Oncology, 2022, 1–14. https://doi.org/10.1155/2022/1612702
Fonsêca, N. C., de Souza, A. B. M., Barros, L. D. P. N., Rosa, L. P., Veigas, K. I. S., da Silva Pereira, A. C., & Oliveira, R. A. G. (2023). Perfil das internações hospitalares por leucemia no Maranhão, 2008-2021: epidemiologia e mortalidade. Revista Eletrônica Acervo Médico, 23(2), e11955-e11955.
Huang, J., Chan, S. C., Ngai, C. H., Lok, V., Zhang, L., Lucero-Prisno, D. E., Xu, W., Zheng, Z.-J., Elcarte, E., Withers, M., & Wong, M. C. S. (2022). Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.904292
Iacobucci, I., & Mullighan, C. G. (2017). Genetic Basis of Acute Lymphoblastic Leukemia. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 35(9), 975–983. https://doi.org/10.1200/JCO.2016.70.7836
Maia, C. S., Lira, P. R. de B., Sousa, J. A. de, Júnior, M. A. D., & Maciel, G. E. de S. (2015). Relação das variáveis epidemiológicas com o número de óbitos na leucemia infantil, Paraíba, BrasiL. Revista saúde & ciência, 4(2), 28–38. https://doi.org/10.35572/rsc.v4i2.249
Martins, K., Araújo, L., Greco, C., Mazzoni, S., & Souza, F. (2023). Estudo retrospectivo e comparativo do número de óbitos por leucemia entre as regiões do Brasil no ano de 2022. Hematology, Transfusion and Cell Therapy, 45, S986. https://doi.org/10.1016/j.htct.2023.09.1771
Miranda-Filho, A., Piñeros, M., Ferlay, J., Soerjomataram, I., Monnereau, A., & Bray, F. (2018). Epidemiological patterns of leukaemia in 184 countries: a population-based study. The Lancet Haematology, 5(1), e14–e24. https://doi.org/10.1016/s2352-3026(17)30232-6
PEJOVIC, T., & SCHWARTZ, P. E. (2002). Leukemias. Clinical Obstetrics and Gynecology, 45(3), 866–878. https://doi.org/10.1097/00003081-200209000-00033
Shitsuka, D. M., Pereira, A. S., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. UFSM.
Short, N. J., Rytting, M. E., & Cortes, J. E. (2018). Acute myeloid leukaemia. The Lancet, 392(10147), 593–606. https://doi.org/10.1016/s0140-6736(18)31041-9
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21660
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21660
Whiteley, A. E., Price, T. T., Cantelli, G., & Sipkins, D. A. (2021). Leukaemia: a model metastatic disease. Nature Reviews Cancer, 21(7), 461–475. https://doi.org/10.1038/s41568-021-00355-z
World Health Organization (WHO). Internacional Agency for Research on Cancer. Leukaemia –Source: Globocan 2020. The Global Cancer Observatory, 2020. Disponível em: https://gco.iarc.fr/today/data/factsheets/cancers/36-Leukaemia-fact-sheet.pdf.Acessado em: 01 de janeiro de 2024.
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Copyright (c) 2024 Daniele Carvalho da Cruz; Sérgio Manuel Coelho Fernando ; Rafael Joseph Macedo Paradis; Avive Carolina Brandão Ribeiro; Ana Victoria Lima Passos da Silva; Carlos da Silva Muniz Filho; Beatriz Rodrigues Ferraz; Luiz Phillipe Silva Azevedo ; Maísa Hortência Passos Gomes; Carla Azevedo Prado; Malanny Santos Araújo
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